Entry
Name
ABC transporters - Leclercia sp. J807
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Leclercia sp. J807 [GN:
lea ]
Gene
GNG26_07495 aliphatic sulfonate ABC transporter substrate-binding protein [KO:K15553 ]
GNG26_03330 thiP; thiamine/thiamine pyrophosphate ABC transporter permease ThiP [KO:K02063 ]
GNG26_08485 potD; spermidine/putrescine ABC transporter substrate-binding protein PotD [KO:K11069 ]
GNG26_07000 potF; spermidine/putrescine ABC transporter substrate-binding protein PotF [KO:K11073 ]
GNG26_17365 proX; glycine betaine/L-proline ABC transporter substrate-binding protein ProX [KO:K02002 ]
GNG26_17360 proW; glycine betaine/L-proline ABC transporter permease ProW [KO:K02001 ]
GNG26_10425 osmX; osmoprotectant ABC transporter substrate-binding protein OsmX [KO:K05845 ]
GNG26_01170 malE; maltose/maltodextrin ABC transporter substrate-binding protein MalE [KO:K10108 ]
GNG26_01175 malK; maltose/maltodextrin ABC transporter ATP-binding protein MalK [KO:K10111 ] [EC:7.5.2.-]
GNG26_12615 ugpC; sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC [KO:K10112 ] [EC:7.5.2.-]
GNG26_18035 ugpC; sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC [KO:K10195 ]
GNG26_19495 mlaD; outer membrane lipid asymmetry maintenance protein MlaD [KO:K02067 ]
GNG26_19500 mlaE; lipid asymmetry maintenance ABC transporter permease subunit MlaE [KO:K02066 ]
GNG26_15170 mglB; galactose/glucose ABC transporter substrate-binding protein MglB [KO:K10540 ]
GNG26_15160 mglC; galactose/methyl galactoside ABC transporter permease MglC [KO:K10541 ]
GNG26_20650 ugpB; sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB [KO:K05813 ]
GNG26_22370 pstS; phosphate ABC transporter substrate-binding protein PstS [KO:K02040 ]
GNG26_15760 argT; lysine/arginine/ornithine ABC transporter substrate-binding protein ArgT [KO:K10013 ]
GNG26_15755 hisJ; histidine ABC transporter substrate-binding protein HisJ [KO:K10014 ]
GNG26_06685 glnH; glutamine ABC transporter substrate-binding protein GlnH [KO:K10036 ]
GNG26_06005 glutamate/aspartate ABC transporter substrate-binding protein [KO:K10001 ]
GNG26_20685 livk; high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK [KO:K01999 ]
GNG26_20730 high-affinity branched-chain amino acid ABC transporter substrate-binding protein [KO:K01999 ]
GNG26_20680 livH; high-affinity branched-chain amino acid ABC transporter permease LivH [KO:K01997 ]
GNG26_14050 livM; high-affinity branched-chain amino acid ABC transporter permease LivM [KO:K01998 ]
GNG26_20675 livM; high-affinity branched-chain amino acid ABC transporter permease LivM [KO:K01998 ]
GNG26_20670 livG; high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG [KO:K01995 ]
GNG26_20665 livF; high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF [KO:K01996 ]
GNG26_03935 metQ; methionine ABC transporter substrate-binding lipoprotein MetQ [KO:K02073 ]
GNG26_12955 oppA; oligopeptide ABC transporter substrate-binding protein OppA [KO:K15580 ]
GNG26_12935 oppF; murein tripeptide/oligopeptide ABC transporter ATP binding protein OppF [KO:K10823 ]
GNG26_06795 gsiB; glutathione ABC transporter substrate-binding protein GsiB [KO:K13889 ]
GNG26_05720 fepB; Fe2+-enterobactin ABC transporter substrate-binding protein [KO:K23185 ]
GNG26_03720 fhuD; Fe(3+)-hydroxamate ABC transporter substrate-binding protein FhuD [KO:K23227 ]
GNG26_03750 btuF; vitamin B12 ABC transporter substrate-binding protein BtuF [KO:K06858 ]
GNG26_19075 lsrB; autoinducer 2 ABC transporter substrate-binding protein LsrB [KO:K10555 ]
GNG26_08450 lolC; lipoprotein-releasing ABC transporter permease subunit LolC [KO:K09808 ]
GNG26_08460 lolE; lipoprotein-releasing ABC transporter permease subunit LolE [KO:K09808 ]
GNG26_08455 lolD; lipoprotein-releasing ABC transporter ATP-binding protein LolD [KO:K09810 ] [EC:7.6.2.-]
GNG26_04810 SmdA family multidrug ABC transporter permease/ATP-binding protein [KO:K18889 ]
GNG26_04815 SmdB family multidrug efflux ABC transporter permease/ATP-binding protein [KO:K18890 ]
GNG26_07265 cydC; cysteine/glutathione ABC transporter ATP-binding protein/permease CydC [KO:K16012 ]
GNG26_07270 cydD; cysteine/glutathione ABC transporter permease/ATP-binding protein CydD [KO:K16013 ]
GNG26_07230 macB; macrolide ABC transporter ATP-binding protein/permease MacB [KO:K05685 ] [EC:7.6.2.-]
Compound
C00093 sn-Glycerol 3-phosphate
C01153 Orthophosphoric monoester
C01181 4-Trimethylammoniobutanoate
C01279 4-Amino-5-hydroxymethyl-2-methylpyrimidine
C03557 2-Aminoethylphosphonate
C03611 Galactose oligosaccharide
C03619 Methyl beta-D-galactoside
C04114 (E)-4-(Trimethylammonio)but-2-enoate
C06705 Capsular polysaccharide
C19872 N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570 alpha-1,5-L-Arabinobiose
C20571 alpha-1,5-L-Arabinotriose
C20572 alpha-1,5-L-Arabinotetraose
Reference
Authors
Tomii K, Kanehisa M.
Title
A comparative analysis of ABC transporters in complete microbial genomes.
Journal
Reference
Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal
Reference
Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal
Reference
Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
Journal
Reference
Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
Journal
Reference
Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
Journal
Reference
Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
Journal
Reference
Authors
Richard-Fogal CL, Frawley ER, Kranz RG
Title
Topology and function of CcmD in cytochrome c maturation.
Journal
Reference
Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
Journal
Reference
Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
Journal
Reference
Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
Journal
Reference
Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
Journal
KO pathway
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