KEGG   PATHWAY: ncx02024
Entry
ncx02024                    Pathway                                
Name
Quorum sensing - Nonomuraea coxensis
Description
Quorum sensing (QS) is a regulatory system that allows bacteria to share information about cell density and adjust gene expression accordingly. All QS bacteria produce and release chemical signal molecules called autoinducers (AIs) that increase in concentration as a function of cell density. The most commonly studied AIs belong to one of the following three categories: acylated homoserine lactones, also referred to as AI-1, used by Gram-negative bacteria; peptide signals, used by Gram-positive bacteria; and AI-2, used by both Gram-negative and Gram-positive bacteria. QS can be divided into at least 4 steps: production of AIs by the bacterial cell; release of AIs, either actively or passively, into the surrounding environment; recognition of AIs by specific receptors; and leading to changes in gene regulation once they exceed a threshold concentration. The processes controlled by QS include virulence, competence, conjugation, antibiotic production, motility, sporulation, and biofilm formation.
Class
Cellular Processes; Cellular community - prokaryotes
Pathway map
ncx02024  Quorum sensing
ncx02024

Other DBs
GO: 0009372
Organism
Nonomuraea coxensis [GN:ncx]
Gene
Nocox_26450  rebG; 4'-demethylrebeccamycin synthase [KO:K18101] [EC:2.4.1.-]
Nocox_17685  aroH2; Phospho-2-dehydro-3-deoxyheptonate aldolase [KO:K01626] [EC:2.5.1.54]
Nocox_40005  kdpE; KDP operon transcriptional regulatory protein KdpE [KO:K07667]
Nocox_32525  hypothetical protein [KO:K02055]
Nocox_36600  hypothetical protein [KO:K02055]
Nocox_09280  spermidine/putrescine ABC transporter periplasmic substrate-binding protein [KO:K02055]
Nocox_32535  spermidine/putrescine ABC transporter membrane protein [KO:K02053]
Nocox_32530  sulfate/thiosulfate transporter subunit [KO:K02054]
Nocox_32540  cysA3; Sulfate/thiosulfate import ATP-binding protein CysA [KO:K02052]
Nocox_13460  potA3; Spermidine/putrescine import ATP-binding protein PotA [KO:K02052]
Nocox_20680  braC2; Leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein precursor [KO:K01999]
Nocox_24165  hypothetical protein [KO:K01999]
Nocox_38175  hypothetical protein [KO:K01999]
Nocox_40320  hypothetical protein [KO:K01999]
Nocox_11490  hypothetical protein [KO:K01999]
Nocox_12950  hypothetical protein [KO:K01999]
Nocox_15750  braC1; Leucine-, isoleucine-, valine-, threonine-, and alanine-binding protein precursor [KO:K01999]
Nocox_15760  hypothetical protein [KO:K01999]
Nocox_20665  livH5; High-affinity branched-chain amino acid transport system permease protein LivH [KO:K01997]
Nocox_24130  livH6; High-affinity branched-chain amino acid transport system permease protein LivH [KO:K01997]
Nocox_24155  livH7; High-affinity branched-chain amino acid transport system permease protein LivH [KO:K01997]
Nocox_38195  livH8; High-affinity branched-chain amino acid transport system permease protein LivH [KO:K01997]
Nocox_40330  livH9; High-affinity branched-chain amino acid transport system permease protein LivH [KO:K01997]
Nocox_11475  livH2; High-affinity branched-chain amino acid transport system permease protein LivH [KO:K01997]
Nocox_12935  livH3; High-affinity branched-chain amino acid transport system permease protein LivH [KO:K01997]
Nocox_15785  livH4; High-affinity branched-chain amino acid transport system permease protein LivH [KO:K01997]
Nocox_20660  leucine/isoleucine/valine transporter permease subunit [KO:K01998]
