KEGG PATHWAY: pbar04145

KEGG

PATHWAY: pbar04145

Entry

pbar04145                   Pathway

Name

Phagosome - Pogonomyrmex barbatus (red harvester ant)

Description

Phagocytosis is the process of taking in relatively large particles by a cell, and is a central mechanism in the tissue remodeling, inflammation, and defense against infectious agents. A phagosome is formed when the specific receptors on the phagocyte surface recognize ligands on the particle surface. After formation, nascent phagosomes progressively acquire digestive characteristics. This maturation of phagosomes involves regulated interaction with the other membrane organelles, including recycling endosomes, late endosomes and lysosomes. The fusion of phagosomes and lysosomes releases toxic products that kill most bacteria and degrade them into fragments. However, some bacteria have strategies to escape the bactericidal mechanisms associated with phagocytosis and survive within host phagocytes.

Class

Cellular Processes; Transport and catabolism

Pathway map

Phagosome

Other DBs

GO:

Organism

Pogonomyrmex barbatus (red harvester ant) [GN:pbar]

Gene

syntaxin-12 [KO:K08488]

actin-5C [KO:K05692]

syntaxin-18 [KO:K08492]

vesicle-trafficking protein SEC22b-B [KO:K08517]

ras-related protein Rab-5C [KO:K07889]

phosphatidylinositol 3-kinase catalytic subunit type 3 [KO:K00914] [EC:2.7.1.137]

hepatocyte growth factor-regulated tyrosine kinase substrate [KO:K12182]

V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]

V-type proton ATPase subunit B [KO:K02147]

V-type proton ATPase subunit C isoform X1 [KO:K02148]

V-type proton ATPase subunit D-like [KO:K02149]

V-type proton ATPase subunit D [KO:K02149]

V-type proton ATPase subunit E [KO:K02150]

V-type proton ATPase subunit F 1 [KO:K02151]

V-type proton ATPase subunit G [KO:K02152]

V-type proton ATPase subunit e 2-like [KO:K02153]

V-type proton ATPase 116 kDa subunit a isoform 1 [KO:K02154]

V-type proton ATPase 116 kDa subunit a isoform 1 isoform X1 [KO:K02154]

V-type proton ATPase subunit d [KO:K02146]

V-type proton ATPase subunit H isoform X1 [KO:K02144]

V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]

V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]

uncharacterized protein LOC105430092 [KO:K03662]

ras-related protein Rab-7a [KO:K07897]

dynein heavy chain, cytoplasmic isoform X1 [KO:K10413]

cytoplasmic dynein 1 intermediate chain-like isoform X1 [KO:K10415]

cytoplasmic dynein 1 light intermediate chain 2 isoform X1 [KO:K10416]

tubulin alpha-1 chain-like [KO:K07374]

tubulin alpha-1 chain [KO:K07374]

tubulin alpha chain-like isoform X1 [KO:K07374]

tubulin alpha-1 chain-like [KO:K07374]

tubulin alpha-2/alpha-4 chain-like isoform X1 [KO:K07374]

LOW QUALITY PROTEIN: tubulin beta chain-like [KO:K07375]

tubulin beta-1 chain [KO:K07375]

tubulin beta chain-like [KO:K07375]

tubulin beta chain-like [KO:K07375]

lysosome-associated membrane glycoprotein 1 isoform X1 [KO:K06528]

1-phosphatidylinositol 3-phosphate 5-kinase isoform X1 [KO:K00921] [EC:2.7.1.150]

uncharacterized protein LOC105424903 [KO:K10089]

nitric oxide synthase, salivary gland [KO:K13240] [EC:1.14.13.39]

cathepsin L1 [KO:K01365] [EC:3.4.22.15]

cathepsin L1-like [KO:K01365] [EC:3.4.22.15]

protein transport protein Sec61 subunit alpha isoform 2 [KO:K10956]

protein transport protein Sec61 subunit beta [KO:K09481]

protein transport protein Sec61 subunit gamma [KO:K07342]

calreticulin [KO:K08057]

calnexin-like isoform X1 [KO:K08054]

integrin beta-PS isoform X1 [KO:K05719]

integrin beta-PS-like [KO:K05719]

uncharacterized protein LOC105427393 [KO:K04659]

LOW QUALITY PROTEIN: scavenger receptor class B member 1-like [KO:K13885]

protein croquemort-like isoform X1 [KO:K13885]

scavenger receptor class B member 1 [KO:K13885]

platelet glycoprotein 4-like [KO:K13885]

protein croquemort-like [KO:K13885]

scavenger receptor class B member 1 [KO:K13885]

sensory neuron membrane protein 1-like [KO:K13885]

ras-related C3 botulinum toxin substrate 1 [KO:K04392]

ras-related protein Rac1 [KO:K04392]

ras-like GTP-binding protein RhoL [KO:K04392]

Compound

1-Phosphatidyl-1D-myo-inositol 3-phosphate

Reference

Authors

Stuart LM, Ezekowitz RA

Title

Phagocytosis: elegant complexity.

Journal

Immunity 22:539-50 (2005)
DOI:10.1016/j.immuni.2005.05.002

Reference

Authors

Tjelle TE, Lovdal T, Berg T

Title

Phagosome dynamics and function.

Journal

Bioessays 22:255-63 (2000)
DOI:10.1002/(SICI)1521-1878(200003)22:3<255::AID-BIES7>3.0.CO;2-R

Reference

Authors

Dupuy AG, Caron E

Title

Integrin-dependent phagocytosis: spreading from microadhesion to new concepts.

Journal

J Cell Sci 121:1773-83 (2008)
DOI:10.1242/jcs.018036

Reference

Authors

Brumell JH, Grinstein S

Title

Salmonella redirects phagosomal maturation.

Journal

Curr Opin Microbiol 7:78-84 (2004)
DOI:10.1016/j.mib.2003.12.005

Reference

Authors

Huynh KK, Eskelinen EL, Scott CC, Malevanets A, Saftig P, Grinstein S

Title

LAMP proteins are required for fusion of lysosomes with phagosomes.

Journal

EMBO J 26:313-24 (2007)
DOI:10.1038/sj.emboj.7601511

Reference

Authors

Luzio JP, Pryor PR, Bright NA

Title

Lysosomes: fusion and function.

Journal

Nat Rev Mol Cell Biol 8:622-32 (2007)
DOI:10.1038/nrm2217

Reference

Authors

Sumimoto H

Title

Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.

Journal

FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x

Related
pathway

Lysosome

Endocytosis

KO pathway

LinkDB

DBGET integrated database retrieval system