KEGG   PATHWAY: ecob02010
Entry
ecob02010                   Pathway                                
Name
ABC transporters - Escherichia coli B C3029
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
Pathway map
ecob02010  ABC transporters
ecob02010

Other DBs
GO: 0043190 0043191 0043192
TC: 3.A.1
Organism
Escherichia coli B C3029 [GN:ecob]
Gene
C3029_16230  thiosulfate transporter subunit [KO:K02048]
C3029_01205  sulfate transporter subunit [KO:K23163]
C3029_16225  sulfate/thiosulfate transporter subunit [KO:K02046]
C3029_16220  cysW; sulfate/thiosulfate transporter permease subunit [KO:K02047]
C3029_16215  sulfate/thiosulfate transporter subunit [KO:K02045] [EC:7.3.2.3]
C3029_05405  tauA; taurine ABC transporter substrate-binding protein [KO:K15551]
C3029_05415  taurine transporter subunit [KO:K15552]
C3029_05410  tauB; taurine transporter ATP-binding subunit [KO:K10831] [EC:7.6.2.7]
C3029_09095  alkanesulfonate transporter substrate-binding subunit [KO:K15553]
C3029_09085  ssuC; alkanesulfonate transporter permease subunit [KO:K15554]
C3029_09080  ssuB; aliphatic sulfonate ABC transporter ATP-binding protein [KO:K15555] [EC:7.6.2.14]
C3029_04085  tbpA; thiamine ABC transporter substrate-binding protein [KO:K02064]
C3029_04080  thiP; thiamine ABC transporter permease [KO:K02063]
C3029_04075  thiQ; thiamine ABC transporter ATP-binding protein [KO:K02062] [EC:7.6.2.15]
C3029_10080  potD; spermidine/putrescine ABC transporter substrate-binding protein [KO:K11069]
C3029_10085  potC; spermidine/putrescine ABC transporter permease [KO:K11070]
C3029_10090  potB; spermidine/putrescine ABC transporter permease [KO:K11071]
C3029_10095  potA; putrescine/spermidine ABC transporter ATP-binding protein [KO:K11072] [EC:7.6.2.11]
C3029_08680  spermidine/putrescine ABC transporter substrate-binding protein [KO:K11073]
C3029_08695  spermidine/putrescine ABC transporter permease [KO:K11074]
C3029_08690  spermidine/putrescine ABC transporter permease [KO:K11075]
C3029_08685  potG; putrescine transporter ATP-binding subunit [KO:K11076] [EC:7.6.2.16]
C3029_17355  proX; glycine/betaine ABC transporter substrate-binding protein [KO:K02002]
C3029_17350  glycine/betaine ABC transporter permease [KO:K02001]
C3029_17345  glycine betaine/L-proline ABC transporter ATP-binding protein [KO:K02000] [EC:7.6.2.9]
C3029_14830  osmoprotectant uptake system substrate-binding protein [KO:K05845]
C3029_14815  osmoprotectant uptake system permease [KO:K05846]
C3029_14825  osmoprotectant uptake system permease [KO:K05846]
C3029_14820  ATP-binding protein [KO:K05847] [EC:7.6.2.9]
C3029_01815  malE; maltose ABC transporter substrate-binding protein MalE [KO:K10108]
C3029_01810  malF; maltose transporter [KO:K10109]
C3029_01805  malG; maltose transporter permease [KO:K10110]
C3029_01825  maltose/maltodextrin transporter ATP-binding protein [KO:K10111] [EC:7.5.2.-]
C3029_11040  sugar ABC transporter ATP-binding protein [KO:K10112] [EC:7.5.2.-]
C3029_16830  sugar ABC transporter substrate-binding protein [KO:K23545]
C3029_16820  sugar ABC transporter permease [KO:K23546]
C3029_16825  heme ABC transporter ATP-binding protein [KO:K23547]
C3029_19970  ABC transporter substrate-binding protein [KO:K07323]
C3029_19975  outer membrane lipid asymmetry maintenance protein MlaD [KO:K02067]
C3029_19980  ABC transporter permease [KO:K02066]
C3029_19965  phospholipid ABC transporter substrate-binding protein [KO:K07122]
C3029_19985  ABC transporter ATP-binding protein [KO:K02065]
C3029_17965  LacI family transcriptional regulator [KO:K10439]
C3029_00265  D-ribose ABC transporter substrate-binding protein [KO:K10439]
C3029_17970  ribose ABC transporter permease [KO:K10440]
