KEGG   PATHWAY: naqu02010
Entry
naqu02010                   Pathway                                
Name
ABC transporters - Nocardioides aquaticus
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
Pathway map
naqu02010  ABC transporters
naqu02010

Other DBs
GO: 0043190 0043191 0043192
TC: 3.A.1
Organism
Nocardioides aquaticus [GN:naqu]
Gene
ENKNEFLB_01760  tauA; Taurine-binding periplasmic protein [KO:K15553]
ENKNEFLB_02716  ssuA; Putative aliphatic sulfonates-binding protein [KO:K15553]
ENKNEFLB_01762  ssuC_1; Putative aliphatic sulfonates transport permease protein SsuC [KO:K15554]
ENKNEFLB_02714  ssuC_2; Putative aliphatic sulfonates transport permease protein SsuC [KO:K15554]
ENKNEFLB_01761  ssuB_1; Aliphatic sulfonates import ATP-binding protein SsuB [KO:K15555] [EC:7.6.2.14]
ENKNEFLB_02715  ssuB_2; Aliphatic sulfonates import ATP-binding protein SsuB [KO:K15555] [EC:7.6.2.14]
ENKNEFLB_03431  modA; Molybdate-binding protein ModA [KO:K02020]
ENKNEFLB_03430  modB; Molybdenum transport system permease protein ModB [KO:K02018]
ENKNEFLB_03429  modC; Molybdenum import ATP-binding protein ModC [KO:K02017] [EC:7.3.2.5]
ENKNEFLB_00558  thiB; Thiamine-binding periplasmic protein [KO:K02064]
ENKNEFLB_00559  cysW; Sulfate transport system permease protein CysW [KO:K02063]
ENKNEFLB_00560  cysA_1; Sulfate/thiosulfate import ATP-binding protein CysA [KO:K02062] [EC:7.6.2.15]
ENKNEFLB_01423  spuE; Spermidine-binding periplasmic protein SpuE [KO:K11069]
ENKNEFLB_01426  ydcV; Inner membrane ABC transporter permease protein YdcV [KO:K11070]
ENKNEFLB_01425  potB; Spermidine/putrescine transport system permease protein PotB [KO:K11071]
ENKNEFLB_01424  potA; Spermidine/putrescine import ATP-binding protein PotA [KO:K11072] [EC:7.6.2.11]
ENKNEFLB_03725  osmX_2; Osmoprotectant-binding protein OsmX [KO:K05845]
ENKNEFLB_00584  osmX_1; Osmoprotectant-binding protein OsmX [KO:K05845]
ENKNEFLB_03726  opuBB; Choline transport system permease protein OpuBB [KO:K05846]
ENKNEFLB_03728  opuCD; Glycine betaine/carnitine/choline transport system permease protein OpuCD [KO:K05846]
ENKNEFLB_00582  opuCB; Carnitine transport permease protein OpuCB [KO:K05846]
ENKNEFLB_00583  yehY; Glycine betaine uptake system permease protein YehY [KO:K05846]
ENKNEFLB_03727  opuCA_2; Glycine betaine/carnitine/choline transport ATP-binding protein OpuCA [KO:K05847] [EC:7.6.2.9]
ENKNEFLB_00581  opuCA_1; Glycine betaine/carnitine/choline transport ATP-binding protein OpuCA [KO:K05847] [EC:7.6.2.9]
ENKNEFLB_03716  sugC_1; Trehalose import ATP-binding protein SugC [KO:K10112] [EC:7.5.2.-]
ENKNEFLB_03720  sugC_2; Trehalose import ATP-binding protein SugC [KO:K10112] [EC:7.5.2.-]
ENKNEFLB_03717  lpqY; Trehalose-binding lipoprotein LpqY [KO:K10236]
ENKNEFLB_03718  sugA; Trehalose transport system permease protein SugA [KO:K10237]
ENKNEFLB_03719  sugB; Trehalose transport system permease protein SugB [KO:K10238]
ENKNEFLB_04063  mlaD; putative phospholipid ABC transporter-binding protein MlaD [KO:K02067]
ENKNEFLB_04064  lprN_1; Lipoprotein LprN [KO:K02067]
ENKNEFLB_04065  lprN_2; Lipoprotein LprN [KO:K02067]
ENKNEFLB_04066  smc_6; Chromosome partition protein Smc [KO:K02067]
ENKNEFLB_04067  hypothetical protein [KO:K02067]
ENKNEFLB_04068  hypothetical protein [KO:K02067]
ENKNEFLB_04069  mlaE_1; putative phospholipid ABC transporter permease protein MlaE [KO:K02066]
ENKNEFLB_04070  mlaE_2; putative phospholipid ABC transporter permease protein MlaE [KO:K02066]
ENKNEFLB_04071  mkl_2; putative ribonucleotide transport ATP-binding protein mkl [KO:K02065]
ENKNEFLB_01201  tmpC; Membrane lipoprotein TmpC [KO:K07335]
ENKNEFLB_01203  rbsC_1; Ribose import permease protein RbsC [KO:K23535]