Nocox_24135  leucine/isoleucine/valine transporter permease subunit [KO:K01998]
Nocox_24160  leucine/isoleucine/valine transporter permease subunit [KO:K01998]
Nocox_38190  leucine/isoleucine/valine transporter permease subunit [KO:K01998]
Nocox_40325  leucine/isoleucine/valine transporter permease subunit [KO:K01998]
Nocox_11470  leucine/isoleucine/valine transporter permease subunit [KO:K01998]
Nocox_12940  livF3; High-affinity branched-chain amino acid transport ATP-binding protein LivF [KO:K01995 K01998]
Nocox_15780  leucine/isoleucine/valine transporter permease subunit [KO:K01998]
Nocox_20675  lptB3; Lipopolysaccharide export system ATP-binding protein LptB [KO:K01995]
Nocox_24125  malK; Maltose/maltodextrin import ATP-binding protein MalK [KO:K01995]
Nocox_24145  lptB4; Lipopolysaccharide export system ATP-binding protein LptB [KO:K01995]
Nocox_38185  phnT; Putative 2-aminoethylphosphonate import ATP-binding protein PhnT [KO:K01995]
Nocox_40340  glnQ8; Glutamine transport ATP-binding protein GlnQ [KO:K01995]
Nocox_11485  lptB1; Lipopolysaccharide export system ATP-binding protein LptB [KO:K01995]
Nocox_15775  lptB2; Lipopolysaccharide export system ATP-binding protein LptB [KO:K01995]
Nocox_19675  metN2; Methionine import ATP-binding protein MetN [KO:K01995]
Nocox_20670  livF7; High-affinity branched-chain amino acid transport ATP-binding protein LivF [KO:K01996]
Nocox_24120  livF8; High-affinity branched-chain amino acid transport ATP-binding protein LivF [KO:K01996]
Nocox_24150  livF9; High-affinity branched-chain amino acid transport ATP-binding protein LivF [KO:K01996]
Nocox_38180  livF10; High-affinity branched-chain amino acid transport ATP-binding protein LivF [KO:K01996]
Nocox_40335  livF11; High-affinity branched-chain amino acid transport ATP-binding protein LivF [KO:K01996]
Nocox_11480  livF2; High-affinity branched-chain amino acid transport ATP-binding protein LivF [KO:K01996]
Nocox_12945  livF4; High-affinity branched-chain amino acid transport ATP-binding protein LivF [KO:K01996]
Nocox_15770  livF5; High-affinity branched-chain amino acid transport ATP-binding protein LivF [KO:K01996]
Nocox_25950  pelA; Pectate trisaccharide-lyase precursor [KO:K01728] [EC:4.2.2.2]
Nocox_11360  pel1; Pectate lyase precursor [KO:K01728] [EC:4.2.2.2]
Nocox_19410  pel2; Pectate trisaccharide-lyase precursor [KO:K01728] [EC:4.2.2.2]
Nocox_20945  lcfB8; Long-chain-fatty-acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
Nocox_23790  lcfB10; Long-chain-fatty-acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
Nocox_30550  Long-chain-fatty-acid--CoA ligase FadD13 [KO:K01897] [EC:6.2.1.3]
Nocox_31465  lcfB12; Long-chain-fatty-acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
Nocox_38110  Long-chain-fatty-acid--CoA ligase FadD15 [KO:K01897] [EC:6.2.1.3]
Nocox_39025  fadD; Long-chain-fatty-acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
Nocox_40350  lcfB14; Long-chain-fatty-acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
Nocox_06490  Long-chain-fatty-acid--CoA ligase FadD13 [KO:K01897] [EC:6.2.1.3]
Nocox_06565  lcfB1; Long-chain-fatty-acid--CoA ligase [KO:K01897] [EC:6.2.1.3]
Nocox_14775  Long-chain-fatty-acid--CoA ligase FadD15 [KO:K01897] [EC:6.2.1.3]
Nocox_17310  Long-chain-fatty-acid--CoA ligase FadD15 [KO:K01897] [EC:6.2.1.3]
Nocox_19740  baiB; Bile acid-coenzyme A ligase [KO:K01897] [EC:6.2.1.3]
Nocox_27705  crp2; cAMP receptor protein [KO:K10914]
Nocox_01605  crp1; cAMP receptor protein [KO:K10914]
Nocox_39375  crp4; cAMP receptor protein [KO:K10914]
