KEGG   PATHWAY: hco02010
Entry
hco02010                    Pathway                                
Name
ABC transporters - Halomonas chromatireducens
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
Pathway map
hco02010  ABC transporters
hco02010

Other DBs
GO: 0043190 0043191 0043192
TC: 3.A.1
Organism
Halomonas chromatireducens [GN:hco]
Gene
LOKO_00895  cysP_1; Thiosulfate-binding protein precursor [KO:K02048]
LOKO_00894  cysT; Sulfate transport system permease protein CysT [KO:K02046]
LOKO_00893  cysW_1; Sulfate transport system permease protein CysW [KO:K02047]
LOKO_00892  cysA_1; Sulfate/thiosulfate import ATP-binding protein CysA [KO:K02045] [EC:7.3.2.3]
LOKO_01993  PBP superfamily domain protein [KO:K05772]
LOKO_01991  cysW_2; Sulfate transport system permease protein CysW [KO:K05773]
LOKO_01992  glnQ_2; Glutamine transport ATP-binding protein GlnQ [KO:K06857] [EC:7.3.2.6]
LOKO_02115  Putative thiamine biosynthesis protein [KO:K15598]
LOKO_02318  modA; Molybdate-binding periplasmic protein precursor [KO:K02020]
LOKO_02317  modB; Molybdenum transport system permease protein ModB [KO:K02018]
LOKO_02316  cysA_3; Sulfate/thiosulfate import ATP-binding protein CysA [KO:K02017] [EC:7.3.2.5]
LOKO_03184  fbpA; Iron-utilization periplasmic protein precursor [KO:K02012]
LOKO_00574  ydcU; Inner membrane ABC transporter permease protein YdcU [KO:K02011]
LOKO_00573  fbpC2_1; Fe(3+) ions import ATP-binding protein FbpC 2 [KO:K02010] [EC:7.2.2.7]
LOKO_01460  potD_2; Spermidine/putrescine-binding periplasmic protein precursor [KO:K11069]
LOKO_01458  potB; Spermidine/putrescine transport system permease protein PotB [KO:K11071]
LOKO_01459  potA_1; Spermidine/putrescine import ATP-binding protein PotA [KO:K11072] [EC:7.6.2.11]
LOKO_01846  potF_2; Putrescine-binding periplasmic protein precursor [KO:K11073]
LOKO_01144  potF_1; Putrescine-binding periplasmic protein precursor [KO:K11073]
LOKO_02567  ydcV_3; Inner membrane ABC transporter permease protein YdcV [KO:K11074]
LOKO_01145  fbpC2_2; Fe(3+) ions import ATP-binding protein FbpC 2 [KO:K11076] [EC:7.6.2.16]
LOKO_01410  osmF; Putative osmoprotectant uptake system substrate-binding protein OsmF precursor [KO:K05845]
LOKO_01411  yehY; Putative osmoprotectant uptake system permease protein YehY [KO:K05846]
LOKO_01413  yehW; Putative osmoprotectant uptake system permease protein YehW [KO:K05846]
LOKO_01412  opuBA; Choline transport ATP-binding protein OpuBA [KO:K05847] [EC:7.6.2.9]
LOKO_00485  malK; Maltose/maltodextrin import ATP-binding protein MalK [KO:K10111] [EC:7.5.2.-]
LOKO_00481  putative ABC transporter-binding protein precursor [KO:K10236]
LOKO_00482  sugA; Trehalose transport system permease protein SugA [KO:K10237]
LOKO_00483  sugB; Trehalose transport system permease protein SugB [KO:K10238]
LOKO_01177  mlaC; putative phospholipid-binding protein MlaC precursor [KO:K07323]
LOKO_01127  paraquat-inducible protein B [KO:K02067]
LOKO_01160  mlaD; putative phospholipid ABC transporter-binding protein MlaD [KO:K02067]
LOKO_01125  mlaE_1; putative phospholipid ABC transporter permease protein MlaE [KO:K02066]
LOKO_01159  mlaE_2; putative phospholipid ABC transporter permease protein MlaE [KO:K02066]
LOKO_01178  hypothetical protein [KO:K07122]
LOKO_01126  putative ABC transporter ATP-binding protein [KO:K02065]
