KEGG   PATHWAY: ppun00290
Entry
ppun00290                   Pathway                                
Name
Valine, leucine and isoleucine biosynthesis - Pseudomonas putida NBRC 14164
Class
Metabolism; Amino acid metabolism
Pathway map
ppun00290  Valine, leucine and isoleucine biosynthesis
ppun00290

Module
ppun_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:ppun00290]
ppun_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:ppun00290]
ppun_M00570  Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine [PATH:ppun00290]
Other DBs
GO: 0009097 0009098 0009099
Organism
Pseudomonas putida NBRC 14164 [GN:ppun]
Gene
PP4_25680  putative threonine dehydratase [KO:K01754] [EC:4.3.1.19]
PP4_24110  ilvA; threonine dehydratase [KO:K01754] [EC:4.3.1.19]
PP4_52140  ilvA; threonine dehydratase [KO:K01754] [EC:4.3.1.19]
PP4_28790  putative threonine dehydratase [KO:K17989] [EC:4.3.1.17 4.3.1.19]
PP4_38470  leuC; 3-isopropylmalate dehydratase large subunit [KO:K01703] [EC:4.2.1.33 4.2.1.35]
PP4_38460  leuD; 3-isopropylmalate dehydratase small subunit [KO:K01704] [EC:4.2.1.33 4.2.1.35]
PP4_38440  leuB; 3-isopropylmalate dehydrogenase [KO:K00052] [EC:1.1.1.85]
PP4_13930  acetolactate synthase large subunit [KO:K01652] [EC:2.2.1.6]
PP4_27490  putative acetolactate synthase large subunit [KO:K01652] [EC:2.2.1.6]
PP4_20670  putative acetolactate synthase large subunit [KO:K01652] [EC:2.2.1.6]
PP4_46580  ilvB; acetolactate synthase large subunit [KO:K01652] [EC:2.2.1.6]
PP4_09430  putative acetolactate synthase large subunit [KO:K01652] [EC:2.2.1.6]
PP4_10990  putative acetolactate synthase large subunit [KO:K01652] [EC:2.2.1.6]
PP4_46570  ilvH; acetolactate synthase small subunit [KO:K01653] [EC:2.2.1.6]
PP4_46560  ilvC; ketol-acid reductoisomerase [KO:K00053] [EC:1.1.1.86]
PP4_51920  ilvD; dihydroxy-acid dehydratase [KO:K01687] [EC:4.2.1.9]
PP4_23280  ilvE; branched-chain amino acid aminotransferase [KO:K00826] [EC:2.6.1.42]
PP4_07440  ldh; leucine dehydrogenase [KO:K00263] [EC:1.4.1.9]
PP4_39120  alaA; alanine aminotransferase AlaA [KO:K14260] [EC:2.6.1.66 2.6.1.2]
PP4_42910  leuA; 2-isopropylmalate synthase [KO:K01649] [EC:2.3.3.13]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00109  2-Oxobutanoate
C00123  L-Leucine
C00141  3-Methyl-2-oxobutanoic acid
C00183  L-Valine
C00188  L-Threonine
C00233  4-Methyl-2-oxopentanoate
C00407  L-Isoleucine
C00671  (S)-3-Methyl-2-oxopentanoic acid
C02226  2-Methylmaleate
C02504  alpha-Isopropylmalate
C02612  (R)-2-Methylmalate
C02631  2-Isopropylmaleate
C04181  3-Hydroxy-3-methyl-2-oxobutanoic acid
C04236  (2S)-2-Isopropyl-3-oxosuccinate
C04272  (R)-2,3-Dihydroxy-3-methylbutanoate
C04411  (2R,3S)-3-Isopropylmalate
C06006  (S)-2-Aceto-2-hydroxybutanoate
C06007  (R)-2,3-Dihydroxy-3-methylpentanoate
C06010  (S)-2-Acetolactate
C06032  D-erythro-3-Methylmalate
C14463  (R)-3-Hydroxy-3-methyl-2-oxopentanoate
Reference
  Authors
Xu H, Zhang Y, Guo X, Ren S, Staempfli AA, Chiao J, Jiang W, Zhao G.
  Title
Isoleucine biosynthesis in Leptospira interrogans serotype lai strain 56601 proceeds via a threonine-independent pathway.
  Journal
J Bacteriol 186:5400-9 (2004)
DOI:10.1128/JB.186.16.5400-5409.2004
Related
pathway
ppun00260  Glycine, serine and threonine metabolism
ppun00280  Valine, leucine and isoleucine degradation
ppun00620  Pyruvate metabolism
KO pathway
ko00290   
LinkDB

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