KEGG   PATHWAY: ptw03070
Entry
ptw03070                    Pathway                                
Name
Bacterial secretion system - Pseudomonas tohonis
Description
Gram-negative bacteria secrete a wide range of proteins whose functions include biogenesis of organelles, such as pilli and flagella, nutrient acquisition, virulence, and efflux of drugs and other toxins. Six distinct secretion systems have been shown to mediate protein export through the inner and outer membranes of Gram-negative bacteria. These pathways are highly conserved throughout the Gram-negative bacterial species. In Gram-positive bacteria, secreted proteins are commonly translocated across the single membrane by the Sec pathway or the two-arginine (Tat) pathway.
Class
Environmental Information Processing; Membrane transport
Pathway map
ptw03070  Bacterial secretion system
ptw03070

Other DBs
GO: 0030253 0015628 0030254 0030255 0046819 0033103 0044098 0043952 0043953
Organism
Pseudomonas tohonis [GN:ptw]
Gene
TUM18999_21880  hypothetical protein [KO:K12340]
TUM18999_26990  hypothetical protein [KO:K12340]
TUM18999_55290  channel protein TolC [KO:K12340]
TUM18999_14160  xqhA_1; type II secretion system protein GspD [KO:K02453]
TUM18999_17190  xcpQ_1; type II secretion system protein D [KO:K02453]
TUM18999_32550  type II secretion system protein GspD [KO:K02453]
TUM18999_36040  xqhA_2; type II secretion system protein GspD [KO:K02453]
TUM18999_60150  xcpQ_2; type II secretion system protein D [KO:K02453]
TUM18999_17200  hypothetical protein [KO:K02452]
TUM18999_32610  hypothetical protein [KO:K02452]
TUM18999_36030  hypothetical protein [KO:K02452]
TUM18999_60140  hypothetical protein [KO:K02452]
TUM18999_17220  xcpS_1; type II secretion system protein F [KO:K02455]
TUM18999_32530  type II secretion system protein GspF [KO:K02455]
TUM18999_36060  xcpS_2; type II secretion system protein F [KO:K02455]
TUM18999_60060  xcpS_3; type II secretion system protein F [KO:K02455]
TUM18999_17230  xcpT_1; type II secretion system protein G [KO:K02456]
TUM18999_32590  type II secretion system protein GspG [KO:K02456]
TUM18999_36070  xcpT_2; type II secretion system protein G [KO:K02456]
TUM18999_60050  xcpT_3; type II secretion system protein G [KO:K02456]
TUM18999_17240  xcpU_1; type II secretion system protein H [KO:K02457]
TUM18999_32620  type II secretion system protein GspH [KO:K02457]
TUM18999_36080  xcpU_2; type II secretion system protein H [KO:K02457]
TUM18999_60040  xcpU_3; type II secretion system protein H [KO:K02457]
TUM18999_17250  xcpV_1; type II secretion system protein I [KO:K02458]
TUM18999_32600  hypothetical protein [KO:K02458]
TUM18999_36090  xcpV_2; type II secretion system protein I [KO:K02458]
TUM18999_60030  xcpV_3; type II secretion system protein I [KO:K02458]
TUM18999_17260  xcpW_1; type II secretion system protein J [KO:K02459]
TUM18999_32630  pseudopilin [KO:K02459]
TUM18999_36100  xcpW_2; type II secretion system protein J [KO:K02459]
TUM18999_60020  xcpW_3; type II secretion system protein J [KO:K02459]
TUM18999_17270  xcpX_1; type II secretion system protein K [KO:K02460]
TUM18999_32580  type II secretion system protein K [KO:K02460]