LOKO_01158  putative ABC transporter ATP-binding protein [KO:K02065]
LOKO_02429  rbsB; D-ribose-binding periplasmic protein precursor [KO:K10439]
LOKO_02430  rbsC; Ribose transport system permease protein RbsC [KO:K10440]
LOKO_02431  mglA; Galactose/methyl galactoside import ATP-binding protein MglA [KO:K10441] [EC:7.5.2.7]
LOKO_03136  Bacterial extracellular solute-binding protein [KO:K17321]
LOKO_03583  ugpB; sn-glycerol-3-phosphate-binding periplasmic protein UgpB precursor [KO:K05813]
LOKO_03582  lacF; Lactose transport system permease protein LacF [KO:K05814]
LOKO_03581  araQ; L-arabinose transport system permease protein AraQ [KO:K05815]
LOKO_03584  ugpC; sn-glycerol-3-phosphate import ATP-binding protein UgpC [KO:K05816] [EC:7.6.2.10]
LOKO_03093  pstS_1; Phosphate-binding protein PstS precursor [KO:K02040]
LOKO_03103  pstS_2; Phosphate-binding protein PstS precursor [KO:K02040]
LOKO_03094  pstC_1; Phosphate transport system permease protein PstC [KO:K02037]
LOKO_03102  pstC_2; Phosphate transport system permease protein PstC [KO:K02037]
LOKO_03095  pstA_1; Phosphate transport system permease protein PstA [KO:K02038]
LOKO_03101  pstA_2; Phosphate transport system permease protein PstA [KO:K02038]
LOKO_03096  pstB3; Phosphate import ATP-binding protein PstB 3 [KO:K02036] [EC:7.3.2.1]
LOKO_03100  pstB; Phosphate import ATP-binding protein PstB [KO:K02036] [EC:7.3.2.1]
LOKO_03545  phnD; Phosphate-import protein PhnD precursor [KO:K02044]
LOKO_03726  ABC transporter, phosphonate, periplasmic substrate-binding protein [KO:K02044]
LOKO_03542  phnE_1; Phosphate-import permease protein PhnE [KO:K02042]
LOKO_03543  phnE_2; Phosphate-import permease protein PhnE [KO:K02042]
LOKO_03724  phnE_4; Phosphate-import permease protein PhnE [KO:K02042]
LOKO_03544  phnC; Phosphate-import ATP-binding protein PhnC [KO:K02041] [EC:7.3.2.2]
LOKO_03725  glnQ_5; Glutamine transport ATP-binding protein GlnQ [KO:K02041] [EC:7.3.2.2]
LOKO_01455  glnH_2; Glutamine-binding periplasmic protein precursor [KO:K10036]
LOKO_01102  glnH_1; Glutamine-binding periplasmic protein precursor [KO:K10036]
LOKO_01456  glnP_1; Glutamine transport system permease protein GlnP [KO:K10037]
LOKO_03747  glnP_2; Glutamine transport system permease protein GlnP [KO:K10037]
LOKO_01457  glnQ_1; Glutamine transport ATP-binding protein GlnQ [KO:K10038] [EC:7.4.2.1]
LOKO_03746  glnQ_6; Glutamine transport ATP-binding protein GlnQ [KO:K10038] [EC:7.4.2.1]
LOKO_03552  aapJ_1; General L-amino acid-binding periplasmic protein AapJ precursor [KO:K09969]
LOKO_03553  aapJ_2; General L-amino acid-binding periplasmic protein AapJ precursor [KO:K09969]
LOKO_03551  glnM; putative glutamine ABC transporter permease protein GlnM [KO:K09970]
LOKO_03550  yhdY; Inner membrane amino-acid ABC transporter permease protein YhdY [KO:K09971]
LOKO_03549  glnQ_4; Glutamine transport ATP-binding protein GlnQ [KO:K09972] [EC:7.4.2.1]
LOKO_03600  argT_1; Lysine-arginine-ornithine-binding periplasmic protein precursor [KO:K10022]
LOKO_03601  argT_2; Lysine-arginine-ornithine-binding periplasmic protein precursor [KO:K10022]
LOKO_03602  hisJ; Histidine-binding periplasmic protein precursor [KO:K10022]
LOKO_03599  hisM; Histidine transport system permease protein HisM [KO:K10023]
LOKO_03598  hisQ; Histidine transport system permease protein HisQ [KO:K10024]
