Entry Name ABC transporters - Escherichia coli W
Description The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class Environmental Information Processing; Membrane transportBRITE hierarchy
Pathway map Ortholog table Other DBs Organism Escherichia coli W [GN:
elw ]
Gene ECW_m0815 modF; fused molybdate transporter subunits of ABC superfamily: ATP-binding components [KO:K05776 ]
ECW_m0065 thiP; fused thiamin transporter subunits of ABC superfamily: membrane components [KO:K02063 ]
ECW_m0962 potF; putrescine transporter subunit: periplasmic-binding component of ABC superfamily [KO:K11073 ]
ECW_m0965 potI; putrescine transporter subunit: membrane component of ABC superfamily [KO:K11074 ]
ECW_m0964 potH; putrescine transporter subunit: membrane component of ABC superfamily [KO:K11075 ]
ECW_m2333 osmF; predicted transporter subunit: periplasmic-binding component of ABC superfamily [KO:K05845 ]
ECW_m2330 yehW; predicted transporter subunit: membrane component of ABC superfamily [KO:K05846 ]
ECW_m2332 yehY; predicted transporter subunit: membrane component of ABC superfamily [KO:K05846 ]
ECW_m2331 yehX; predicted transporter subunit: ATP-binding component of ABC superfamily [KO:K05847 ] [EC:7.6.2.9 ]
ECW_m4399 malK; fused maltose transport subunit, ATP-binding component of ABC superfamily/regulatory protein [KO:K10111 ] [EC:7.5.2.-]
ECW_m2774 yphF; predicted sugar transporter subunit: periplasmic-binding component of ABC superfamily [KO:K23545 ]
ECW_m2772 yphD; predicted sugar transporter subunit: membrane component of ABC superfamily [KO:K23546 ]
ECW_m2773 yphE; fused predicted sugar transporter subunits of ABC superfamily: ATP-binding components [KO:K23547 ]
ECW_m3466 yrbE; predicted toluene transporter subunit: membrane component of ABC superfamily [KO:K02066 ]
ECW_m3467 yrbF; predicted toluene transporter subunit: ATP-binding component of ABC superfamily [KO:K02065 ]
ECW_m4052 rbsA; fused D-ribose transporter subunits of ABC superfamily: ATP-binding components [KO:K10441 ] [EC:7.5.2.7 ]
ECW_m2073 araH; fused L-arabinose transporter subunits of ABC superfamily: membrane components [KO:K10538 ]
ECW_m2074 araG; fused L-arabinose transporter subunits of ABC superfamily: ATP-binding components [KO:K10539 ] [EC:7.5.2.12 ]
ECW_m4589 ytfQ; predicted sugar transporter subunit: periplasmic-binding component of ABC superfamily [KO:K23508 ]
ECW_m4592 yjfF; predicted sugar transporter subunit: membrane component of ABC superfamily [KO:K23509 ]
ECW_m4591 ytfT; predicted sugar transporter subunit: membrane component of ABC superfamily [KO:K23509 ]
ECW_m4590 ytfR; predicted sugar transporter subunit: ATP-binding component of ABC superfamily [KO:K10820 ] [EC:7.5.2.9 ]
ECW_m2350 mglA; fused methyl-galactoside transporter subunits of ABC superfamily: ATP-binding components [KO:K10542 ] [EC:7.5.2.11 ]
ECW_m3841 xylG; fused D-xylose transporter subunits of ABC superfamily: ATP-binding components [KO:K10545 ] [EC:7.5.2.10 ]
ECW_m4465 phnD; phosphonate/organophosphate ester transporter subunit [KO:K02044 ]
ECW_m4464 phnE; phosphonate ABC transporter, inner membrane subunit [KO:K02042 ]
ECW_m2496 hisM; histidine/lysine/arginine/ornithine transporter subunit [KO:K10015 ]
ECW_m2497 hisQ; histidine/lysine/arginine/ornithine transporter subunit [KO:K10016 ]
ECW_m2498 hisJ; histidine/lysine/arginine/ornithine transporter subunit [KO:K10014 ]
ECW_m2092 yecS; predicted transporter subunit: membrane component of ABC superfamily [KO:K10009 ]
ECW_m2091 yecC; predicted transporter subunit: ATP-binding component of ABC superfamily [KO:K10010 ] [EC:7.4.2.1 ]
ECW_m1427 mppA; murein tripeptide (L-ala-gamma-D-glutamyl-meso-DAP) transporter subunit [KO:K15580 ]
ECW_m1390 sapA; predicted antimicrobial peptide transporter subunit [KO:K19226 ]
ECW_m1389 sapB; predicted antimicrobial peptide transporter subunit [KO:K19227 ]
ECW_m1388 sapC; predicted antimicrobial peptide transporter subunit [KO:K19228 ]
ECW_m1387 sapD; predicted antimicrobial peptide transporter subunit [KO:K19229 ]
ECW_m1386 sapF; predicted antimicrobial peptide transporter subunit [KO:K19230 ]
ECW_m0888 gsiB; predicted peptide transporter subunit: periplasmic-binding component of ABC superfamily [KO:K13889 ]
ECW_m0889 gsiC; predicted peptide transporter subunit: membrane component of ABC superfamily [KO:K13890 ]
ECW_m0890 gsiD; predicted peptide transporter subunit: membrane component of ABC superfamily [KO:K13891 ]
ECW_m0887 gsiA; fused predicted peptide transport subunits of ABC superfamily: ATP-binding components [KO:K13892 ]
ECW_m2382 yejF; fused predicted oligopeptide transporter subunits of ABC superfamilly: ATP-binding components [KO:K13896 ]
