KEGG   PATHWAY: hdh02024
Entry
hdh02024                    Pathway                                
Name
Quorum sensing - Pikeienuella piscinae
Description
Quorum sensing (QS) is a regulatory system that allows bacteria to share information about cell density and adjust gene expression accordingly. All QS bacteria produce and release chemical signal molecules called autoinducers (AIs) that increase in concentration as a function of cell density. The most commonly studied AIs belong to one of the following three categories: acylated homoserine lactones, also referred to as AI-1, used by Gram-negative bacteria; peptide signals, used by Gram-positive bacteria; and AI-2, used by both Gram-negative and Gram-positive bacteria. QS can be divided into at least 4 steps: production of AIs by the bacterial cell; release of AIs, either actively or passively, into the surrounding environment; recognition of AIs by specific receptors; and leading to changes in gene regulation once they exceed a threshold concentration. The processes controlled by QS include virulence, competence, conjugation, antibiotic production, motility, sporulation, and biofilm formation.
Class
Cellular Processes; Cellular community - prokaryotes
Pathway map
hdh02024  Quorum sensing
hdh02024

Other DBs
GO: 0009372
Organism
Pikeienuella piscinae [GN:hdh]
Gene
G5B40_02815  hfq; RNA chaperone Hfq [KO:K03666]
G5B40_00380  anthranilate synthase component I [KO:K01657] [EC:4.1.3.27]
G5B40_07590  aminodeoxychorismate/anthranilate synthase component II [KO:K01658] [EC:4.1.3.27]
G5B40_20785  3-deoxy-7-phosphoheptulonate synthase class II [KO:K01626] [EC:2.5.1.54]
G5B40_11695  extracellular solute-binding protein [KO:K02055]
G5B40_04570  hypothetical protein [KO:K02053]
G5B40_11680  ABC transporter permease [KO:K02053]
G5B40_11685  ABC transporter permease [KO:K02054]
G5B40_11690  ABC transporter ATP-binding protein [KO:K02052]
G5B40_10010  ABC transporter substrate-binding protein [KO:K01999]
G5B40_03810  ABC transporter substrate-binding protein [KO:K01999]
G5B40_01750  ABC transporter substrate-binding protein [KO:K01999]
G5B40_02310  ABC transporter substrate-binding protein [KO:K01999]
G5B40_06415  ABC transporter substrate-binding protein [KO:K01999]
G5B40_09330  ABC transporter substrate-binding protein [KO:K01999]
G5B40_09820  ABC transporter substrate-binding protein [KO:K01999]
G5B40_10305  ABC transporter substrate-binding protein [KO:K01999]
G5B40_11350  ABC transporter substrate-binding protein [KO:K01999]
G5B40_12170  ABC transporter substrate-binding protein [KO:K01999]
G5B40_15325  ABC transporter substrate-binding protein [KO:K01999]
G5B40_15435  ABC transporter substrate-binding protein [KO:K01999]
G5B40_19705  ABC transporter substrate-binding protein [KO:K01999]
G5B40_20095  ABC transporter substrate-binding protein [KO:K01999]
G5B40_01745  branched-chain amino acid ABC transporter permease [KO:K01997]
G5B40_02315  branched-chain amino acid ABC transporter permease [KO:K01997]
G5B40_03805  branched-chain amino acid ABC transporter permease [KO:K01997]
G5B40_06420  branched-chain amino acid ABC transporter permease [KO:K01997]
G5B40_09325  branched-chain amino acid ABC transporter permease [KO:K01997]
G5B40_09835  branched-chain amino acid ABC transporter permease [KO:K01997]
G5B40_10000  branched-chain amino acid ABC transporter permease [KO:K01997]
G5B40_10290  branched-chain amino acid ABC transporter permease [KO:K01997]
G5B40_11335  branched-chain amino acid ABC transporter permease [KO:K01997]
G5B40_12165  branched-chain amino acid ABC transporter permease [KO:K01997]
