KEGG   PATHWAY: epa04814
Entry
epa04814                    Pathway                                
Name
Motor proteins - Exaiptasia diaphana (Aiptasia)
Class
Cellular Processes; Cell motility
Pathway map
epa04814  Motor proteins
epa04814

Organism
Exaiptasia diaphana (Aiptasia) [GN:epa]
Gene
110244215  cytoplasmic dynein 1 intermediate chain 2 [KO:K10415]
110249806  cytoplasmic dynein 1 light intermediate chain 1 [KO:K10416]
110249189  LOW QUALITY PROTEIN: cytoplasmic dynein 2 light intermediate chain 1-like [KO:K10417]
110236476  dynein light chain 2, cytoplasmic [KO:K10418]
110236485  dynein light chain LC6, flagellar outer arm-like [KO:K10418]
110253089  dynein light chain roadblock-type 2 [KO:K10419]
110254368  dynein light chain Tctex-type 1 [KO:K10420]
110239654  tctex1 domain-containing protein 1-B [KO:K25421]
110233689  dynein heavy chain 10, axonemal [KO:K10408]
110232395  dynein heavy chain 7, axonemal [KO:K10408]
110237545  dynein heavy chain 8, axonemal [KO:K10408]
110237944  dynein beta chain, flagellar outer arm [KO:K10408]
110240251  LOW QUALITY PROTEIN: dynein heavy chain 6, axonemal-like [KO:K10408]
110240114  dynein beta chain, ciliary [KO:K10408]
110251851  dynein heavy chain 8, axonemal [KO:K10408]
110244179  dynein heavy chain 6, axonemal [KO:K10408]
110246052  LOW QUALITY PROTEIN: dynein heavy chain 2, axonemal-like [KO:K10408]
110244368  dynein heavy chain 1, axonemal-like [KO:K10408]
110242392  dynein heavy chain 5, axonemal-like [KO:K10408]
110250153  dynein heavy chain 3, axonemal [KO:K10408]
110245843  dynein heavy chain 5, axonemal [KO:K10408]
110247907  dynein heavy chain 3, axonemal [KO:K10408]
110248946  dynein heavy chain 12, axonemal [KO:K10408]
110244164  dynein heavy chain 6, axonemal [KO:K10408]
110243167  dynein intermediate chain 2, ciliary [KO:K10409]
110248904  dynein intermediate chain 3, ciliary [KO:K11143]
110255127  WD repeat-containing protein 63 [KO:K24722]
110251261  WD repeat-containing protein 78 [KO:K24723]
110248919  WD repeat-containing protein 78 [KO:K24723]
110235122  33 kDa inner dynein arm light chain, axonemal [KO:K10410]
110232655  dynein light chain 1, axonemal [KO:K10411]
110253808  dynein light chain 4, axonemal [KO:K10412]
110246464  dynactin subunit 1 [KO:K04648]
110242168  dynactin subunit 2 [KO:K10424]
110253209  dynactin subunit 3 [KO:K10425]
110241462  dynactin subunit 4 [KO:K10426]
110253794  dynactin subunit 5 [KO:K10427]
110248589  dynactin subunit 6 [KO:K10428]
110250426  alpha-centractin [KO:K16575]
110247194  actin-related protein 10 [KO:K16576]
110233495  F-actin-capping protein subunit alpha-2 [KO:K10364]
110237192  F-actin-capping protein subunit beta isoform X1 [KO:K10365]
110234976  BICD family-like cargo adapter 1 [KO:K16756]
110249217  protein Hook homolog [KO:K16536]
110234048  LOW QUALITY PROTEIN: tubulin alpha-2/alpha-4 chain [KO:K07374]
110233265  tubulin alpha-1 chain [KO:K07374]
110233266  tubulin alpha-3 chain [KO:K07374]
110234269  tubulin alpha chain [KO:K07374]
110234279  tubulin alpha-1 chain [KO:K07374]
110244565  tubulin alpha-1D chain [KO:K07374]
110244566  tubulin alpha-1C chain [KO:K07374]
