KEGG   PATHWAY: riu02020
Entry
riu02020                    Pathway                                
Name
Two-component system - Rahnella inusitata
Description
Two-component signal transduction systems enable bacteria to sense, respond, and adapt to changes in their environment or in their intracellular state. Each two-component system consists of a sensor protein-histidine kinase (HK) and a response regulator (RR). In the prototypical two-component pathway, the sensor HK phosphorylates its own conserved His residue in response to a signal(s) in the environment. Subsequently, the phosphoryl group of HK is transferred onto a specific Asp residue on the RR. The activated RR can then effect changes in cellular physiology, often by regulating gene expression. Two-component pathways thus often enable cells to sense and respond to stimuli by inducing changes in transcription.
Class
Environmental Information Processing; Signal transduction
Pathway map
riu02020  Two-component system
riu02020

Other DBs
GO: 0000160
Organism
Rahnella inusitata [GN:riu]
Gene
I2123_18895  phoR; phosphate regulon sensor histidine kinase PhoR [KO:K07636] [EC:2.7.13.3]
I2123_18900  phoB; phosphate response regulator transcription factor PhoB [KO:K07657]
I2123_11765  phoA; alkaline phosphatase [KO:K01077] [EC:3.1.3.1]
I2123_01960  pstS; phosphate ABC transporter substrate-binding protein PstS [KO:K02040]
I2123_09620  phoQ; two-component system sensor histidine kinase PhoQ [KO:K07637] [EC:2.7.13.3]
I2123_09625  phoP; two-component system response regulator PhoP [KO:K07660]
I2123_04790  phosphatase PAP2 family protein [KO:K09474] [EC:3.1.3.2]
I2123_07960  phosphatase PAP2 family protein [KO:K09474] [EC:3.1.3.2]
I2123_03120  envZ; two-component system sensor histidine kinase EnvZ [KO:K07638] [EC:2.7.13.3]
I2123_03115  ompR; two-component system response regulator OmpR [KO:K07659]
I2123_08870  ompC; porin OmpC [KO:K09475]
I2123_11130  ompC; porin OmpC [KO:K09475]
I2123_16385  ompC; porin OmpC [KO:K09476]
I2123_01255  cpxA; envelope stress sensor histidine kinase CpxA [KO:K07640] [EC:2.7.13.3]
I2123_01250  cpxR; envelope stress response regulator transcription factor CpxR [KO:K07662]
I2123_21225  mzrA; EnvZ/OmpR regulon moderator MzrA [KO:K25864]
I2123_12505  rstB; two-component system sensor histidine kinase RstB [KO:K07639] [EC:2.7.13.3]
I2123_12510  rstA; two-component system response regulator RstA [KO:K07661]
I2123_19850  degP; serine endoprotease DegP [KO:K04771] [EC:3.4.21.107]
I2123_07375  baeS; two-component system sensor histidine kinase BaeS [KO:K07642] [EC:2.7.13.3]
I2123_07370  baeR; two-component system response regulator BaeR [KO:K07664]
I2123_05980  MdtA/MuxA family multidrug efflux RND transporter periplasmic adaptor subunit [KO:K07799]
I2123_05985  efflux RND transporter permease subunit [KO:K07788]
I2123_05990  efflux RND transporter permease subunit [KO:K07789]
I2123_07380  mdtD; multidrug transporter subunit MdtD [KO:K18326]
I2123_18220  acrD; multidrug efflux RND transporter permease AcrD [KO:K18324]
I2123_04435  pmrB; two-component system sensor histidine kinase PmrB [KO:K07643] [EC:2.7.13.3]
I2123_04440  pmrA; two-component system response regulator PmrA [KO:K07771]
I2123_10275  arnB; UDP-4-amino-4-deoxy-L-arabinose aminotransferase [KO:K07806] [EC:2.6.1.87]
I2123_03940  heavy metal sensor histidine kinase [KO:K07644] [EC:2.7.13.3]
I2123_04025  Cu(+)/Ag(+) sensor histidine kinase [KO:K07644] [EC:2.7.13.3]
I2123_16985  heavy metal sensor histidine kinase [KO:K07644] [EC:2.7.13.3]
I2123_03945  heavy metal response regulator transcription factor [KO:K07665]
I2123_04020  response regulator transcription factor CusR [KO:K07665]
I2123_16990  heavy metal response regulator transcription factor [KO:K07665]
I2123_04015  efflux transporter outer membrane subunit [KO:K07796]
I2123_04010  cusF; cation efflux system protein CusF [KO:K07810]
I2123_13980  copper-binding protein [KO:K07810]
I2123_04005  efflux RND transporter periplasmic adaptor subunit [KO:K07798]
I2123_13990  efflux RND transporter periplasmic adaptor subunit [KO:K07798]
