KEGG   PATHWAY: pmon02020
Entry
pmon02020                   Pathway                                
Name
Two-component system - Pseudomonas monteilii SB3078
Description
Two-component signal transduction systems enable bacteria to sense, respond, and adapt to changes in their environment or in their intracellular state. Each two-component system consists of a sensor protein-histidine kinase (HK) and a response regulator (RR). In the prototypical two-component pathway, the sensor HK phosphorylates its own conserved His residue in response to a signal(s) in the environment. Subsequently, the phosphoryl group of HK is transferred onto a specific Asp residue on the RR. The activated RR can then effect changes in cellular physiology, often by regulating gene expression. Two-component pathways thus often enable cells to sense and respond to stimuli by inducing changes in transcription.
Class
Environmental Information Processing; Signal transduction
Pathway map
pmon02020  Two-component system
pmon02020

Other DBs
GO: 0000160
Organism
Pseudomonas monteilii SB3078 [GN:pmon]
Gene
X969_25550  histidine kinase [KO:K07636] [EC:2.7.13.3]
X969_25545  chemotaxis protein CheY [KO:K07657]
X969_25595  phosphate-binding protein [KO:K02040]
X969_09260  phosphate ABC transporter substrate-binding protein [KO:K02040]
X969_15800  membrane protein [KO:K02040]
X969_19710  sensor histidine kinase [KO:K07637] [EC:2.7.13.3]
X969_19715  transcriptional regulator [KO:K07660]
X969_27420  ATPase [KO:K07638] [EC:2.7.13.3]
X969_27415  chemotaxis protein CheY [KO:K07659]
X969_18775  chemotaxis protein CheY [KO:K07662]
X969_19735  sensor histidine kinase [KO:K07639] [EC:2.7.13.3]
X969_19740  transcriptional regulator [KO:K07661]
X969_20775  serine peptidase [KO:K04771] [EC:3.4.21.107]
X969_27875  sensor histidine kinase [KO:K07641] [EC:2.7.13.3]
X969_27870  transcriptional regulator [KO:K07663]
X969_14800  multidrug transporter [KO:K07799]
X969_14795  multidrug transporter [KO:K07788]
X969_14790  acriflavine resistance protein B [KO:K07789]
X969_20730  sensor histidine kinase [KO:K07644] [EC:2.7.13.3]
X969_25835  ATPase [KO:K07644] [EC:2.7.13.3]
X969_06680  ATPase [KO:K07644] [EC:2.7.13.3]
X969_26190  sensor histidine kinase [KO:K07644] [EC:2.7.13.3]
X969_02525  sensor histidine kinase [KO:K07644] [EC:2.7.13.3]
X969_20725  transcriptional regulator [KO:K07665]
X969_25830  transcriptional regulator [KO:K07665]
X969_26185  transcriptional regulator [KO:K07665]
X969_26265  transcriptional regulator [KO:K07665]
X969_02530  transcriptional regulator [KO:K07665]
X969_06685  transcriptional regulator [KO:K07665]
X969_25860  hypothetical protein [KO:K07810]
X969_25850  cytochrome C biogenesis protein [KO:K07798]
X969_25855  cation transporter [KO:K07787]
X969_08940  sensor histidine kinase [KO:K07645] [EC:2.7.13.3]
X969_17310  sensor histidine kinase [KO:K07645] [EC:2.7.13.3]
X969_08935  transcriptional regulator [KO:K07666]
X969_17315  transcriptional regulator [KO:K07666]
X969_18165  flagellar biosynthesis protein FliC [KO:K02406]
X969_18015  RNA polymerase sigma 70 [KO:K02405]