Nocox_38655  manA2; Mannan endo-1,4-beta-mannosidase precursor [KO:K01218] [EC:3.2.1.78]
Nocox_26200  hypothetical protein [KO:K20333]
Nocox_15185  ribD1; Riboflavin biosynthesis protein RibD [KO:K11752] [EC:3.5.4.26 1.1.1.193]
Nocox_39170  oppA2; Oligopeptide-binding protein OppA precursor [KO:K15580]
Nocox_39165  gsiC4; Glutathione transport system permease protein GsiC [KO:K15581]
Nocox_39160  oppC3; Oligopeptide transport system permease protein OppC [KO:K15582]
Nocox_39155  oppD8; Oligopeptide transport ATP-binding protein OppD [KO:K15583]
Nocox_39150  oppF10; Oligopeptide transport ATP-binding protein OppF [KO:K10823]
Nocox_26165  gsiB2; Glutathione-binding protein GsiB precursor [KO:K02035]
Nocox_27265  gsiB3; Glutathione-binding protein GsiB precursor [KO:K02035]
Nocox_28545  appA2; Oligopeptide-binding protein AppA precursor [KO:K02035]
Nocox_30180  hbpA2; Heme-binding protein A precursor [KO:K02035]
Nocox_33700  ddpA2; putative D,D-dipeptide-binding periplasmic protein DdpA precursor [KO:K02035]
Nocox_33745  ddpA3; putative D,D-dipeptide-binding periplasmic protein DdpA precursor [KO:K02035]
Nocox_03070  appA1; Oligopeptide-binding protein AppA precursor [KO:K02035]
Nocox_17395  oppA1; Oligopeptide-binding protein OppA precursor [KO:K02035]
Nocox_18085  hbpA1; Heme-binding protein A precursor [KO:K02035]
Nocox_18385  ddpA1; putative D,D-dipeptide-binding periplasmic protein DdpA precursor [KO:K02035]
Nocox_19475  gsiB1; Glutathione-binding protein GsiB precursor [KO:K02035]
Nocox_07215  nikA; Nickel-binding periplasmic protein precursor [KO:K02035]
Nocox_26160  dppB6; Dipeptide transport system permease protein DppB [KO:K02033]
Nocox_27270  gsiC3; Glutathione transport system permease protein GsiC [KO:K02033]
Nocox_28550  dppB7; Dipeptide transport system permease protein DppB [KO:K02033]
Nocox_30175  dppB8; Dipeptide transport system permease protein DppB [KO:K02033]
Nocox_03075  dppB1; Dipeptide transport system permease protein DppB [KO:K02033]
Nocox_07210  dppB2; Dipeptide transport system permease protein DppB [KO:K02033]
Nocox_17390  dppB4; Dipeptide transport system permease protein DppB [KO:K02033]
Nocox_18090  gsiC1; Glutathione transport system permease protein GsiC [KO:K02033]
Nocox_18380  dppB5; Dipeptide transport system permease protein DppB [KO:K02033]
Nocox_19480  gsiC2; Glutathione transport system permease protein GsiC [KO:K02033]
Nocox_33740  dppB10; Dipeptide transport system permease protein DppB [KO:K02033]
Nocox_26170  gsiD2; Glutathione transport system permease protein GsiD [KO:K02034]
Nocox_27275  ddpC3; putative D,D-dipeptide transport system permease protein DdpC [KO:K02034]
Nocox_28555  dppC3; Dipeptide transport system permease protein DppC [KO:K02034]
Nocox_30170  dppC4; Dipeptide transport system permease protein DppC [KO:K02034]
Nocox_33735  ddpC4; putative D,D-dipeptide transport system permease protein DdpC [KO:K02034]
Nocox_03080  dppC1; Dipeptide transport system permease protein DppC [KO:K02034]
Nocox_07205  oppD2; Oligopeptide transport ATP-binding protein OppD [KO:K02031 K02034]
Nocox_17385  dppC2; Dipeptide transport system permease protein DppC [KO:K02034]
Nocox_18095  gsiD1; Glutathione transport system permease protein GsiD [KO:K02034]
Nocox_18375  ddpC1; putative D,D-dipeptide transport system permease protein DdpC [KO:K02034]
Nocox_19485  ddpC2; putative D,D-dipeptide transport system permease protein DdpC [KO:K02034]
Nocox_26155  oppD5; Oligopeptide transport ATP-binding protein OppD [KO:K02031]
