KEGG   PATHWAY: mtub00790
Entry
mtub00790                   Pathway                                
Name
Folate biosynthesis - Mycobacterium tuberculosis 7199-99
Class
Metabolism; Metabolism of cofactors and vitamins
Pathway map
mtub00790  Folate biosynthesis
mtub00790

Other DBs
GO: 0046656
Organism
Mycobacterium tuberculosis 7199-99 [GN:mtub]
Gene
MT7199_3672  GTP CYCLOHYDROLASE I FOLE (GTP-CH-I) [KO:K01495] [EC:3.5.4.16]
MT7199_3670  putative DIHYDRONEOPTERIN ALDOLASE FOLB (DHNA) [KO:K01633] [EC:4.1.2.25 5.1.99.8 1.13.11.81]
MT7199_3669  2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDI NE PYROPHOSPHOKINASE FOLK (7,8-DIHYDRO-6-HYDROXYMETHYLPTERIN-PYROPHOSPHOKINASE) (HPPK) (6-HYDROXYMETHYL-7,8-DIHYDROPTERIN PYROPHOSPHOKINASE) (PPPK) (2-AMINO-4-HYDROXY-6-HYDROXYMETHYLDIHYDROPTERIDINE DIPHOSPHOKINASE) (7,8-DIHYDRO-6-HYDROXYMETHYLPTERIN-DIPHOSPHOKINASE) (6-HYDROXYMETHYL-7,8-DIHYDROPTERIN DIPHOSPHOKINASE) [KO:K00950] [EC:2.7.6.3]
MT7199_3671  DIHYDROPTEROATE SYNTHASE 1 FOLP (DHPS 1) (DIHYDROPTEROATE PYROPHOSPHORYLASE 1) (DIHYDROPTEROATE DIPHOSPHORYLASE 1) [KO:K00796] [EC:2.5.1.15]
MT7199_1236  putative DIHYDROPTEROATE SYNTHASE 2 FOLP2 (DHPS 2) (Dihydropteroate pyrophosphorylase 2) [KO:K00796] [EC:2.5.1.15]
MT7199_2796  DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) [KO:K00287] [EC:1.5.1.3]
MT7199_2480  folC; putative FOLYLPOLYGLUTAMATE SYNTHASE protein FOLC (FOLYLPOLY-GAMMA-GLUTAMATE SYNTHETASE) (FPGS) [KO:K11754] [EC:6.3.2.12 6.3.2.17]
MT7199_1446  putative RIBOFLAVIN BIOSYNTHESIS protein RIBA2 : GTP cyclohydrolase II + 3,4-dihydroxy-2-butanone 4-phosphate synthase (DHBP synthase) [KO:K14652] [EC:4.1.99.12 3.5.4.25]
MT7199_1966  putative Riboflavin biosynthesis protein ribA1 (GTP cyclohydrolase II) [KO:K14652] [EC:4.1.99.12 3.5.4.25]
MT7199_0013  putative ANTHRANILATE SYNTHASE COMPONENT II TRPG (GLUTAMINE AMIDOTRANSFERASE) [KO:K01664] [EC:2.6.1.85]
MT7199_1029  putative para-aminobenzoate synthase component I PABD [KO:K01665] [EC:2.6.1.85]
MT7199_0831  putative AMINO ACID AMINOTRANSFERASE [KO:K02619] [EC:4.1.3.38]
MT7199_3143  moaB1; putative PTERIN-4-ALPHA-CARBINOLAMINE DEHYDRATASE MOAB1 (PHS) [KO:K01724] [EC:4.2.1.96]
MT7199_1189  hypothetical protein [KO:K01724] [EC:4.2.1.96]
MT7199_3142  putative MOLYBDENUM COFACTOR BIOSYNTHESIS protein A MOAA1 [KO:K03639] [EC:4.1.99.22]
MT7199_0888  putative MOLYBDENUM COFACTOR BIOSYNTHESIS protein A2 MOAA2 [KO:K03639] [EC:4.1.99.22]
MT7199_3369  Molybdenum cofactor biosynthesis protein A 1 [KO:K03639] [EC:4.1.99.22]
MT7199_3144  putative MOLYBDENUM COFACTOR BIOSYNTHESIS protein C MOAC1 [KO:K03637] [EC:4.6.1.17]
MT7199_0883  putative MOLYBDENUM COFACTOR BIOSYNTHESIS protein C 2 MOAC2 [KO:K03637] [EC:4.6.1.17]
