KEGG ORTHOLOGY: K10375

ORTHOLOGY: K10375

Entry

K10375                      KO

Symbol

TPM4

Name

tropomyosin 4

Pathway

map04260

Cardiac muscle contraction

map04261

Adrenergic signaling in cardiomyocytes

map04814

Motor proteins

map04820

Cytoskeleton in muscle cells

map05410

Hypertrophic cardiomyopathy

map05414

Dilated cardiomyopathy

Disease

H01235

Bleeding disorder platelet-type

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09142 Cell motility
   04814 Motor proteins
    K10375  TPM4; tropomyosin 4
   04820 Cytoskeleton in muscle cells
    K10375  TPM4; tropomyosin 4
09150 Organismal Systems
  09153 Circulatory system
   04260 Cardiac muscle contraction
    K10375  TPM4; tropomyosin 4
   04261 Adrenergic signaling in cardiomyocytes
    K10375  TPM4; tropomyosin 4
09160 Human Diseases
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    K10375  TPM4; tropomyosin 4
   05414 Dilated cardiomyopathy
    K10375  TPM4; tropomyosin 4
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins
    K10375  TPM4; tropomyosin 4
Cytoskeleton proteins [BR:ko04812]
Eukaryotic cytoskeleton proteins
  Actin filaments / Microfilaments
   Actin-binding proteins
    Tropomyosins
     K10375  TPM4; tropomyosin 4

Other DBs

GO:

0005862

Genes

HSA:	7171(TPM4)

PTR:	100612873(TPM4) 129137216

PPS:	100989077 100993094(TPM4) 117975372

GGO:	101129329 101129425(TPM4) 129526105 134756755

PON:	100439681(TPM4)

PPYG:

129020920(TPM4)

NLE:	100595904(TPM4)

HMH:	116478630(TPM4)

SSYN:

129460802(TPM4)

MCC:	719428(TPM4)

MCF:	101866884(TPM4) 102140314

MTHB:

126942316 126956661

MNI:	105493839(TPM4)

CSAB:

103234097(TPM4)

CATY:

105601632(TPM4)

PANU:

101013573(TPM4) 110743595

TGE:	112613359(TPM4) 112626369

MLEU:

105540104(TPM4)

RRO:	104661006(TPM4)

RBB:	108543293(TPM4)

TFN:	117063653 117074867(TPM4)

PTEH:

111554269(TPM4)

CANG:

105519782(TPM4)

CJC:	100412931(TPM4)

SBQ:	101051580(TPM4) 104651778

CIMI:

108284460(TPM4)

ANAN:

105705179 105724087 105729204(TPM4)

CSYR:

103276591(TPM4)

MMUR:

105867958(TPM4)

LCAT:

123637914(TPM4)

PCOQ:

105825707(TPM4)

OGA:	100943790(TPM4)

MMU:	326618(Tpm4)

MCAL:

110299670(Tpm4)

RNO:	24852(Tpm4)

MCOC:

116069542(Tpm4)

ANU:	117721483(Tpm4)

ASYL:

127668356(Tpm4)

MUN:	110558745(Tpm4)

CGE:	100761146(Tpm4)

MAUA:

101836260(Tpm4)

PROB:

127217265(Tpm4)

PLEU:

114685849 114709571(Tpm4)

MORG:

121462685(Tpm4)

MFOT:

126492229 126506366 126507881

AAMP:

119811831(Tpm4)

NGI:	103726930(Tpm4)

HGL:	101709758(Tpm4) 101721424

CPOC:

100734693(Tpm4)

CCAN:

109689061(Tpm4) 109692301

DORD:

105994731(Tpm4)

DSP:	122100886(Tpm4)

DMER:

138810976 138817823

PLOP:

125348963(Tpm4)

NCAR:

124968391

MMMA:

107145315(Tpm4)

ITI:	101959803 101976078(Tpm4)

OCU:

100343175

OPI:	101535879(TPM4)

OCZ:	121163373(TPM4)

TUP:	102482207(TPM4)

GVR:	103603073(TPM4)

CFA:	609879(TPM4)

CLUD:

112666673(TPM4)

VVP:	112913137(TPM4) 112920713

VLG:	121472573 121495369(TPM4)

NPO:	129521619(TPM4)

AML:	100470823(TPM4)

UMR:	103677161(TPM4)

UAH:	113256639(TPM4)

UAR:	123779893(TPM4)

ELK:

