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Entry
Name
ABC transporters - Proteus mirabilis HI4320
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
BRITE hierarchy
Pathway map
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Organism
Proteus mirabilis HI4320 [GN:
pmr ]
Gene
PMI1835 cysP; sulfate/thiosulfate ABC transporter, thiosulfate-binding protein [KO:K02048 ]
PMI3204 sbp; sulfate-binding protein (sulfate starvation-induced protein) [KO:K23163 ]
PMI1834 cysT; sulfate/thiosulfate ABC transporter, permease protein [KO:K02046 ]
PMI1833 cysW; sulfate/thiosulfate ABC transporter, permease protein [KO:K02047 ]
PMI0597 modA; molybdate ABC transporter, substrate-binding protein [KO:K02020 ]
PMI0598 modB; molybdenum ABC transporter, permease protein [KO:K02018 ]
PMI0591 modF; putative molybdenum transport ATP-binding protein (photorepair protein) [KO:K05776 ]
PMI0190 afuA; putative ferric ABC transporter, iron-binding protein [KO:K02012 ]
PMI0189 afuB; putative ferric ABC transporter, permease protein [KO:K02011 ]
PMI2322 thiB; thiamine ABC transporter, substrate-binding protein [KO:K02064 ]
PMI2323 thiP; thiamine ABC transporter, permease protein [KO:K02063 ]
PMI2734 potD; spermidine/putrescine ABC transporter, substrate-binding periplasmic protein [KO:K11069 ]
PMI2735 potC; spermidine/putrescine ABC transporter, permease protein [KO:K11070 ]
PMI2736 potB; spermidine/putrescine ABC transporter, permease protein [KO:K11071 ]
PMI0410 proX; putative glycine betaine/L-proline ABC transporter, substrate-binding protein [KO:K02002 ]
PMI0411 proW; glycine betaine/L-proline ABC transporter, permease protein [KO:K02001 ]
PMI0412 proV; glycine betaine/L-proline ABC transporter, ATP-binding protein [KO:K02000 ] [EC:7.6.2.9 ]
PMI0090 rbsB; D-ribose ABC transporter, substrate-binding periplasmic protein [KO:K10439 ]
PMI0091 rbsC; ribose ABC transporter, permease protein [KO:K10440 ]
PMI3617 ugpB; glycerol-3-phosphate ABC transporter, substrate-binding protein [KO:K05813 ]
PMI3616 ugpA; sn-glycerol-3-phosphate ABC transporter, permease protein [KO:K05814 ]
PMI3615 ugpE; sn-glycerol-3-phosphate ABC transporter, permease protein [KO:K05815 ]
PMI2893 pstS; phosphate ABC transporter, substrate-binding protein [KO:K02040 ]
PMI2894 pstC; phosphate ABC transporter, permease protein [KO:K02037 ]
PMI2895 pstA; phosphate ABC transporter, permease protein [KO:K02038 ]
PMI0681 artI; arginine ABC transporter, substrate-binding protein [KO:K09997 ]
PMI0679 artM; arginine ABC transporter, permease protein [KO:K09998 ]
PMI0680 artQ; arginine ABC transporter, permease protein [KO:K09999 ]
PMI0437 gltI; glutamate/aspartate ABC transporter, substrate-binding protein [KO:K10001 ]
PMI0435 gltK; glutamate/aspartate ABC transporter, permease protein [KO:K10002 ]
PMI0436 gltJ; glutamate/aspartate ABC transporter, permease protein [KO:K10003 ]
PMI2261 metQ; D-methionine ABC transporter, substrate-binding lipoprotein [KO:K02073 ]
PMI1247 metQ; probable D-methionine-binding lipoprotein [KO:K02073 ]
PMI2260 metI; D-methionine ABC transporter, permease protein [KO:K02072 ]
PMI2259 metN; D-methionine ABC transporter, ATP-binding protein [KO:K02071 ]
PMI1475 oppA; oligopeptide ABC transporter, oligopeptide-binding protein [KO:K15580 ]
PMI1367 mppA; periplasmic murein peptide-binding protein precursor [KO:K15580 ]
PMI1476 oppA2; oligopeptide ABC transporter, oligopeptide-binding protein [KO:K15580 ]
PMI1474 oppB; oligopeptide ABC transporter, permease protein [KO:K15581 ]
PMI1473 oppC; oligopeptide ABC transporter, permease protein [KO:K15582 ]
