KEGG   PATHWAY: pmr02010
Entry
pmr02010                    Pathway                                
Name
ABC transporters - Proteus mirabilis HI4320
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
Pathway map
pmr02010  ABC transporters
pmr02010

Other DBs
GO: 0043190 0043191 0043192
TC: 3.A.1
Organism
Proteus mirabilis HI4320 [GN:pmr]
Gene
PMI1835  cysP; sulfate/thiosulfate ABC transporter, thiosulfate-binding protein [KO:K02048]
PMI3204  sbp; sulfate-binding protein (sulfate starvation-induced protein) [KO:K23163]
PMI1834  cysT; sulfate/thiosulfate ABC transporter, permease protein [KO:K02046]
PMI1833  cysW; sulfate/thiosulfate ABC transporter, permease protein [KO:K02047]
PMI1832  cysA; sulfate/thiosulfate ABC transporter, ATP-binding protein [KO:K02045] [EC:7.3.2.3]
PMI0597  modA; molybdate ABC transporter, substrate-binding protein [KO:K02020]
PMI1539  ABC transporter, substrate-binding protein [KO:K02020]
PMI0598  modB; molybdenum ABC transporter, permease protein [KO:K02018]
PMI1538  ABC transporter, permease protein [KO:K02018]
PMI0599  modC; molybdenum ABC transporter, ATP-binding protein [KO:K02017] [EC:7.3.2.5]
PMI1537  ABC transporter ATP-binding protein [KO:K02017] [EC:7.3.2.5]
PMI0591  modF; putative molybdenum transport ATP-binding protein (photorepair protein) [KO:K05776]
PMI3071  ABC transporter, substrate-binding protein [KO:K02012]
PMI0190  afuA; putative ferric ABC transporter, iron-binding protein [KO:K02012]
PMI3070  ABC transporter permease protein [KO:K02011]
PMI0189  afuB; putative ferric ABC transporter, permease protein [KO:K02011]
PMI0188  afuC; ferric cation import ABC transporter, ATP-binding protein [KO:K02010] [EC:7.2.2.7]
PMI2322  thiB; thiamine ABC transporter, substrate-binding protein [KO:K02064]
PMI2323  thiP; thiamine ABC transporter, permease protein [KO:K02063]
PMI2324  thiQ; thiamine ABC transporter, ATP-binding protein [KO:K02062] [EC:7.6.2.15]
PMI2734  potD; spermidine/putrescine ABC transporter, substrate-binding periplasmic protein [KO:K11069]
PMI2735  potC; spermidine/putrescine ABC transporter, permease protein [KO:K11070]
PMI2736  potB; spermidine/putrescine ABC transporter, permease protein [KO:K11071]
PMI2737  potA; spermidine/putrescine ABC transporter, ATP-binding protein [KO:K11072] [EC:7.6.2.11]
PMI0410  proX; putative glycine betaine/L-proline ABC transporter, substrate-binding protein [KO:K02002]
PMI0411  proW; glycine betaine/L-proline ABC transporter, permease protein [KO:K02001]
PMI0412  proV; glycine betaine/L-proline ABC transporter, ATP-binding protein [KO:K02000] [EC:7.6.2.9]
PMI3658  putative toluene tolerance protein [KO:K07323]
PMI3657  putative exported protein [KO:K02067]
PMI3656  putative membrane protein [KO:K02066]
PMI3659  putative anti-sigma factor antagonist [KO:K07122]
PMI3655  ABC transporter ATP-binding protein [KO:K02065]
PMI0090  rbsB; D-ribose ABC transporter, substrate-binding periplasmic protein [KO:K10439]
PMI0091  rbsC; ribose ABC transporter, permease protein [KO:K10440]
PMI0092  rbsA; ribose ABC transporter, ATP-binding protein [KO:K10441] [EC:7.5.2.7]
PMI0093  rbsD; high affinity ribose transport protein [KO:K06726] [EC:5.4.99.62]
PMI3617  ugpB; glycerol-3-phosphate ABC transporter, substrate-binding protein [KO:K05813]
PMI3616  ugpA; sn-glycerol-3-phosphate ABC transporter, permease protein [KO:K05814]
PMI3615  ugpE; sn-glycerol-3-phosphate ABC transporter, permease protein [KO:K05815]