110248898  tubulin alpha-1A chain [KO:K07374]
110245449  tubulin alpha-1A chain [KO:K07374]
110247468  tubulin alpha-8 chain isoform X2 [KO:K07374]
110233318  tubulin beta chain [KO:K07375]
110255137  LOW QUALITY PROTEIN: tubulin beta chain [KO:K07375]
110238520  tubulin beta chain isoform X1 [KO:K07375]
110238521  tubulin beta chain [KO:K07375]
110251177  tubulin beta-4B chain [KO:K07375]
110243670  tubulin beta chain [KO:K07375]
110253960  tubulin gamma-1 chain [KO:K10389]
110250667  tubulin delta chain [KO:K10390]
110248285  uncharacterized protein LOC110248285 [KO:K10390]
110248341  tubulin beta-3 chain [KO:K10390]
110249730  tubulin epsilon chain [KO:K10391]
110232406  kinesin heavy chain isoform X1 [KO:K10396]
110240479  kinesin light chain [KO:K10407]
110251630  kinesin-like protein KIF3A [KO:K10394]
110242565  kinesin-like protein KIF3B [KO:K20196]
110244815  kinesin-associated protein 3 [KO:K25388]
110243706  kinesin-like protein KIF17 isoform X1 [KO:K20198]
110235951  kinesin-like protein KIF17 [KO:K20198]
110253635  kinesin-like protein unc-104 [KO:K10392]
110244144  kinesin-like protein KIF28P [KO:K10392]
110245809  kinesin-like protein KIF28P [KO:K10392]
110236942  kinesin-like protein KIF13B [KO:K17914]
110239736  kinesin-like protein KIF14 [KO:K17915]
110242737  kinesin-like protein KIF14 [KO:K17915]
110242021  kinesin-like protein KIF16B [KO:K17916]
110247283  kinesin-like protein KIF16B [KO:K17916]
110239151  kinesin-like protein KIF16B [KO:K17916]
110239208  kinesin-like protein KIF16B isoform X1 [KO:K17916]
110249471  chromosome-associated kinesin KIF4 [KO:K10395]
110236408  kinesin-like protein KIF21A [KO:K24185]
110238621  kinesin-like protein KIF11-B [KO:K10398]
110251828  uncharacterized protein LOC110251828 [KO:K10402]
110250576  centromere-associated protein E [KO:K11498]
110238878  kinesin-like protein kif7 isoform X2 [KO:K11498]
110251450  kinesin-like protein KIF15 isoform X1 [KO:K11498]
110239286  kinesin-like protein KIF19 [KO:K10401]
110249748  kinesin-like protein KIF18A [KO:K10401]
110250511  kinesin-like protein KIF19 [KO:K26157]
110238211  kinesin-like protein KIN-7K, chloroplastic isoform X1 [KO:K10397]
110251642  LOW QUALITY PROTEIN: kinesin-like protein KIF9 [KO:K10397]
110252649  kinesin-like protein KIF6 [KO:K10397]
110247621  kinesin-like protein KIF12 [KO:K10399]
110233472  kinesin-like protein KIF15 isoform X1 [KO:K10400]
110243083  kinesin-like protein KIN-13A [KO:K10393]
110236929  kinesin-like protein KIF2A [KO:K10393]
110242638  carboxy-terminal kinesin 2 [KO:K10405]
110236066  kinesin-like protein klpA [KO:K10405]
110236067  kinesin-like protein KIN-14N [KO:K10405]
110236415  kinesin-like protein KIFC3 [KO:K10406]
110236583  kinesin-like protein KIFC3 [KO:K10406]
110250013  kinesin-like protein KIN-14S [KO:K10406]
110250016  kinesin-like protein KIF25 [KO:K18627]
110233287  unconventional myosin-Id [KO:K10356]
110237228  unconventional myosin-Ie isoform X1 [KO:K10356]
110239667  unconventional myosin-Ic [KO:K10356]
110253402  unconventional myosin-Ib [KO:K10356]
110252617  unconventional myosin-If [KO:K10356]
