Entry
Name
ABC transporters - Klebsiella pneumoniae JM45
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Klebsiella pneumoniae JM45 [GN:
kpj ]
Gene
N559_4101 taurine ABC transporter periplasmic substrate-binding protein [KO:K15551 ]
N559_3309 alkanesulfonate ABC transporter periplasmic substrate-binding protein [KO:K15553 ]
N559_2182 putative ABC-type taurine transport system periplasmic binding component [KO:K15553 ]
N559_2162 putative ABC transport system periplasmic binding component [KO:K02020 ]
N559_1993 molybdate ABC transporter periplasmic substrate-binding protein [KO:K02020 ]
N559_3563 putative molybdenum transport ATP-binding protein ModF [KO:K05776 ]
N559_4363 thiamin/thiamine pyrophosphate ABC superfamily ATP binding cassette transporter, binding protein [KO:K02064 ]
N559_4364 thiamine/thiamine pyrophosphate ABC superfamily ATP binding cassette transporter, membrane protein [KO:K02063 ]
N559_3166 spermidine/putrescine ABC transporter periplasmic substrate-binding protein [KO:K11069 ]
N559_3165 spermidine/putrescine ABC transporter membrane protein [KO:K11070 ]
N559_3164 spermidine/putrescine ABC transporter membrane protein [KO:K11071 ]
N559_3395 putrescine transporter subunit: periplasmic-binding component of ABC superfamily [KO:K11073 ]
N559_3393 putrescine transporter subunit: membrane component of ABC superfamily [KO:K11075 ]
N559_1223 glycine betaine/L-proline ABC superfamily ATP binding cassette transporter, binding protein [KO:K02002 ]
N559_1224 glycine betaine/L-proline transport system permease protein ProW [KO:K02001 ]
N559_1689 glycine betaine/choline ABC transporter membrane protein [KO:K05845 ]
N559_1690 putative ABC-type proline/glycine betaine transport system permease component [KO:K05846 ]
N559_1692 glycine betaine/choline ABC transporter membrane protein [KO:K05846 ]
N559_4876 maltose/maltodextrin transporter ATP-binding protein [KO:K10111 ] [EC:7.5.2.-]
N559_3975 putative binding-protein-dependent transport systems inner membrane component [KO:K15772 ]
N559_0980 putative binding-protein-dependent transport systems inner membrane component [KO:K10194 ]
N559_0564 ABC transporter periplasmic substrate-binding protein [KO:K02067 ]
N559_2574 putative ABC transporter, nucleotide binding/ATPase protein [KO:K10439 ]
N559_3684 sugar ABC transporter periplasmic substrate-binding protein [KO:K10439 ]
N559_3686 putative ABC-type sugar transport system permease component [KO:K10440 ]
N559_2570 putative ribose/xylose/arabinose/galactoside ABC-type transport system permease component [KO:K10440 ]
N559_4677 putative D-ribose transport system periplasmic binding component [KO:K23508 ]
N559_1670 beta-methylgalactoside transporter inner membrane component [KO:K10541 ]
N559_0219 D-xylose ABC superfamily ATP binding cassette transporter, binding protein [KO:K10543 ]
N559_0217 D-xylose transport permease ABC transporter membrane protein [KO:K10544 ]
N559_5069 rhamnose transport system substrate-binding component [KO:K10559 ]
N559_5070 rhamnose ABC transport system ATP-binding component [KO:K10562 ] [EC:7.5.2.-]
N559_3730 periplasmic binding protein/LacI transcriptional regulator [KO:K17202 ]
N559_3732 putative ribose ABC transport system ATP-binding component [KO:K17204 ]
N559_2032 putative rhizopine uptake ABC transport system periplasmic solute-binding protein precursor [KO:K17213 ]
N559_0016 phosphate ABC transporter periplasmic substrate-binding protein PstS [KO:K02040 ]
N559_4126 phosphonate ABC transporter, periplasmic phosphonate binding protein [KO:K02044 ]
N559_5255 ABC-type phosphate/phosphonate transport system, periplasmic component [KO:K02044 ]
N559_1552 lysine-arginine-ornithine-binding periplasmic protein [KO:K10013 ]
N559_3817 amino acid ABC transporter periplasmic amino acid-binding protein [KO:K10013 ]
N559_1555 histidine and lysine/arginine/ornithine ABC transporter membrane protein [KO:K10015 ]
N559_1553 histidine ABC transporter periplasmic substrate-binding protein [KO:K10014 ]
N559_3387 arginine 3rd transport system periplasmic binding protein [KO:K09996 ]
N559_3384 arginine 3rd transport system periplasmic binding protein [KO:K09997 ]
N559_3642 glutamate/aspartate ABC superfamily ATP binding cassette transporter, permease protein [KO:K10002 ]
N559_0331 high-affinity branched-chain amino acid transporter periplasmic binding component [KO:K01999 ]
N559_0334 high-affinity branched-chain amino acid transporter periplasmic binding component [KO:K01999 ]