C3029_00260  rbsC; ribose ABC transporter permease [KO:K10440]
C3029_17975  D-ribose transporter ATP-binding protein [KO:K10441] [EC:7.5.2.7]
C3029_00255  ribose ABC transporter ATP-binding protein RbsA [KO:K10441] [EC:7.5.2.7]
C3029_13950  sugar ABC transporter substrate-binding protein [KO:K10537]
C3029_13940  araH; L-arabinose transporter permease [KO:K10538]
C3029_13945  araG; L-arabinose transporter ATP-binding protein [KO:K10539] [EC:7.5.2.12]
C3029_02840  sugar ABC transporter substrate-binding protein [KO:K23508]
C3029_02850  sugar ABC transporter permease [KO:K23509]
C3029_02855  sugar ABC transporter permease [KO:K23509]
C3029_02845  sugar ABC transporter ATP-binding protein [KO:K10820] [EC:7.5.2.9]
C3029_14915  mglC; beta-methylgalactoside transporter permease [KO:K10541]
C3029_14920  sugar ABC transporter ATP-binding protein [KO:K10542] [EC:7.5.2.11]
C3029_21920  xylF; D-xylose transporter subunit XylF [KO:K10543]
C3029_21930  sugar ABC transporter permease [KO:K10544]
C3029_02110  allose ABC transporter [KO:K10549]
C3029_02100  allose ABC transporter [KO:K10550]
C3029_02105  allose ABC transporter ATP-binding protein [KO:K10551] [EC:7.5.2.8]
C3029_21275  glycerol-3-phosphate ABC transporter substrate-binding protein [KO:K05813]
C3029_21270  glycerol-3-phosphate transporter permease [KO:K05814]
C3029_21265  glycerol-3-phosphate transporter [KO:K05815]
C3029_21260  ugpC; glycerol-3-phosphate transporter ATP-binding subunit [KO:K05816] [EC:7.6.2.10]
C3029_00135  phosphate ABC transporter substrate-binding protein [KO:K02040]
C3029_00130  pstC; phosphate transporter permease subunit PstC [KO:K02037]
C3029_00125  pstA; phosphate transporter permease subunit PtsA [KO:K02038]
C3029_00120  phosphate ABC transporter ATP-binding protein [KO:K02036] [EC:7.3.2.1]
C3029_02190  phosphonate ABC transporter substrate-binding protein [KO:K02044]
C3029_02185  phosphonate ABC transporter permease [KO:K02042]
C3029_02195  phosphonate ABC transporter ATP-binding protein [KO:K02041] [EC:7.3.2.2]
C3029_15735  histidine ABC transporter substrate-binding protein HisJ [KO:K10013]
C3029_15720  amino acid ABC transporter permease [KO:K10015]
C3029_15725  amino acid ABC transporter permease [KO:K10016]
C3029_15715  amino acid transporter [KO:K10017] [EC:7.4.2.1]
C3029_15730  histidine ABC transporter substrate-binding protein HisJ [KO:K10014]
C3029_08320  glnH; glutamine ABC transporter substrate-bindnig protein [KO:K10036]
C3029_08315  glnP; glutamine ABC transporter permease [KO:K10037]
C3029_08310  glnQ; glutamine ABC transporter ATP-binding protein [KO:K10038] [EC:7.4.2.1]
C3029_08710  arginine ABC transporter substrate-binding protein [KO:K09996]
C3029_08725  arginine ABC transporter substrate-binding protein [KO:K09997]
C3029_08715  artM; arginine transporter permease subunit ArtM [KO:K09998]
C3029_08720  arginine transporter permease subunit ArtQ [KO:K09999]
C3029_08730  arginine ABC transporter ATP-binding protein [KO:K10000] [EC:7.4.2.1]
C3029_06900  amino acid transporter [KO:K10001]
C3029_06890  amino acid ABC transporter permease [KO:K10002]
C3029_06895  amino acid ABC transporter permease [KO:K10003]
C3029_20340  amino acid ABC transporter substrate-binding protein [KO:K09969]
C3029_20345  amino acid ABC transporter permease [KO:K09970]
C3029_20350  amino acid ABC transporter permease [KO:K09971]
C3029_20355  ABC transporter ATP-binding protein [KO:K09972] [EC:7.4.2.1]
C3029_21305  leucine ABC transporter subunit substrate-binding protein LivK [KO:K01999]
C3029_21320  leucine ABC transporter subunit substrate-binding protein LivK [KO:K01999]
C3029_21300  branched-chain amino acid transporter permease subunit LivH [KO:K01997]