MT7199_3367  putative MOLYBDENUM COFACTOR BIOSYNTHESIS protein C 3 MOAC3 [KO:K03637] [EC:4.6.1.17]
MT7199_0885  putative MOLYBDENUM COFACTOR BIOSYNTHESIS protein E2 MOAE2 (MOLYBDOPTERIN CONVERTING FACTOR LARGE SUBUNIT) (MOLYBDOPTERIN [MPT] CONVERTING FACTOR, SUBUNIT 2) [KO:K03635] [EC:2.8.1.12]
MT7199_3152  putative MOLYBDENUM COFACTOR BIOSYNTHESIS protein E MOAE1 (MOLYBDOPTERIN CONVERTING FACTOR LARGE SUBUNIT) (MOLYBDOPTERIN [MPT] CONVERTING FACTOR, SUBUNIT 2) [KO:K03635] [EC:2.8.1.12]
MT7199_3366  putative MOAD-MOAE FUSION protein MOAX [KO:K21142] [EC:2.8.1.12]
MT7199_1018  putative MOLYBDOPTERIN BIOSYNTHESIS protein MOEA1 [KO:K03750] [EC:2.10.1.1]
MT7199_0445  putative MOLYBDOPTERIN BIOSYNTHESIS protein MOEA2 [KO:K03750] [EC:2.10.1.1]
MT7199_0351  hypothetical protein [KO:K07141] [EC:2.7.7.76]
MT7199_0377  hypothetical protein [KO:K07141] [EC:2.7.7.76]
MT7199_2486  putative MOLYBDOPTERIN-GUANINE DINUCLEOTIDE BIOSYNTHESIS protein A MOBA [KO:K03752] [EC:2.7.7.77]
Compound
C00044  GTP
C00101  Tetrahydrofolate
C00119  5-Phospho-alpha-D-ribose 1-diphosphate
C00156  4-Hydroxybenzoate
C00251  Chorismate
C00266  Glycolaldehyde
C00268  Dihydrobiopterin
C00272  Tetrahydrobiopterin
C00415  Dihydrofolate
C00504  Folate
C00568  4-Aminobenzoate
C00835  Sepiapterin
C00921  Dihydropteroate
C01217  5,6,7,8-Tetrahydromethanopterin
C01300  6-(Hydroxymethyl)-7,8-dihydropterin
C01304  2,5-Diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one
C02587  Pyrimidodiazepine
C02953  7,8-Dihydrobiopterin
C03541  THF-polyglutamate
C03684  6-Pyruvoyltetrahydropterin
C04244  6-Lactoyl-5,6,7,8-tetrahydropterin
C04807  6-Hydroxymethyl-7,8-dihydropterin diphosphate
C04874  7,8-Dihydroneopterin
C04895  7,8-Dihydroneopterin 3'-triphosphate
C05922  Formamidopyrimidine nucleoside triphosphate
C05923  2,5-Diaminopyrimidine nucleoside triphosphate
C05924  Molybdopterin
C05925  Dihydroneopterin phosphate
C05926  Neopterin
C05927  7,8-Dihydromethanopterin
C06148  2,5-Diamino-6-(5'-triphosphoryl-3',4'-trihydroxy-2'-oxopentyl)-amino-4-oxopyrimidine
C06313  Biopterin
C09332  THF-L-glutamate
C11355  4-Amino-4-deoxychorismate
C15522  4a-Hydroxytetrahydrobiopterin
C15996  7-Cyano-7-carbaguanine
C16675  7-Aminomethyl-7-carbaguanine
C18237  Molybdoenzyme molybdenum cofactor
C18239  Precursor Z
C18802  Tetrahydrosarcinapterin
C19848  Adenylated molybdopterin
C19871  Guanylyl molybdenum cofactor
C20239  6-Carboxy-5,6,7,8-tetrahydropterin
C20248  7-Carboxy-7-carbaguanine
C20264  L-threo-Tetrahydrobiopterin
C20559  4-(beta-D-Ribofuranosyl)aniline 5'-phosphate
C20562  N-[(7,8-Dihydropterin-6-yl)methyl]-4-(beta-D-ribofuranosyl)aniline 5'-phosphate
