KEGG   PATHWAY: ppsa04138
Entry
ppsa04138                   Pathway                                
Name
Autophagy - yeast - Podospora pseudoanserina
Description
Autophagy is a non-selective and bulk intracellular degradation system of eukaryotic cells and is highly conserved from yeast to human. In this process, the double-membrane vesicle, known as autophagosome, is formed and sequesters organelles or portions of cytosol. The autophagosome is subsequently fused with the vacuole for breakdown by resident hydrolases, and the resulting metabolites are delivered for reuse. In yeast, nutrient withdrawal is the primary stimulus that induces autophagy. Autophagy plays a central role in normal development and cell homeostasis of yeast.
Class
Cellular Processes; Transport and catabolism
Pathway map
ppsa04138  Autophagy - yeast
ppsa04138

Other DBs
GO: 0006914
Organism
Podospora pseudoanserina [GN:ppsa]
Gene
QC764_123850  ras1; RAS1 protein [KO:K07827]
QC764_201010  ras2; RAS2 protein [KO:K07827]
QC764_118940  PKA4; cytochrome c oxidase subunit 1 [KO:K04345] [EC:2.7.11.11]
QC764_604540  hypothetical protein [KO:K21157] [EC:2.7.11.1]
QC764_0030780  SNF1_1; Protein kinase [KO:K12761] [EC:2.7.11.1]
QC764_710890  ATG1; Serine/threonine-protein kinase [KO:K08269] [EC:2.7.11.1]
QC764_001500  ATG13; autophagy protein 13 [KO:K08331]
QC764_704900  uncharacterized protein [KO:K08329]
QC764_505550  ATG9; autophagy protein atg9 [KO:K17907]
QC764_212950  ATG2; autophagy-related protein 2 [KO:K17906]
QC764_603970  ATG18; autophagy protein [KO:K17908]
QC764_604640  ATG27; type II membrane protein [KO:K21141]
QC764_114210  ATG11; oligomeric, coiled-coil, peripheral membrane protein [KO:K08330]
QC764_213930  ARP2_1; Actin-related protein 2 [KO:K17260]
QC764_307470  ARP3; Actin-related protein 3 [KO:K18584]
QC764_107210  arc1; ARP2/3 actin-organizing complex subunit Sop2 [KO:K05757]
QC764_117600  ARC35; Arp complex subunit [KO:K05758]
QC764_502810  ARC18; subunit of the Arp2/3 complex [KO:K05756]
QC764_120940  ARC19; Arp complex subunit [KO:K05755]
QC764_604010  ARC15; arp2/3 complex subunit [KO:K05754]
QC764_109070  SCH9; Serine/threonine-protein kinase [KO:K19800] [EC:2.7.11.1]
QC764_213340  tmk2; mitogen activated protein kinase 2 [KO:K04464] [EC:2.7.11.24]
QC764_508370  LCB1; serine palmitoyltransferase component [KO:K00654] [EC:2.3.1.50]
QC764_114810  KOG1; Target of rapamycin complex 1 subunit kog1 [KO:K07204]
QC764_409630  TOR1; phosphatidylinositol kinase-related protein kinase tor1 [KO:K07203] [EC:2.7.11.1]
QC764_212360  LST8; TOR complex subunit lst8 [KO:K08266]
QC764_606130  TAP42; Type 2A phosphatase-associated protein 42 [KO:K17606]
QC764_601940  PPH1; Serine/threonine-protein phosphatase PP2A catalytic subunit [KO:K04382] [EC:3.1.3.16]
QC764_708490  TIP41; Tap42 interacting protein [KO:K17607]
QC764_117910  RIM15; rim15, signal transduction response regulator [KO:K12767] [EC:2.7.11.36]
QC764_210500  GCN2; eukaryotic translation initiation factor 2-alpha kinase [KO:K16196] [EC:2.7.11.1]
QC764_605980  hypothetical protein [KO:K03237]
QC764_117320  PCL5; PHO85 cyclin-5 [KO:K21197]
QC764_305250  ATG8; ubiquitin-like protein atg8 [KO:K08341]
QC764_111020  atg6; Vacuolar protein sorting-associated protein atg6 [KO:K08334]
QC764_601830  VPS15; Serine/threonine-protein kinase [KO:K08333] [EC:2.7.11.1]
QC764_120030  VPS34; Phosphatidylinositol (PI) 3-kinase [KO:K00914] [EC:2.7.1.137]
QC764_609890  hypothetical protein [KO:K00915] [EC:2.7.1.140 2.7.1.151]
QC764_604660  KCS1; inositol polyphosphate kinase kcs1 [KO:K07756] [EC:2.7.4.21]
QC764_706700  YMR1; phosphatidylinositol-3-phosphatase ymr1 [KO:K18083] [EC:3.1.3.64 3.1.3.95]
QC764_407460  atg12; Ubiquitin-like protein [KO:K08336]
QC764_201770  ATG7; Autophagy protein 7 [KO:K08337]
QC764_200160  ATG5; autophagy protein 5 [KO:K08339]
QC764_120610  ATG3; E2-like enzyme [KO:K08343]
QC764_505430  ATG4; Cysteine protease atg4 [KO:K08342] [EC:3.4.22.-]
QC764_702920  uncharacterized protein [KO:K08502]
QC764_111030  vti1; t-SNARE VTI1 [KO:K08493]