G5B40_15320  branched-chain amino acid ABC transporter permease [KO:K01997]
G5B40_15440  branched-chain amino acid ABC transporter permease [KO:K01997]
G5B40_19710  branched-chain amino acid ABC transporter permease [KO:K01997]
G5B40_20080  branched-chain amino acid ABC transporter permease [KO:K01997]
G5B40_01740  branched-chain amino acid ABC transporter permease [KO:K01998]
G5B40_15445  branched-chain amino acid ABC transporter permease [KO:K01998]
G5B40_02320  branched-chain amino acid ABC transporter permease [KO:K01998]
G5B40_06425  branched-chain amino acid ABC transporter permease [KO:K01998]
G5B40_09320  branched-chain amino acid ABC transporter permease [KO:K01998]
G5B40_09840  branched-chain amino acid ABC transporter permease [KO:K01998]
G5B40_10005  branched-chain amino acid ABC transporter permease [KO:K01998]
G5B40_10285  branched-chain amino acid ABC transporter permease [KO:K01998]
G5B40_11330  branched-chain amino acid ABC transporter permease [KO:K01998]
G5B40_12160  branched-chain amino acid ABC transporter permease [KO:K01998]
G5B40_15315  branched-chain amino acid ABC transporter permease [KO:K01998]
G5B40_19715  branched-chain amino acid ABC transporter permease [KO:K01998]
G5B40_20090  branched-chain amino acid ABC transporter permease [KO:K01998]
G5B40_01735  ABC transporter ATP-binding protein [KO:K01995]
G5B40_02325  ABC transporter ATP-binding protein [KO:K01995]
G5B40_03795  ABC transporter ATP-binding protein [KO:K01995]
G5B40_06405  ABC transporter ATP-binding protein [KO:K01995]
G5B40_09315  ABC transporter ATP-binding protein [KO:K01995]
G5B40_09825  ABC transporter ATP-binding protein [KO:K01995]
G5B40_09990  ABC transporter ATP-binding protein [KO:K01995]
G5B40_10280  ABC transporter ATP-binding protein [KO:K01995]
G5B40_11345  ABC transporter ATP-binding protein [KO:K01995]
G5B40_12155  ABC transporter ATP-binding protein [KO:K01995]
G5B40_15310  ABC transporter ATP-binding protein [KO:K01995]
G5B40_15450  ABC transporter ATP-binding protein [KO:K01995]
G5B40_19720  ABC transporter ATP-binding protein [KO:K01995]
G5B40_20065  ABC transporter ATP-binding protein [KO:K01995]
G5B40_01730  ATP-binding cassette domain-containing protein [KO:K01996]
G5B40_02330  ABC transporter ATP-binding protein [KO:K01996]
G5B40_03790  ABC transporter ATP-binding protein [KO:K01996]
G5B40_06410  ABC transporter ATP-binding protein [KO:K01996]
G5B40_09310  ABC transporter ATP-binding protein [KO:K01996]
G5B40_09830  ABC transporter ATP-binding protein [KO:K01996]
G5B40_09995  ABC transporter ATP-binding protein [KO:K01996]
G5B40_11340  ABC transporter ATP-binding protein [KO:K01996]
G5B40_12150  ABC transporter ATP-binding protein [KO:K01996]
G5B40_15305  ABC transporter ATP-binding protein [KO:K01996]
G5B40_15455  ABC transporter ATP-binding protein [KO:K01996]
G5B40_19725  ABC transporter ATP-binding protein [KO:K01996]
G5B40_20100  ABC transporter ATP-binding protein [KO:K01996]
G5B40_15395  hypothetical protein [KO:K20276]
G5B40_11990  AMP-binding protein [KO:K01897] [EC:6.2.1.3]
G5B40_20060  long-chain fatty acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
G5B40_08640  Crp/Fnr family transcriptional regulator [KO:K10914]
G5B40_12630  Crp/Fnr family transcriptional regulator [KO:K10914]
G5B40_14855  transcriptional repressor [KO:K09823]
G5B40_12885  ribA; GTP cyclohydrolase II [KO:K01497] [EC:3.5.4.25]
G5B40_03725  ribD; bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD [KO:K11752] [EC:3.5.4.26 1.1.1.193]
G5B40_00610  ABC transporter substrate-binding protein [KO:K02035]
G5B40_01055  peptide ABC transporter substrate-binding protein [KO:K02035]