X969_23450  flagellar motor protein MotA [KO:K02556]
X969_17990  motC; flagellar motor protein [KO:K02556]
X969_17015  histidine kinase [KO:K07646] [EC:2.7.13.3]
X969_17010  Fis family transcriptional regulator [KO:K07667]
X969_17030  ATPase [KO:K01546]
X969_17025  potassium-transporting ATPase subunit B [KO:K01547] [EC:7.2.2.6]
X969_17020  ATPase [KO:K01548]
X969_17035  potassium-transporting ATPase F [KO:K01545]
X969_20820  sensor histidine kinase [KO:K07649] [EC:2.7.13.3]
X969_20825  transcriptional regulator [KO:K07774]
X969_20845  tripartite tricarboxylate transporter TctA [KO:K07793]
X969_20840  membrane protein [KO:K07794]
X969_20835  C4-dicarboxylate ABC transporter substrate-binding protein [KO:K07795]
X969_26595  cytochrome B561 [KO:K02259] [EC:1.17.99.9]
X969_26025  chromosomal replication initiation protein [KO:K02313]
X969_19645  membrane protein [KO:K14205] [EC:2.3.2.3]
X969_19615  membrane protein [KO:K18093] [EC:3.4.21.-]
X969_19825  porin [KO:K18093] [EC:3.4.21.-]
X969_07980  porin [KO:K18093] [EC:3.4.21.-]
X969_25210  membrane protein [KO:K18093] [EC:3.4.21.-]
X969_04395  histidine kinase [KO:K19609] [EC:2.7.13.3]
X969_04390  transcriptional regulator [KO:K19610]
X969_07125  outer membrane receptor FepA [KO:K19611]
X969_27035  chemotaxis protein CheY [KO:K08083]
X969_21685  GDP-mannose 6-dehydrogenase [KO:K00066] [EC:1.1.1.132]
X969_09415  sensor histidine kinase [KO:K07675] [EC:2.7.13.3]
X969_04385  chemotaxis protein CheY [KO:K07678] [EC:2.7.13.3]
X969_16715  chemotaxis protein CheY [KO:K07689]
X969_09420  LuxR family transcriptional regulator [KO:K07689]
X969_04865  carbon storage regulator [KO:K03563]
X969_08095  carbon storage regulator CsrA [KO:K03563]
X969_18370  carbon storage regulator [KO:K03563]
X969_15985  carbon storage regulator CsrA [KO:K03563]
X969_13815  sensor histidine kinase [KO:K07679] [EC:2.7.13.3]
X969_06375  histidine kinase [KO:K07679] [EC:2.7.13.3]
X969_06380  LuxR family transcriptional regulator [KO:K07690]
X969_13810  LuxR family transcriptional regulator [KO:K07690]
X969_20490  LuxR family transcriptional regulator [KO:K07690]
X969_11785  ampC; beta-lactamase [KO:K01467] [EC:3.5.2.6]
X969_01300  LuxR family transcriptional regulator [KO:K27077]
X969_07685  hypothetical protein [KO:K27078]
X969_07670  spore coat protein [KO:K27078]
X969_07665  spore coat protein [KO:K27078]
X969_07660  spore coat protein [KO:K27078]
X969_07655  spore coat protein [KO:K27078]
X969_07675  type 1 pili usher pathway chaperone CsuC [KO:K07346]
X969_07680  fimbrial biogenesis outer membrane usher protein [KO:K07347]
X969_05565  ferrous iron transporter B [KO:K07347]
X969_04095  glnD; PII uridylyl-transferase [KO:K00990] [EC:2.7.7.59]
X969_24165  sensor histidine kinase [KO:K07708] [EC:2.7.13.3]
X969_24170  glnG; nitrogen regulation protein NR(I) [KO:K07712]
X969_09295  glutamine synthetase [KO:K01915] [EC:6.3.1.2]
X969_15165  glutamine synthetase [KO:K01915] [EC:6.3.1.2]
X969_24155  glnA; glutamine synthetase [KO:K01915] [EC:6.3.1.2]
X969_24870  glutamine synthetase [KO:K01915] [EC:6.3.1.2]
X969_24880  glutamine synthetase [KO:K01915] [EC:6.3.1.2]