Nocox_28560  oppD6; Oligopeptide transport ATP-binding protein OppD [KO:K02031]
Nocox_30165  oppD7; Oligopeptide transport ATP-binding protein OppD [KO:K02031]
Nocox_33730  ddpD2; putative D,D-dipeptide transport ATP-binding protein DdpD [KO:K02031]
Nocox_03085  oppD1; Oligopeptide transport ATP-binding protein OppD [KO:K02031]
Nocox_17380  oppD3; Oligopeptide transport ATP-binding protein OppD [KO:K02031]
Nocox_18100  ddpD1; putative D,D-dipeptide transport ATP-binding protein DdpD [KO:K02031]
Nocox_18370  oppD4; Oligopeptide transport ATP-binding protein OppD [KO:K02031]
Nocox_19490  gsiA2; Glutathione import ATP-binding protein GsiA [KO:K02031 K02032]
Nocox_27295  gsiA3; Glutathione import ATP-binding protein GsiA [KO:K02031 K02032]
Nocox_26150  oppF6; Oligopeptide transport ATP-binding protein OppF [KO:K02032]
Nocox_28565  oppF7; Oligopeptide transport ATP-binding protein OppF [KO:K02032]
Nocox_33725  oppF9; Oligopeptide transport ATP-binding protein OppF [KO:K02032]
Nocox_07200  oppF2; Oligopeptide transport ATP-binding protein OppF [KO:K02032]
Nocox_17375  oppF3; Oligopeptide transport ATP-binding protein OppF [KO:K02032]
Nocox_18365  oppF5; Oligopeptide transport ATP-binding protein OppF [KO:K02032]
Nocox_42495  yidC; Membrane protein insertase YidC [KO:K03217]
Nocox_00635  misCB; Membrane protein insertase MisCB precursor [KO:K03217]
Nocox_19875  bifunctional preprotein translocase subunit SecD/SecF [KO:K12257]
Nocox_04140  preprotein translocase subunit SecE [KO:K03073]
Nocox_26945  preprotein translocase subunit SecG [KO:K03075]
Nocox_04335  preprotein translocase subunit SecY [KO:K03076]
Nocox_27490  preprotein translocase subunit YajC [KO:K03210]
Nocox_34520  preprotein translocase subunit SecA [KO:K03070] [EC:7.4.2.8]
Nocox_06165  preprotein translocase subunit SecA [KO:K03070] [EC:7.4.2.8]
Nocox_34870  ftsY; Signal recognition particle receptor FtsY [KO:K03110]
Nocox_08810  ffh; Signal recognition particle protein [KO:K03106] [EC:3.6.5.4]
Compound
C00007  Oxygen
C00009  Orthophosphate
C00059  Sulfate
C00232  Succinate semialdehyde
C00334  4-Aminobutanoate
C00547  L-Noradrenaline
C00788  L-Adrenaline
C01019  L-Fucose
C11837  N-Butyryl-L-homoserine lactone
C11841  N-(3-Oxooctanoyl)homoserine lactone
C11844  N-Heptanoylhomoserine lactone
C11845  N-(3-Hydroxy-7-cis-tetradecenoyl)homoserine lactone
C11848  2-Heptyl-3-hydroxy-quinolone
C16421  AI-2
C16463  3',5'-Cyclic diGMP
C16640  CAI-1
C18049  N-Acyl-L-homoserine lactone
C18206  cis-11-Methyl-2-dodecenoic acid
C20643  2-Heptyl-4(1H)-quinolone
C20677  N-(4-Coumaroyl)-L-homoserine lactone
C20959  (4S)-4-Hydroxy-5-phosphooxypentane-2,3-dione
C21195  N-(3-Hydroxybutanoyl)-L-homoserine lactone
C21197  N-Hexanoyl-L-homoserine lactone
C21198  N-(3-Oxohexanoyl)-L-homoserine lactone
C21199  N-Octanoyl-L-homoserine lactone
C21200  N-3-Hydroxyoctanoyl-L-homoserine lactone
C21201  N-3-Oxo-dodecanoyl-L-homoserine lactone
C21202  cis-2-Dodecenoic acid
C21220  AIP-1
C21221  CSP
C21222  CSP
C21223  Blp
C21224  SHP2
C21225  SHP3
C21226  cCF10
C21227  iCF10
C21228  cAD1
C21229  iAD1
C21230  ComX pheromone
C21231  PhrA pentapeptide
C21232  PhrC pentapeptide
C21233  PhrE pentapeptide
C21234  PhrF pentapeptide
C21235  PhrG pentapeptide
C21236  PhrH pentapeptide
C21237  PhrK pentapeptide
C21238  NprX peptide
C21239  PapR peptide
C21241  AIP-2
C21242  AIP-3
C21243  AIP-4
C21244  AgrD peptide
C21245  AgrD1 peptide
C21246  GBAP
C21382  R-THMF
Reference
PMID:22712853
  Authors
Pereira CS, Thompson JA, Xavier KB
  Title
AI-2-mediated signalling in bacteria.