110243403  unconventional myosin-Ib [KO:K10356]
110238126  uncharacterized protein LOC110238126 isoform X1 [KO:K08834] [EC:2.7.11.1]
110244925  myosin-IIIb [KO:K08834] [EC:2.7.11.1]
110237605  LOW QUALITY PROTEIN: unconventional myosin-Va-like isoform X3 [KO:K10357]
110245650  unconventional myosin-VIIa [KO:K10357]
110239414  unconventional myosin-VI [KO:K10358]
110243201  myosin-VIIa [KO:K10359]
110231827  unconventional myosin-IXa [KO:K10360]
110233597  unconventional myosin-XVIIIa isoform X1 [KO:K10362]
110252408  unconventional myosin-XVIIIa isoform X1 [KO:K10362]
110239943  myosin heavy chain, striated muscle isoform X1 [KO:K17751]
110239967  myosin-10 [KO:K10352]
110239394  myosin-2 essential light chain [KO:K12751]
110254571  myosin-2 essential light chain [KO:K12751]
110238723  myosin-2 essential light chain [KO:K12751]
110238732  myosin-2 essential light chain [KO:K12751]
110254707  myosin-2 essential light chain-like [KO:K12751]
110255013  myosin-2 essential light chain [KO:K12751]
110244381  myosin-2 essential light chain [KO:K12751]
110231520  myosin regulatory light polypeptide 9 [KO:K12757]
110245010  myosin regulatory light chain 12B [KO:K12757]
110240986  myosin regulatory light chain 12A [KO:K12757]
110240987  myosin regulatory light chain 12B-like [KO:K12757]
110253888  actin, cytoplasmic 1 [KO:K05692]
110231650  putative calmodulin-like protein 6 [KO:K05865]
110247528  tropomyosin-2 [KO:K10373]
110253560  tropomyosin [KO:K10373]
110238843  probable cyclin-dependent serine/threonine-protein kinase DDB_G0278487 [KO:K10373]
110234407  tropomyosin [KO:K10374]
110252089  uncharacterized protein LOC110252089 [KO:K10374]
110237794  uncharacterized protein LOC110237794 [KO:K10375]
Reference
PMID:21092854
  Authors
Hirokawa N, Niwa S, Tanaka Y
  Title
Molecular motors in neurons: transport mechanisms and roles in brain function, development, and disease.
  Journal
Neuron 68:610-38 (2010)
DOI:10.1016/j.neuron.2010.09.039
Reference
PMID:25470043 (PDB:4RH7)
  Authors
Schmidt H, Zalyte R, Urnavicius L, Carter AP
  Title
Structure of human cytoplasmic dynein-2 primed for its power stroke.
  Journal
Nature 518:435-438 (2015)
DOI:10.1038/nature14023
Reference
PMID:22398446 (PDB:3VKG 3VKH)
  Authors
Kon T, Oyama T, Shimo-Kon R, Imamula K, Shima T, Sutoh K, Kurisu G
  Title
The 2.8 A crystal structure of the dynein motor domain.
  Journal
Nature 484:345-50 (2012)
DOI:10.1038/nature10955
Reference
PMID:22997337 (PDB:3J1T 3J1U)
  Authors
Redwine WB, Hernandez-Lopez R, Zou S, Huang J, Reck-Peterson SL, Leschziner AE
  Title
Structural basis for microtubule binding and release by dynein.
  Journal
Science 337:1532-1536 (2012)
DOI:10.1126/science.1224151
Reference
PMID:26410600
  Authors
Gibbs KL, Greensmith L, Schiavo G
  Title
Regulation of Axonal Transport by Protein Kinases.
  Journal
Trends Biochem Sci 40:597-610 (2015)
DOI:10.1016/j.tibs.2015.08.003
Reference
PMID:28602352 (PDB:5NUG 5NVS 5NVU 5NW4)
  Authors
Zhang K, Foster HE, Rondelet A, Lacey SE, Bahi-Buisson N, Bird AW, Carter AP
  Title
Cryo-EM Reveals How Human Cytoplasmic Dynein Is Auto-inhibited and Activated.