PMI3614  ugpC; sn-glycerol-3-phosphate ABC transporter, ATP-binding protein [KO:K05816] [EC:7.6.2.10]
PMI2893  pstS; phosphate ABC transporter, substrate-binding protein [KO:K02040]
PMI2894  pstC; phosphate ABC transporter, permease protein [KO:K02037]
PMI2895  pstA; phosphate ABC transporter, permease protein [KO:K02038]
PMI2896  pstB; phosphate ABC transporter, ATP-binding protein [KO:K02036] [EC:7.3.2.1]
PMI0681  artI; arginine ABC transporter, substrate-binding protein [KO:K09997]
PMI0679  artM; arginine ABC transporter, permease protein [KO:K09998]
PMI0680  artQ; arginine ABC transporter, permease protein [KO:K09999]
PMI0682  artP; arginine ABC transporter, ATP-binding protein [KO:K10000] [EC:7.4.2.1]
PMI0437  gltI; glutamate/aspartate ABC transporter, substrate-binding protein [KO:K10001]
PMI0435  gltK; glutamate/aspartate ABC transporter, permease protein [KO:K10002]
PMI0436  gltJ; glutamate/aspartate ABC transporter, permease protein [KO:K10003]
PMI0434  gltL; glutamate/aspartate ABC transporter, ATP-binding protein [KO:K10004] [EC:7.4.2.1]
PMI1318  nlpA; lipoprotein-28 [KO:K02073]
PMI2261  metQ; D-methionine ABC transporter, substrate-binding lipoprotein [KO:K02073]
PMI3020  probable lipoprotein [KO:K02073]
PMI1247  metQ; probable D-methionine-binding lipoprotein [KO:K02073]
PMI2260  metI; D-methionine ABC transporter, permease protein [KO:K02072]
PMI2259  metN; D-methionine ABC transporter, ATP-binding protein [KO:K02071]
PMI1475  oppA; oligopeptide ABC transporter, oligopeptide-binding protein [KO:K15580]
PMI1367  mppA; periplasmic murein peptide-binding protein precursor [KO:K15580]
PMI1476  oppA2; oligopeptide ABC transporter, oligopeptide-binding protein [KO:K15580]
PMI1474  oppB; oligopeptide ABC transporter, permease protein [KO:K15581]
PMI1473  oppC; oligopeptide ABC transporter, permease protein [KO:K15582]
PMI1472  oppD; oligopeptide ABC transporter, ATP-binding protein [KO:K15583]
PMI1471  oppF; oligopeptide ABC transporter, ATP-binding protein [KO:K10823]
PMI2847  dppA; dipeptide ABC transporter, substrate-binding protein [KO:K12368]
PMI2846  dppB; dipeptide ABC transporter, permease protein [KO:K12369]
PMI2845  dppC; dipeptide ABC transporter, permease protein [KO:K12370]
PMI2844  dppD; dipeptide ABC transporter, ATP-binding protein [KO:K12371]
PMI2843  dppF; dipeptide ABC transporter, ATP-binding protein [KO:K12372]
PMI1378  sapA; peptide transport periplasmic protein [KO:K19226]
PMI1379  sapB; peptide transport system permease protein [KO:K19227]
PMI1380  sapC; peptide transport system permease protein [KO:K19228]
PMI1381  sapD; peptide transport system ATP-binding protein [KO:K19229]
PMI1382  sapF; peptide transport system ATP-binding protein [KO:K19230]
PMI2947  ABC transporter. substrate-binding protein [KO:K15584]
PMI2946  ABC-transporter, permease protein [KO:K15585]
PMI2945  ABC transporter, permease protein [KO:K15586]
PMI2944  ABC transporter, ATP-binding protein [KO:K15587] [EC:7.2.2.11]
PMI2943  ABC transporter, ATP-binding protein [KO:K10824] [EC:7.2.2.11]
PMI0213  putative periplasmic binding protein [KO:K06858]
PMI1041  btuC; vitamin B12 import system permease protein [KO:K06073]
PMI1042  btuD; putative vitamin B12 transport ATP-binding protein [KO:K06074] [EC:7.6.2.8]
PMI1152  znuA; high-affinity zinc uptake system substrate-binding protein [KO:K09815]
PMI1150  znuB; high-affinity zinc uptake system membrane protein [KO:K09816]
PMI1151  znuC; high-affinity zinc uptake system ATP-binding protein [KO:K09817] [EC:7.2.2.20]