  Journal
FEMS Microbiol Rev 37:156-81 (2013)
DOI:10.1111/j.1574-6976.2012.00345.x
Reference
PMID:23965960
  Authors
Verma SC, Miyashiro T
  Title
Quorum sensing in the squid-Vibrio symbiosis.
  Journal
Int J Mol Sci 14:16386-401 (2013)
DOI:10.3390/ijms140816386
Reference
PMID:24348467
  Authors
Norsworthy AN, Visick KL
  Title
Gimme shelter: how Vibrio fischeri successfully navigates an animal's multiple environments.
  Journal
Front Microbiol 4:356 (2013)
DOI:10.3389/fmicb.2013.00356
Reference
PMID:24065108
  Authors
Papaioannou E, Utari PD, Quax WJ
  Title
Choosing an appropriate infection model to study quorum sensing inhibition in Pseudomonas infections.
  Journal
Int J Mol Sci 14:19309-40 (2013)
DOI:10.3390/ijms140919309
Reference
PMID:20738404
  Authors
Heeb S, Fletcher MP, Chhabra SR, Diggle SP, Williams P, Camara M
  Title
Quinolones: from antibiotics to autoinducers.
  Journal
FEMS Microbiol Rev 35:247-74 (2011)
DOI:10.1111/j.1574-6976.2010.00247.x
Reference
PMID:25866808
  Authors
Rasamiravaka T, Labtani Q, Duez P, El Jaziri M
  Title
The formation of biofilms by Pseudomonas aeruginosa: a review of the natural and synthetic compounds interfering with control mechanisms.
  Journal
Biomed Res Int 2015:759348 (2015)
DOI:10.1155/2015/759348
Reference
PMID:11544214
  Authors
Whiteley M, Greenberg EP
  Title
Promoter specificity elements in Pseudomonas aeruginosa quorum-sensing-controlled genes.
  Journal
J Bacteriol 183:5529-34 (2001)
DOI:10.1128/JB.183.19.5529-5534.2001
Reference
PMID:11497469
  Authors
Chin-A-Woeng TF, van den Broek D, de Voer G, van der Drift KM, Tuinman S, Thomas-Oates JE, Lugtenberg BJ, Bloemberg GV
  Title
Phenazine-1-carboxamide production in the biocontrol strain Pseudomonas chlororaphis PCL1391 is regulated by multiple factors secreted into the growth medium.
  Journal
Mol Plant Microbe Interact 14:969-79 (2001)
DOI:10.1094/MPMI.2001.14.8.969
Reference
PMID:19696934
  Authors
Hughes DT, Clarke MB, Yamamoto K, Rasko DA, Sperandio V
  Title
The QseC adrenergic signaling cascade in Enterohemorrhagic E. coli (EHEC).
  Journal
PLoS Pathog 5:e1000553 (2009)
DOI:10.1371/journal.ppat.1000553
Reference
PMID:22144490
  Authors
Njoroge J, Sperandio V
  Title
Enterohemorrhagic Escherichia coli virulence regulation by two bacterial adrenergic kinases, QseC and QseE.
  Journal
Infect Immun 80:688-703 (2012)
DOI:10.1128/IAI.05921-11
Reference
PMID:23160491
  Authors
Pacheco AR, Curtis MM, Ritchie JM, Munera D, Waldor MK, Moreira CG, Sperandio V
  Title
Fucose sensing regulates bacterial intestinal colonization.
