Entry Name ABC transporters - Escherichia coli W
Description The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class Environmental Information Processing; Membrane transportBRITE hierarchy
Pathway map Ortholog table Other DBs Organism Escherichia coli W [GN:
ell ]
Gene WFL_12980 cysW; sulfate/thiosulfate transporter permease subunit [KO:K02047 ]
WFL_05095 ssuA; alkanesulfonate transporter substrate-binding subunit [KO:K15553 ]
WFL_03950 modF; putative molybdenum transport ATP-binding protein ModF [KO:K05776 ]
WFL_06015 potD; spermidine/putrescine ABC transporter periplasmic substrate-binding protein [KO:K11069 ]
WFL_06020 potC; spermidine/putrescine ABC transporter membrane protein [KO:K11070 ]
WFL_06025 potB; spermidine/putrescine ABC transporter membrane protein [KO:K11071 ]
WFL_04685 potF; putrescine transporter subunit: periplasmic-binding component of ABC superfamily [KO:K11073 ]
WFL_04700 potI; putrescine transporter subunit: membrane component of ABC superfamily [KO:K11074 ]
WFL_04695 potH; putrescine transporter subunit: membrane component of ABC superfamily [KO:K11075 ]
WFL_14055 proX; glycine betaine transporter periplasmic subunit [KO:K02002 ]
WFL_11410 osmF; putative transporter subunit: periplasmic-binding component of ABC superfamily protein [KO:K05845 ]
WFL_11395 yehW; ABC transporter quaternary amine uptake (QAT) family, permease protein [KO:K05846 ]
WFL_11405 yehY; putative transporter subunit: permease component of ABC superfamily protein [KO:K05846 ]
WFL_11400 yehX; putative transporter subunit: ATP-binding component of ABC superfamily transporter [KO:K05847 ] [EC:7.6.2.9 ]
WFL_21395 malK; maltose/maltodextrin transporter ATP-binding protein [KO:K10111 ] [EC:7.5.2.-]
WFL_06895 jcjV; putative sugar transporter subunit [KO:K10112 ] [EC:7.5.2.-]
WFL_13585 yphF; putative sugar transporter subunit: periplasmic-binding component of ABC superfamily protein [KO:K23545 ]
WFL_13580 yphE; fused putative sugar transporter subunits of ABC superfamily: ATP-binding components [KO:K23547 ]
WFL_16945 mlaC; ABC transporter periplasmic binding protein MlaC [KO:K07323 ]
WFL_16955 yrbE; toluene transporter subunit: membrane component of ABC superfamily [KO:K02066 ]
WFL_16960 yrbF; putative ABC transporter ATP-binding protein YrbF [KO:K02065 ]
WFL_10180 araF; L-arabinose ABC transporter substrate binding component [KO:K10537 ]
WFL_22350 yjfF; inner membrane ABC transporter permease protein YjfF [KO:K23509 ]
WFL_11500 mglB; methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB [KO:K10540 ]
WFL_11490 mglC; beta-methylgalactoside transporter inner membrane component [KO:K10541 ]
WFL_18130 ugpB; glycerol-3-phosphate transporter periplasmic binding protein [KO:K05813 ]
WFL_18120 ugpE; glycerol-3-phosphate transporter membrane protein [KO:K05815 ]
WFL_19685 pstS; phosphate ABC transporter periplasmic substrate-binding protein PstS [KO:K02040 ]
WFL_21720 phnD; phosphonate/organophosphate ester transporter subunit PhnD [KO:K02044 ]
WFL_21715 phnE; membrane channel protein component of Pn transporter [KO:K02042 ]
WFL_12235 argT; ABC transporter lysine/arginine/ornithine binding periplasmic protein [KO:K10013 ]
WFL_12220 hisM; histidine/lysine/arginine/ornithine ABC transporter permease HisM [KO:K10015 ]
WFL_12225 hisQ; histidine/lysine/arginine/ornithine ABC transporter permease HisQ [KO:K10016 ]
WFL_12230 hisJ; histidine ABC transporter substrate-binding protein HisJ [KO:K10014 ]
WFL_04715 artJ; arginine-binding periplasmic protein 2 precursor [KO:K09996 ]
WFL_04730 artI; putative ABC transporter arginine-binding protein [KO:K09997 ]
WFL_03515 gltK; glutamate/aspartate transport system permease GltK [KO:K10002 ]
WFL_03520 gltJ; glutamate/aspartate transport system permease GltJ [KO:K10003 ]
WFL_17295 yhdW; putative amino-acid ABC transporter-binding protein yhdW precursor [KO:K09969 ]
WFL_18155 livK; leucine ABC transporter subunit substrate-binding protein LivK [KO:K01999 ]
WFL_18175 livJ; leucine ABC transporter subunit substrate-binding protein LivJ [KO:K01999 ]
WFL_18150 livH; branched-chain amino acid transporter permease subunit LivH [KO:K01997 ]
WFL_18145 livM; leucine/isoleucine/valine transporter permease subunit [KO:K01998 ]
WFL_18140 livG; leucine/isoleucine/valine transporter ATP-binding subunit [KO:K01995 ]
WFL_18135 livF; leucine/isoleucine/valine transporter ATP-binding subunit [KO:K01996 ]
WFL_00960 metQ; DL-methionine transporter substrate-binding subunit [KO:K02073 ]
WFL_06505 oppA; oligopeptide ABC transporter substrate-binding protein OppA [KO:K15580 ]