X969_25440  glutamine synthetase [KO:K01915] [EC:6.3.1.2]
X969_13250  glutamine synthetase [KO:K01915] [EC:6.3.1.2]
X969_18995  glutamine synthetase [KO:K01915] [EC:6.3.1.2]
X969_01680  histidine kinase [KO:K07709] [EC:2.7.13.3]
X969_22390  Fis family transcriptional regulator [KO:K07713]
X969_13845  Fis family transcriptional regulator [KO:K07714]
X969_13380  short chain fatty acid transporter [KO:K02106]
X969_01340  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
X969_22000  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
X969_06970  acetyl-CoA acetyltransferase [KO:K00626] [EC:2.3.1.9]
X969_15520  3-ketoacyl-CoA thiolase [KO:K00626] [EC:2.3.1.9]
X969_20915  cytochrome C biogenesis protein CcmE [KO:K10125] [EC:2.7.13.3]
X969_27505  ATPase [KO:K10125] [EC:2.7.13.3]
X969_20920  Fis family transcriptional regulator [KO:K10126]
X969_27500  Fis family transcriptional regulator [KO:K10126]
X969_08855  C4-dicarboxylate ABC transporter [KO:K11103]
X969_07190  C4-dicarboxylate ABC transporter [KO:K11103]
X969_19705  C4-dicarboxylate ABC transporter [KO:K11103]
X969_09780  C4-dicarboxylate ABC transporter [KO:K11103]
X969_03140  RNA polymerase factor sigma-54 [KO:K03092]
X969_01610  fimbrial protein [KO:K02650]
X969_26710  histidine kinase [KO:K11383] [EC:2.7.13.3]
X969_26715  chemotaxis protein CheY [KO:K11384]
X969_15550  chemotaxis protein CheR [KO:K00575] [EC:2.1.1.80]
X969_18235  chemotaxis protein CheR [KO:K00575] [EC:2.1.1.80]
X969_10255  chemotaxis protein [KO:K13924] [EC:2.1.1.80 3.1.1.61]
X969_12860  chemotaxis protein [KO:K13924] [EC:2.1.1.80 3.1.1.61]
X969_13820  pili assembly chaperone [KO:K03406]
X969_19495  methyl-accepting chemotaxis protein [KO:K03406]
X969_24020  methyl-accepting chemotaxis protein [KO:K03406]
X969_19900  methyl-accepting chemotaxis protein [KO:K03406]
X969_05245  chemotaxis protein [KO:K03406]
X969_01350  chemotaxis protein [KO:K03406]
X969_21090  chemotaxis protein [KO:K03406]
X969_06475  methyl-accepting chemotaxis protein [KO:K03406]
X969_02400  chemotaxis protein [KO:K03406]
X969_07160  chemotaxis protein [KO:K03406]
X969_11705  methyl-accepting chemotaxis protein [KO:K03406]
X969_22115  methyl-accepting chemotaxis protein [KO:K03406]
X969_27785  methyl-accepting chemotaxis protein [KO:K03406]
X969_27800  chemotaxis protein [KO:K03406]
X969_14640  methyl-accepting chemotaxis protein [KO:K03406]
X969_06430  chemotaxis protein [KO:K03776]
X969_07200  chemotaxis protein [KO:K03776]
X969_18870  chemotaxis protein [KO:K03776]
X969_17970  chemotaxis protein CheW [KO:K03408]
X969_17975  chemotaxis protein CheW [KO:K03408]
X969_18000  chemotaxis protein CheA [KO:K03407] [EC:2.7.13.3]
X969_18010  chemotaxis protein CheY [KO:K03413]
X969_17995  chemotaxis protein CheY [KO:K03412] [EC:3.1.1.61 3.5.1.44]
X969_15545  chemotaxis protein CheB [KO:K03412] [EC:3.1.1.61 3.5.1.44]
X969_06535  chemotaxis protein CheW [KO:K03415]
X969_02555  chemotaxis protein CheW [KO:K03415]
X969_18240  chemotaxis protein CheW [KO:K03415]
X969_23870  chemotaxis protein [KO:K02660]
X969_23875  type IV pili signal transduction protein PilI [KO:K02659]
