KEGG PATHWAY: lak04145

KEGG

PATHWAY: lak04145

Entry

lak04145                    Pathway

Name

Phagosome - Lingula anatina

Description

Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.

Class

Cellular Processes; Transport and catabolism

Pathway map

Phagosome

Other DBs

GO:

Organism

Lingula anatina [GN:lak]

Gene

actin, adductor muscle [KO:K05692]

actin, adductor muscle [KO:K05692]

actin, cytoplasmic 2 [KO:K05692]

actin, adductor muscle-like [KO:K05692]

actin, cytoplasmic 2 [KO:K05692]

actin-1 [KO:K05692]

syntaxin-18 isoform X1 [KO:K08492]

vesicle-trafficking protein SEC22b-like isoform X1 [KO:K08517]

vesicle-trafficking protein SEC22b isoform X1 [KO:K08517]

early endosome antigen 1-like [KO:K12478]

early endosome antigen 1-like [KO:K12478]

early endosome antigen 1-like [KO:K12478]

phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]

hepatocyte growth factor-regulated tyrosine kinase substrate [KO:K12182]

V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]

V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]

V-type proton ATPase subunit B [KO:K02147]

V-type proton ATPase subunit C 1-B [KO:K02148]

V-type proton ATPase subunit D [KO:K02149]

V-type proton ATPase subunit E [KO:K02150]

V-type proton ATPase subunit F [KO:K02151]

V-type proton ATPase subunit G-like [KO:K02152]

V-type proton ATPase subunit G-like [KO:K02152]

V-type proton ATPase 116 kDa subunit a isoform X1 [KO:K02154]

V-type proton ATPase 116 kDa subunit a-like [KO:K02154]

V-type proton ATPase subunit d 1 [KO:K02146]

V-type proton ATPase subunit d 1 [KO:K02146]

V-type proton ATPase subunit H [KO:K02144]

V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]

V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]

V-type proton ATPase subunit S1-like [KO:K03662]

V-type proton ATPase subunit S1-like [KO:K03662]

ras-related protein Rab-7a [KO:K07897]

ras-related protein Rab-7a isoform X1 [KO:K07897]

ras-related protein Rab-7a [KO:K07897]

cytoplasmic dynein 2 heavy chain 1 [KO:K10414]

cytoplasmic dynein 1 intermediate chain 2 isoform X1 [KO:K10415]

cytoplasmic dynein 1 intermediate chain 2-like [KO:K10415]

cytoplasmic dynein 1 light intermediate chain 2 isoform X1 [KO:K10416]

tubulin alpha-1D chain-like [KO:K07374]

uncharacterized protein LOC106154991 [KO:K07374]

tubulin alpha chain, testis-specific-like isoform X1 [KO:K07374]

tubulin alpha-1A chain-like [KO:K07374]

tubulin alpha-1 chain-like [KO:K07374]

tubulin alpha-1A chain-like isoform X2 [KO:K07374]

tubulin alpha-1A chain [KO:K07374]

tubulin alpha-1A chain-like [KO:K07374]

tubulin alpha-8 chain-like isoform X1 [KO:K07374]

tubulin alpha-8 chain isoform X1 [KO:K07374]

tubulin alpha-1A chain-like [KO:K07374]

tubulin alpha-2/alpha-4 chain [KO:K07374]

tubulin beta-4B chain [KO:K07375]

tubulin beta chain-like isoform X1 [KO:K07375]

tubulin beta chain-like isoform X1 [KO:K07375]

tubulin beta chain isoform X1 [KO:K07375]

tubulin beta-4B chain [KO:K07375]

tubulin beta chain [KO:K07375]

tubulin beta chain [KO:K07375]

tubulin beta chain [KO:K07375]

tubulin beta chain-like [KO:K07375]

tubulin beta-4B chain [KO:K07375]

LAMP family protein lmp-1 [KO:K06528]

1-phosphatidylinositol 3-phosphate 5-kinase-like [KO:K00921] [EC:2.7.1.150]