I2123_04000  CusA/CzcA family heavy metal efflux RND transporter [KO:K07787]
I2123_13995  efflux RND transporter permease subunit [KO:K07787]
I2123_19950  qseC; two-component system sensor histidine kinase QseC [KO:K07645] [EC:2.7.13.3]
I2123_19955  response regulator [KO:K07666]
I2123_14920  flhD; flagellar transcriptional regulator FlhD [KO:K02403]
I2123_14915  flhC; flagellar transcriptional regulator FlhC [KO:K02402]
I2123_11340  FliC/FljB family flagellin [KO:K02406]
I2123_11345  RNA polymerase sigma factor FliA [KO:K02405]
I2123_14910  motA; flagellar motor stator protein MotA [KO:K02556]
I2123_17520  kdpD; two-component system sensor histidine kinase KdpD [KO:K07646] [EC:2.7.13.3]
I2123_17525  kdpE; two-component system response regulator KdpE [KO:K07667]
I2123_17505  kdpA; potassium-transporting ATPase subunit KdpA [KO:K01546]
I2123_17510  kdpB; potassium-transporting ATPase subunit KdpB [KO:K01547] [EC:7.2.2.6]
I2123_17515  kdpC; potassium-transporting ATPase subunit KdpC [KO:K01548]
I2123_17500  K(+)-transporting ATPase subunit F [KO:K01545]
I2123_21305  arcB; aerobic respiration two-component sensor histidine kinase ArcB [KO:K07648] [EC:2.7.13.3]
I2123_20560  arcA; two-component system response regulator ArcA [KO:K07773]
I2123_07885  glycoside hydrolase family 68 protein [KO:K00692] [EC:2.4.1.10]
I2123_02040  dnaA; chromosomal replication initiator protein DnaA [KO:K02313]
I2123_10865  ddpX; D-alanyl-D-alanine dipeptidase [KO:K08641] [EC:3.4.13.22]
I2123_05970  M15 family metallopeptidase [KO:K07260] [EC:3.4.17.14]
I2123_23605  TonB-dependent siderophore receptor [KO:K19611]
I2123_05805  sensor histidine kinase [KO:K07700] [EC:2.7.13.3]
I2123_05800  response regulator [KO:K07702]
I2123_06940  dcuS; two-component system sensor histidine kinase DcuS [KO:K07701] [EC:2.7.13.3]
I2123_06935  dcuR; two-component system response regulator DcuR [KO:K07703]
I2123_16720  NAD-dependent malic enzyme [KO:K00027] [EC:1.1.1.38]
I2123_13620  narX; nitrate/nitrite two-component system sensor histidine kinase NarX [KO:K07673] [EC:2.7.13.3]
I2123_13625  narL; two-component system response regulator NarL [KO:K07684]
I2123_11630  nitrate reductase subunit alpha [KO:K00370] [EC:1.7.5.1 1.7.99.-]
I2123_11635  narH; nitrate reductase subunit beta [KO:K00371] [EC:1.7.5.1 1.7.99.-]
I2123_11645  narI; respiratory nitrate reductase subunit gamma [KO:K00374] [EC:1.7.5.1 1.7.99.-]
I2123_11640  narJ; nitrate reductase molybdenum cofactor assembly chaperone [KO:K00373]
I2123_02245  fdnG; formate dehydrogenase-N subunit alpha [KO:K08348] [EC:1.17.5.3]
I2123_04130  frdA; fumarate reductase (quinol) flavoprotein subunit [KO:K00244] [EC:1.3.5.1]
I2123_04125  succinate dehydrogenase/fumarate reductase iron-sulfur subunit [KO:K00245] [EC:1.3.5.1]
I2123_04120  frdC; fumarate reductase subunit FrdC [KO:K00246]
I2123_04115  frdD; fumarate reductase subunit FrdD [KO:K00247]
I2123_13170  uhpC; MFS transporter family glucose-6-phosphate receptor UhpC [KO:K07783]
I2123_13165  MASE1 domain-containing protein [KO:K20263] [EC:2.7.13.3]
I2123_13160  response regulator transcription factor [KO:K20264]
I2123_06435  rcsF; Rcs stress response system protein RcsF [KO:K06080]
I2123_08465  rcsC; two-component system sensor histidine kinase RcsC [KO:K07677] [EC:2.7.13.3]
I2123_08475  rcsD; phosphotransferase RcsD [KO:K07676] [EC:2.7.13.3]
I2123_14060  rcsA; transcriptional regulator RcsA [KO:K07781]
I2123_20600  rcsA; transcriptional regulator RcsA [KO:K07781]
I2123_08470  rcsB; transcriptional regulator RcsB [KO:K07687]
I2123_05265  barA; two-component sensor histidine kinase BarA [KO:K07678] [EC:2.7.13.3]
I2123_09205  uvrY; UvrY/SirA/GacA family response regulator transcription factor [KO:K07689]
I2123_11660  response regulator transcription factor [KO:K07689]
I2123_23025  LuxR family transcriptional regulator [KO:K07782]
I2123_05445  csrA; carbon storage regulator CsrA [KO:K03563]
I2123_24555  transporter substrate-binding domain-containing protein [KO:K07679] [EC:2.7.13.3]
I2123_24550  response regulator transcription factor [KO:K07690]