X969_23865  chemotaxis protein CheA [KO:K06596]
X969_23885  chemotaxis protein CheY [KO:K02657]
X969_23880  chemotaxis protein CheY [KO:K02658]
X969_23860  chemotaxis protein [KO:K06598]
X969_03870  chemotaxis protein CheR [KO:K13486]
X969_03860  chemotaxis protein [KO:K13487]
X969_03865  chemotaxis protein CheW [KO:K13488]
X969_03875  chemotaxis protein CheW [KO:K13489]
X969_03880  chemotaxis protein CheA [KO:K13490]
X969_03885  chemotaxis protein CheY [KO:K13491] [EC:3.1.1.61]
X969_03890  diguanylate cyclase [KO:K11444] [EC:2.7.7.65]
X969_07650  ATPase [KO:K11354] [EC:2.7.13.3]
X969_14610  LuxR family transcriptional regulator [KO:K14987]
X969_18140  ATPase AAA [KO:K10941]
X969_18130  sensor histidine kinase [KO:K10942] [EC:2.7.13.3]
X969_18125  Fis family transcriptional regulator [KO:K10943]
X969_20610  sensor histidine kinase [KO:K17060] [EC:2.7.13.3]
X969_20615  Fis family transcriptional regulator [KO:K17061]
X969_20605  artP; arginine ABC transporter ATP-binding protein [KO:K10004] [EC:7.4.2.1]
X969_20600  glutamate/aspartate transporter permease GltK [KO:K10002]
X969_20595  amino acid ABC transporter permease [KO:K10003]
X969_20590  ABC transporter [KO:K10001]
X969_08385  glutaminase [KO:K05597] [EC:3.5.1.38]
X969_00495  transcriptional regulator [KO:K10914]
X969_08520  glutaminase [KO:K01425] [EC:3.5.1.2]
X969_03005  sensor histidine kinase [KO:K15011] [EC:2.7.13.3]
X969_03010  chemotaxis protein CheY [KO:K15012]
X969_21550  iron-sulfur protein [KO:K00411] [EC:7.1.1.8]
X969_21545  cytochrome B [KO:K00412]
X969_21540  cytochrome C [KO:K00413]
X969_17455  cytochrome oxidase subunit I [KO:K00404] [EC:7.1.1.9]
X969_17475  cytochrome oxidase subunit I [KO:K00404] [EC:7.1.1.9]
X969_17460  peptidase S41 [KO:K00405]
X969_17480  peptidase S41 [KO:K00405]
X969_17465  cytochrome C oxidase [KO:K00407]
X969_17485  cytochrome oxidase [KO:K00407]
X969_17470  cytochrome CBB3 [KO:K00406]
X969_17490  cytochrome CBB3 [KO:K00406]
X969_22075  cytochrome D ubiquinol oxidase subunit I [KO:K00425] [EC:7.1.1.7]
X969_10430  cytochrome D ubiquinol oxidase subunit I [KO:K00425] [EC:7.1.1.7]
X969_22070  ubiquinol oxidase subunit II, cyanide insensitive [KO:K00426] [EC:7.1.1.7]
X969_10435  cytochrome D oxidase subunit II [KO:K00426] [EC:7.1.1.7]
X969_23540  channel protein TolC [KO:K12340]
X969_05130  channel protein TolC [KO:K12340]
X969_13365  sugar ABC transporter substrate-binding protein [KO:K01991]
X969_05645  phosphotyrosine protein phosphatase [KO:K25307] [EC:3.1.3.48]
X969_05185  UDP-N-acetylglucosamine 2-epimerase [KO:K01791] [EC:5.1.3.14]
X969_00065  RNA polymerase sigma factor [KO:K23514]
X969_14755  RNA polymerase sigma factor [KO:K23514]
X969_26895  RNA polymerase sigma factor [KO:K23514]
X969_00060  amino acid ABC transporter substrate-binding protein [KO:K07165]
X969_14630  peptide ABC transporter substrate-binding protein [KO:K07165]
X969_14750  sugar ABC transporter substrate-binding protein [KO:K07165]
X969_01915  peptide ABC transporter substrate-binding protein [KO:K07165]
X969_21835  sugar ABC transporter substrate-binding protein [KO:K07165]