ENKNEFLB_01204  hypothetical protein [KO:K23536]
ENKNEFLB_01202  mglA_1; Galactose/methyl galactoside import ATP-binding protein MglA [KO:K23537]
ENKNEFLB_03938  ytfQ; ABC transporter periplasmic-binding protein YtfQ [KO:K10439]
ENKNEFLB_03939  rbsC_2; Ribose import permease protein RbsC [KO:K10440]
ENKNEFLB_03940  mglA_2; Galactose/methyl galactoside import ATP-binding protein MglA [KO:K10441] [EC:7.5.2.7]
ENKNEFLB_01159  xylF_2; D-xylose-binding periplasmic protein [KO:K10543]
ENKNEFLB_00826  xylF_1; D-xylose-binding periplasmic protein [KO:K10543]
ENKNEFLB_01157  xylH_2; Xylose transport system permease protein XylH [KO:K10544]
ENKNEFLB_00828  xylH_1; Xylose transport system permease protein XylH [KO:K10544]
ENKNEFLB_01158  frcA_2; Fructose import ATP-binding protein FrcA [KO:K10545] [EC:7.5.2.10]
ENKNEFLB_00827  frcA_1; Fructose import ATP-binding protein FrcA [KO:K10545] [EC:7.5.2.10]
ENKNEFLB_00333  lsrB; Autoinducer 2-binding protein LsrB [KO:K10559]
ENKNEFLB_00330  lsrC; Autoinducer 2 import system permease protein LsrC [KO:K10560]
ENKNEFLB_00331  lsrD; Autoinducer 2 import system permease protein LsrD [KO:K10561]
ENKNEFLB_00329  rbsA; Ribose import ATP-binding protein RbsA [KO:K10562] [EC:7.5.2.-]
ENKNEFLB_00724  pstS2; Phosphate-binding protein PstS2 [KO:K02040]
ENKNEFLB_00725  pstC2; Phosphate transport system permease protein PstC 2 [KO:K02037]
ENKNEFLB_00726  pstA1; Phosphate transport system permease protein PstA 1 [KO:K02038]
ENKNEFLB_00727  pstB1; Phosphate import ATP-binding protein PstB 1 [KO:K02036] [EC:7.3.2.1]
ENKNEFLB_03969  glnH_1; ABC transporter glutamine-binding protein GlnH [KO:K10005]
ENKNEFLB_03970  glnM_1; putative glutamine ABC transporter permease protein GlnM [KO:K10006]
ENKNEFLB_03971  glnP; putative glutamine ABC transporter permease protein GlnP [KO:K10007]
ENKNEFLB_03968  glnQ_1; Glutamine transport ATP-binding protein GlnQ [KO:K10008] [EC:7.4.2.1]
ENKNEFLB_01075  hypothetical protein [KO:K01999]
ENKNEFLB_03161  braC; Leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein [KO:K01999]
ENKNEFLB_00165  Leu/Ile/Val-binding protein [KO:K01999]
ENKNEFLB_01077  livH_3; High-affinity branched-chain amino acid transport system permease protein LivH [KO:K01997]
ENKNEFLB_03156  livH_4; High-affinity branched-chain amino acid transport system permease protein LivH [KO:K01997]
ENKNEFLB_00228  livH_1; High-affinity branched-chain amino acid transport system permease protein LivH [KO:K01997]
ENKNEFLB_01076  livH_2; High-affinity branched-chain amino acid transport system permease protein LivH [KO:K01998]
ENKNEFLB_03157  hypothetical protein [KO:K01998]
ENKNEFLB_00227  frcC; Fructose import permease protein FrcC [KO:K01998]
ENKNEFLB_01079  lptB_3; Lipopolysaccharide export system ATP-binding protein LptB [KO:K01995]
ENKNEFLB_03158  lptB_4; Lipopolysaccharide export system ATP-binding protein LptB [KO:K01995]
ENKNEFLB_00229  lptB_2; Lipopolysaccharide export system ATP-binding protein LptB [KO:K01995]
ENKNEFLB_01078  livF_3; High-affinity branched-chain amino acid transport ATP-binding protein LivF [KO:K01996]
ENKNEFLB_03159  livF_4; High-affinity branched-chain amino acid transport ATP-binding protein LivF [KO:K01996]
ENKNEFLB_00230  livF_2; High-affinity branched-chain amino acid transport ATP-binding protein LivF [KO:K01996]
ENKNEFLB_04263  yhfQ; Putative ABC transporter substrate-binding lipoprotein YhfQ [KO:K25286]
ENKNEFLB_04262  yfiZ; putative siderophore transport system permease protein YfiZ [KO:K23186]
ENKNEFLB_04261  fecD; Fe(3+) dicitrate transport system permease protein FecD [KO:K23187]