C3029_21295  livM; branched-chain amino acid ABC transporter permease [KO:K01998]
C3029_21290  livG; high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG [KO:K01995]
C3029_21285  livF; ABC transporter ATP-binding protein [KO:K01996]
C3029_22535  hypothetical protein [KO:K02073]
C3029_04760  metQ; DL-methionine transporter substrate-binding subunit [KO:K02073]
C3029_04765  DL-methionine transporter permease subunit [KO:K02072]
C3029_04770  metN; DL-methionine transporter ATP-binding subunit [KO:K02071]
C3029_10615  peptide ABC transporter substrate-binding protein [KO:K15580]
C3029_11105  peptide ABC transporter substrate-binding protein [KO:K15580]
C3029_10620  oppB; oligopeptide transporter permease [KO:K15581]
C3029_10625  peptide ABC transporter permease [KO:K15582]
C3029_10630  oppD; oligopeptide transporter ATP-binding component [KO:K15583]
C3029_10635  peptide ABC transporter ATP-binding protein [KO:K10823]
C3029_21790  peptide ABC transporter substrate-binding protein [KO:K12368]
C3029_21780  peptide transporter [KO:K12369]
C3029_21775  peptide transporter [KO:K12370]
C3029_21770  dppD; peptide ABC transporter ATP-binding protein [KO:K12371]
C3029_21765  dppF; peptide ABC transporter ATP-binding protein [KO:K12372]
C3029_10915  peptide ABC transporter substrate-binding protein [KO:K19226]
C3029_10910  peptide ABC transporter permease [KO:K19227]
C3029_10905  peptide ABC transporter permease [KO:K19228]
C3029_10900  peptide ABC transporter ATP-binding protein [KO:K19229]
C3029_10895  peptide ABC transporter ATP-binding protein [KO:K19230]
C3029_21400  nickel ABC transporter substrate-binding protein [KO:K15584]
C3029_21405  nickel ABC transporter permease subunit NikB [KO:K15585]
C3029_21410  nikC; nickel ABC transporter permease subunit NikC [KO:K15586]
C3029_21415  nikD; nickel import ATP-binding protein NikD [KO:K15587] [EC:7.2.2.11]
C3029_21420  nikE; nickel import ATP-binding protein NikE [KO:K10824] [EC:7.2.2.11]
C3029_08420  glutathione ABC transporter substrate-binding protein [KO:K13889]
C3029_08425  glutathione ABC transporter permease [KO:K13890]
C3029_08430  glutathione ABC transporter permease [KO:K13891]
C3029_08415  glutathione ABC transporter ATP-binding protein [KO:K13892]
C3029_15075  antibiotic ABC transporter substrate-binding protein [KO:K13893]
C3029_15080  microcin ABC transporter permease [KO:K13894]
C3029_15085  microcin ABC transporter permease [KO:K13895]
C3029_15090  microcin ABC transporter ATP-binding protein [KO:K13896]
C3029_03155  fecB; iron-dicitrate transporter substrate-binding subunit [KO:K23181]
C3029_03145  fecD; iron-dicitrate transporter subunit FecD [KO:K23182]
C3029_03150  fecC; iron-dicitrate transporter permease subunit [KO:K23183]
C3029_03140  iron ABC transporter [KO:K23184] [EC:7.2.2.18]
C3029_06575  iron-enterobactin ABC transporter substrate-binding protein [KO:K23185]
C3029_06565  iron-enterobactin transporter [KO:K23186]
C3029_06560  iron-enterobactin transporter permease [KO:K23187]
C3029_06555  iron-enterobactin transporter ATP-binding protein [KO:K23188] [EC:7.2.2.17 7.2.2.-]
C3029_04535  iron-hydroxamate transporter substrate-binding subunit [KO:K23227]
C3029_04540  iron-hydroxamate transporter permease subunit [KO:K23228]
C3029_04530  iron-hydroxamate transporter ATP-binding subunit [KO:K10829] [EC:7.2.2.16]
C3029_04565  cobalamin-binding protein [KO:K06858]
C3029_12935  vtamin B12-transporter permease [KO:K06073]
C3029_12925  vitamin B12-transporter ATPase [KO:K06074] [EC:7.6.2.8]
C3029_13745  znuA; zinc ABC transporter substrate-binding protein [KO:K09815]
C3029_13755  znuB; high-affinity zinc transporter membrane component [KO:K09816]