X969_02905  peptide ABC transporter substrate-binding protein [KO:K07165]
X969_03400  glycerol-3-phosphate ABC transporter substrate-binding protein [KO:K07165]
X969_09820  iron dicitrate transporter FecR [KO:K07165]
X969_26890  peptide ABC transporter substrate-binding protein [KO:K07165]
X969_05515  histidine kinase [KO:K20973] [EC:2.7.13.3]
X969_17085  sensor histidine kinase [KO:K20974] [EC:2.7.13.3]
X969_09380  sensor histidine kinase [KO:K20975] [EC:2.7.13.3]
X969_18080  sensor histidine kinase [KO:K20976]
X969_18085  chemotaxis protein CheY [KO:K20977]
X969_18090  anti-anti-sigma regulatory factor [KO:K20978]
X969_18250  anti-sigma-28 factor FlgM [KO:K02398]
Compound
C00007  Oxygen
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00034  Manganese
C00036  Oxaloacetate
C00038  Zinc cation
C00042  Succinate
C00049  L-Aspartate
C00064  L-Glutamine
C00070  Copper
C00088  Nitrite
C00092  D-Glucose 6-phosphate
C00122  Fumarate
C00149  (S)-Malate
C00158  Citrate
C00164  Acetoacetate
C00237  CO
C00238  Potassium cation
C00244  Nitrate
C00282  Hydrogen
C00291  Nickel
C00305  Magnesium cation
C00399  Ubiquinone
C00533  Nitric oxide
C00547  L-Noradrenaline
C00697  Nitrogen
C00788  L-Adrenaline
C00828  Menaquinone
C01019  L-Fucose
C01104  Trimethylamine N-oxide
C01667  Bacitracin
C02084  Tetrathionate
C05757  (3R)-3-Hydroxydodecanoyl-[acyl-carrier protein]
C05818  2-Demethylmenaquinone
C06230  Fe-enterobactin
C06689  Vancomycin
C06696  Lead
C11612  Polymyxin B
C11842  N-(3-(S)-Hydroxybutyryl)homoserine lactone
C11849  3-Hydroxy-palmitic acid methyl ester
C12008  Ramoplanin A2
C13768  Colistin sulfate
C14819  Fe3+
C16421  AI-2
C16463  3',5'-Cyclic diGMP
C16640  CAI-1
C16665  12-Methyltetradecanoic acid
C18206  cis-11-Methyl-2-dodecenoic acid
C21220  AIP-1
C21221  CSP
C21241  AIP-2
C21242  AIP-3
C21243  AIP-4
C21245  AgrD1 peptide
D07746  Colistin (INN)
D08401  Polymyxin B (INN)
Reference
PMID:15522865
  Authors
Yamamoto K, Hirao K, Oshima T, Aiba H, Utsumi R, Ishihama A.
  Title
Functional characterization in vitro of all two-component signal transduction systems from Escherichia coli.
  Journal
J Biol Chem 280:1448-56 (2005)
DOI:10.1074/jbc.M410104200
Reference
PMID:16030210
  Authors
Abdel-Fattah WR, Chen Y, Eldakak A, Hulett FM.
  Title
Bacillus subtilis phosphorylated PhoP: direct activation of the E(sigma)A- and repression of the E(sigma)E-responsive phoB-PS+V promoters during pho response.
  Journal
J Bacteriol 187:5166-78 (2005)
DOI:10.1128/JB.187.15.5166-5178.2005
Reference
PMID:15813739
  Authors
Navarre WW, Halsey TA, Walthers D, Frye J, McClelland M, Potter JL, Kenney LJ, Gunn JS, Fang FC, Libby SJ.
  Title
Co-regulation of Salmonella enterica genes required for virulence and resistance to antimicrobial peptides by SlyA and PhoP/PhoQ.
  Journal
Mol Microbiol 56:492-508 (2005)
DOI:10.1111/j.1365-2958.2005.04553.x
Reference
PMID:11973328
  Authors
Cai SJ, Inouye M.
  Title
EnvZ-OmpR interaction and osmoregulation in Escherichia coli.
  Journal
J Biol Chem 277:24155-61 (2002)
DOI:10.1074/jbc.M110715200
Reference
PMID:16077119
  Authors
Batchelor E, Walthers D, Kenney LJ, Goulian M.