ENKNEFLB_04260  yusV; putative siderophore transport system ATP-binding protein YusV [KO:K23188] [EC:7.2.2.17 7.2.2.-]
ENKNEFLB_01728  znuC_1; High-affinity zinc uptake system ATP-binding protein ZnuC [KO:K11603] [EC:7.2.2.5]
ENKNEFLB_01729  hpf_1; Putative metal ABC transporter substrate-binding protein Hpf [KO:K19975]
ENKNEFLB_01727  mntB_1; Manganese transport system membrane protein MntB [KO:K19976]
ENKNEFLB_02015  znuA; High-affinity zinc uptake system protein ZnuA [KO:K09815]
ENKNEFLB_02013  znuB; High-affinity zinc uptake system membrane protein ZnuB [KO:K09816]
ENKNEFLB_02014  znuC_2; High-affinity zinc uptake system ATP-binding protein ZnuC [KO:K09817] [EC:7.2.2.20]
ENKNEFLB_03466  larMN; putative fused nickel transport protein LarMN [KO:K02007]
ENKNEFLB_03464  ecfT_2; Energy-coupling factor transporter transmembrane protein EcfT [KO:K02008]
ENKNEFLB_03463  ecfA3; Energy-coupling factor transporter ATP-binding protein EcfA3 [KO:K02006]
ENKNEFLB_01318  bioY; Biotin transporter BioY [KO:K03523]
ENKNEFLB_01316  bioN; Energy-coupling factor transporter transmembrane protein BioN [KO:K16783]
ENKNEFLB_01317  bioM; Biotin transport ATP-binding protein BioM [KO:K16784] [EC:7.6.2.-]
ENKNEFLB_03332  ecfT_1; Energy-coupling factor transporter transmembrane protein EcfT [KO:K16785]
ENKNEFLB_03321  tagG; Teichoic acid translocation permease protein TagG [KO:K09690]
ENKNEFLB_03320  tagH; Teichoic acids export ATP-binding protein TagH [KO:K09691] [EC:7.5.2.14]
ENKNEFLB_02978  drrA_7; Daunorubicin/doxorubicin resistance ATP-binding protein DrrA [KO:K20459]
ENKNEFLB_03526  ftsX; Cell division protein FtsX [KO:K09811]
ENKNEFLB_03527  ftsE; Cell division ATP-binding protein FtsE [KO:K09812]
ENKNEFLB_03176  msbA_4; Lipid A export ATP-binding/permease protein MsbA [KO:K18889]
ENKNEFLB_02184  cydD; ATP-binding/permease protein CydD [KO:K16014]
Compound
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00032  Heme
C00034  Manganese
C00037  Glycine
C00038  Zinc cation
C00041  L-Alanine
C00047  L-Lysine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00062  L-Arginine
C00064  L-Glutamine
C00065  L-Serine
C00070  Copper
C00077  L-Ornithine
C00079  L-Phenylalanine
C00086  Urea
C00088  Nitrite
C00089  Sucrose
C00093  sn-Glycerol 3-phosphate
C00095  D-Fructose
C00098  Oligopeptide
C00107  Dipeptide
C00114  Choline
C00116  Glycerol
C00120  Biotin
C00121  D-Ribose
C00123  L-Leucine
C00134  Putrescine
C00135  L-Histidine
C00137  myo-Inositol
C00140  N-Acetyl-D-glucosamine
C00148  L-Proline
C00151  L-Amino acid
C00159  D-Mannose
C00175  Cobalt ion
C00181  D-Xylose
C00183  L-Valine
C00185  Cellobiose
C00188  L-Threonine
C00208  Maltose
C00212  Adenosine
C00243  Lactose
C00244  Nitrate
C00245  Taurine
C00255  Riboflavin
C00259  L-Arabinose
C00288  HCO3-
C00291  Nickel
C00294  Inosine
C00299  Uridine
C00315  Spermidine
C00320  Thiosulfate
C00330  Deoxyguanosine
C00333  D-Galacturonate
C00338  Lipopolysaccharide
C00378  Thiamine
C00379  Xylitol
C00387  Guanosine
C00392  Mannitol
C00407  L-Isoleucine
C00430  5-Aminolevulinate
C00470  Pectate
C00475  Cytidine
C00487  Carnitine
C00491  L-Cystine
C00492  Raffinose
C00503  Erythritol
C00526  Deoxyuridine
C00559  Deoxyadenosine
C00719  Betaine
C00794  D-Sorbitol
C00855  D-Methionine
C00865  Phospholipid
C00881  Deoxycytidine
C00919  Choline sulfate
C00973  Cyclomaltodextrin
C01083  alpha,alpha-Trehalose
C01153  Orthophosphoric monoester
C01157  Hydroxyproline
C01177  Inositol 1-phosphate
C01181  4-Trimethylammoniobutanoate
C01279  4-Amino-5-hydroxymethyl-2-methylpyrimidine
C01330  Sodium cation
C01417  Cyanate
C01487  D-Allose
C01606  Phthalate
C01630  Xylobiose
C01667  Bacitracin
C01674  Chitobiose
C01682  Nopaline