LOKO_03597  occP; Octopine permease ATP-binding protein P [KO:K10025] [EC:7.4.2.1]
LOKO_01651  hypothetical protein [KO:K01999]
LOKO_01652  Receptor family ligand binding region [KO:K01999]
LOKO_00012  braC; Leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein precursor [KO:K01999]
LOKO_00998  hypothetical protein [KO:K01999]
LOKO_01005  hypothetical protein [KO:K01999]
LOKO_02168  hypothetical protein [KO:K01999]
LOKO_01650  livH_4; High-affinity branched-chain amino acid transport system permease protein LivH [KO:K01997]
LOKO_00014  livH_1; High-affinity branched-chain amino acid transport system permease protein LivH [KO:K01997]
LOKO_00999  livH_2; High-affinity branched-chain amino acid transport system permease protein LivH [KO:K01997]
LOKO_01007  livH_3; High-affinity branched-chain amino acid transport system permease protein LivH [KO:K01997]
LOKO_02167  livH_5; High-affinity branched-chain amino acid transport system permease protein LivH [KO:K01997]
LOKO_01649  hypothetical protein [KO:K01998]
LOKO_00013  leucine/isoleucine/valine transporter permease subunit [KO:K01998]
LOKO_01000  leucine/isoleucine/valine transporter permease subunit [KO:K01998]
LOKO_01006  leucine/isoleucine/valine transporter permease subunit [KO:K01998]
LOKO_02166  leucine/isoleucine/valine transporter permease subunit [KO:K01998]
LOKO_00016  lptB_1; Lipopolysaccharide export system ATP-binding protein LptB [KO:K01995]
LOKO_00995  lptB_2; Lipopolysaccharide export system ATP-binding protein LptB [KO:K01995]
LOKO_01004  lptB_3; Lipopolysaccharide export system ATP-binding protein LptB [KO:K01995]
LOKO_02170  tcyC; L-cystine import ATP-binding protein TcyC [KO:K01995]
LOKO_00015  livF_1; High-affinity branched-chain amino acid transport ATP-binding protein LivF [KO:K01996]
LOKO_00996  livF_2; High-affinity branched-chain amino acid transport ATP-binding protein LivF [KO:K01996]
LOKO_01003  livF_3; High-affinity branched-chain amino acid transport ATP-binding protein LivF [KO:K01996]
LOKO_02169  livF_4; High-affinity branched-chain amino acid transport ATP-binding protein LivF [KO:K01996]
LOKO_02060  metQ; D-methionine-binding lipoprotein MetQ precursor [KO:K02073]
LOKO_02059  metI; D-methionine transport system permease protein MetI [KO:K02072]
LOKO_02058  metN; Methionine import ATP-binding protein MetN [KO:K02071]
LOKO_03697  amiC_2; Aliphatic amidase expression-regulating protein [KO:K11959]
LOKO_03696  livH_6; High-affinity branched-chain amino acid transport system permease protein LivH [KO:K11960]
LOKO_03695  leucine/isoleucine/valine transporter permease subunit [KO:K11961]
LOKO_03694  lptB_5; Lipopolysaccharide export system ATP-binding protein LptB [KO:K11962]
LOKO_03693  livF_5; High-affinity branched-chain amino acid transport ATP-binding protein LivF [KO:K11963]
LOKO_02128  appA_2; Oligopeptide-binding protein AppA precursor [KO:K13893]
LOKO_02129  yejB; Inner membrane ABC transporter permease protein YejB [KO:K13894]
LOKO_02130  yejE; Inner membrane ABC transporter permease protein YejE [KO:K13895]
LOKO_02131  gsiA_3; Glutathione import ATP-binding protein GsiA [KO:K13896]
LOKO_01291  lolE; Lipoprotein-releasing system transmembrane protein LolE [KO:K09808]
LOKO_01292  lolD; Lipoprotein-releasing system ATP-binding protein LolD [KO:K09810] [EC:7.6.2.-]
LOKO_02867  Heme exporter protein D (CcmD) [KO:K02196]