N559_0335 branched-chain amino acid transporter permease subunit LivH [KO:K01997 ]
N559_4110 high-affinity branched-chain amino acid ABC transporter membrane protein [KO:K01997 ]
N559_1984 ABC-type high-affinity branched-chain amino acid transport system permease component [KO:K01997 ]
N559_0336 leucine/isoleucine/valine transporter permease subunit [KO:K01998 ]
N559_0337 leucine/isoleucine/valine transporter ATP-binding subunit [KO:K01995 ]
N559_4112 ATP-binding component of high-affinity branched-chain amino acid transport system [KO:K01995 ]
N559_2655 putative ABC-type metal ion transport system, periplasmic component/surface antigen [KO:K02073 ]
N559_1086 putative ABC-type metal ion transport system periplasmic component [KO:K02073 ]
N559_2657 putative ABC-type metal ion transport system inner membrane component [KO:K02072 ]
N559_1085 putative ABC-type metal ion transport system permease component [KO:K02072 ]
N559_2656 D- and L-methionine ABC transporter ATP-binding protein [KO:K02071 ]
N559_1084 putative D- and L-methionine transporter ATP-binding component [KO:K02071 ]
N559_2701 high-affinity branched-chain amino acid ABC transport system permease component [KO:K11961 ]
N559_2084 oligopeptide ABC transporter periplasmic substrate-binding protein [KO:K15580 ]
N559_2088 ATP-binding protein of oligopeptide ABC transport system [KO:K10823 ]
N559_0304 nickel ABC transporter, periplasmic nickel-binding protein [KO:K15584 ]
N559_3468 peptide ABC transporter periplasmic substrate-binding protein [KO:K13889 ]
N559_1643 oligopeptide ABC transporter periplasmic substrate-binding protein [KO:K13893 ]
N559_5137 iron(III) dicitrate transport system permease protein FecD [KO:K23182 ]
N559_5138 fe(3+) dicitrate transport system permease protein FecC [KO:K23183 ]
N559_3717 iron-enterobactin transporter periplasmic binding protein [KO:K23185 ]
N559_4248 iron-hydroxamate transporter substrate-binding subunit [KO:K23227 ]
N559_2113 vitamin B12 ABC superfamily ATP binding cassette transporter, permease protein [KO:K06073 ]
N559_1156 iron ABC superfamily ATP binding cassette transporter, binding protein [KO:K11604 ]
N559_1154 iron transport system inner membrane permease component [KO:K11605 ]
N559_0667 autoinducer 2 ABC transporter, periplasmic substrate-binding protein LsrB [KO:K10555 ]
N559_3172 outer membrane-specific lipoprotein transporter subunit LolE [KO:K09808 ]
N559_3174 outer membrane-specific lipoprotein transporter subunit LolC [KO:K09808 ]
N559_3173 putative ATP-binding component of a transport system [KO:K09810 ] [EC:7.6.2.-]
N559_3995 putative multidrug transporter membrane\ATP-binding component [KO:K18889 ]
N559_4756 microcin H47 ABC transporter, permease/ATP-binding protein [KO:K13409 ]
N559_3361 cysteine/glutathione ABC transporter membrane/ATP-binding component [KO:K16013 ]
N559_3368 macrolide transporter ATP-binding/permease protein [KO:K05685 ] [EC:7.6.2.-]
Compound
C00093 sn-Glycerol 3-phosphate
C01153 Orthophosphoric monoester
C01181 4-Trimethylammoniobutanoate
C01279 4-Amino-5-hydroxymethyl-2-methylpyrimidine
C03557 2-Aminoethylphosphonate
C03611 Galactose oligosaccharide
C03619 Methyl beta-D-galactoside
C04114 (E)-4-(Trimethylammonio)but-2-enoate
C06705 Capsular polysaccharide
C19872 N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570 alpha-1,5-L-Arabinobiose
C20571 alpha-1,5-L-Arabinotriose
C20572 alpha-1,5-L-Arabinotetraose
Reference
Authors
Tomii K, Kanehisa M.
Title
A comparative analysis of ABC transporters in complete microbial genomes.
Journal
Reference
Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal
Reference
Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal
Reference
Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
Journal
Reference
Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
Journal
Reference
Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
Journal
Reference
Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
Journal
Reference
Authors
Richard-Fogal CL, Frawley ER, Kranz RG
Title
Topology and function of CcmD in cytochrome c maturation.
Journal
Reference
Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
Journal
Reference
Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
Journal
Reference
Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
Journal
Reference
Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
Journal
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