TUM18999_36110  hypothetical protein [KO:K02460]
TUM18999_60010  xcpX_2; type II secretion system protein K [KO:K02460]
TUM18999_17280  xcpY_1; type II secretion system protein L [KO:K02461]
TUM18999_32570  type II secretion system protein [KO:K02461]
TUM18999_36120  hypothetical protein [KO:K02461]
TUM18999_60000  xcpY_2; type II secretion system protein L [KO:K02461]
TUM18999_17290  xcpZ; type II secretion system protein M [KO:K02462]
TUM18999_32560  type II secretion system protein [KO:K02462]
TUM18999_36130  hypothetical protein [KO:K02462]
TUM18999_59990  hypothetical protein [KO:K02462]
TUM18999_17210  xcpR_1; type II secretion system protein E [KO:K02454] [EC:7.4.2.8]
TUM18999_32540  hxcR; putative type II secretion system protein HxcR [KO:K02454] [EC:7.4.2.8]
TUM18999_36050  xcpR_2; type II secretion system protein E [KO:K02454] [EC:7.4.2.8]
TUM18999_58390  secretion pathway ATPase [KO:K02454] [EC:7.4.2.8]
TUM18999_60070  xcpR_3; type II secretion system protein E [KO:K02454] [EC:7.4.2.8]
TUM18999_49600  secD; protein translocase subunit SecD [KO:K03072]
TUM18999_49590  secF; protein-export membrane protein SecF [KO:K03074]
TUM18999_07930  secE; protein translocase subunit SecE [KO:K03073]
TUM18999_52760  secG; protein-export membrane protein SecG [KO:K03075]
TUM18999_08260  secY; protein translocase subunit SecY [KO:K03076]
TUM18999_49610  preprotein translocase subunit YajC [KO:K03210]
TUM18999_61730  yidC; membrane protein insertase YidC [KO:K03217]
TUM18999_13500  secA; protein translocase subunit SecA [KO:K03070] [EC:7.4.2.8]
TUM18999_05130  hypothetical protein [KO:K03110]
TUM18999_56920  secB; protein-export protein SecB [KO:K03071]
TUM18999_49040  ffh; signal recognition particle protein [KO:K03106] [EC:3.6.5.4]
TUM18999_56370  tatA; Sec-independent protein translocase protein TatA [KO:K03116]
TUM18999_56380  hypothetical protein [KO:K03117]
TUM18999_56390  tatC; sec-independent protein translocase protein TatC [KO:K03118]
TUM18999_29950  hypothetical protein [KO:K11904]
TUM18999_30000  vgrG1; type VI secretion system protein VgrG [KO:K11904]
TUM18999_59140  type IV secretion protein Rhs [KO:K11904]
TUM18999_30060  hcp1; protein hcp1 [KO:K11903]
TUM18999_59160  hypothetical protein [KO:K11903]
TUM18999_30110  type VI secretion lipoprotein [KO:K11906]
TUM18999_59050  hypothetical protein [KO:K11906]
TUM18999_30140  icmF1; type VI secretion protein IcmF [KO:K11891]
TUM18999_59090  type VI secretion protein VasK [KO:K11891]
TUM18999_30130  hypothetical protein [KO:K11892]
TUM18999_59180  type VI secretion protein ImpK [KO:K11892]
TUM18999_30010  clpV1; protein ClpV1 [KO:K11907]
TUM18999_59150  ClpV1 family T6SS ATPase [KO:K11907]
TUM18999_30170  ppkA; serine/threonine protein kinase [KO:K11912] [EC:2.7.11.1]
TUM18999_30100  hypothetical protein [KO:K11913]
TUM18999_30160  pppA; serine/threonine protein phosphatase [KO:K11915] [EC:3.1.3.16]
Compound
C00002  ATP
Reference
PMID:11173102
  Authors
Kim JF.
  Title
Revisiting the chlamydial type III protein secretion system: clues to the origin of type III protein secretion.
  Journal
Trends Genet 17:65-9 (2001)
DOI:10.1016/S0168-9525(00)02175-2
Reference
PMID:11309112
  Authors
Plano GV, Day JB, Ferracci F.