G5B40_01755  ABC transporter substrate-binding protein [KO:K02035]
G5B40_01840  ABC transporter substrate-binding protein [KO:K02035]
G5B40_03690  ABC transporter substrate-binding protein [KO:K02035]
G5B40_05260  ABC transporter substrate-binding protein [KO:K02035]
G5B40_06315  hypothetical protein [KO:K02035]
G5B40_06460  ABC transporter substrate-binding protein [KO:K02035]
G5B40_06710  ABC transporter substrate-binding protein [KO:K02035]
G5B40_08700  twin-arginine translocation signal domain-containing protein [KO:K02035]
G5B40_09425  ABC transporter substrate-binding protein [KO:K02035]
G5B40_11740  peptide ABC transporter substrate-binding protein [KO:K02035]
G5B40_12275  ABC transporter substrate-binding protein [KO:K02035]
G5B40_13250  ABC transporter substrate-binding protein [KO:K02035]
G5B40_14930  ABC transporter substrate-binding protein [KO:K02035]
G5B40_15120  hypothetical protein [KO:K02035]
G5B40_15645  ABC transporter substrate-binding protein [KO:K02035]
G5B40_15685  ABC transporter substrate-binding protein [KO:K02035]
G5B40_16460  ABC transporter substrate-binding protein [KO:K02035]
G5B40_18630  ABC transporter substrate-binding protein [KO:K02035]
G5B40_19935  ABC transporter substrate-binding protein [KO:K02035]
G5B40_09415  ABC transporter permease [KO:K02033]
G5B40_00605  ABC transporter permease [KO:K02033]
G5B40_01050  ABC transporter permease [KO:K02033]
G5B40_01760  ABC transporter permease [KO:K02033]
G5B40_03695  ABC transporter permease [KO:K02033]
G5B40_05275  ABC transporter permease [KO:K02033]
G5B40_06310  ABC transporter permease [KO:K02033]
G5B40_06455  ABC transporter permease [KO:K02033]
G5B40_06720  ABC transporter permease [KO:K02033]
G5B40_08705  ABC transporter permease [KO:K02033]
G5B40_08870  ABC transporter permease [KO:K02033]
G5B40_09070  ABC transporter permease [KO:K02033]
G5B40_11735  ABC transporter permease [KO:K02033]
G5B40_12280  ABC transporter permease [KO:K02033]
G5B40_13245  ABC transporter permease [KO:K02033]
G5B40_14935  ABC transporter permease [KO:K02033]
G5B40_15135  ABC transporter permease [KO:K02033]
G5B40_15650  ABC transporter permease [KO:K02033]
G5B40_15690  ABC transporter permease [KO:K02033]
G5B40_16465  ABC transporter permease [KO:K02033]
G5B40_18635  ABC transporter permease [KO:K02033]
G5B40_19930  ABC transporter permease [KO:K02033]
G5B40_00600  ABC transporter permease [KO:K02034]
G5B40_01045  ABC transporter permease [KO:K02034]
G5B40_01765  ABC transporter permease [KO:K02034]
G5B40_03700  ABC transporter permease [KO:K02034]
G5B40_05270  ABC transporter permease [KO:K02034]
G5B40_06305  ABC transporter permease [KO:K02034]
G5B40_06450  ABC transporter permease [KO:K02034]
G5B40_06725  ABC transporter permease [KO:K02034]
G5B40_08710  ABC transporter permease [KO:K02034]
G5B40_08875  ABC transporter permease [KO:K02034]
G5B40_09065  ABC transporter permease [KO:K02034]
G5B40_09420  ABC transporter permease [KO:K02034]
G5B40_11730  ABC transporter permease [KO:K02034]
G5B40_12285  ABC transporter permease [KO:K02034]
G5B40_13240  ABC transporter permease [KO:K02034]
G5B40_14940  ABC transporter permease [KO:K02034]
G5B40_15140  ABC transporter permease [KO:K02034]
G5B40_15655  ABC transporter permease [KO:K02034]
G5B40_15695  ABC transporter permease [KO:K02034]
G5B40_16470  ABC transporter permease [KO:K02034]
G5B40_18640  ABC transporter permease [KO:K02034]
G5B40_19925  ABC transporter permease [KO:K02034]
G5B40_11725  ABC transporter ATP-binding protein [KO:K02031]
G5B40_00595  ABC transporter ATP-binding protein [KO:K02031 K02032]
