KEGG   PATHWAY: nmel00591
Entry
nmel00591                   Pathway                                
Name
Linoleic acid metabolism - Numida meleagris (helmeted guineafowl)
Class
Metabolism; Lipid metabolism
Pathway map
nmel00591  Linoleic acid metabolism
nmel00591

Other DBs
GO: 0043651
Organism
Numida meleagris (helmeted guineafowl) [GN:nmel]
Gene
110399689  group 10 secretory phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
110405684  PLA2G10; group 10 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
110407907  PROCA1; protein PROCA1 [KO:K01047] [EC:3.1.1.4]
110386986  basic phospholipase A2 homolog 1-like [KO:K01047] [EC:3.1.1.4]
110386987  basic phospholipase A2 Cdr-13-like [KO:K01047] [EC:3.1.1.4]
110398621  PLA2G12A; group XIIA secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
110406224  PLA2G3; group 3 secretory phospholipase A2 [KO:K01047] [EC:3.1.1.4]
110408501  phospholipase A2, membrane associated-like [KO:K01047] [EC:3.1.1.4]
110408502  group IIE secretory phospholipase A2-like [KO:K01047] [EC:3.1.1.4]
110400253  PLA2G12B; group XIIB secretory phospholipase A2-like protein isoform X1 [KO:K01047] [EC:3.1.1.4]
110406422  phospholipase A2, minor isoenzyme-like [KO:K01047] [EC:3.1.1.4]
110406423  phospholipase A2, minor isoenzyme-like [KO:K01047] [EC:3.1.1.4]
110401265  cytosolic phospholipase A2 beta-like isoform X1 [KO:K16342] [EC:3.1.1.4]
110402446  PLA2G4A; cytosolic phospholipase A2 [KO:K16342] [EC:3.1.1.4]
110401489  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
110401490  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
110401864  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
110401865  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
110401871  PLA2G4F; cytosolic phospholipase A2 zeta isoform X1 [KO:K16342] [EC:3.1.1.4]
110401872  cytosolic phospholipase A2 epsilon-like isoform X1 [KO:K16342] [EC:3.1.1.4]
110401665  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
110401676  cytosolic phospholipase A2 epsilon-like [KO:K16342] [EC:3.1.1.4]
110392785  PLA2G6; 85/88 kDa calcium-independent phospholipase A2 [KO:K16343] [EC:3.1.1.4]
110396340  PLB1; phospholipase B1, membrane-associated [KO:K14621] [EC:3.1.1.4 3.1.1.5]
110399446  cytochrome P450 2C9-like [KO:K07413] [EC:1.14.14.1]
110402810  cytochrome P450 2J2-like isoform X1 [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
110402814  cytochrome P450 2J2-like [KO:K07418] [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
110405948  cytochrome P450 3A29-like isoform X1 [KO:K07424] [EC:1.14.14.1]
110406034  cytochrome P450 3A9-like [KO:K07424] [EC:1.14.14.1]
Compound
C00157  Phosphatidylcholine
C00219  Arachidonate
C01595  Linoleate
C03242  Dihomo-gamma-linolenate
C04056  Rumenic acid
C04717  (9Z,11E)-(13S)-13-Hydroperoxyoctadeca-9,11-dienoic acid
C06426  (6Z,9Z,12Z)-Octadecatrienoic acid
C07289  Crepenynate
C07338  (9Z,12Z)-(11S)-11-Hydroperoxyoctadeca-9,12-dienoic acid
C07354  (7S,8S)-DiHODE
C14762  13(S)-HODE
C14765  13-OxoODE
C14766  9-OxoODE
C14767  9(S)-HODE
C14825  9(10)-EpOME
C14826  12(13)-EpOME
C14827  9(S)-HPODE
C14828  9,10-DHOME
C14829  12,13-DHOME
C14831  8(R)-HPODE
C14832  12,13-Epoxy-9-hydroxy-10-octadecenoate
C14833  9,12,13-TriHOME
C14834  9,10-Epoxy-13-hydroxy-11-octadecenoate
C14835  9,10,13-TriHOME
C14836  9,10-12,13-Diepoxyoctadecanoate
C14837  9,10-Dihydroxy-12,13-epoxyoctadecanoate
C19937  (8E,10R,12Z)-10-Hydroperoxy-8,12-octadecadienoate
C20186  5S,8R-DiHODE
C22918  (9Z,11E)-12-[(1E)-Hex-1-en-1-yloxy]dodeca-9,11-dienoic acid
Reference
  Authors
Nowak G, Grant DF, Moran JH.
  Title
Linoleic acid epoxide promotes the maintenance of mitochondrial function and active Na+ transport following hypoxia.
  Journal
Toxicol Lett 147:161-75 (2004)
DOI:10.1016/j.toxlet.2003.11.002
Reference
  Authors
Shureiqi I, Jiang W, Zuo X, Wu Y, Stimmel JB, Leesnitzer LM, Morris JS, Fan HZ, Fischer SM, Lippman SM.
  Title
The 15-lipoxygenase-1 product 13-S-hydroxyoctadecadienoic acid down-regulates PPAR-delta to induce apoptosis in colorectal cancer cells.
  Journal
Proc Natl Acad Sci U S A 100:9968-73 (2003)
DOI:10.1073/pnas.1631086100
Reference
  Authors
Spiteller G.
  Title
Do changes in the cell membrane structure induce the generation of lipid peroxidation products which serve as first signalling molecules in cell to cell communication?
  Journal
Prostaglandins Leukot Essent Fatty Acids 67:151-62 (2002)
DOI:10.1054/plef.2002.0413
Reference
  Authors
Jude AR, Little JM, Bull AW, Podgorski I, Radominska-Pandya A.
  Title
13-hydroxy- and 13-oxooctadecadienoic acids: novel substrates for human UDP-glucuronosyltransferases.
  Journal
Drug Metab Dispos 29:652-5 (2001)
Reference
PMID:9694817
  Authors
Su C, Sahlin M, Oliw EH.
  Title
A protein radical and ferryl intermediates are generated by linoleate diol synthase, a ferric hemeprotein with dioxygenase and hydroperoxide isomerase activities.
  Journal
J Biol Chem 273:20744-51 (1998)
DOI:10.1074/jbc.273.33.20744
Reference
PMID:1634517
  Authors
Brodowsky ID, Hamberg M, Oliw EH.
  Title
A linoleic acid (8R)-dioxygenase and hydroperoxide isomerase of the fungus Gaeumannomyces graminis. Biosynthesis of (8R)-hydroxylinoleic acid and (7S,8S)-dihydroxylinoleic acid from (8R)-hydroperoxylinoleic acid.
  Journal
J Biol Chem 267:14738-45 (1992)
Reference
  Authors
Hamberg M, Hamberg G.
  Title
Peroxygenase-Catalyzed Fatty Acid Epoxidation in Cereal Seeds (Sequential Oxidation of Linoleic Acid into 9(S),12(S),13(S)-Trihydroxy-10(E)-Octadecenoic Acid).
  Journal
Plant Physiol 110:807-815 (1996)
DOI:10.1104/pp.110.3.807
Reference
PMID:8765137
  Authors
Moghaddam M, Motoba K, Borhan B, Pinot F, Hammock BD.
  Title
Novel metabolic pathways for linoleic and arachidonic acid metabolism.
  Journal
Biochim Biophys Acta 1290:327-39 (1996)
DOI:10.1016/0304-4165(96)00037-2
Related
pathway
nmel00590  Arachidonic acid metabolism
KO pathway
ko00591   
LinkDB

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