  Title
Type III export: new uses for an old pathway.
  Journal
Mol Microbiol 40:284-93 (2001)
DOI:10.1046/j.1365-2958.2001.02354.x
Reference
PMID:11413015
  Authors
Gauthier A, Finlay BB.
  Title
Bacterial pathogenesis: the answer to virulence is in the pore.
  Journal
Curr Biol 11:R264-7 (2001)
DOI:10.1016/S0960-9822(01)00134-8
Reference
PMID:10047550
  Authors
Burns DL.
  Title
Biochemistry of type IV secretion.
  Journal
Curr Opin Microbiol 2:25-9 (1999)
DOI:10.1016/S1369-5274(99)80004-6
Reference
PMID:10920394
  Authors
Christie PJ, Vogel JP.
  Title
Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cells.
  Journal
Trends Microbiol 8:354-60 (2000)
DOI:10.1016/S0966-842X(00)01792-3
Reference
PMID:11309113
  Authors
Christie PJ.
  Title
Type IV secretion: intercellular transfer of macromolecules by systems ancestrally related to conjugation machines.
  Journal
Mol Microbiol 40:294-305 (2001)
DOI:10.1046/j.1365-2958.2001.02302.x
Reference
PMID:10481178
  Authors
Nunn D.
  Title
Bacterial type II protein export and pilus biogenesis: more than just homologies?
  Journal
Trends Cell Biol 9:402-8 (1999)
DOI:10.1016/S0962-8924(99)01634-7
Reference
PMID:11309111
  Authors
Sandkvist M.
  Title
Biology of type II secretion.
  Journal
Mol Microbiol 40:271-83 (2001)
DOI:10.1046/j.1365-2958.2001.02403.x
Reference
PMID:11349009
  Authors
Sandkvist M.
  Title
Type II secretion and pathogenesis.
  Journal
Infect Immun 69:3523-35 (2001)
DOI:10.1128/IAI.69.6.3523-3535.2001
Reference
PMID:15546664
  Authors
Delepelaire P
  Title
Type I secretion in gram-negative bacteria.
  Journal
Biochim Biophys Acta 1694:149-61 (2004)
DOI:10.1016/j.bbamcr.2004.05.001
Reference
PMID:18406342
  Authors
Hazes B, Frost L
  Title
Towards a systems biology approach to study type II/IV secretion systems.
  Journal
Biochim Biophys Acta 1778:1839-50 (2008)
DOI:10.1016/j.bbamem.2008.03.011
Reference
PMID:16448494
  Authors
Johnson TL, Abendroth J, Hol WG, Sandkvist M
  Title
Type II secretion: from structure to function.
  Journal
FEMS Microbiol Lett 255:175-86 (2006)
DOI:10.1111/j.1574-6968.2006.00102.x
Reference
PMID:15546665
  Authors
Filloux A
  Title
The underlying mechanisms of type II protein secretion.
  Journal
Biochim Biophys Acta 1694:163-79 (2004)
DOI:10.1016/j.bbamcr.2004.05.003
Reference
PMID:19396170
  Authors
Spreter T, Yip CK, Sanowar S, Andre I, Kimbrough TG, Vuckovic M, Pfuetzner RA, Deng W, Yu AC, Finlay BB, Baker D, Miller SI, Strynadka NC
  Title
A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system.
  Journal
Nat Struct Mol Biol 16:468-76 (2009)
DOI:10.1038/nsmb.1603
Reference
PMID:15590783
  Authors
Ghosh P
  Title
Process of protein transport by the type III secretion system.
  Journal
Microbiol Mol Biol Rev 68:771-95 (2004)
DOI:10.1128/MMBR.68.4.771-795.2004
Reference
PMID:12360191
  Authors
Cornelis GR
  Title
The Yersinia Ysc-Yop 'type III' weaponry.
