Entry
Name
ABC transporters - Klebsiella pneumoniae subsp. pneumoniae HS11286
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
BRITE hierarchy
Pathway map
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Other DBs
Organism
Klebsiella pneumoniae subsp. pneumoniae HS11286 [GN:
kpm ]
Gene
KPHS_38410 sulfate/thiosulfate transport system thiosulfate-binding component [KO:K02048 ]
KPHS_30910 putative ABC transporter periplasmic solute-binding protein [KO:K15553 ]
KPHS_18520 aliphatic sulfonate ABC transporter substrate-binding protein [KO:K15553 ]
KPHS_30900 putative ABC-type taurine transport system periplasmic binding component [KO:K15553 ]
KPHS_32840 molybdate ABC transporter periplasmic substrate-binding protein [KO:K02020 ]
KPHS_07810 thiamin/thiamine pyrophosphate ABC superfamily ATP binding cassette transporter, binding protein [KO:K02064 ]
KPHS_07800 thiamine/thiamine pyrophosphate ABC superfamily ATP binding cassette transporter, membrane protein [KO:K02063 ]
KPHS_20060 spermidine/putrescine ABC transporter substrate-binding protein [KO:K11069 ]
KPHS_17620 spermidine/putrescine transport system periplasmic substrate-binding component [KO:K11073 ]
KPHS_17650 spermidine/putrescine transport system permease component [KO:K11074 ]
KPHS_52300 2-aminoethylphosphonate ABC transporter ATP-binding protein [KO:K11083 ]
KPHS_40830 glycine/betaine/proline transport system periplasmic binding component [KO:K02002 ]
KPHS_36280 putative ABC-type proline/glycine betaine transport system inner membrane component [KO:K05846 ]
KPHS_36300 putative ABC-type proline/glycine betaine transport system permease component [KO:K05846 ]
KPHS_02590 maltose/maltodextrin transporter ATP-binding protein [KO:K10111 ] [EC:7.5.2.-]
KPHS_11720 putative binding-protein-dependent transport systems inner membrane component [KO:K15772 ]
KPHS_43210 putative inner membrane permease of oligogalacturonide ABC transporter [KO:K10193 ]
KPHS_43220 putative binding-protein-dependent transport systems inner membrane component [KO:K10194 ]
KPHS_26740 putative ABC transporter, nucleotide binding/ATPase protein [KO:K10439 ]
KPHS_03300 ribose ABC superfamily ATP binding cassette transporter, permease protein [KO:K10440 ]
KPHS_04640 putative D-ribose transport system periplasmic binding component [KO:K23508 ]
KPHS_36490 beta-methylgalactoside transporter inner membrane protein [KO:K10541 ]
KPHS_50890 D-xylose ABC superfamily ATP binding cassette transporter, binding protein [KO:K10543 ]
KPHS_14290 putative ribose ABC transport system ATP-binding component [KO:K17204 ]
KPHS_49660 glycerol-3-phosphate transporter periplasmic binding protein [KO:K05813 ]
KPHS_05360 putative SN-glycerol-3-phosphate transport system permease [KO:K05814 ]
KPHS_10240 phosphonate ABC superfamily ATP binding cassette transporter, binding protein [KO:K02044 ]
KPHS_10220 phosphonate ABC superfamily ATP binding cassette transporter, permease protein [KO:K02042 ]
KPHS_37650 histidine and lysine/arginine/ornithine ABC transporter permease [KO:K10015 ]
KPHS_37660 histidine and lysine/arginine/ornithine transport system ABC transporter permease [KO:K10016 ]
KPHS_17700 arginine 3rd transport system periplasmic binding protein [KO:K09996 ]
KPHS_17730 arginine ABC transporter periplasmic substrate-binding protein ArtI [KO:K09997 ]
KPHS_15190 glutamate/aspartate ABC superfamily ATP binding cassette transporter, permease protein [KO:K10002 ]
KPHS_49730 high-affinity branched-chain amino acid ABC transporter substrate-binding protein [KO:K01999 ]
KPHS_49770 high-affinity branched-chain amino acid transporter periplasmic binding component [KO:K01999 ]
KPHS_10410 high-affinity branched-chain amino acid ABC transporter substrate-binding protein [KO:K01999 ]
KPHS_32960 high-affinity branched-chain amino acid ABC transporter substrate-binding protein [KO:K01999 ]
KPHS_49720 high-affinity branched-chain amino acid transporter membrane component [KO:K01997 ]
KPHS_10400 high-affinity branched-chain amino acid ABC transporter membrane protein [KO:K01997 ]
KPHS_32950 high-affinity branched-chain amino acid ABC transporter membrane protein [KO:K01997 ]