111143852

LLV:

125083050

MPUF:

101688400(TPM4)

MNP:	132011119(TPM4)

MLK:	131823690(TPM4)

NVS:	122894421 122909640(TPM4)

ORO:	101381281(TPM4)

EJU:	114196410(TPM4)

ZCA:	113916640(TPM4)

MLX:	118006002(TPM4)

NSU:	110574570(TPM4)

LWW:

102729513

FCA:	101092247(TPM4)

PYU:	121010942(TPM4)

PCOO:

112852654(TPM4)

PBG:	122488668(TPM4)

PVIV:

125161229(TPM4)

LRUF:

124523607

LGF:	123605466(TPM4)

AJU:

106985923

PTG:	102959126(TPM4)

PPAD:

109247528(TPM4)

PUC:

125929170

PLEZ:

122214106(TPM4)

HHV:	120239171(TPM4)

BTA:	535277(TPM4)

BOM:	102288210(TPM4)

BIU:	109561470(TPM4)

BBUB:

102403764(TPM4)

BBIS:

104992642(TPM4) 105000925

CHX:	102180482(TPM4)

OAS:	101117499(TPM4)

BTAX:

128051408(TPM4) 128058184

CSUM:

138085398(TPM4) 138090747

ODA:	120864185(TPM4)

CCAD:

122440667(TPM4)

MREE:

136155611(TPM4)

OVR:	110145881(TPM4)

MBEZ:

129558205(TPM4)

SSC:	397608(TPM4)

CFR:	102517416(TPM4)

CBAI:

105082520(TPM4)

CDK:	105101819(TPM4)

VPC:	102525596(TPM4)

BACU:

103008460(TPM4)

BMUS:

118891847(TPM4)

LVE:	103089632(TPM4)

OOR:	101274446(TPM4)

LALB:

132517419(TPM4)

GMF:	115865446(TPM4)

DDP:	132422945(TPM4)

DLE:	111166617(TPM4)

PCAD:

102992634(TPM4)

PSIU:

116747113 116752207(TPM4)

PPHC:

136121712(TPM4)

NASI:

112414712(TPM4)

ECB:	100147533(TPM4)

EPZ:	103540448(TPM4)

EAI:	106846854(TPM4)

MYB:	102250863(TPM4)

MYD:	102754728(TPM4)

MMYO:

118652567(TPM4)

MLF:	102436703(TPM4)

MDT:	132234882(TPM4)

MYUM:

139011073(TPM4)

PKL:	118706576(TPM4)

EFUS:

103300900(TPM4)

MNA:	107534317(TPM4)

DRO:	112305157(TPM4)

SHON:

118975051(TPM4)

AJM:	119046770(TPM4)

PDIC:

114502582(TPM4)

PHAS:

123828376(TPM4)

MMF:	118615726(TPM4)

PPAM:

129074943(TPM4)

HAI:	109382489(TPM4)

RFQ:	117037839(TPM4)

PALE:

102887876(TPM4)

PGIG:

120606488(TPM4)

PVP:	105296655(TPM4)

RAY:	107517241(TPM4)

MJV:	108384583(TPM4)

TOD:	119241067(TPM4)

SARA:

101539888(TPM4)

SFUM:

130028951(TPM4)

SETR:

126029452(TPM4)

LAV:	100671189(TPM4)

TMU:

101353940

ETF:	101664610(TPM4)

DNM:

101431928

MDO:	100617065(TPM4)

GAS:	123243464(TPM4)

SHR:	100932168(TPM4)

AFZ:

127545042

PCW:	110196120(TPM4)

TVP:	118828027 118848677(TPM4)

PBRV:

138172269 138172368(TPM4)

MLAO:

141500848 141500850(TPM4)

OAA:	100087711(TPM4)

TACU:

119950030(TPM4)

GGA:	107055375(TPM4)

PCOC:

116235681(TPM4)

MGP:	100540818(TPM4)

CJO:	107325494(TPM4)

TPAI:

128088840(TPM4)

LMUT:

125684878(TPM4)

NMEL:

110389034(TPM4)

APLA:

101791313(TPM4)

ACYG:

106044978(TPM4)

CATA:

118258736(TPM4)

AFUL:

116499172(TPM4)

TGU:	100190669(TPM4) 100192321(TPM2)

LSR:	110475737(TPM4)

SCAN:

103822891(TPM2) 103824118(TPM4)

PMOA:

120514179(TPM4)

OTC:	121347514(TPM4)

PRUF:

121349896(TPM4)

ATRC:

139602188(TPM4)

GFR:	102043502(TPM4)

FAB:	101809633(TPM4) 101821367(TPM2)

OMA:	130264506(TPM4)

PHI:	102114014(TPM4)

PMAJ:

107215487(TPM4)

CCAE:

111940187(TPM4)

CCW:	104697355(TPM4)

CBRC:

103621183(TPM4)

ACOE:

138099844(TPM4)

ETL:	114067119(TPM4)

ZAB:	102061970(TPM4)

ZLE:	135458981(TPM4)

ACHL:

103811008

SVG:	106857121(TPM4)

MMEA:

130586221(TPM4)

HRT:	120763331(TPM4)

SATI:

136372000(TPM4)

CCIC:

134054510(TPM4)

FPG:	101921697(TPM4)

FCH:	102055978(TPM4)

CCRI:

104165400

NNT:

104407718

SHAB:

115618351(TPM4)

ACUN:

113489375(TPM4)

TALA:

104367947(TPM4)

ACHC:

115348892(TPM4)

HALD:

104318607

HLE:	104828513(TPM4)

AGEN:

126042000

HHAR:

128148072(TPM4)

GCL:

127025673

CSTI:

104550723

LDI:	104342347(TPM4)

MNB:

103778803

DPUB:

104300378(TPM4)

PPUS:

135192342(TPM4)

AVIT:

104267704

BRHI:

104489620

EGZ:	104124363(TPM4)

NNI:	104018733(TPM4)

PCRI:

104024452

PCAO:

104047757

PADL:

103912175(TPM4)

AFOR:

103902928(TPM4)

FGA:

104082532

CBOR:

142093782(TPM4)

GSTE:

104262858

CBOY:

140643656(TPM4)

MAME:

142420304(TPM4)

CLV:	102093255(TPM4)

CNIC:

135999213(TPM4)

MUI:

PGUU:

PLET:

EHS:

CMAC:

104474963(TPM4)

CUCA:

104060943(TPM4)

TEO:

104370338

BREG:

104641641

OHA:	104327978(TPM4)

ACAR:

104519280

CPEA:

104388879(TPM4)

CVF:	104295419(TPM4)

RTD:	128900577(TPM4)

CRID:

134526334(TPM4)

LMIC:

141734181(TPM4)

AAM:	106494274(TPM4)

AROW:

112966713(TPM4)

NPD:	112943895(TPM4)

TGT:	104572821(TPM4)

DNE:	112986604(TPM4)

SCAM:

104146014(TPM4)

ASN:	102381569(TPM4)

AMJ:	102563083(TPM4)

CPOO:

109312383(TPM4)

GGN:	109295028(TPM4)

PSS:

102456979

CIZ:	142002152(TPM4)

CMY:	102930308(TPM4)

CCAY:

125627315(TPM4)

DCC:	119848211(TPM4)

CPIC:

101933171(TPM4)

TST:	117868971(TPM4)

CABI:

116823152(TPM4)

MRV:	120391612(TPM4)

ACS:

100567759

ASAO:

132780948(TPM4)

PVT:	110072551(TPM4)

SUND:

121917664 121917808

PBI:

103049418

PMUR:

107282211(TPM4)

CTIG:

120305959(TPM4)

TSR:

106554664

PGUT:

117677394(TPM4)

PCAE:

139316490(TPM4)

APRI:

131188145(TPM4)

PTEX:

113435179

NSS:	113414166(TPM4)

VKO:

123016504

PMUA:

114588372(TPM4)

PRAF:

128405593(TPM4)

ZVI:	118085922(TPM4)

HCG:	128346934(TPM4)

GJA:	107121701(TPM4)

EMC:	129329775(TPM4)

XLA:	379469(tpm4.L) 379628(tpm4.S)

XTR:	549841(tpm4)

NPR:	108786385(TPM4)

RTEM:

120913229(TPM4) 120945477

ACAT:

141105953(TPM4)

PADS:

140326374(TPM4)

BBUF:

120989523(TPM4)

BGAR:

122919644(TPM4)

DTC:	141049698(TPM4)

PWL:	138267734(TPM4)

MUO:

115481182

GSH:

117365110

DRE:	324244(tpm4b) 406437(tpm4a)

SRX:	107715082 107750945 107754596 107757474

SANH:

107653617 107665514 107687908 107696831

SGH:	107552722 107561904 107588080(tpm4) 107596277

CCAR:

109046618 109046625(tpm4a) 109065233(tpm4b)

CAUA:

113040154 113040162 113045266 113064828 113111309

CGIB:

127938098 127942743 127951105 127987911

PTET:

122328219(tpm4a) 122335597(tpm4b)

LROH:

127153511(tpm4a) 127182146(tpm4b)

GRF:	141339207 141339236 141343762(tpm4b)

OMC:	131529971(tpm4a) 131550832(tpm4b)

PPRM:

120460865(tpm4b) 120486449(tpm4a)

RKG:	130089315(tpm4a) 130105615(tpm4b)

MAMB:

125250167(tpm4b) 125251081(tpm4a)

CIDE:

127498970 127520249

CERY:

137002847(tpm4b) 137027681(tpm4a)

MASI:

127437937 127438930 127441453 127442526

TROS:

130548954(tpm4a) 130554020(tpm4b)

TDW:	130417311(tpm4b) 130429642(tpm4a)

MANU:

129443180 129452759(tpm4a) 141362407

PDAB:

135727063(tpm4a) 135744351

IPU:	108271248(tpm4a) 108280645(tpm4b)

IFU:	128614227(tpm4a) 128624144(tpm4b)

PHYP:

113533505 113536483(tpm4)

SMEO:

124391187(tpm4a) 124402980(tpm4b)

TFD:	113645289(tpm4b) 113650800(tpm4a)

TVC:	132845088(tpm4b) 132854329(tpm4a)

CGAR:

128513234(tpm4b) 128543271(tpm4a)

NGRA:

132871805(tpm4b) 132899411(tpm4a)

TRN:	134302408(tpm4b) 134331829(tpm4a)

AMEX:

103021908(tpm4b) 103036175(tpm4a)

CMAO:

118796776(tpm4b) 118818834(tpm4a)

EEE:	113574496 113582878

CHAR:

105907060 122130194(tpm4a)

SPIL:

134058320(tpm4a) 134067064(tpm4b)

ASAD:

121677826(tpm4a) 121679464

TRU:	445912(tpm4-1) 446097(tpm4-2)

TFS:	130529355(tpm4a) 130538593

TNG:	GSTEN00027747G001

LCO:	104923636(tpm4) 104931432

NCC:	104956979 104961393

TBEN:

117495648(tpm4a) 117500267

CGOB:

115006694(tpm4) 115022456

PGEO:

117445754(tpm4a) 117462202

GACU:

117541108(tpm4a) 117541758(tpm4b)

EMAC:

134865841 134870048(tpm4a)

ELY:	117254123(tpm4a) 117271526

EFO:	125895501(tpm4a) 125902522

PLEP:

121940783 121951022

SLUC:

116045890 116055233(tpm4a)

ECRA:

117951108(tpm4a) 117954525

ESP:	116695136(tpm4) 116698591

PFLV:

114562149 114564868

GAT:	120814495 120824246(tpm4a)

PPUG:

119209675 119217253(tpm4a)

AFB:	129089258 129095068(tpm4a)

CLUM:

117729760 117746560

PSWI:

130193746 130198508

CANA:

137794521(tpm4a) 137803639

CVE:	137866088 137870233(tpm4a)

MSAM:

119900746(tpm4a) 119901854

SCHU:

122878035(tpm4a) 122887450(tpm4b)

CUD:	121512085(tpm4a) 121520403

SPUL:

138607282(tpm4a) 138611269(tpm4b)

LMIX:

132963089(tpm4a) 132979455

HTC:	141788602(tpm4a) 141804406

ALAT:

119011418 119029252(tpm4a)

ASTR:

137598603(tpm4a) 137611941

MZE:	101474423 101476541(tpm4)

ONL:	100690441(tpm4) 100703626

OAU:	116309224(tpm4a) 116313402

OLA:	101160801(tpm4) 101167740

OML:	112147236(tpm4b) 112150655(tpm4a)

CSAI:

133452429(tpm4b) 133458391(tpm4a)

XMA:	102218802 102224849(tpm4)

XCO:	114146153 114151241(tpm4)

XHE:	116721369 116725554(tpm4)

PRET:

103463529(tpm4) 103479776

PFOR:

103146061 103156889

PLAI:

106936184 106939899

PMEI:

106914771 106929302

GAF:	122838506(tpm4a) 122840614(tpm4b)

PPRL:

129378092 129378570(tpm4a)

CVG:	107085936 107097316(tpm4)

CTUL:

119780856(tpm4a) 119785210

GMU:	124869755(tpm4b) 124874339(tpm4a)

NFU:	107383605 107393167(tpm4)

KMR:	108230748(tpm4a) 108232925(tpm4b)

ALIM:

106521568(tpm4) 106537044

NWH:	119415210 119430660(tpm4a)

AOCE:

111570619(tpm4a) 111575491(tpm4b)

EJA:	138198783(tpm4a) 138203157

BFRE:

138617430 138621188(tpm4a)

MCEP:

125009525(tpm4a) 125011420(tpm4b)

CSEM:

103396474 103397000(tpm4)

POV:	109625590(tpm4) 109645665

SSEN:

122761590 122780379(tpm4a)

SSOE:

131466269(tpm4a) 131466497

HHIP:

117760667(tpm4a) 117777737

HSP:	118118091 118120825(tpm4a)

PPLT:

128448275(tpm4a) 128454736

SMAU:

118310733(tpm4b) 118318524(tpm4a)

LCF:	108881392(tpm4a) 108884187(tpm4b)

SDU:	111231002 111232124(tpm4)

SLAL:

111654268 111669140

XGL:	120791155(tpm4a) 120798940

HCQ:	109507403 109532055

SSCV:

125973837(tpm4a) 125985221

SBIA:

133503344(tpm4a) 133510605

PEE:	133405849(tpm4a) 133411328

PTAO:

133480706(tpm4a) 133488649

BPEC:

110160108(tpm4) 110164086

ENY:	140353442(tpm4a) 140356061

MALB:

109955456 109967418(tpm4)

BSPL:

114844006(tpm4b) 114853279(tpm4a)

SJO:	128361261(tpm4a) 128368594

SSCO:

133985317(tpm4a) 133990249

TTY:	137187837(tpm4a) 137194446

GMH:	115548938 115555582

SASA:

100195128(tpm4) 106569628(TPM1) 106573547

STRU:

115151754 115157544 115158167

OTW:	112250800 112252201 112260901

OMY:	110502055(tpm4a) 110524211 110530806

OGO:	123997136 123998882(tpm4a) 124009505

ONE:	115108241 115109214 115114773

OKI:	109874576 109889191 109902439

OKE:	118375116(tpm4a) 118388865 118401752

OMM:	135509347 135512710 135524585

OCLA:

139377672 139386807 139409117

SALP:

111952571 111976112 112068990

SNH:	120053768 120054728 120056134

SFON:

129810828 129813564 129867280

CCLU:

121533600(tpm4a) 121535426(tpm4b) 121576805

ELS:	105011474(tpm4) 105022485

OEP:	134011198(tpm4a) 134036906

SFM:	108921714 108930578

PKI:	111847603(tpm4) 111860236

AANG:

118225372(tpm4a) 118228913

AROT:

135252941(tpm4a) 135257837

CCOG:

133125913(tpm4a) 133128094

LOC:	102695226(tpm4)

PSPA:

121300559 121301189

ARUT:

117401406 117966226

PSEX:

120537799(tpm4a)

LCM:	102348803(TPM4)

CMK:

RTP:

CPUN:

HOC:

SCAU:

LERI:

HAKA:

PFLL:

DMO:	Dmoj_GI10893

DAZ:

108618085

TCF:

131883409

NAI:	NECAME_03598

HRO:	HELRODRAFT_165857

OSN:

115213976

NVE:	5510284 5519741

EPA:

110237794

ATEN:

116287308 116303629 116306804

ADF:	107327519 107333686 107347542

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:	114519310 114522561 114528456 114539491

XEN:

124444137

HMG:

105850868

» show all

Reference

PMID:11563548

Authors

Perry SV

Title

Vertebrate tropomyosin: distribution, properties and function.

Journal

J Muscle Res Cell Motil 22:5-49 (2001)
DOI:10.1023/A:1010303732441

Reference

PMID:3612796

Authors

MacLeod AR, Talbot K, Smillie LB, Houlker C

Title

Characterization of a cDNA defining a gene family encoding TM30p1, a human fibroblast tropomyosin.

Journal

J Mol Biol 194:1-10 (1987)
DOI:10.1016/0022-2836(87)90710-8

Sequence

[hsa:7171]

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