  Journal
Nat Rev Mol Cell Biol 3:742-52 (2002)
DOI:10.1038/nrm932
Reference
PMID:17215876
  Authors
Baron C
  Title
VirB8: a conserved type IV secretion system assembly factor and drug target.
  Journal
Biochem Cell Biol 84:890-9 (2006)
DOI:10.1139/o06-148
Reference
PMID:17943123
  Authors
Kwok T, Zabler D, Urman S, Rohde M, Hartig R, Wessler S, Misselwitz R, Berger J, Sewald N, Konig W, Backert S
  Title
Helicobacter exploits integrin for type IV secretion and kinase activation.
  Journal
Nature 449:862-6 (2007)
DOI:10.1038/nature06187
Reference
PMID:16092524
  Authors
Christie PJ, Cascales E
  Title
Structural and dynamic properties of bacterial type IV secretion systems (review).
  Journal
Mol Membr Biol 22:51-61 (2005)
DOI:10.1080/09687860500063316
Reference
PMID:15546668
  Authors
Christie PJ
  Title
Type IV secretion: the Agrobacterium VirB/D4 and related conjugation systems.
  Journal
Biochim Biophys Acta 1694:219-34 (2004)
DOI:10.1016/j.bbamcr.2004.02.013
Reference
PMID:15590781
  Authors
Henderson IR, Navarro-Garcia F, Desvaux M, Fernandez RC, Ala'Aldeen D
  Title
Type V protein secretion pathway: the autotransporter story.
  Journal
Microbiol Mol Biol Rev 68:692-744 (2004)
DOI:10.1128/MMBR.68.4.692-744.2004
Reference
PMID:9778731
  Authors
Henderson IR, Navarro-Garcia F, Nataro JP
  Title
The great escape: structure and function of the autotransporter proteins.
  Journal
Trends Microbiol 6:370-8 (1998)
DOI:10.1016/S0966-842X(98)01318-3
Reference
PMID:18524912
  Authors
Filloux A, Hachani A, Bleves S
  Title
The bacterial type VI secretion machine: yet another player for protein transport across membranes.
  Journal
Microbiology 154:1570-83 (2008)
DOI:10.1099/mic.0.2008/016840-0
Reference
PMID:19251641
  Authors
Leiman PG, Basler M, Ramagopal UA, Bonanno JB, Sauder JM, Pukatzki S, Burley SK, Almo SC, Mekalanos JJ
  Title
Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin.
  Journal
Proc Natl Acad Sci U S A 106:4154-9 (2009)
DOI:10.1073/pnas.0813360106
Reference
PMID:17603507
  Authors
Kulasekara HD, Miller SI
  Title
Threonine phosphorylation times bacterial secretion.
  Journal
Nat Cell Biol 9:734-6 (2007)
DOI:10.1038/ncb0707-734
Reference
PMID:18078384
  Authors
Driessen AJ, Nouwen N
  Title
Protein translocation across the bacterial cytoplasmic membrane.
  Journal
Annu Rev Biochem 77:643-67 (2008)
DOI:10.1146/annurev.biochem.77.061606.160747
Reference
PMID:14641032
  Authors
Pool MR
  Title
Getting to the membrane: how is co-translational protein targeting to the endoplasmic reticulum regulated?
  Journal
Biochem Soc Trans 31:1232-7 (2003)
DOI:10.1042/bst0311232
Reference
PMID:19299134
  Authors
Desvaux M, Hebraud M, Talon R, Henderson IR
  Title
Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
  Journal
Trends Microbiol 17:139-45 (2009)
DOI:10.1016/j.tim.2009.01.004
Reference
PMID:15063851
  Authors
Nakatogawa H, Murakami A, Ito K
  Title
Control of SecA and SecM translation by protein secretion.
  Journal
Curr Opin Microbiol 7:145-50 (2004)
DOI:10.1016/j.mib.2004.01.001
KO pathway
ko03070   
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