KEGG   PATHWAY: pcoo03460
Entry
pcoo03460                   Pathway                                
Name
Fanconi anemia pathway - Puma concolor (puma)
Description
The Fanconi anemia pathway is required for the efficient repair of damaged DNA, especially interstrand cross-links (ICLs). DNA ICL is directly recognized by FANCM and associated proteins, that recruit the FA core complex. The FA core complex monoubiquitinates FANCD2 and FANCI. The monoubiquitinated FANCD2/FANCI becomes an active form and interacts with a series of DNA repair proteins and facilitates downstream repair pathways. Fanconi anemia is caused by mutations in one of at least 13 FA genes and is characterized by congenital growth abnormalities, bone marrow failure and cancer predisposition.
Class
Genetic Information Processing; Replication and repair
Pathway map
pcoo03460  Fanconi anemia pathway
pcoo03460

Other DBs
GO: 0043240
Organism
Puma concolor (puma) [GN:pcoo]
Gene
112852913  ATRIP; ATR-interacting protein [KO:K10905]
112850504  ATR; serine/threonine-protein kinase ATR isoform X1 [KO:K06640] [EC:2.7.11.1]
112851160  FAAP24; Fanconi anemia core complex-associated protein 24 [KO:K10898]
112864662  CENPX; centromere protein X isoform X1 [KO:K15360]
112853250  TELO2; telomere length regulation protein TEL2 homolog [KO:K11137]
112864621  FAAP100; Fanconi anemia core complex-associated protein 100 [KO:K10993]
112857219  FANCA; LOW QUALITY PROTEIN: Fanconi anemia group A protein [KO:K10888]
112871698  FANCB; Fanconi anemia group B protein [KO:K10889]
112868676  FANCC; Fanconi anemia group C protein [KO:K10890]
112862841  FANCE; Fanconi anemia group E protein [KO:K10892]
112866083  FANCF; Fanconi anemia group F protein [KO:K10893]
112850381  FANCG; Fanconi anemia group G protein [KO:K10894]
112868831  FANCL; E3 ubiquitin-protein ligase FANCL [KO:K10606] [EC:2.3.2.27]
112849353  WDR48; WD repeat-containing protein 48 isoform X1 [KO:K15361]
112872172  USP1; ubiquitin carboxyl-terminal hydrolase 1 [KO:K11832] [EC:3.4.19.12]
112857870  UBE2T; ubiquitin-conjugating enzyme E2 T [KO:K13960] [EC:2.3.2.23]
112856200  FANCI; Fanconi anemia group I protein isoform X1 [KO:K10895]
112857882  FANCD2; Fanconi anemia group D2 protein [KO:K10891]
112860373  BRCA2; breast cancer type 2 susceptibility protein [KO:K08775]
112853320  PALB2; partner and localizer of BRCA2 [KO:K10897]
112853834  RAD51C; DNA repair protein RAD51 homolog 3 [KO:K10870]
112855399  RAD51; DNA repair protein RAD51 homolog 1 isoform X1 [KO:K04482]
112854200  BRCA1; breast cancer type 1 susceptibility protein isoform X1 [KO:K10605] [EC:2.3.2.27]
112855443  BRIP1; LOW QUALITY PROTEIN: Fanconi anemia group J protein [KO:K15362] [EC:5.6.2.3]
112856326  FAN1; fanconi-associated nuclease 1 [KO:K15363] [EC:3.1.21.- 3.1.4.1]
112849340  MLH1; DNA mismatch repair protein Mlh1 isoform X1 [KO:K08734]
112859955  PMS2; mismatch repair endonuclease PMS2 [KO:K10858]
112868893  REV1; DNA repair protein REV1 isoform X1 [KO:K03515] [EC:2.7.7.-]
112862018  REV3L; DNA polymerase zeta catalytic subunit [KO:K02350] [EC:2.7.7.7]
112862795  POLH; DNA polymerase eta [KO:K03509] [EC:2.7.7.7]
112868256  POLI; DNA polymerase iota isoform X1 [KO:K03510] [EC:2.7.7.7]
112861098  POLK; DNA polymerase kappa [KO:K03511] [EC:2.7.7.7]
112868724  RMI1; recQ-mediated genome instability protein 1 [KO:K10990]
112853354  RMI2; recQ-mediated genome instability protein 2 [KO:K15365]
112857079  TOP3A; DNA topoisomerase 3-alpha [KO:K03165] [EC:5.6.2.1]
112870179  TOP3B; DNA topoisomerase 3-beta-1 [KO:K03165] [EC:5.6.2.1]
112855307  BLM; Bloom syndrome protein isoform X1 [KO:K10901] [EC:5.6.2.4]
112853065  RPA1; LOW QUALITY PROTEIN: replication protein A 70 kDa DNA-binding subunit [KO:K07466]
112870788  RPA2; replication protein A 32 kDa subunit [KO:K10739]
112866727  RPA3; replication protein A 14 kDa subunit [KO:K10740]
112851946  MUS81; crossover junction endonuclease MUS81 [KO:K08991] [EC:3.1.22.-]
112854073  EME1; crossover junction endonuclease EME1 [KO:K10882] [EC:3.1.22.-]
112853324  ERCC4; LOW QUALITY PROTEIN: DNA repair endonuclease XPF [KO:K10848] [EC:3.1.-.-]
112853176  SLX4; structure-specific endonuclease subunit SLX4 [KO:K10484]
Reference
PMID:18047734
  Authors
Jacquemont C, Taniguchi T
  Title
The Fanconi anemia pathway and ubiquitin.
  Journal
BMC Biochem 8 Suppl 1:S10 (2007)
DOI:10.1186/1471-2091-8-S1-S10
Reference
PMID:19805513
  Authors
Bhagwat N, Olsen AL, Wang AT, Hanada K, Stuckert P, Kanaar R, D'Andrea A, Niedernhofer LJ, McHugh PJ
  Title
XPF-ERCC1 participates in the Fanconi anemia pathway of cross-link repair.
  Journal
Mol Cell Biol 29:6427-37 (2009)
DOI:10.1128/MCB.00086-09
Reference
PMID:21701511
  Authors
Deans AJ, West SC
  Title
DNA interstrand crosslink repair and cancer.
  Journal
Nat Rev Cancer 11:467-80 (2011)
DOI:10.1038/nrc3088
Reference
PMID:20064461
  Authors
Deans AJ, West SC
  Title
FANCM connects the genome instability disorders Bloom's Syndrome and Fanconi Anemia.
  Journal
Mol Cell 36:943-53 (2009)
DOI:10.1016/j.molcel.2009.12.006
Reference
PMID:20039786
  Authors
Muniandy PA, Liu J, Majumdar A, Liu ST, Seidman MM
  Title
DNA interstrand crosslink repair in mammalian cells: step by step.
  Journal
Crit Rev Biochem Mol Biol 45:23-49 (2010)
DOI:10.3109/10409230903501819
Reference
PMID:18518821
  Authors
Ciccia A, McDonald N, West SC
  Title
Structural and functional relationships of the XPF/MUS81 family of proteins.
  Journal
Annu Rev Biochem 77:259-87 (2008)
DOI:10.1146/annurev.biochem.77.070306.102408
Related
pathway
pcoo03430  Mismatch repair
pcoo03440  Homologous recombination
KO pathway
ko03460   
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