PMI1472 oppD; oligopeptide ABC transporter, ATP-binding protein [KO:K15583 ]
PMI1471 oppF; oligopeptide ABC transporter, ATP-binding protein [KO:K10823 ]
PMI2847 dppA; dipeptide ABC transporter, substrate-binding protein [KO:K12368 ]
PMI2846 dppB; dipeptide ABC transporter, permease protein [KO:K12369 ]
PMI2845 dppC; dipeptide ABC transporter, permease protein [KO:K12370 ]
PMI2844 dppD; dipeptide ABC transporter, ATP-binding protein [KO:K12371 ]
PMI2843 dppF; dipeptide ABC transporter, ATP-binding protein [KO:K12372 ]
PMI1379 sapB; peptide transport system permease protein [KO:K19227 ]
PMI1380 sapC; peptide transport system permease protein [KO:K19228 ]
PMI1381 sapD; peptide transport system ATP-binding protein [KO:K19229 ]
PMI1382 sapF; peptide transport system ATP-binding protein [KO:K19230 ]
PMI1041 btuC; vitamin B12 import system permease protein [KO:K06073 ]
PMI1152 znuA; high-affinity zinc uptake system substrate-binding protein [KO:K09815 ]
PMI1150 znuB; high-affinity zinc uptake system membrane protein [KO:K09816 ]
PMI1027 sitA; iron ABC transporter, periplasmic substrate-binding protein [KO:K11604 ]
PMI1026 sitB; iron ABC transporter, ATP-binding protein [KO:K11607 ]
PMI0878 lolC; lipoprotein releasing system, transmembrane protein [KO:K09808 ]
PMI0880 lolE; lipoprotein-releasing system transmembrane protein [KO:K09808 ]
PMI0879 lolD; lipoprotein releasing system, ATP-binding protein [KO:K09810 ] [EC:7.6.2.-]
PMI2603 nrpA; putative siderophore ABC transporter, ATP-binding/permease protein [KO:K14698 ] [EC:7.-.-.-]
PMI2604 nrpB; putative siderophore ABC transporter, ATP-binding/permease protein [KO:K14699 ] [EC:7.-.-.-]
PMI0124 mdlA; putative efflux ABC transporter, ATP-binding membrane protein [KO:K18889 ]
PMI0125 mdlB; putative efflux ABC transporter, ATP-binding membrane protein [KO:K18890 ]
PMI0693 cydC; ABC transporter, ATP-binding and permease protein [KO:K16012 ]
PMI0694 cydD; ABC transporter, ATP-binding and permease protein [KO:K16013 ]
PMI0687 macB; macrolide-specific ABC-type efflux carrier [KO:K05685 ] [EC:7.6.2.-]
Compound
C00093 sn-Glycerol 3-phosphate
C01153 Orthophosphoric monoester
C01181 4-Trimethylammoniobutanoate
C01279 4-Amino-5-hydroxymethyl-2-methylpyrimidine
C03557 2-Aminoethylphosphonate
C03611 Galactose oligosaccharide
C03619 Methyl beta-D-galactoside
C04114 (E)-4-(Trimethylammonio)but-2-enoate
C06705 Capsular polysaccharide
C19872 N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570 alpha-1,5-L-Arabinobiose
C20571 alpha-1,5-L-Arabinotriose
C20572 alpha-1,5-L-Arabinotetraose
Reference
Authors
Tomii K, Kanehisa M.
Title
A comparative analysis of ABC transporters in complete microbial genomes.
Journal
Reference
Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal
Reference
Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal
Reference
Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
Journal
Reference
Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
Journal
Reference
Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
Journal
Reference
Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
Journal
Reference
Authors
Richard-Fogal CL, Frawley ER, Kranz RG
Title
Topology and function of CcmD in cytochrome c maturation.
Journal
Reference
Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
Journal
Reference
Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
Journal
Reference
Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
Journal
Reference
Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
Journal
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