G5B40_01770  ABC transporter ATP-binding protein [KO:K02031 K02032]
G5B40_03705  ABC transporter ATP-binding protein [KO:K02031 K02032]
G5B40_05265  ABC transporter ATP-binding protein [KO:K02031 K02032]
G5B40_06445  ABC transporter ATP-binding protein [KO:K02031 K02032]
G5B40_06730  ABC transporter ATP-binding protein [KO:K02031 K02032]
G5B40_08880  ABC transporter ATP-binding protein [KO:K02031]
G5B40_09060  ABC transporter ATP-binding protein [KO:K02031]
G5B40_12290  ABC transporter ATP-binding protein [KO:K02031 K02032]
G5B40_13255  ABC transporter ATP-binding protein [KO:K02031 K02032]
G5B40_15125  ABC transporter ATP-binding protein [KO:K02031]
G5B40_15660  ABC transporter ATP-binding protein [KO:K02031]
G5B40_16475  ABC transporter ATP-binding protein [KO:K02031 K02032]
G5B40_18645  ABC transporter ATP-binding protein [KO:K02031 K02032]
G5B40_14945  ABC transporter ATP-binding protein [KO:K02031]
G5B40_15700  ABC transporter ATP-binding protein [KO:K02031]
G5B40_01065  ABC transporter ATP-binding protein [KO:K02031]
G5B40_08720  dipeptide ABC transporter ATP-binding protein [KO:K02032]
G5B40_15705  ABC transporter ATP-binding protein [KO:K02032]
G5B40_11720  ATP-binding cassette domain-containing protein [KO:K02032]
G5B40_15130  ABC transporter ATP-binding protein [KO:K02032]
G5B40_14950  ATP-binding cassette domain-containing protein [KO:K02032]
G5B40_01060  dipeptide ABC transporter ATP-binding protein [KO:K02032]
G5B40_17565  yidC; membrane protein insertase YidC [KO:K03217]
G5B40_16745  secE; preprotein translocase subunit SecE [KO:K03073]
G5B40_16875  secG; preprotein translocase subunit SecG [KO:K03075]
G5B40_20375  secY; preprotein translocase subunit SecY [KO:K03076]
G5B40_03295  yajC; preprotein translocase subunit YajC [KO:K03210]
G5B40_16425  secA; preprotein translocase subunit SecA [KO:K03070] [EC:7.4.2.8]
G5B40_19880  ftsY; signal recognition particle-docking protein FtsY [KO:K03110]
G5B40_13000  secB; protein-export chaperone SecB [KO:K03071]
G5B40_08145  ffh; signal recognition particle protein [KO:K03106] [EC:3.6.5.4]
Compound
C00007  Oxygen
C00009  Orthophosphate
C00059  Sulfate
C00232  Succinate semialdehyde
C00334  4-Aminobutanoate
C00547  L-Noradrenaline
C00788  L-Adrenaline
C01019  L-Fucose
C11837  N-Butyryl-L-homoserine lactone
C11841  N-(3-Oxooctanoyl)homoserine lactone
C11844  N-Heptanoylhomoserine lactone
C11845  N-(3-Hydroxy-7-cis-tetradecenoyl)homoserine lactone
C11848  2-Heptyl-3-hydroxy-quinolone
C16421  AI-2
C16463  3',5'-Cyclic diGMP
C16640  CAI-1
C18049  N-Acyl-L-homoserine lactone
C18206  cis-11-Methyl-2-dodecenoic acid
C20643  2-Heptyl-4(1H)-quinolone
C20677  N-(4-Coumaroyl)-L-homoserine lactone
C20959  (4S)-4-Hydroxy-5-phosphooxypentane-2,3-dione
C21195  N-(3-Hydroxybutanoyl)-L-homoserine lactone
C21197  N-Hexanoyl-L-homoserine lactone
C21198  N-(3-Oxohexanoyl)-L-homoserine lactone
C21199  N-Octanoyl-L-homoserine lactone
C21200  N-3-Hydroxyoctanoyl-L-homoserine lactone
C21201  N-3-Oxo-dodecanoyl-L-homoserine lactone
C21202  cis-2-Dodecenoic acid
C21220  AIP-1
C21221  CSP
C21222  CSP
C21223  Blp
C21224  SHP2
C21225  SHP3
C21226  cCF10
C21227  iCF10
C21228  cAD1
C21229  iAD1
C21230  ComX pheromone
C21231  PhrA pentapeptide
C21232  PhrC pentapeptide
C21233  PhrE pentapeptide
C21234  PhrF pentapeptide
C21235  PhrG pentapeptide
C21236  PhrH pentapeptide
C21237  PhrK pentapeptide
C21238  NprX peptide
C21239  PapR peptide
C21241  AIP-2
C21242  AIP-3
C21243  AIP-4
C21244  AgrD peptide
C21245  AgrD1 peptide
C21246  GBAP
C21382  R-THMF
Reference
PMID:22712853
  Authors
Pereira CS, Thompson JA, Xavier KB
  Title
AI-2-mediated signalling in bacteria.