PMI1027  sitA; iron ABC transporter, periplasmic substrate-binding protein [KO:K11604]
PMI1025  sitC; iron ABC transporter, membrane protein [KO:K11605]
PMI1024  sitD; iron ABC transporter, membrane protein [KO:K11606]
PMI1026  sitB; iron ABC transporter, ATP-binding protein [KO:K11607]
PMI0878  lolC; lipoprotein releasing system, transmembrane protein [KO:K09808]
PMI0880  lolE; lipoprotein-releasing system transmembrane protein [KO:K09808]
PMI0879  lolD; lipoprotein releasing system, ATP-binding protein [KO:K09810] [EC:7.6.2.-]
PMI3465  putative permease [KO:K07091]
PMI3466  putative permease [KO:K11720]
PMI3649  putative ABC transporter ATP-binding protein [KO:K06861] [EC:7.5.2.5]
PMI3607  ftsX; cell division protein [KO:K09811]
PMI3606  ftsE; cell division ATP-binding protein [KO:K09812]
PMI2603  nrpA; putative siderophore ABC transporter, ATP-binding/permease protein [KO:K14698] [EC:7.-.-.-]
PMI2604  nrpB; putative siderophore ABC transporter, ATP-binding/permease protein [KO:K14699] [EC:7.-.-.-]
PMI0718  msbA; lipid A export ATP-binding/permease protein [KO:K11085] [EC:7.5.2.6]
PMI0124  mdlA; putative efflux ABC transporter, ATP-binding membrane protein [KO:K18889]
PMI0125  mdlB; putative efflux ABC transporter, ATP-binding membrane protein [KO:K18890]
PMI0278  zapB; Type I secretion ATP-binding protein [KO:K12536]
PMI0693  cydC; ABC transporter, ATP-binding and permease protein [KO:K16012]
PMI0694  cydD; ABC transporter, ATP-binding and permease protein [KO:K16013]
PMI0687  macB; macrolide-specific ABC-type efflux carrier [KO:K05685] [EC:7.6.2.-]
PMI3705  putative ABC transporter ATP-binding protein [KO:K02471]
Compound
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00032  Heme
C00034  Manganese
C00037  Glycine
C00038  Zinc cation
C00041  L-Alanine
C00047  L-Lysine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00062  L-Arginine
C00064  L-Glutamine
C00065  L-Serine
C00070  Copper
C00077  L-Ornithine
C00079  L-Phenylalanine
C00086  Urea
C00088  Nitrite
C00089  Sucrose
C00093  sn-Glycerol 3-phosphate
C00095  D-Fructose
C00098  Oligopeptide
C00107  Dipeptide
C00114  Choline
C00116  Glycerol
C00120  Biotin
C00121  D-Ribose
C00123  L-Leucine
C00134  Putrescine
C00135  L-Histidine
C00137  myo-Inositol
C00140  N-Acetyl-D-glucosamine
C00148  L-Proline
C00151  L-Amino acid
C00159  D-Mannose
C00175  Cobalt ion
C00181  D-Xylose
C00183  L-Valine
C00185  Cellobiose
C00188  L-Threonine
C00208  Maltose
C00212  Adenosine
C00243  Lactose
C00244  Nitrate
C00245  Taurine
C00255  Riboflavin
C00259  L-Arabinose
C00288  HCO3-
C00291  Nickel
C00294  Inosine
C00299  Uridine
C00315  Spermidine
C00320  Thiosulfate
C00330  Deoxyguanosine
C00333  D-Galacturonate
C00338  Lipopolysaccharide
C00378  Thiamine
C00379  Xylitol
C00387  Guanosine
C00392  Mannitol
C00407  L-Isoleucine
C00430  5-Aminolevulinate
C00470  Pectate
C00475  Cytidine
C00487  Carnitine
C00491  L-Cystine
C00492  Raffinose
C00503  Erythritol
C00526  Deoxyuridine
C00559  Deoxyadenosine
C00719  Betaine
C00794  D-Sorbitol
C00855  D-Methionine
C00865  Phospholipid
C00881  Deoxycytidine
C00919  Choline sulfate
C00973  Cyclomaltodextrin
C01083  alpha,alpha-Trehalose
C01153  Orthophosphoric monoester
C01157  Hydroxyproline
C01177  Inositol 1-phosphate
C01181  4-Trimethylammoniobutanoate
C01279  4-Amino-5-hydroxymethyl-2-methylpyrimidine
C01330  Sodium cation
C01417  Cyanate
C01487  D-Allose
C01606  Phthalate
C01630  Xylobiose
C01667  Bacitracin
C01674  Chitobiose
C01682  Nopaline
C01684  D-Rhamnose