KPHS_49700 leucine/isoleucine/valine transporter ATP-binding subunit [KO:K01995 ]
KPHS_10380 ATP-binding component of high-affinity branched-chain amino acid transport system [KO:K01995 ]
KPHS_32920 ATP-binding component of high-affinity branched-chain amino acid transport system [KO:K01995 ]
KPHS_49690 branched-chain amino acid transport system ATP-binding protein [KO:K01996 ]
KPHS_25870 D-methionine ABC superfamily ATP binding cassette transporter, binding protein [KO:K02073 ]
KPHS_42210 putative ABC-type metal ion transport system periplasmic component [KO:K02073 ]
KPHS_25850 putative ABC-type metal ion transport system inner membrane component [KO:K02072 ]
KPHS_42220 putative ABC-type metal ion transport system permease component [KO:K02072 ]
KPHS_42230 putative D- and L-methionine transporter ATP-binding component [KO:K02071 ]
KPHS_25390 high-affinity branched-chain amino acid ABC transporter membrane protein [KO:K11960 ]
KPHS_25400 high-affinity branched-chain amino acid ABC transport system permease component [KO:K11961 ]
KPHS_22230 periplasmic murein tripeptide (L-Ala-gamma-D-Glut-m-DAP) permease [KO:K15580 ]
KPHS_50050 nickel ABC transporter periplasmic substrate-binding protein [KO:K15584 ]
KPHS_14450 iron-enterobactin transporter periplasmic binding protein [KO:K23185 ]
KPHS_09020 hydroxamate-dependent iron transport system permease component [KO:K23228 ]
KPHS_31620 vitamin B12 ABC superfamily ATP binding cassette transporter, permease protein [KO:K06073 ]
KPHS_41530 iron ABC superfamily ATP binding cassette transporter, binding protein [KO:K11604 ]
KPHS_41550 iron ABC superfamily ATP binding cassette transporter, membrane protein [KO:K11605 ]
KPHS_46370 autoinducer-2 ABC superfamily ATP binding cassette transporter, binding protein [KO:K10555 ]
KPHS_35500 lipopolysaccharide O-antigen ABC transport system transmembrane component [KO:K09690 ]
KPHS_19970 outer membrane-specific lipoprotein transporter subunit LolC [KO:K09808 ]
KPHS_19990 outer membrane-specific lipoprotein transporter subunit LolE [KO:K09808 ]
KPHS_34630 permease and ATP-binding protein of yersiniabactin-iron ABC transporter YbtQ [KO:K14699 ] [EC:7.-.-.-]
KPHS_11540 putative multidrug transporter membrane/ATP-binding components [KO:K18890 ]
KPHS_03830 microcin H47 ABC transporter, permease/ATP-binding protein [KO:K13409 ]
KPHS_17960 cytochrome-related transport system ATP-binding component [KO:K16012 ]
KPHS_17970 cysteine/glutathione ABC transporter membrane/ATP-binding protein [KO:K16013 ]
KPHS_17900 ABC-type macrolide transport system efflux carrier [KO:K05685 ] [EC:7.6.2.-]
KPHS_36970 multidrug transporter membrane protein/ATP-binding component [KO:K06159 ]
Compound
C00093 sn-Glycerol 3-phosphate
C01153 Orthophosphoric monoester
C01181 4-Trimethylammoniobutanoate
C01279 4-Amino-5-hydroxymethyl-2-methylpyrimidine
C03557 2-Aminoethylphosphonate
C03611 Galactose oligosaccharide
C03619 Methyl beta-D-galactoside
C04114 (E)-4-(Trimethylammonio)but-2-enoate
C06705 Capsular polysaccharide
C19872 N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570 alpha-1,5-L-Arabinobiose
C20571 alpha-1,5-L-Arabinotriose
C20572 alpha-1,5-L-Arabinotetraose
Reference
Authors
Tomii K, Kanehisa M.
Title
A comparative analysis of ABC transporters in complete microbial genomes.
Journal
Reference
Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal
Reference
Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal
Reference
Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
Journal
Reference
Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
Journal
Reference
Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
Journal
Reference
Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
Journal
Reference
Authors
Richard-Fogal CL, Frawley ER, Kranz RG
Title
Topology and function of CcmD in cytochrome c maturation.
Journal
Reference
Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
Journal
Reference
Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
Journal
Reference
Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
Journal
Reference
Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
Journal
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