  Journal
Nature 492:113-7 (2012)
DOI:10.1038/nature11623
Reference
PMID:22778415
  Authors
Hirakawa H, Harwood CS, Pechter KB, Schaefer AL, Greenberg EP
  Title
Antisense RNA that affects Rhodopseudomonas palustris quorum-sensing signal receptor expression.
  Journal
Proc Natl Acad Sci U S A 109:12141-6 (2012)
DOI:10.1073/pnas.1200243109
Reference
PMID:14617175
  Authors
Danino VE, Wilkinson A, Edwards A, Downie JA
  Title
Recipient-induced transfer of the symbiotic plasmid pRL1JI in Rhizobium leguminosarum bv. viciae is regulated by a quorum-sensing relay.
  Journal
Mol Microbiol 50:511-25 (2003)
DOI:10.1046/j.1365-2958.2003.03699.x
Reference
PMID:12448738
  Authors
Wisniewski-Dye F, Downie JA
  Title
Quorum-sensing in Rhizobium.
  Journal
Antonie Van Leeuwenhoek 81:397-407 (2002)
DOI:10.1023/A:1020501104051
Reference
PMID:10368158
  Authors
Rodelas B, Lithgow JK, Wisniewski-Dye F, Hardman A, Wilkinson A, Economou A, Williams P, Downie JA
  Title
Analysis of quorum-sensing-dependent control of rhizosphere-expressed (rhi) genes in Rhizobium leguminosarum bv. viciae.
  Journal
J Bacteriol 181:3816-23 (1999)
DOI:10.1128/JB.181.12.3816-3823.1999
Reference
PMID:24550924
  Authors
Lang J, Faure D
  Title
Functions and regulation of quorum-sensing in Agrobacterium tumefaciens.
  Journal
Front Plant Sci 5:14 (2014)
DOI:10.3389/fpls.2014.00014
Reference
PMID:23710277
  Authors
Planamente S, Morera S, Faure D
  Title
In planta fitness-cost of the Atu4232-regulon encoding for a selective GABA-binding sensor in Agrobacterium.
  Journal
Commun Integr Biol 6:e23692 (2013)
DOI:10.4161/cib.23692
Reference
PMID:16943991
  Authors
Barnard AM, Salmond GP
  Title
Quorum sensing in Erwinia species.
  Journal
Anal Bioanal Chem 387:415-23 (2007)
DOI:10.1007/s00216-006-0701-1
Reference
PMID:17360277
  Authors
Barnard AM, Bowden SD, Burr T, Coulthurst SJ, Monson RE, Salmond GP
  Title
Quorum sensing, virulence and secondary metabolite production in plant soft-rotting bacteria.
  Journal
Philos Trans R Soc Lond B Biol Sci 362:1165-83 (2007)
DOI:10.1098/rstb.2007.2042
Reference
PMID:19843225
  Authors
Carlier A, Burbank L, von Bodman SB
  Title
Identification and characterization of three novel EsaI/EsaR quorum-sensing controlled stewartan exopolysaccharide biosynthetic genes in Pantoea stewartii ssp. stewartii.
  Journal
Mol Microbiol 74:903-13 (2009)
DOI:10.1111/j.1365-2958.2009.06906.x
Reference
PMID:7665477
  Authors
Beck von Bodman S, Farrand SK
  Title
Capsular polysaccharide biosynthesis and pathogenicity in Erwinia stewartii require induction by an N-acylhomoserine lactone autoinducer.
  Journal
J Bacteriol 177:5000-8 (1995)
DOI:10.1128/JB.177.17.5000-5008.1995
Reference
PMID:19761612
  Authors
O'Grady EP, Viteri DF, Malott RJ, Sokol PA
  Title
Reciprocal regulation by the CepIR and CciIR quorum sensing systems in Burkholderia cenocepacia.
  Journal
BMC Genomics 10:441 (2009)
DOI:10.1186/1471-2164-10-441
Reference
PMID:16041013
  Authors
Malott RJ, Baldwin A, Mahenthiralingam E, Sokol PA
  Title
Characterization of the cciIR quorum-sensing system in Burkholderia cenocepacia.
  Journal
Infect Immun 73:4982-92 (2005)
DOI:10.1128/IAI.73.8.4982-4992.2005
Reference
PMID:22949660
  Authors
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