KEGG   PATHWAY: hrj03440
Entry
hrj03440                    Pathway                                
Name
Homologous recombination - Haliotis rubra (blacklip abalone)
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
hrj03440  Homologous recombination
hrj03440

Other DBs
GO: 0000724
Organism
Haliotis rubra (blacklip abalone) [GN:hrj]
Gene
124281808  single-stranded DNA-binding protein, mitochondrial-like isoform X1 [KO:K03111]
124266222  DNA repair protein RAD50-like isoform X1 [KO:K10866] [EC:3.6.-.-]
124291727  LOW QUALITY PROTEIN: double-strand break repair protein MRE11-like [KO:K10865]
124259427  LOW QUALITY PROTEIN: nibrin-like [KO:K10867]
124277804  LOW QUALITY PROTEIN: serine-protein kinase ATM-like [KO:K04728] [EC:2.7.11.1]
124261800  BRCA1-associated RING domain protein 1-like isoform X1 [KO:K10683]
124258729  uncharacterized protein LOC124258729 [KO:K20773] [EC:3.1.-.-]
124271423  Fanconi anemia group J protein homolog [KO:K15362] [EC:5.6.2.3]
124278635  LOW QUALITY PROTEIN: DNA topoisomerase 2-binding protein 1-like [KO:K10728]
124281916  uncharacterized protein LOC124281916 isoform X1 [KO:K20775]
124258514  BRISC and BRCA1-A complex member 1-like [KO:K20776]
124287380  BRISC and BRCA1-A complex member 2-like [KO:K12173]
124279956  lys-63-specific deubiquitinase BRCC36-like [KO:K11864] [EC:3.4.19.-]
124257334  LOW QUALITY PROTEIN: uncharacterized protein LOC124257334 [KO:K08775]
124278642  26S proteasome complex subunit SEM1-like [KO:K10881]
124268132  LOW QUALITY PROTEIN: synaptonemal complex protein 3-like [KO:K19528]
124275382  synaptonemal complex protein 3-like [KO:K19528]
124277642  LOW QUALITY PROTEIN: replication protein A 70 kDa DNA-binding subunit-like [KO:K07466]
124285931  LOW QUALITY PROTEIN: replication protein A 32 kDa subunit-like [KO:K10739]
124253485  replication protein A 14 kDa subunit-like [KO:K10740]
124289893  DNA repair protein RAD51 homolog 1 [KO:K04482]
124253253  LOW QUALITY PROTEIN: DNA repair and recombination protein rhm52-like [KO:K10873]
124260551  DNA repair protein RAD51 homolog 2-like [KO:K10869]
124284734  DNA repair protein RAD51 homolog 3-like [KO:K10870]
124267749  DNA repair protein RAD51 homolog 4-like [KO:K10871]
124269840  DNA repair protein XRCC2-like [KO:K10879]
124285429  DNA repair protein XRCC3-like isoform X1 [KO:K10880]
124284039  DNA repair and recombination protein RAD54-like [KO:K10875] [EC:5.6.2.-]
124288883  DNA repair and recombination protein RAD54B-like isoform X1 [KO:K10877] [EC:5.6.2.-]
124270372  LOW QUALITY PROTEIN: DNA polymerase delta catalytic subunit-like [KO:K02327] [EC:2.7.7.7]
124264070  DNA polymerase delta subunit 2-like [KO:K02328]
124273265  LOW QUALITY PROTEIN: DNA polymerase delta subunit 3-like [KO:K03504]
124280860  DNA polymerase delta subunit 4-like [KO:K03505]
124279848  Bloom syndrome protein homolog [KO:K10901] [EC:5.6.2.4]
124278021  DNA topoisomerase 3-alpha-like [KO:K03165] [EC:5.6.2.1]
124289410  LOW QUALITY PROTEIN: DNA topoisomerase 3-alpha-like [KO:K03165] [EC:5.6.2.1]
124268690  DNA topoisomerase 3-beta-1-like [KO:K03165] [EC:5.6.2.1]
124255262  crossover junction endonuclease MUS81-like [KO:K08991] [EC:3.1.22.-]
Reference
PMID:18086882
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
PMID:17571595
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
PMID:18430459
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
PMID:15902993
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
PMID:12589470
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
PMID:16935872
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
PMID:17395553
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   
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