QC764_605220  SEC18; transport between ER and Golgi ATPase protein [KO:K06027] [EC:3.6.4.6]
QC764_306520  SEC17; vesicular-fusion protein S17 [KO:K15296]
QC764_203480  GTP14; Ypt/Rab-type GTPase Rab7 [KO:K07897]
QC764_110180  MON1; Vacuolar fusion protein mon1 [KO:K20195]
QC764_309790  VPS11; Vacuolar protein sorting-associated protein 11 [KO:K20179]
QC764_706430  vps16; Vacuolar protein sorting-associated protein 16 [KO:K20180]
QC764_708330  PEP3; tethering complex subunit [KO:K20181]
QC764_109390  VPS33; Vacuolar protein-sorting-associated protein 33 [KO:K20182]
QC764_212160  hypothetical protein [KO:K20177]
QC764_106550  VPS8; Vacuolar protein sorting-associated protein 8 [KO:K20178]
QC764_0052450  VAM6; Vacuolar morphogenesis protein 6 [KO:K20183]
QC764_502070  VPS41; Vacuolar protein sorting-associated protein 41 [KO:K20184]
QC764_702360  VPS45; vacuolar protein sorting-associated protein 45 [KO:K12479]
QC764_509000  APR1; aspartic proteinase precursor [KO:K01381] [EC:3.4.23.25]
QC764_112990  PRB1; proteinase B [KO:K01336] [EC:3.4.21.48 3.4.21.-]
QC764_710230  ATG15; putative lipase atg15 [KO:K17900] [EC:3.1.1.3]
QC764_108750  ATG22; Autophagy protein 22 [KO:K06902]
QC764_205820  hypothetical protein [KO:K14209]
QC764_400120  hypothetical protein [KO:K14209]
Compound
C00350  Phosphatidylethanolamine
C01194  1-Phosphatidyl-D-myo-inositol
C04549  1-Phosphatidyl-1D-myo-inositol 3-phosphate
Reference
PMID:11099404
  Authors
Klionsky DJ, Emr SD.
  Title
Autophagy as a regulated pathway of cellular degradation.
  Journal
Science 290:1717-21 (2000)
DOI:10.1126/science.290.5497.1717
Reference
PMID:15752997
  Authors
Thompson AR, Vierstra RD.
  Title
Autophagic recycling: lessons from yeast help define the process in plants.
  Journal
Curr Opin Plant Biol 8:165-73 (2005)
DOI:10.1016/j.pbi.2005.01.013
Reference
PMID:15928708
  Authors
Lum JJ, DeBerardinis RJ, Thompson CB.
  Title
Autophagy in metazoans: cell survival in the land of plenty.
  Journal
Nat Rev Mol Cell Biol 6:439-48 (2005)
DOI:10.1038/nrm1660
Reference
PMID:15978794
  Authors
Reggiori F, Klionsky DJ.
  Title
Autophagosomes: biogenesis from scratch?
  Journal
Curr Opin Cell Biol 17:415-22 (2005)
DOI:10.1016/j.ceb.2005.06.007
Reference
PMID:16200202
  Authors
Levine B, Yuan J.
  Title
Autophagy in cell death: an innocent convict?
  Journal
J Clin Invest 115:2679-88 (2005)
DOI:10.1172/JCI26390
Reference
PMID:19491929
  Authors
Nakatogawa H, Suzuki K, Kamada Y, Ohsumi Y
  Title
Dynamics and diversity in autophagy mechanisms: lessons from yeast.
  Journal
Nat Rev Mol Cell Biol 10:458-67 (2009)
DOI:10.1038/nrm2708
Reference
PMID:19653858
  Authors
He C, Klionsky DJ
  Title
Regulation mechanisms and signaling pathways of autophagy.
  Journal
Annu Rev Genet 43:67-93 (2009)
DOI:10.1146/annurev-genet-102808-114910
Reference
PMID:19802558
  Authors
Yang Z, Klionsky DJ
  Title
An overview of the molecular mechanism of autophagy.
  Journal
Curr Top Microbiol Immunol 335:1-32 (2009)
DOI:10.1007/978-3-642-00302-8_1
Reference
PMID:21187343
  Authors
Chen Y, Klionsky DJ
  Title
The regulation of autophagy - unanswered questions.
  Journal
J Cell Sci 124:161-70 (2011)
DOI:10.1242/jcs.064576
Reference
PMID:21801009
  Authors
Mizushima N, Yoshimori T, Ohsumi Y
  Title
The role of Atg proteins in autophagosome formation.
  Journal
Annu Rev Cell Dev Biol 27:107-32 (2011)
DOI:10.1146/annurev-cellbio-092910-154005
Reference
PMID:23733851
  Authors
Reggiori F, Klionsky DJ
  Title
Autophagic processes in yeast: mechanism, machinery and regulation.
  Journal
Genetics 194:341-61 (2013)
DOI:10.1534/genetics.112.149013
Reference
PMID:24928445
  Authors
Jin M, Klionsky DJ
  Title
Regulation of autophagy: modulation of the size and number of autophagosomes.
  Journal
FEBS Lett 588:2457-63 (2014)
DOI:10.1016/j.febslet.2014.06.015
Reference
PMID:25948417
  Authors
Noda NN, Fujioka Y
  Title
Atg1 family kinases in autophagy initiation.
  Journal
Cell Mol Life Sci 72:3083-96 (2015)
DOI:10.1007/s00018-015-1917-z
KO pathway
ko04138   
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