ECW_m0150 fhuB; fused iron-hydroxamate transporter subunits of ABC superfamily: membrane components [KO:K23228 ]
ECW_m0155 btuF; vitamin B12 transporter subunit: periplasmic-binding component of ABC superfamily [KO:K06858 ]
ECW_m1880 btuC; vitamin B12 transporter subunit: membrane component of ABC superfamily [KO:K06073 ]
ECW_m1878 btuD; vitamin B12 transporter subunit: ATP-binding component of ABC superfamily [KO:K06074 ] [EC:7.6.2.8 ]
ECW_m2032 znuA; zinc transporter subunit: periplasmic-binding component of ABC superfamily [KO:K09815 ]
ECW_m2034 znuB; zinc transporter subunit: membrane component of ABC superfamily [KO:K09816 ]
ECW_m3186 cbiO1; cobalt ABC transporter ATP-binding component [KO:K16786 ] [EC:7.-.-.-]
ECW_m3187 cbiO2; cobalt ABC transporter ATP-binding component [KO:K16787 ] [EC:7.-.-.-]
ECW_m1642 lsrA; fused AI2 transporter subunits of ABC superfamily: ATP-binding components [KO:K10558 ]
ECW_m1224 ycfU; outer membrane-specific lipoprotein transporter subunit [KO:K09808 ]
ECW_m1226 lolE; outer membrane-specific lipoprotein transporter subunit [KO:K09808 ]
ECW_m1225 lolD; outer membrane-specific lipoprotein transporter subunit [KO:K09810 ] [EC:7.6.2.-]
ECW_m3723 ftsX; predicted transporter subunit: membrane component of ABC superfamily [KO:K09811 ]
ECW_m3724 ftsE; predicted transporter subunit: ATP-binding component of ABC superfamily [KO:K09812 ]
ECW_m1024 msbA; fused lipid transporter subunits of ABC superfamily: membrane component/ATP-binding component [KO:K11085 ] [EC:7.5.2.6 ]
ECW_m0520 mdlA; fused predicted multidrug transporter subunits of ABC superfamily: ATP-binding components [KO:K18889 ]
ECW_m0521 mdlB; fused predicted multidrug transporter subunits of ABC superfamily: ATP-binding components [KO:K18890 ]
ECW_m0996 cydC; fused cysteine transporter subunits of ABC superfamily: membrane component/ATP-binding component [KO:K16012 ]
ECW_m0997 cydD; fused cysteine transporter subunits of ABC superfamily: membrane component/ATP-binding component [KO:K16013 ]
ECW_m0988 macB; fused macrolide transporter subunits of ABC superfamily: ATP-binding component/membrane component [KO:K05685 ] [EC:7.6.2.-]
ECW_m2412 yojI; fused predicted multidrug transport subunits of ABC superfamily: membrane component/ATP-binding component [KO:K06159 ]
ECW_m1624 yddA; fused predicted multidrug transporter subunits of ABC superfamily: membrane component/ATP-binding component [KO:K02471 ]
Compound C00093 sn-Glycerol 3-phosphate
C01153 Orthophosphoric monoester
C01181 4-Trimethylammoniobutanoate
C01279 4-Amino-5-hydroxymethyl-2-methylpyrimidine
C03557 2-Aminoethylphosphonate
C03611 Galactose oligosaccharide
C03619 Methyl beta-D-galactoside
C04114 (E)-4-(Trimethylammonio)but-2-enoate
C06705 Capsular polysaccharide
C19872 N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570 alpha-1,5-L-Arabinobiose
C20571 alpha-1,5-L-Arabinotriose
C20572 alpha-1,5-L-Arabinotetraose
Reference Authors Tomii K, Kanehisa M.
Title A comparative analysis of ABC transporters in complete microbial genomes.
Journal Reference Authors Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
Title Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal Reference Authors Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
Title Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal Reference Authors Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
Title Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
Journal Reference Authors Quintero MJ, Montesinos ML, Herrero A, Flores E
Title Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
Journal Reference Authors Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
Title ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
Journal Reference Authors Valladares A, Montesinos ML, Herrero A, Flores E.
Title An ABC-type, high-affinity urea permease identified in cyanobacteria.
Journal Reference Authors Richard-Fogal CL, Frawley ER, Kranz RG
Title Topology and function of CcmD in cytochrome c maturation.
Journal Reference Authors Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
Title The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
Journal Reference Authors Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
Title The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
Journal Reference Authors Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
Title Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
Journal Reference Authors Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
Title MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
Journal KO pathway LinkDB All DBs
