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Entry
Name
ABC transporters - Escherichia coli P12b
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Escherichia coli P12b [GN:
elp ]
Gene
P12B_c0923 ssuA; ABC transporter, periplasmic substrate-binding protein, aliphatic sulfonates family [KO:K15553 ]
P12B_c0921 ssuC; Putative aliphatic sulfonates transport permease protein ssuC [KO:K15554 ]
P12B_c0726 modB; ABC-type molybdate transport system, permease component [KO:K02018 ]
P12B_c0723 modF; Putative molybdenum transport ATP-binding protein modF [KO:K05776 ]
P12B_c1983 potD; Spermidine/putrescine-binding periplasmic protein precursor [KO:K11069 ]
P12B_c1981 potB; Spermidine/putrescine ABC transporter, permease protein PotB [KO:K11071 ]
P12B_c0839 potF; putrescine transporter subunit: periplasmic-binding component of ABC superfamily [KO:K11073 ]
P12B_c0842 potI; putrescine transporter subunit: membrane component of ABC superfamily [KO:K11074 ]
P12B_c0841 potH; putrescine transporter subunit: membrane component of ABC superfamily [KO:K11075 ]
P12B_c2787 proX; Glycine betaine-binding periplasmic protein precursor [KO:K02002 ]
P12B_c2786 proW; Glycine betaine/L-proline ABC transporter, permease protein [KO:K02001 ]
P12B_c2228 yehZ; Substrate-binding region of ABC-type glycine betaine transport system precursor [KO:K05845 ]
P12B_c2225 yehW; ABC transporter, quaternary amine uptake (QAT) family, permease protein [KO:K05846 ]
P12B_c2227 yehY; ABC transporter, quaternary amine uptake (QAT) family, permease protein [KO:K05846 ]
P12B_c4142 malK; Maltose/maltodextrin import ATP-binding protein malK [KO:K10111 ] [EC:7.5.2.-]
P12B_c1776 ycjV; ABC-type sugar transport systems, ATPase component [KO:K10112 ] [EC:7.5.2.-]
P12B_c2649 yphF; ABC transporter periplasmic-binding protein yphF precursor [KO:K23545 ]
P12B_c1187 araF; L-arabinose ABC transporter, periplasmic L-arabinose-binding protein [KO:K10537 ]
P12B_c4332 ytfQ; Putative sugar ABC transporter, periplasmic sugar-binding protein [KO:K23508 ]
P12B_c4335 ytfT; Inner membrane ABC transporter permease protein ytfT [KO:K23509 ]
P12B_c3551 ugpB; sn-glycerol-3-phosphate-binding periplasmic protein ugpB precursor [KO:K05813 ]
P12B_c3550 ugpA; sn-glycerol-3-phosphate transport system permease protein ugpA [KO:K05814 ]
P12B_c3549 ugpE; sn-glycerol-3-phosphate transport system permease protein ugpE [KO:K05815 ]
P12B_c4208 phnD; Phosphonate ABC transporter, periplasmic phosphonate binding protein precursor [KO:K02044 ]
P12B_c4207 phnE; Membrane channel protein component of Pn transporter [KO:K02042 ]
P12B_c2403 argT; Lysine-arginine-ornithine-binding periplasmic protein precursor [KO:K10013 ]
P12B_c0636 gltK; Glutamate/aspartate transport system permease protein gltK [KO:K10002 ]
P12B_c0637 gltJ; Glutamate/aspartate transport system permease protein gltJ [KO:K10003 ]
P12B_c3374 Amino acid ABC transporter, periplasmic amino acid-binding protein [KO:K09969 ]
P12B_c3375 yhdX; Putative amino-acid ABC transporter permease protein yhdX [KO:K09970 ]
P12B_c3376 yhdY; Polar amino acid ABC transporter, inner membrane subunit [KO:K09971 ]
P12B_c1145 fliY; Extracellular solute-binding protein family 3 precursor [KO:K02424 ]
P12B_c3556 livK; High-affinity branched-chain amino acid ABC transporter, periplasmic leucine-specific-binding protein LivK [KO:K01999 ]
P12B_c3558 livJ; High-affinity amino acid transport protein, periplasmic binding protein [KO:K01999 ]
P12B_c3555 livH; High-affinity branched-chain amino acid transport system permease protein livH [KO:K01997 ]
P12B_c3554 livM; High-affinity branched-chain amino acid ABC transporter, permease protein LivM [KO:K01998 ]
P12B_c3553 livG; High-affinity branched-chain amino acid transport ATP-binding protein livG [KO:K01995 ]