  Title
The Escherichia coli CpxA-CpxR envelope stress response system regulates expression of the porins ompF and ompC.
  Journal
J Bacteriol 187:5723-31 (2005)
DOI:10.1128/JB.187.16.5723-5731.2005
Reference
PMID:12107133
  Authors
Nagakubo S, Nishino K, Hirata T, Yamaguchi A.
  Title
The putative response regulator BaeR stimulates multidrug resistance of Escherichia coli via a novel multidrug exporter system, MdtABC.
  Journal
J Bacteriol 184:4161-7 (2002)
DOI:10.1128/JB.184.15.4161-4167.2002
Reference
PMID:15322361
  Authors
Hagiwara D, Yamashino T, Mizuno T.
  Title
A Genome-wide view of the Escherichia coli BasS-BasR two-component system implicated in iron-responses.
  Journal
Biosci Biotechnol Biochem 68:1758-67 (2004)
DOI:10.1271/bbb.68.1758
Reference
PMID:11004187
  Authors
Munson GP, Lam DL, Outten FW, O'Halloran TV.
  Title
Identification of a copper-responsive two-component system on the chromosome of Escherichia coli K-12.
  Journal
J Bacteriol 182:5864-71 (2000)
DOI:10.1128/JB.182.20.5864-5871.2000
Reference
PMID:11929534
  Authors
Sperandio V, Torres AG, Kaper JB.
  Title
Quorum sensing Escherichia coli regulators B and C (QseBC): a novel two-component regulatory system involved in the regulation of flagella and motility by quorum sensing in E. coli.
  Journal
Mol Microbiol 43:809-21 (2002)
DOI:10.1046/j.1365-2958.2002.02803.x
Reference
PMID:14604015
  Authors
Epstein W.
  Title
The roles and regulation of potassium in bacteria.
  Journal
Prog Nucleic Acid Res Mol Biol 75:293-320 (2003)
DOI:10.1016/S0079-6603(03)75008-9
Reference
PMID:10648521
  Authors
Ansaldi M, Simon G, Lepelletier M, Mejean V.
  Title
The TorR high-affinity binding site plays a key role in both torR autoregulation and torCAD operon expression in Escherichia coli.
  Journal
J Bacteriol 182:961-6 (2000)
DOI:10.1128/JB.182.4.961-966.2000
Reference
PMID:15326287
  Authors
Malpica R, Franco B, Rodriguez C, Kwon O, Georgellis D.
  Title
Identification of a quinone-sensitive redox switch in the ArcB sensor kinase.
  Journal
Proc Natl Acad Sci U S A 101:13318-23 (2004)
DOI:10.1073/pnas.0403064101
Reference
PMID:2666399
  Authors
Widenhorn KA, Somers JM, Kay WW.
  Title
Genetic regulation of the tricarboxylate transport operon (tctI) of Salmonella typhimurium.
  Journal
J Bacteriol 171:4436-41 (1989)
DOI:10.1128/JB.171.8.4436-4441.1989
Reference
PMID:11555295
  Authors
Hyyrylainen HL, Bolhuis A, Darmon E, Muukkonen L, Koski P, Vitikainen M, Sarvas M, Pragai Z, Bron S, van Dijl JM, Kontinen VP.
  Title
A novel two-component regulatory system in Bacillus subtilis for the survival of severe secretion stress.
  Journal
Mol Microbiol 41:1159-72 (2001)
DOI:10.1046/j.1365-2958.2001.02576.x
Reference
PMID:10972837
  Authors
Zhang X, Hulett FM.
  Title
ResD signal transduction regulator of aerobic respiration in Bacillus subtilis: ctaA promoter regulation.
  Journal
Mol Microbiol 37:1208-19 (2000)
DOI:10.1046/j.1365-2958.2000.02076.x
Reference
PMID:15937169
  Authors
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  Title
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Related
pathway
pmon00190  Oxidative phosphorylation
pmon00550  Peptidoglycan biosynthesis
pmon00910  Nitrogen metabolism
pmon02030  Bacterial chemotaxis
pmon02040  Flagellar assembly
pmon03070  Bacterial secretion system
KO pathway
ko02020   
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