C3029_13750  znuC; Mn2+/Zn2+ABC transporter ATP-binding protein [KO:K09817] [EC:7.2.2.20]
C3029_11950  autoinducer 2-binding protein lsrB [KO:K10555]
C3029_11945  histidine kinase [KO:K10557]
C3029_10035  outer membrane-specific lipoprotein transporter subunit LolC [KO:K09808]
C3029_10045  outer membrane-specific lipoprotein transporter subunit LolE [KO:K09808]
C3029_10040  lolD; lipoprotein ABC transporter ATP-binding protein [KO:K09810] [EC:7.6.2.-]
C3029_15175  cytochrome C biogenesis protein CcmD [KO:K02196]
C3029_15180  heme ABC transporter permease [KO:K02195]
C3029_15185  heme ABC transporter permease [KO:K02194]
C3029_15190  heme ABC transporter ATP-binding protein CcmA [KO:K02193] [EC:7.6.2.5]
C3029_18890  LPS export ABC transporter permease LptF [KO:K07091]
C3029_03000  LPS export ABC transporter permease LptF [KO:K07091]
C3029_18885  LPS export ABC transporter permease LptG [KO:K11720]
C3029_03005  LPS export ABC transporter permease LptG [KO:K11720]
C3029_20015  LPS export ABC transporter ATP-binding protein [KO:K06861] [EC:7.5.2.5]
C3029_21330  ftsX; cell division protein FtsX [KO:K09811]
C3029_21335  cell division ATP-binding protein FtsE [KO:K09812]
C3029_08980  lipid A export permease/ATP-binding protein MsbA [KO:K11085] [EC:7.5.2.6]
C3029_05845  multidrug ABC transporter ATP-binding protein [KO:K18889]
C3029_05850  multidrug ABC transporter ATP-binding protein [KO:K18890]
C3029_08845  cysteine/glutathione ABC transporter ATP-binding protein/permease CydC [KO:K16012]
C3029_08850  cysteine/glutathione ABC transporter permease/ATP-binding protein CydD [KO:K16013]
C3029_08810  macrolide transporter [KO:K05685] [EC:7.6.2.-]
C3029_15245  multidrug transporter membrane component/ATP-binding component [KO:K06159]
C3029_11860  multidrug ABC transporter ATP-binding protein [KO:K02471]
Compound
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00032  Heme
C00034  Manganese
C00037  Glycine
C00038  Zinc cation
C00041  L-Alanine
C00047  L-Lysine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00062  L-Arginine
C00064  L-Glutamine
C00065  L-Serine
C00070  Copper
C00077  L-Ornithine
C00079  L-Phenylalanine
C00086  Urea
C00088  Nitrite
C00089  Sucrose
C00093  sn-Glycerol 3-phosphate
C00095  D-Fructose
C00098  Oligopeptide
C00107  Dipeptide
C00114  Choline
C00116  Glycerol
C00120  Biotin
C00121  D-Ribose
C00123  L-Leucine
C00134  Putrescine
C00135  L-Histidine
C00137  myo-Inositol
C00140  N-Acetyl-D-glucosamine
C00148  L-Proline
C00151  L-Amino acid
C00159  D-Mannose
C00175  Cobalt ion
C00181  D-Xylose
C00183  L-Valine
C00185  Cellobiose
C00188  L-Threonine
C00208  Maltose
C00212  Adenosine
C00243  Lactose
C00244  Nitrate
C00245  Taurine
C00255  Riboflavin
C00259  L-Arabinose
C00288  HCO3-
C00291  Nickel
C00294  Inosine
C00299  Uridine
C00315  Spermidine
C00320  Thiosulfate
C00330  Deoxyguanosine
C00333  D-Galacturonate
C00338  Lipopolysaccharide
C00378  Thiamine
C00379  Xylitol
C00387  Guanosine
C00392  Mannitol
C00407  L-Isoleucine
C00430  5-Aminolevulinate
C00470  Pectate
C00475  Cytidine
C00487  Carnitine
C00491  L-Cystine
C00492  Raffinose
C00503  Erythritol
C00526  Deoxyuridine
C00559  Deoxyadenosine
C00719  Betaine
C00794  D-Sorbitol
C00855  D-Methionine
C00865  Phospholipid
C00881  Deoxycytidine
C00919  Choline sulfate
C00973  Cyclomaltodextrin
C01083  alpha,alpha-Trehalose
C01153  Orthophosphoric monoester
C01157  Hydroxyproline
C01177  Inositol 1-phosphate
C01181  4-Trimethylammoniobutanoate
C01279  4-Amino-5-hydroxymethyl-2-methylpyrimidine
C01330  Sodium cation
C01417  Cyanate
C01487  D-Allose
C01606  Phthalate
C01630  Xylobiose
C01667  Bacitracin