P12B_c0186 metQ; D-methionine ABC transporter, periplasmic D-methionine-binding lipoprotein [KO:K02073 ]
P12B_c0187 yaeE; D-methionine transport system permease protein metI [KO:K02072 ]
P12B_c1896 oppB; Oligopeptide transport system permease protein oppB [KO:K15581 ]
P12B_c1895 oppC; Oligopeptide transport system permease protein oppC [KO:K15582 ]
P12B_c1893 oppF; Oligopeptide ABC transporter, ATP-binding protein OppF [KO:K10823 ]
P12B_c1799 sapA; Peptide transport periplasmic protein sapA precursor [KO:K19226 ]
P12B_c3573 nikA; Nickel ABC transporter, periplasmic nickel-binding protein NikA [KO:K15584 ]
P12B_c2273 yejA; ABC transporter, peripllasmic solute-binding proteins [KO:K13893 ]
P12B_c2274 yejB; Inner membrane ABC transporter permease protein yejB [KO:K13894 ]
P12B_c4392 fecD; Iron(III) dicitrate transport system permease protein fecD [KO:K23182 ]
P12B_c4393 fecD; Iron(III) dicitrate transport system permease protein fecD [KO:K23182 ]
P12B_c4394 fecC; Iron(III) dicitrate transport system permease protein fecC [KO:K23183 ]
P12B_c0577 fepB; Ferrienterobactin-binding periplasmic protein precursor [KO:K23185 ]
P12B_c0575 fepD; ABC-type Fe3+-siderophore transport system, permease component [KO:K23186 ]
P12B_c0574 fepG; Ferric enterobactin transport system permease protein fepG [KO:K23187 ]
P12B_c0140 fhuD; Ferrichrome ABC transporter, periplasmic ferrichrome-binding protein [KO:K23227 ]
P12B_c1562 lsrC; Autoinducer-2 ABC transporter, permease protein LsrC [KO:K10556 ]
P12B_c1561 ydeZ; Autoinducer-2 ABC transporter, permease protein LsrD [KO:K10557 ]
P12B_c3179 kpsM; ABC-type polysaccharide/polyol phosphate export systems, permease component [KO:K09688 ]
P12B_c1988 lolE; Lipoprotein-releasing system transmembrane protein lolE [KO:K09808 ]
P12B_c1990 ycfU; outer membrane-specific lipoprotein transporter subunit LolC [KO:K09808 ]
P12B_c0871 cydC; ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease/ATP-binding protein CydC precursor [KO:K16012 ]
P12B_c0872 cydD; ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [KO:K16013 ]
P12B_c0864 macB; Macrolide export ATP-binding/permease protein macB [KO:K05685 ] [EC:7.6.2.-]
P12B_c1633 yddA; Inner membrane ABC transporter ATP-binding protein yddA [KO:K02471 ]
Compound
C00093 sn-Glycerol 3-phosphate
C01153 Orthophosphoric monoester
C01181 4-Trimethylammoniobutanoate
C01279 4-Amino-5-hydroxymethyl-2-methylpyrimidine
C03557 2-Aminoethylphosphonate
C03611 Galactose oligosaccharide
C03619 Methyl beta-D-galactoside
C04114 (E)-4-(Trimethylammonio)but-2-enoate
C06705 Capsular polysaccharide
C19872 N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570 alpha-1,5-L-Arabinobiose
C20571 alpha-1,5-L-Arabinotriose
C20572 alpha-1,5-L-Arabinotetraose
Reference
Authors
Tomii K, Kanehisa M.
Title
A comparative analysis of ABC transporters in complete microbial genomes.
Journal
Reference
Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal
Reference
Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal
Reference
Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
Journal
Reference
Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
Journal
Reference
Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
Journal
Reference
Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
Journal
Reference
Authors
Richard-Fogal CL, Frawley ER, Kranz RG
Title
Topology and function of CcmD in cytochrome c maturation.
Journal
Reference
Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
Journal
Reference
Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
Journal
Reference
Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
Journal
Reference
Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
Journal
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