1-phosphatidylinositol 3-phosphate 5-kinase [KO:K00921] [EC:2.7.1.150]

cation-dependent mannose-6-phosphate receptor [KO:K10089]

uncharacterized protein LOC106150578 [KO:K10089]

cation-dependent mannose-6-phosphate receptor-like [KO:K10089]

cation-dependent mannose-6-phosphate receptor isoform X1 [KO:K10089]

uncharacterized protein LOC106160699 [KO:K10089]

putative mannose 6-phosphate receptor-like protein C530.09c [KO:K10089]

uncharacterized protein LOC106163386 [KO:K10089]

cation-dependent mannose-6-phosphate receptor isoform X1 [KO:K10089]

nitric oxide synthase, salivary gland-like isoform X1 [KO:K13240] [EC:1.14.13.39]

cathepsin L1 [KO:K01365] [EC:3.4.22.15]

cathepsin L1 isoform X1 [KO:K01365] [EC:3.4.22.15]

cathepsin L1 [KO:K01365] [EC:3.4.22.15]

cathepsin L1 [KO:K01365] [EC:3.4.22.15]

cathepsin L1 [KO:K01365] [EC:3.4.22.15]

cathepsin L1-like [KO:K01365] [EC:3.4.22.15]

cathepsin L1-like [KO:K01365] [EC:3.4.22.15]

cathepsin L1 [KO:K01365] [EC:3.4.22.15]

cathepsin L1 [KO:K01365] [EC:3.4.22.15]

protein transport protein Sec61 subunit alpha [KO:K10956]

protein transport protein Sec61 subunit alpha [KO:K10956]

protein transport protein Sec61 subunit beta-like [KO:K09481]

calreticulin-like [KO:K08057]

calnexin isoform X1 [KO:K08054]

calnexin isoform X1 [KO:K08054]

integrin beta-PS [KO:K05719]

cartilage oligomeric matrix protein-like [KO:K04659]

uncharacterized protein LOC106169518 [KO:K04659]

macrophage mannose receptor 1-like [KO:K06560]

macrophage mannose receptor 1-like [KO:K06560]

uncharacterized protein LOC106164412 [KO:K06560]

macrophage mannose receptor 1-like [KO:K06560]

macrophage mannose receptor 1-like [KO:K06560]

macrophage mannose receptor 1-like [KO:K06560]

macrophage mannose receptor 1-like [KO:K06560]

macrophage mannose receptor 1-like [KO:K06560]

macrophage mannose receptor 1-like [KO:K06560]

macrophage mannose receptor 1-like [KO:K06560]

macrophage mannose receptor 1-like [KO:K06560]

macrophage mannose receptor 1-like [KO:K06560]

macrophage mannose receptor 1 [KO:K06560]

macrophage mannose receptor 1-like [KO:K06560]

macrophage receptor MARCO-like [KO:K13884]

cytochrome b-245 light chain-like [KO:K08009]

cytochrome b-245 heavy chain [KO:K21421] [EC:1.-.-.-]

dual oxidase 2-like [KO:K21421] [EC:1.-.-.-]

ras-related C3 botulinum toxin substrate 1 [KO:K04392]

ras-related C3 botulinum toxin substrate 2 isoform X1 [KO:K04392]

Compound

1-Phosphatidyl-1D-myo-inositol 3-phosphate

Reference

Authors

Stuart LM, Ezekowitz RA

Title

Phagocytosis: elegant complexity.

Journal

Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002

Reference

Authors

Tjelle TE, Lovdal T, Berg T

Title

Phagosome dynamics and function.

Journal

Bioessays 22:255-63 (2000)
DOI:10.1002/(SICI)1521-1878(200003)22:3<255::AID-BIES7>3.0.CO;2-R

Reference

Authors

Dupuy AG, Caron E

Title

Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.

Journal

J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036

Reference

Authors

Brumell JH, Grinstein S

Title

Salmonella redirects phagosomal maturation.

Journal

Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005

Reference

Authors

Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S

Title

LAMP proteins are required for fusion of lysosomes with phagosomes.

Journal

EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511

Reference

Authors

Luzio JP, Pryor PR, Bright NA

Title

Lysosomes: fusion and function.

Journal

Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217

Reference

Authors

Sumimoto H

Title

Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.

Journal

FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x

Related
pathway

Lysosome

Endocytosis

KO pathway

LinkDB

DBGET integrated database retrieval system