  Journal
FEMS Microbiol Rev 37:156-81 (2013)
DOI:10.1111/j.1574-6976.2012.00345.x
Reference
PMID:23965960
  Authors
Verma SC, Miyashiro T
  Title
Quorum sensing in the squid-Vibrio symbiosis.
  Journal
Int J Mol Sci 14:16386-401 (2013)
DOI:10.3390/ijms140816386
Reference
PMID:24348467
  Authors
Norsworthy AN, Visick KL
  Title
Gimme shelter: how Vibrio fischeri successfully navigates an animal's multiple environments.
  Journal
Front Microbiol 4:356 (2013)
DOI:10.3389/fmicb.2013.00356
Reference
PMID:24065108
  Authors
Papaioannou E, Utari PD, Quax WJ
  Title
Choosing an appropriate infection model to study quorum sensing inhibition in Pseudomonas infections.
  Journal
Int J Mol Sci 14:19309-40 (2013)
DOI:10.3390/ijms140919309
Reference
PMID:20738404
  Authors
Heeb S, Fletcher MP, Chhabra SR, Diggle SP, Williams P, Camara M
  Title
Quinolones: from antibiotics to autoinducers.
  Journal
FEMS Microbiol Rev 35:247-74 (2011)
DOI:10.1111/j.1574-6976.2010.00247.x
Reference
PMID:25866808
  Authors
Rasamiravaka T, Labtani Q, Duez P, El Jaziri M
  Title
The formation of biofilms by Pseudomonas aeruginosa: a review of the natural and synthetic compounds interfering with control mechanisms.
  Journal
Biomed Res Int 2015:759348 (2015)
DOI:10.1155/2015/759348
Reference
PMID:11544214
  Authors
Whiteley M, Greenberg EP
  Title
Promoter specificity elements in Pseudomonas aeruginosa quorum-sensing-controlled genes.
  Journal
J Bacteriol 183:5529-34 (2001)
DOI:10.1128/JB.183.19.5529-5534.2001
Reference
PMID:11497469
  Authors
Chin-A-Woeng TF, van den Broek D, de Voer G, van der Drift KM, Tuinman S, Thomas-Oates JE, Lugtenberg BJ, Bloemberg GV
  Title
Phenazine-1-carboxamide production in the biocontrol strain Pseudomonas chlororaphis PCL1391 is regulated by multiple factors secreted into the growth medium.
  Journal
Mol Plant Microbe Interact 14:969-79 (2001)
DOI:10.1094/MPMI.2001.14.8.969
Reference
PMID:19696934
  Authors
Hughes DT, Clarke MB, Yamamoto K, Rasko DA, Sperandio V
  Title
The QseC adrenergic signaling cascade in Enterohemorrhagic E. coli (EHEC).
  Journal
PLoS Pathog 5:e1000553 (2009)
DOI:10.1371/journal.ppat.1000553
Reference
PMID:22144490
  Authors
Njoroge J, Sperandio V
  Title
Enterohemorrhagic Escherichia coli virulence regulation by two bacterial adrenergic kinases, QseC and QseE.
  Journal
Infect Immun 80:688-703 (2012)
DOI:10.1128/IAI.05921-11
Reference
PMID:23160491
  Authors
Pacheco AR, Curtis MM, Ritchie JM, Munera D, Waldor MK, Moreira CG, Sperandio V
  Title
Fucose sensing regulates bacterial intestinal colonization.