LOKO_02868  ccmC; Heme exporter protein C [KO:K02195]
LOKO_02869  ccmB; Heme exporter protein B [KO:K02194]
LOKO_02870  ccmA; Cytochrome c biogenesis ATP-binding export protein CcmA [KO:K02193] [EC:7.6.2.5]
LOKO_02906  lptF; Lipopolysaccharide export system permease protein LptF [KO:K07091]
LOKO_02907  lptG; Lipopolysaccharide export system permease protein LptG [KO:K11720]
LOKO_01152  lptB_4; Lipopolysaccharide export system ATP-binding protein LptB [KO:K06861] [EC:7.5.2.5]
LOKO_01674  ABC-2 family transporter protein [KO:K19341]
LOKO_01675  yxlF; putative ABC transporter ATP-binding protein YxlF [KO:K19340]
LOKO_03013  ftsX; Cell division protein FtsX [KO:K09811]
LOKO_03014  ftsE; Cell division ATP-binding protein FtsE [KO:K09812]
LOKO_01298  msbA_2; Lipid A export ATP-binding/permease protein MsbA [KO:K11085] [EC:7.5.2.6]
LOKO_03233  Putative multidrug export ATP-binding/permease protein [KO:K18893]
LOKO_01961  apxIB; Toxin RTX-I translocation ATP-binding protein [KO:K12541]
LOKO_01049  Putative multidrug export ATP-binding/permease protein [KO:K16012]
LOKO_01048  cydD; ATP-binding/permease protein CydD [KO:K16013]
Compound
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00032  Heme
C00034  Manganese
C00037  Glycine
C00038  Zinc cation
C00041  L-Alanine
C00047  L-Lysine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00062  L-Arginine
C00064  L-Glutamine
C00065  L-Serine
C00070  Copper
C00077  L-Ornithine
C00079  L-Phenylalanine
C00086  Urea
C00088  Nitrite
C00089  Sucrose
C00093  sn-Glycerol 3-phosphate
C00095  D-Fructose
C00098  Oligopeptide
C00107  Dipeptide
C00114  Choline
C00116  Glycerol
C00120  Biotin
C00121  D-Ribose
C00123  L-Leucine
C00134  Putrescine
C00135  L-Histidine
C00137  myo-Inositol
C00140  N-Acetyl-D-glucosamine
C00148  L-Proline
C00151  L-Amino acid
C00159  D-Mannose
C00175  Cobalt ion
C00181  D-Xylose
C00183  L-Valine
C00185  Cellobiose
C00188  L-Threonine
C00208  Maltose
C00212  Adenosine
C00243  Lactose
C00244  Nitrate
C00245  Taurine
C00255  Riboflavin
C00259  L-Arabinose
C00288  HCO3-
C00291  Nickel
C00294  Inosine
C00299  Uridine
C00315  Spermidine
C00320  Thiosulfate
C00330  Deoxyguanosine
C00333  D-Galacturonate
C00338  Lipopolysaccharide
C00378  Thiamine
C00379  Xylitol
C00387  Guanosine
C00392  Mannitol
C00407  L-Isoleucine
C00430  5-Aminolevulinate
C00470  Pectate
C00475  Cytidine
C00487  Carnitine
C00491  L-Cystine
C00492  Raffinose
C00503  Erythritol
C00526  Deoxyuridine
C00559  Deoxyadenosine
C00719  Betaine
C00794  D-Sorbitol
C00855  D-Methionine
C00865  Phospholipid
C00881  Deoxycytidine
C00919  Choline sulfate
C00973  Cyclomaltodextrin
C01083  alpha,alpha-Trehalose
C01153  Orthophosphoric monoester
C01157  Hydroxyproline
C01177  Inositol 1-phosphate
C01181  4-Trimethylammoniobutanoate
C01279  4-Amino-5-hydroxymethyl-2-methylpyrimidine
C01330  Sodium cation
C01417  Cyanate
C01487  D-Allose
C01606  Phthalate
C01630  Xylobiose
C01667  Bacitracin
C01674  Chitobiose
C01682  Nopaline
C01684  D-Rhamnose
C01762  Xanthosine
C01834  Lipoprotein
C01835  Maltotriose
C01935  Maltodextrin
C01946  Oleandomycin
C02160  Isomaltotriose
C02273  Digalacturonate
C03557  2-Aminoethylphosphonate
C03611  Galactose oligosaccharide
C03619  Methyl beta-D-galactoside
C04114  (E)-4-(Trimethylammonio)but-2-enoate
C04137  Octopine