C20566  7,8-Dihydroneopterin 2'-phosphate
C20567  7,8-Dihydroneopterin 2',3'-cyclic phosphate
C21007  5,6,7,8-Tetrahydromonapterin
C21008  7,8-Dihydromonapterin
C21065  7,8-Dihydroxanthopterin
C21094  7,8-Dihydromonapterin 3'-triphosphate
C21107  4-(beta-D-Ribofuranosyl)phenol 5'-phosphate
C21310  (8S)-3',8-Cyclo-7,8-dihydroguanosine 5'-triphosphate
C21485  Cytidylyl molybdenum cofactor
C21486  Thio-molybdenum cofactor
C21640  6-(1'-Hydroxy-2'-oxopropyl)-tetrahydropterin
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:19675644
  Authors
Schwarz G, Mendel RR, Ribbe MW
  Title
Molybdenum cofactors, enzymes and pathways.
  Journal
Nature 460:839-47 (2009)
DOI:10.1038/nature08302
Reference
PMID:16632608
  Authors
Hanzelmann P, Schindelin H
  Title
Binding of 5'-GTP to the C-terminal FeS cluster of the radical S-adenosylmethionine enzyme MoaA provides insights into its mechanism.
  Journal
Proc Natl Acad Sci U S A 103:6829-34 (2006)
DOI:10.1073/pnas.0510711103
Reference
PMID:18092812
  Authors
Daniels JN, Wuebbens MM, Rajagopalan KV, Schindelin H
  Title
Crystal structure of a molybdopterin synthase-precursor Z complex: insight into its sulfur transfer mechanism and its role in molybdenum cofactor deficiency.
  Journal
Biochemistry 47:615-26 (2008)
DOI:10.1021/bi701734g
Reference
PMID:12571226
  Authors
Wuebbens MM, Rajagopalan KV
  Title
Mechanistic and mutational studies of Escherichia coli molybdopterin synthase clarify the final step of molybdopterin biosynthesis.
  Journal
J Biol Chem 278:14523-32 (2003)
DOI:10.1074/jbc.M300453200
Reference
PMID:21867484
  Authors
Werner ER, Blau N, Thony B
  Title
Tetrahydrobiopterin: biochemistry and pathophysiology.
  Journal
Biochem J 438:397-414 (2011)
DOI:10.1042/BJ20110293
Reference
PMID:12893295
  Authors
Iino T, Tabata M, Takikawa S, Sawada H, Shintaku H, Ishikura S, Hara A
  Title
Tetrahydrobiopterin is synthesized from 6-pyruvoyl-tetrahydropterin by the human aldo-keto reductase AKR1 family members.
  Journal
Arch Biochem Biophys 416:180-7 (2003)
DOI:10.1016/S0003-9861(03)00295-9
Reference
PMID:1902669
  Authors
Park YS, Heizmann CW, Wermuth B, Levine RA, Steinerstauch P, Guzman J, Blau N
  Title
Human carbonyl and aldose reductases: new catalytic functions in tetrahydrobiopterin biosynthesis.
  Journal
Biochem Biophys Res Commun 175:738-44 (1991)
DOI:10.1016/0006-291X(91)91628-P
Related
pathway
mtub00230  Purine metabolism
mtub00362  Benzoate degradation
mtub00400  Phenylalanine, tyrosine and tryptophan biosynthesis
mtub00670  One carbon pool by folate
mtub00680  Methane metabolism
KO pathway
ko00790   
LinkDB

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