  Journal
Nature 492:113-7 (2012)
DOI:10.1038/nature11623
Reference
PMID:22778415
  Authors
Hirakawa H, Harwood CS, Pechter KB, Schaefer AL, Greenberg EP
  Title
Antisense RNA that affects Rhodopseudomonas palustris quorum-sensing signal receptor expression.
  Journal
Proc Natl Acad Sci U S A 109:12141-6 (2012)
DOI:10.1073/pnas.1200243109
Reference
PMID:14617175
  Authors
Danino VE, Wilkinson A, Edwards A, Downie JA
  Title
Recipient-induced transfer of the symbiotic plasmid pRL1JI in Rhizobium leguminosarum bv. viciae is regulated by a quorum-sensing relay.
  Journal
Mol Microbiol 50:511-25 (2003)
DOI:10.1046/j.1365-2958.2003.03699.x
Reference
PMID:12448738
  Authors
Wisniewski-Dye F, Downie JA
  Title
Quorum-sensing in Rhizobium.
  Journal
Antonie Van Leeuwenhoek 81:397-407 (2002)
DOI:10.1023/A:1020501104051
Reference
PMID:10368158
  Authors
Rodelas B, Lithgow JK, Wisniewski-Dye F, Hardman A, Wilkinson A, Economou A, Williams P, Downie JA
  Title
Analysis of quorum-sensing-dependent control of rhizosphere-expressed (rhi) genes in Rhizobium leguminosarum bv. viciae.
  Journal
J Bacteriol 181:3816-23 (1999)
DOI:10.1128/JB.181.12.3816-3823.1999
Reference
PMID:24550924
  Authors
Lang J, Faure D
  Title
Functions and regulation of quorum-sensing in Agrobacterium tumefaciens.
  Journal
Front Plant Sci 5:14 (2014)
DOI:10.3389/fpls.2014.00014
Reference
PMID:23710277
  Authors
Planamente S, Morera S, Faure D
  Title
In planta fitness-cost of the Atu4232-regulon encoding for a selective GABA-binding sensor in Agrobacterium.
  Journal
Commun Integr Biol 6:e23692 (2013)
DOI:10.4161/cib.23692
Reference
PMID:16943991
  Authors
Barnard AM, Salmond GP
  Title
Quorum sensing in Erwinia species.
  Journal
Anal Bioanal Chem 387:415-23 (2007)
DOI:10.1007/s00216-006-0701-1
Reference
PMID:17360277
  Authors
Barnard AM, Bowden SD, Burr T, Coulthurst SJ, Monson RE, Salmond GP
  Title
Quorum sensing, virulence and secondary metabolite production in plant soft-rotting bacteria.
  Journal
Philos Trans R Soc Lond B Biol Sci 362:1165-83 (2007)
DOI:10.1098/rstb.2007.2042
Reference
PMID:19843225
  Authors
Carlier A, Burbank L, von Bodman SB
  Title
Identification and characterization of three novel EsaI/EsaR quorum-sensing controlled stewartan exopolysaccharide biosynthetic genes in Pantoea stewartii ssp. stewartii.
  Journal
Mol Microbiol 74:903-13 (2009)
DOI:10.1111/j.1365-2958.2009.06906.x
Reference
PMID:7665477
  Authors
Beck von Bodman S, Farrand SK
  Title
Capsular polysaccharide biosynthesis and pathogenicity in Erwinia stewartii require induction by an N-acylhomoserine lactone autoinducer.
  Journal
J Bacteriol 177:5000-8 (1995)
DOI:10.1128/JB.177.17.5000-5008.1995
Reference
PMID:19761612
  Authors
O'Grady EP, Viteri DF, Malott RJ, Sokol PA
  Title
Reciprocal regulation by the CepIR and CciIR quorum sensing systems in Burkholderia cenocepacia.
  Journal
BMC Genomics 10:441 (2009)
DOI:10.1186/1471-2164-10-441
Reference
PMID:16041013
  Authors
Malott RJ, Baldwin A, Mahenthiralingam E, Sokol PA
  Title
Characterization of the cciIR quorum-sensing system in Burkholderia cenocepacia.
  Journal
Infect Immun 73:4982-92 (2005)
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Related
pathway
hdh00405  Phenazine biosynthesis
hdh02040  Flagellar assembly
KO pathway
ko02024   
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