Entry
Name
ABC transporters - Leclercia sp. Colony189
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
BRITE hierarchy
Pathway map
Ortholog table
Other DBs
Organism
Leclercia sp. Colony189 [GN:
ler ]
Gene
GNG29_07865 aliphatic sulfonate ABC transporter substrate-binding protein [KO:K15553 ]
GNG29_03835 thiP; thiamine/thiamine pyrophosphate ABC transporter permease ThiP [KO:K02063 ]
GNG29_08850 potD; spermidine/putrescine ABC transporter substrate-binding protein PotD [KO:K11069 ]
GNG29_07370 potF; spermidine/putrescine ABC transporter substrate-binding protein PotF [KO:K11073 ]
GNG29_17975 proX; glycine betaine/L-proline ABC transporter substrate-binding protein ProX [KO:K02002 ]
GNG29_17970 proW; glycine betaine/L-proline ABC transporter permease ProW [KO:K02001 ]
GNG29_10325 osmX; osmoprotectant ABC transporter substrate-binding protein OsmX [KO:K05845 ]
GNG29_01145 malE; maltose/maltodextrin ABC transporter substrate-binding protein MalE [KO:K10108 ]
GNG29_01150 malK; maltose/maltodextrin ABC transporter ATP-binding protein MalK [KO:K10111 ] [EC:7.5.2.-]
GNG29_18630 ugpC; sn-glycerol-3-phosphate ABC transporter ATP-binding protein UgpC [KO:K10195 ]
GNG29_20315 mlaD; outer membrane lipid asymmetry maintenance protein MlaD [KO:K02067 ]
GNG29_20320 mlaE; lipid asymmetry maintenance ABC transporter permease subunit MlaE [KO:K02066 ]
GNG29_15335 mglB; galactose/glucose ABC transporter substrate-binding protein MglB [KO:K10540 ]
GNG29_15325 mglC; galactose/methyl galactoside ABC transporter permease MglC [KO:K10541 ]
GNG29_21450 ugpB; sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB [KO:K05813 ]
GNG29_23030 pstS; phosphate ABC transporter substrate-binding protein PstS [KO:K02040 ]
GNG29_15910 argT; lysine/arginine/ornithine ABC transporter substrate-binding protein ArgT [KO:K10013 ]
GNG29_15905 hisJ; histidine ABC transporter substrate-binding protein HisJ [KO:K10014 ]
GNG29_07045 glnH; glutamine ABC transporter substrate-binding protein GlnH [KO:K10036 ]
GNG29_06325 glutamate/aspartate ABC transporter substrate-binding protein [KO:K10001 ]
GNG29_21475 livk; high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK [KO:K01999 ]
GNG29_21515 high-affinity branched-chain amino acid ABC transporter substrate-binding protein [KO:K01999 ]
GNG29_21470 livH; high-affinity branched-chain amino acid ABC transporter permease LivH [KO:K01997 ]
GNG29_21465 livM; high-affinity branched-chain amino acid ABC transporter permease LivM [KO:K01998 ]
GNG29_21460 livG; high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG [KO:K01995 ]
GNG29_21455 livF; high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF [KO:K01996 ]
GNG29_04450 metQ; methionine ABC transporter substrate-binding lipoprotein MetQ [KO:K02073 ]
GNG29_12665 oppA; oligopeptide ABC transporter substrate-binding protein OppA [KO:K15580 ]
GNG29_12645 oppF; murein tripeptide/oligopeptide ABC transporter ATP binding protein OppF [KO:K10823 ]
GNG29_07155 gsiB; glutathione ABC transporter substrate-binding protein GsiB [KO:K13889 ]
GNG29_06040 fepB; Fe2+-enterobactin ABC transporter substrate-binding protein [KO:K23185 ]
GNG29_04230 fhuD; Fe(3+)-hydroxamate ABC transporter substrate-binding protein FhuD [KO:K23227 ]
GNG29_04260 btuF; vitamin B12 ABC transporter substrate-binding protein BtuF [KO:K06858 ]
GNG29_19885 lsrB; autoinducer 2 ABC transporter substrate-binding protein LsrB [KO:K10555 ]
GNG29_08815 lolC; lipoprotein-releasing ABC transporter permease subunit LolC [KO:K09808 ]
GNG29_08825 lolE; lipoprotein-releasing ABC transporter permease subunit LolE [KO:K09808 ]
GNG29_08820 lolD; lipoprotein-releasing ABC transporter ATP-binding protein LolD [KO:K09810 ] [EC:7.6.2.-]
GNG29_05255 SmdA family multidrug ABC transporter permease/ATP-binding protein [KO:K18889 ]
GNG29_05260 SmdB family multidrug efflux ABC transporter permease/ATP-binding protein [KO:K18890 ]
GNG29_07635 cydC; cysteine/glutathione ABC transporter ATP-binding protein/permease CydC [KO:K16012 ]
GNG29_07640 cydD; cysteine/glutathione ABC transporter permease/ATP-binding protein CydD [KO:K16013 ]
GNG29_07600 macB; macrolide ABC transporter ATP-binding protein/permease MacB [KO:K05685 ] [EC:7.6.2.-]
Compound
C00093 sn-Glycerol 3-phosphate
C01153 Orthophosphoric monoester
C01181 4-Trimethylammoniobutanoate
C01279 4-Amino-5-hydroxymethyl-2-methylpyrimidine
C03557 2-Aminoethylphosphonate
C03611 Galactose oligosaccharide
C03619 Methyl beta-D-galactoside
C04114 (E)-4-(Trimethylammonio)but-2-enoate
C06705 Capsular polysaccharide
C19872 N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570 alpha-1,5-L-Arabinobiose
C20571 alpha-1,5-L-Arabinotriose
C20572 alpha-1,5-L-Arabinotetraose
Reference
Authors
Tomii K, Kanehisa M.
Title
A comparative analysis of ABC transporters in complete microbial genomes.
Journal
Reference
Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal
Reference
Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal
Reference
Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
Journal
Reference
Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
Journal
Reference
Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
Journal
Reference
Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
Journal
Reference
Authors
Richard-Fogal CL, Frawley ER, Kranz RG
Title
Topology and function of CcmD in cytochrome c maturation.
Journal
Reference
Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
Journal
Reference
Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
Journal
Reference
Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
Journal
Reference
Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
Journal
KO pathway
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