C05349  Ciprofloxacin
C05402  Melibiose
C05512  Deoxyinosine
C05776  Vitamin B12
C06227  Fe(III)hydroxamate
C06229  Fe(III)dicitrate
C06230  Fe-enterobactin
C06232  Molybdate
C06687  Norfloxacin
C06705  Capsular polysaccharide
C06706  Lipo-oligosaccharide
C06707  Teichoic acid
C06767  Hemine
C07662  Sparfloxacin
C07663  Moxifloxacin
C11612  Polymyxin B
C13768  Colistin sulfate
C14818  Fe2+
C14819  Fe3+
C15521  Alkanesulfonate
C15719  Coelichelin
C16421  AI-2
C16692  Mannopine
C19609  Nickel(2+)
C19872  N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570  alpha-1,5-L-Arabinobiose
C20571  alpha-1,5-L-Arabinotriose
C20572  alpha-1,5-L-Arabinotetraose
C20573  Aldotetraouronic acid
C20679  Tungstate
C21066  D-Galactofuranose
C22040  S-Methyl-L-cysteine
G00457  Maltotetraose
Reference
PMID:9799792
  Authors
Tomii K, Kanehisa M.
  Title
A comparative analysis of ABC transporters in complete microbial genomes.
  Journal
Genome Res 8:1048-59 (1998)
DOI:10.1101/gr.8.10.1048
Reference
PMID:18424520
  Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
  Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
J Bacteriol 190:4460-9 (2008)
DOI:10.1128/JB.00270-08
Reference
PMID:18375759
  Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
  Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
Proc Natl Acad Sci U S A 105:5537-42 (2008)
DOI:10.1073/pnas.0801196105
Reference
PMID:10557362
  Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
  Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
  Journal
Proc Natl Acad Sci U S A 96:13571-6 (1999)
DOI:10.1073/pnas.96.23.13571
Reference
PMID:11731493
  Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
  Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
  Journal
Genome Res 11:2034-40 (2001)
DOI:10.1101/gr.196301
Reference
PMID:16135226
  Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
  Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
  Journal
Mol Microbiol 57:1582-92 (2005)
DOI:10.1111/j.1365-2958.2005.04791.x
Reference
PMID:11929526
  Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
  Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
  Journal
Mol Microbiol 43:703-15 (2002)
DOI:10.1046/j.1365-2958.2002.02778.x
Reference
PMID:18326572
  Authors
Richard-Fogal CL, Frawley ER, Kranz RG
  Title
Topology and function of CcmD in cytochrome c maturation.
  Journal
J Bacteriol 190:3489-93 (2008)
DOI:10.1128/JB.00146-08
Reference
PMID:16109926
  Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
  Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
  Journal
J Bacteriol 187:5861-7 (2005)
DOI:10.1128/JB.187.17.5861-5867.2005
Reference
PMID:17873039
  Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
  Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
  Journal
J Bacteriol 189:8361-5 (2007)
DOI:10.1128/JB.01028-07
Reference
PMID:17214741
  Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
  Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
  Journal
Mol Microbiol 63:895-910 (2007)
DOI:10.1111/j.1365-2958.2006.05549.x
Reference
PMID:18805970
  Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
  Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
  Journal
J Bacteriol 190:7693-8 (2008)
DOI:10.1128/JB.00853-08
KO pathway
ko02010   
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