C01684  D-Rhamnose
C01762  Xanthosine
C01834  Lipoprotein
C01835  Maltotriose
C01935  Maltodextrin
C01946  Oleandomycin
C02160  Isomaltotriose
C02273  Digalacturonate
C03557  2-Aminoethylphosphonate
C03611  Galactose oligosaccharide
C03619  Methyl beta-D-galactoside
C04114  (E)-4-(Trimethylammonio)but-2-enoate
C04137  Octopine
C05349  Ciprofloxacin
C05402  Melibiose
C05512  Deoxyinosine
C05776  Vitamin B12
C06227  Fe(III)hydroxamate
C06229  Fe(III)dicitrate
C06230  Fe-enterobactin
C06232  Molybdate
C06687  Norfloxacin
C06705  Capsular polysaccharide
C06706  Lipo-oligosaccharide
C06707  Teichoic acid
C06767  Hemine
C07662  Sparfloxacin
C07663  Moxifloxacin
C11612  Polymyxin B
C13768  Colistin sulfate
C14818  Fe2+
C14819  Fe3+
C15521  Alkanesulfonate
C15719  Coelichelin
C16421  AI-2
C16692  Mannopine
C19609  Nickel(2+)
C19872  N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570  alpha-1,5-L-Arabinobiose
C20571  alpha-1,5-L-Arabinotriose
C20572  alpha-1,5-L-Arabinotetraose
C20573  Aldotetraouronic acid
C20679  Tungstate
C21066  D-Galactofuranose
C22040  S-Methyl-L-cysteine
G00457  Maltotetraose
Reference
PMID:9799792
  Authors
Tomii K, Kanehisa M.
  Title
A comparative analysis of ABC transporters in complete microbial genomes.
  Journal
Genome Res 8:1048-59 (1998)
DOI:10.1101/gr.8.10.1048
Reference
PMID:18424520
  Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
  Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
J Bacteriol 190:4460-9 (2008)
DOI:10.1128/JB.00270-08
Reference
PMID:18375759
  Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
  Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
Proc Natl Acad Sci U S A 105:5537-42 (2008)
DOI:10.1073/pnas.0801196105
Reference
PMID:10557362
  Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
  Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
  Journal
Proc Natl Acad Sci U S A 96:13571-6 (1999)
DOI:10.1073/pnas.96.23.13571
Reference
PMID:11731493
  Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
  Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
  Journal
Genome Res 11:2034-40 (2001)
DOI:10.1101/gr.196301
Reference
PMID:16135226
  Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
  Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
  Journal
Mol Microbiol 57:1582-92 (2005)
DOI:10.1111/j.1365-2958.2005.04791.x
Reference
PMID:11929526
  Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
  Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
  Journal
Mol Microbiol 43:703-15 (2002)
DOI:10.1046/j.1365-2958.2002.02778.x
Reference
PMID:18326572
  Authors
Richard-Fogal CL, Frawley ER, Kranz RG
  Title
Topology and function of CcmD in cytochrome c maturation.
  Journal
J Bacteriol 190:3489-93 (2008)
DOI:10.1128/JB.00146-08
Reference
PMID:16109926
  Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
  Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
  Journal
J Bacteriol 187:5861-7 (2005)
DOI:10.1128/JB.187.17.5861-5867.2005
Reference
PMID:17873039
  Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
  Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
  Journal
J Bacteriol 189:8361-5 (2007)
DOI:10.1128/JB.01028-07
Reference
PMID:17214741
  Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
  Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
  Journal
Mol Microbiol 63:895-910 (2007)
DOI:10.1111/j.1365-2958.2006.05549.x
Reference
PMID:18805970
  Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
  Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
  Journal
J Bacteriol 190:7693-8 (2008)
DOI:10.1128/JB.00853-08
KO pathway
ko02010   
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