  Journal
Cell 169:1303-1314.e18 (2017)
DOI:10.1016/j.cell.2017.05.025
Reference
PMID:25814576 (PDB:5ADX 5AFR 5AFU)
  Authors
Urnavicius L, Zhang K, Diamant AG, Motz C, Schlager MA, Yu M, Patel NA, Robinson CV, Carter AP
  Title
The structure of the dynactin complex and its interaction with dynein.
  Journal
Science 347:1441-1446 (2015)
DOI:10.1126/science.aaa4080
Reference
PMID:29420470 (PDB:5OWO 6F1T 6F1U 6F1V 6F1Y 6F1Z 6F38 6F3A)
  Authors
Urnavicius L, Lau CK, Elshenawy MM, Morales-Rios E, Motz C, Yildiz A, Carter AP
  Title
Cryo-EM shows how dynactin recruits two dyneins for faster movement.
  Journal
Nature 554:202-206 (2018)
DOI:10.1038/nature25462
Reference
PMID:29662141
  Authors
Reck-Peterson SL, Redwine WB, Vale RD, Carter AP
  Title
The cytoplasmic dynein transport machinery and its many cargoes.
  Journal
Nat Rev Mol Cell Biol 19:382-398 (2018)
DOI:10.1038/s41580-018-0004-3
Reference
PMID:23434508 (PDB:3J2U)
  Authors
Asenjo AB, Chatterjee C, Tan D, DePaoli V, Rice WJ, Diaz-Avalos R, Silvestry M, Sosa H
  Title
Structural model for tubulin recognition and deformation by kinesin-13 microtubule depolymerases.
  Journal
Cell Rep 3:759-68 (2013)
DOI:10.1016/j.celrep.2013.01.030
Reference
PMID:10338210 (PDB:1B7T)
  Authors
Houdusse A, Kalabokis VN, Himmel D, Szent-Gyorgyi AG, Cohen C
  Title
Atomic structure of scallop myosin subfragment S1 complexed with MgADP: a novel conformation of the myosin head.
  Journal
Cell 97:459-70 (1999)
DOI:10.1016/s0092-8674(00)80756-4
Reference
PMID:9428521 (PDB:3KIN)
  Authors
Kozielski F, Sack S, Marx A, Thormahlen M, Schonbrunn E, Biou V, Thompson A, Mandelkow EM, Mandelkow E
  Title
The crystal structure of dimeric kinesin and implications for microtubule-dependent motility.
  Journal
Cell 91:985-94 (1997)
DOI:10.1016/s0092-8674(00)80489-4
Reference
PMID:8316857 (PDB:2MYS)
  Authors
Rayment I, Rypniewski WR, Schmidt-Base K, Smith R, Tomchick DR, Benning MM, Winkelmann DA, Wesenberg G, Holden HM
  Title
Three-dimensional structure of myosin subfragment-1: a molecular motor.
  Journal
Science 261:50-8 (1993)
DOI:10.1126/science.8316857
Reference
PMID:20428469
  Authors
Parker D, Bryant Z, Delp SL
  Title
Coarse-Grained Structural Modeling of Molecular Motors Using Multibody Dynamics.
  Journal
Cell Mol Bioeng 2:366-374 (2009)
DOI:10.1007/s12195-009-0084-4
Reference
PMID:21314430
  Authors
Dominguez R, Holmes KC
  Title
Actin structure and function.
  Journal
Annu Rev Biophys 40:169-86 (2011)
DOI:10.1146/annurev-biophys-042910-155359
Reference
PMID:31919429 (PDB:6KN7 6KN8)
  Authors
Yamada Y, Namba K, Fujii T
  Title
Cardiac muscle thin filament structures reveal calcium regulatory mechanism.
  Journal
Nat Commun 11:153 (2020)
DOI:10.1038/s41467-019-14008-1
Reference
PMID:33912943
  Authors
Kruppa AJ, Buss F
  Title
Motor proteins at the mitochondria-cytoskeleton interface.
  Journal
J Cell Sci 134:239092 (2021)
DOI:10.1242/jcs.226084
KO pathway
ko04814   
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