KEGG   PATHWAY: psaa00290
Entry
psaa00290                   Pathway                                
Name
Valine, leucine and isoleucine biosynthesis - Paraburkholderia sabiae
Class
Metabolism; Amino acid metabolism
Pathway map
psaa00290  Valine, leucine and isoleucine biosynthesis
psaa00290

Module
psaa_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:psaa00290]
psaa_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:psaa00290]
psaa_M00570  Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine [PATH:psaa00290]
Other DBs
GO: 0009097 0009098 0009099
Organism
Paraburkholderia sabiae [GN:psaa]
Gene
QEN71_22070  threonine/serine dehydratase [KO:K01754] [EC:4.3.1.19]
QEN71_01985  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
QEN71_14710  eutB; hydroxyectoine utilization dehydratase EutB [KO:K01754] [EC:4.3.1.19]
QEN71_09705  serine/threonine dehydratase family protein [KO:K17989] [EC:4.3.1.17 4.3.1.19]
QEN71_17605  leuC; 3-isopropylmalate dehydratase large subunit [KO:K01703] [EC:4.2.1.33 4.2.1.35]
QEN71_39725  aconitase family protein [KO:K01703] [EC:4.2.1.33 4.2.1.35]
QEN71_17615  leuD; 3-isopropylmalate dehydratase small subunit [KO:K01704] [EC:4.2.1.33 4.2.1.35]
QEN71_41445  isocitrate/isopropylmalate dehydrogenase family protein [KO:K00052] [EC:1.1.1.85]
QEN71_17620  leuB; 3-isopropylmalate dehydrogenase [KO:K00052] [EC:1.1.1.85]
QEN71_24220  acetolactate synthase 3 catalytic subunit [KO:K01652] [EC:2.2.1.6]
QEN71_24490  acetolactate synthase large subunit [KO:K01652] [EC:2.2.1.6]
QEN71_29225  thiamine pyrophosphate-binding protein [KO:K01652] [EC:2.2.1.6]
QEN71_31345  acetolactate synthase large subunit [KO:K01652] [EC:2.2.1.6]
QEN71_38245  ilvB; biosynthetic-type acetolactate synthase large subunit [KO:K01652] [EC:2.2.1.6]
QEN71_40210  ilvB; biosynthetic-type acetolactate synthase large subunit [KO:K01652] [EC:2.2.1.6]
QEN71_16935  thiamine pyrophosphate-binding protein [KO:K01652] [EC:2.2.1.6]
QEN71_24215  ilvN; acetolactate synthase small subunit [KO:K01653] [EC:2.2.1.6]
QEN71_24210  ilvC; ketol-acid reductoisomerase [KO:K00053] [EC:1.1.1.86]
QEN71_35985  ilvC; ketol-acid reductoisomerase [KO:K00053] [EC:1.1.1.86]
QEN71_21090  ilvD; dihydroxy-acid dehydratase [KO:K01687] [EC:4.2.1.9]
QEN71_25180  ilvD; dihydroxy-acid dehydratase [KO:K01687] [EC:4.2.1.9]
QEN71_35705  ilvD; dihydroxy-acid dehydratase [KO:K01687] [EC:4.2.1.9]
QEN71_02410  branched-chain amino acid transaminase [KO:K00826] [EC:2.6.1.42]
QEN71_15260  amino acid dehydrogenase [KO:K00263] [EC:1.4.1.9]
QEN71_22405  pyridoxal phosphate-dependent aminotransferase [KO:K14260] [EC:2.6.1.66 2.6.1.2]
QEN71_24190  2-isopropylmalate synthase [KO:K01649] [EC:2.3.3.13]
QEN71_01640  leuA; 2-isopropylmalate synthase [KO:K01649] [EC:2.3.3.13]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00109  2-Oxobutanoate
C00123  L-Leucine
C00141  3-Methyl-2-oxobutanoic acid
C00183  L-Valine
C00188  L-Threonine
C00233  4-Methyl-2-oxopentanoate
C00407  L-Isoleucine
C00671  (S)-3-Methyl-2-oxopentanoic acid
C02226  2-Methylmaleate
C02504  alpha-Isopropylmalate
C02612  (R)-2-Methylmalate
C02631  2-Isopropylmaleate
C04181  3-Hydroxy-3-methyl-2-oxobutanoic acid
C04236  (2S)-2-Isopropyl-3-oxosuccinate
C04272  (R)-2,3-Dihydroxy-3-methylbutanoate
C04411  (2R,3S)-3-Isopropylmalate
C06006  (S)-2-Aceto-2-hydroxybutanoate
C06007  (R)-2,3-Dihydroxy-3-methylpentanoate
C06010  (S)-2-Acetolactate
C06032  D-erythro-3-Methylmalate
C14463  (R)-3-Hydroxy-3-methyl-2-oxopentanoate
Reference
PMID:15292141
  Authors
Xu H, Zhang Y, Guo X, Ren S, Staempfli AA, Chiao J, Jiang W, Zhao G.
  Title
Isoleucine biosynthesis in Leptospira interrogans serotype lai strain 56601 proceeds via a threonine-independent pathway.
  Journal
J Bacteriol 186:5400-9 (2004)
DOI:10.1128/JB.186.16.5400-5409.2004
Related
pathway
psaa00260  Glycine, serine and threonine metabolism
psaa00280  Valine, leucine and isoleucine degradation
psaa00620  Pyruvate metabolism
KO pathway
ko00290   
LinkDB

DBGET integrated database retrieval system