C01762  Xanthosine
C01834  Lipoprotein
C01835  Maltotriose
C01935  Maltodextrin
C01946  Oleandomycin
C02160  Isomaltotriose
C02273  Digalacturonate
C03557  2-Aminoethylphosphonate
C03611  Galactose oligosaccharide
C03619  Methyl beta-D-galactoside
C04114  (E)-4-(Trimethylammonio)but-2-enoate
C04137  Octopine
C05349  Ciprofloxacin
C05402  Melibiose
C05512  Deoxyinosine
C05776  Vitamin B12
C06227  Fe(III)hydroxamate
C06229  Fe(III)dicitrate
C06230  Fe-enterobactin
C06232  Molybdate
C06687  Norfloxacin
C06705  Capsular polysaccharide
C06706  Lipo-oligosaccharide
C06707  Teichoic acid
C06767  Hemine
C07662  Sparfloxacin
C07663  Moxifloxacin
C11612  Polymyxin B
C13768  Colistin sulfate
C14818  Fe2+
C14819  Fe3+
C15521  Alkanesulfonate
C15719  Coelichelin
C16421  AI-2
C16692  Mannopine
C19609  Nickel(2+)
C19872  N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570  alpha-1,5-L-Arabinobiose
C20571  alpha-1,5-L-Arabinotriose
C20572  alpha-1,5-L-Arabinotetraose
C20573  Aldotetraouronic acid
C20679  Tungstate
C21066  D-Galactofuranose
C22040  S-Methyl-L-cysteine
G00457  Maltotetraose
Reference
PMID:9799792
  Authors
Tomii K, Kanehisa M.
  Title
A comparative analysis of ABC transporters in complete microbial genomes.
  Journal
Genome Res 8:1048-59 (1998)
DOI:10.1101/gr.8.10.1048
Reference
  Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
  Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
J Bacteriol 190:4460-9 (2008)
DOI:10.1128/JB.00270-08
Reference
  Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
  Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
Proc Natl Acad Sci U S A 105:5537-42 (2008)
DOI:10.1073/pnas.0801196105
Reference
  Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
  Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
  Journal
Proc Natl Acad Sci U S A 96:13571-6 (1999)
DOI:10.1073/pnas.96.23.13571
Reference
  Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
  Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
  Journal
Genome Res 11:2034-40 (2001)
DOI:10.1101/gr.196301
Reference
  Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
  Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
  Journal
Mol Microbiol 57:1582-92 (2005)
DOI:10.1111/j.1365-2958.2005.04791.x
Reference
  Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
  Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
  Journal
Mol Microbiol 43:703-15 (2002)
DOI:10.1046/j.1365-2958.2002.02778.x
Reference
  Authors
Richard-Fogal CL, Frawley ER, Kranz RG
  Title
Topology and function of CcmD in cytochrome c maturation.
  Journal
J Bacteriol 190:3489-93 (2008)
DOI:10.1128/JB.00146-08
Reference
  Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
  Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
  Journal
J Bacteriol 187:5861-7 (2005)
DOI:10.1128/JB.187.17.5861-5867.2005
Reference
  Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
  Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
  Journal
J Bacteriol 189:8361-5 (2007)
DOI:10.1128/JB.01028-07
Reference
  Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
  Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
  Journal
Mol Microbiol 63:895-910 (2007)
DOI:10.1111/j.1365-2958.2006.05549.x
Reference
  Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
  Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
  Journal
J Bacteriol 190:7693-8 (2008)
DOI:10.1128/JB.00853-08
KO pathway
ko02010   
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