PATHWAY: loc00533 Help
Entry
Name
Glycosaminoglycan biosynthesis - keratan sulfate - Lepisosteus oculatus (spotted gar)
Description
Keratan sulfate (KS) is a glycosaminoglycan with the basic disaccharide unit of N-acetyllactosamine, Gal(b1-4)GlcNAc(b1-3), with sulfate esters at C-6 of GlcNAc and Gal residues. There are two types of KS distinguished by the protein linkage: type I for N-linked via the N-glycan core structure and type II for O-linked via the O-glycan core 2 structure.
Class
Metabolism; Glycan biosynthesis and metabolism
BRITE hierarchy
Pathway map
loc00533 Glycosaminoglycan biosynthesis - keratan sulfate
Ortholog table
Other DBs
Organism
Lepisosteus oculatus (spotted gar) [GN:
loc ]
Gene
102682540 carbohydrate sulfotransferase 5-like isoform X1 [KO:K09671 ] [EC:2.8.2.-]
102695683 b3gnt7; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 [KO:K09664 ] [EC:2.4.1.-]
102698902 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7-like [KO:K09664 ] [EC:2.4.1.-]
102688225 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7-like [KO:K09664 ] [EC:2.4.1.-]
102696165 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7-like [KO:K09664 ] [EC:2.4.1.-]
102698126 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7-like [KO:K09664 ] [EC:2.4.1.-]
102692834 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7-like isoform X1 [KO:K09664 ] [EC:2.4.1.-]
102688431 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7-like [KO:K09664 ] [EC:2.4.1.-]
102690643 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7-like [KO:K09664 ] [EC:2.4.1.-]
102684544 st3gal3; CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase isoform X1 [KO:K00781 ] [EC:2.4.3.6 ]
Reference
Authors
Funderburgh JL.
Title
Keratan sulfate: structure, biosynthesis, and function.
Journal
Reference
Authors
Seko A, Yamashita K.
Title
beta1,3-N-Acetylglucosaminyltransferase-7 (beta3Gn-T7) acts efficiently on keratan sulfate-related glycans.
Journal
Reference
Authors
Seko A, Dohmae N, Takio K, Yamashita K.
Title
Beta 1,4-galactosyltransferase (beta 4GalT)-IV is specific for GlcNAc 6-O-sulfate. Beta 4GalT-IV acts on keratan sulfate-related glycans and a precursor glycan of 6-sulfosialyl-Lewis X.
Journal
Related pathway
loc00512 Mucin type O-glycan biosynthesis
KO pathway
LinkDB
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