C01674  Chitobiose
C01682  Nopaline
C01684  D-Rhamnose
C01762  Xanthosine
C01834  Lipoprotein
C01835  Maltotriose
C01935  Maltodextrin
C01946  Oleandomycin
C02160  Isomaltotriose
C02273  Digalacturonate
C03557  2-Aminoethylphosphonate
C03611  Galactose oligosaccharide
C03619  Methyl beta-D-galactoside
C04114  (E)-4-(Trimethylammonio)but-2-enoate
C04137  Octopine
C05349  Ciprofloxacin
C05402  Melibiose
C05512  Deoxyinosine
C05776  Vitamin B12
C06227  Fe(III)hydroxamate
C06229  Fe(III)dicitrate
C06230  Fe-enterobactin
C06232  Molybdate
C06687  Norfloxacin
C06705  Capsular polysaccharide
C06706  Lipo-oligosaccharide
C06707  Teichoic acid
C06767  Hemine
C07662  Sparfloxacin
C07663  Moxifloxacin
C11612  Polymyxin B
C13768  Colistin sulfate
C14818  Fe2+
C14819  Fe3+
C15521  Alkanesulfonate
C15719  Coelichelin
C16421  AI-2
C16692  Mannopine
C19609  Nickel(2+)
C19872  N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570  alpha-1,5-L-Arabinobiose
C20571  alpha-1,5-L-Arabinotriose
C20572  alpha-1,5-L-Arabinotetraose
C20573  Aldotetraouronic acid
C20679  Tungstate
C21066  D-Galactofuranose
C22040  S-Methyl-L-cysteine
G00457  Maltotetraose
Reference
PMID:9799792
  Authors
Tomii K, Kanehisa M.
  Title
A comparative analysis of ABC transporters in complete microbial genomes.
  Journal
Genome Res 8:1048-59 (1998)
DOI:10.1101/gr.8.10.1048
Reference
PMID:18424520
  Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
  Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
J Bacteriol 190:4460-9 (2008)
DOI:10.1128/JB.00270-08
Reference
PMID:18375759
  Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
  Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
Proc Natl Acad Sci U S A 105:5537-42 (2008)
DOI:10.1073/pnas.0801196105
Reference
PMID:10557362
  Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
  Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
  Journal
Proc Natl Acad Sci U S A 96:13571-6 (1999)
DOI:10.1073/pnas.96.23.13571
Reference
PMID:11731493
  Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
  Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
  Journal
Genome Res 11:2034-40 (2001)
DOI:10.1101/gr.196301
Reference
PMID:16135226
  Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
  Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
  Journal
Mol Microbiol 57:1582-92 (2005)
DOI:10.1111/j.1365-2958.2005.04791.x
Reference
PMID:11929526
  Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
  Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
  Journal
Mol Microbiol 43:703-15 (2002)
DOI:10.1046/j.1365-2958.2002.02778.x
Reference
PMID:18326572
  Authors
Richard-Fogal CL, Frawley ER, Kranz RG
  Title
Topology and function of CcmD in cytochrome c maturation.
  Journal
J Bacteriol 190:3489-93 (2008)
DOI:10.1128/JB.00146-08
Reference
PMID:16109926
  Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
  Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
  Journal
J Bacteriol 187:5861-7 (2005)
DOI:10.1128/JB.187.17.5861-5867.2005
Reference
PMID:17873039
  Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
  Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
  Journal
J Bacteriol 189:8361-5 (2007)
DOI:10.1128/JB.01028-07
Reference
PMID:17214741
  Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
  Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
  Journal
Mol Microbiol 63:895-910 (2007)
DOI:10.1111/j.1365-2958.2006.05549.x
Reference
PMID:18805970
  Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
  Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
  Journal
J Bacteriol 190:7693-8 (2008)
DOI:10.1128/JB.00853-08
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