WFL_06965 mppA; murein tripeptide (L-ala-gamma-D-glutamyl-meso-DAP) transporter subunit [KO:K15580 ]
WFL_06525 oppF; oligopeptide ABC transporter ATP-binding protein OppF [KO:K10823 ]
WFL_06775 sapA; antimicrobial peptide ABC transporter periplasmic binding protein SapA [KO:K19226 ]
WFL_06770 sapB; antimicrobial peptide ABC transporter permease SapB [KO:K19227 ]
WFL_06765 sapC; antimicrobial peptide ABC transporter permease SapC [KO:K19228 ]
WFL_06760 sapD; antimicrobial peptide ABC transporter ATP-binding protein [KO:K19229 ]
WFL_06755 sapF; antimicrobial peptide ABC system ATP-binding protein SapF [KO:K19230 ]
WFL_04320 gsiB; glutathione ABC transporter substrate-binding protein GsiB [KO:K13889 ]
WFL_11640 yejA; putative oligopeptide transporter subunit; periplasmic-binding component of ABC superfamily transporter [KO:K13893 ]
WFL_11655 yejF; microcin C ABC transporter ATP-binding protein YejF [KO:K13896 ]
WFL_03215 fepB; iron-enterobactin transporter periplasmic binding protein [KO:K23185 ]
WFL_00740 fhuD; iron-hydroxamate transporter substrate-binding subunit [KO:K23227 ]
WFL_09970 znuA; high-affinity zinc transporter periplasmic component [KO:K09815 ]
WFL_09980 znuB; high-affinity zinc transporter membrane component [KO:K09816 ]
WFL_15560 putative ATP-binding protein of ABC transport system [KO:K16787 ] [EC:7.-.-.-]
WFL_08040 lsrA; autoinducer 2 ABC transporter ATP-binding protein LsrA [KO:K10558 ]
WFL_05980 ycfU; outer membrane-specific lipoprotein transporter subunit LolC [KO:K09808 ]
WFL_05990 lolE; outer membrane-specific lipoprotein transporter subunit LolE [KO:K09808 ]
WFL_05985 lolD; lipoprotein transporter ATP-binding subunit [KO:K09810 ] [EC:7.6.2.-]
WFL_22505 lptF; lipopolysaccharide ABC transporter permease LptF [KO:K07091 ]
WFL_02585 mdlA; putative multidrug transporter membrane\ATP-binding components [KO:K18889 ]
WFL_02590 mdlB; putative multidrug transporter membrane\ATP-binding components [KO:K18890 ]
WFL_04840 cydC; cysteine/glutathione ABC transporter membrane/ATP-binding component [KO:K16012 ]
WFL_04845 cydD; cysteine/glutathione ABC transporter membrane/ATP-binding component [KO:K16013 ]
WFL_04810 macB; macrolide transporter ATP-binding/permease protein [KO:K05685 ] [EC:7.6.2.-]
WFL_11805 yojI; multidrug transporter membrane component/ATP-binding component [KO:K06159 ]
WFL_07950 yddA; putative multidrug transporter fused subunits of ABC superfamily transporter: permease component; ATP-binding component [KO:K02471 ]
Compound C00093 sn-Glycerol 3-phosphate
C01153 Orthophosphoric monoester
C01181 4-Trimethylammoniobutanoate
C01279 4-Amino-5-hydroxymethyl-2-methylpyrimidine
C03557 2-Aminoethylphosphonate
C03611 Galactose oligosaccharide
C03619 Methyl beta-D-galactoside
C04114 (E)-4-(Trimethylammonio)but-2-enoate
C06705 Capsular polysaccharide
C19872 N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570 alpha-1,5-L-Arabinobiose
C20571 alpha-1,5-L-Arabinotriose
C20572 alpha-1,5-L-Arabinotetraose
Reference Authors Tomii K, Kanehisa M.
Title A comparative analysis of ABC transporters in complete microbial genomes.
Journal Reference Authors Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
Title Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal Reference Authors Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
Title Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal Reference Authors Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
Title Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
Journal Reference Authors Quintero MJ, Montesinos ML, Herrero A, Flores E
Title Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
Journal Reference Authors Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
Title ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
Journal Reference Authors Valladares A, Montesinos ML, Herrero A, Flores E.
Title An ABC-type, high-affinity urea permease identified in cyanobacteria.
Journal Reference Authors Richard-Fogal CL, Frawley ER, Kranz RG
Title Topology and function of CcmD in cytochrome c maturation.
Journal Reference Authors Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
Title The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
Journal Reference Authors Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
Title The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
Journal Reference Authors Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
Title Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
Journal Reference Authors Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
Title MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
Journal KO pathway LinkDB All DBs