I2123_24565  response regulator transcription factor [KO:K07690]
I2123_19785  spore coat protein U domain-containing protein [KO:K27078]
I2123_19790  spore coat U domain-containing protein [KO:K27078]
I2123_19795  spore coat protein U domain-containing protein [KO:K27078]
I2123_19810  spore coat protein U domain-containing protein [KO:K27078]
I2123_19800  molecular chaperone [KO:K07346]
I2123_02810  fimbrial biogenesis outer membrane usher protein [KO:K07347]
I2123_03100  fimbrial biogenesis outer membrane usher protein [KO:K07347]
I2123_11685  fimbrial outer membrane usher protein [KO:K07347]
I2123_19805  fimbrial biogenesis outer membrane usher protein [KO:K07347]
I2123_22560  fimbrial biogenesis outer membrane usher protein [KO:K07347]
I2123_23445  fimbrial biogenesis outer membrane usher protein [KO:K07347]
I2123_06285  glnD; bifunctional uridylyltransferase/uridylyl-removing protein GlnD [KO:K00990] [EC:2.7.7.59]
I2123_07090  glnB; nitrogen regulatory protein P-II [KO:K04751]
I2123_01755  glnL; nitrogen regulation protein NR(II) [KO:K07708] [EC:2.7.13.3]
I2123_01760  glnG; nitrogen regulation protein NR(I) [KO:K07712]
I2123_01750  glnA; glutamate--ammonia ligase [KO:K01915] [EC:6.3.1.2]
I2123_02500  dicarboxylate/amino acid:cation symporter [KO:K11103]
I2123_21445  rpoN; RNA polymerase factor sigma-54 [KO:K03092]
I2123_07075  HAMP domain-containing histidine kinase [KO:K07711] [EC:2.7.13.3]
I2123_07085  glrR; two-component system response regulator GlrR [KO:K07715]
I2123_14835  cheR; protein-glutamate O-methyltransferase CheR [KO:K00575] [EC:2.1.1.80]
I2123_04270  Cache 3/Cache 2 fusion domain-containing protein [KO:K03406]
I2123_06955  HAMP domain-containing protein [KO:K03406]
I2123_17125  PAS domain-containing methyl-accepting chemotaxis protein [KO:K03406]
I2123_17290  Tar ligand binding domain-containing protein [KO:K03406]
I2123_17555  Tar ligand binding domain-containing protein [KO:K03406]
I2123_21830  MCP four helix bundle domain-containing protein [KO:K03406]
I2123_24480  MCP four helix bundle domain-containing protein [KO:K03406]
I2123_02010  methyl-accepting chemotaxis protein [KO:K03406]
I2123_02325  methyl-accepting chemotaxis protein [KO:K03406]
I2123_04365  Tar ligand binding domain-containing protein [KO:K05874]
I2123_14845  Tar ligand binding domain-containing protein [KO:K05874]
I2123_05960  HAMP domain-containing protein [KO:K05875]
I2123_17190  HAMP domain-containing protein [KO:K05875]
I2123_02230  methyl-accepting chemotaxis protein [KO:K05875]
I2123_14065  Tar ligand binding domain-containing protein [KO:K05876]
I2123_22815  Tar ligand binding domain-containing protein [KO:K05876]
I2123_14840  Tar ligand binding domain-containing protein [KO:K05877]
I2123_22810  PAS domain-containing protein [KO:K03776]
I2123_14895  cheW; chemotaxis protein CheW [KO:K03408]
I2123_14900  cheA; chemotaxis protein CheA [KO:K03407] [EC:2.7.13.3]
I2123_14825  cheY; chemotaxis response regulator CheY [KO:K03413]
I2123_14830  chemotaxis response regulator protein-glutamate methylesterase [KO:K03412] [EC:3.1.1.61 3.5.1.44]
I2123_14350  chemotaxis protein CheV [KO:K03415]
I2123_24560  response regulator [KO:K02658]
I2123_25255  PhnD/SsuA/transferrin family substrate-binding protein [KO:K13040] [EC:2.7.13.3]
I2123_25260  ttrR; two-component system response regulator TtrR [KO:K13041]
I2123_25240  ttrA; tetrathionate reductase subunit TtrA [KO:K08357]
I2123_25250  ttrB; tetrathionate reductase subunit TtrB [KO:K08358]
I2123_25245  ttrC; tetrathionate reductase subunit TtrC [KO:K08359]
I2123_17690  amino acid ABC transporter ATP-binding protein [KO:K10004] [EC:7.4.2.1]
I2123_17685  gltK; glutamate/aspartate ABC transporter permease GltK [KO:K10002]
I2123_17680  amino acid ABC transporter permease [KO:K10003]
I2123_17675  amino acid ABC transporter substrate-binding protein [KO:K10001]
I2123_03295  crp; cAMP-activated global transcriptional regulator CRP [KO:K10914]
I2123_04715  crotonase/enoyl-CoA hydratase family protein [KO:K13816]
I2123_19570  glsB; glutaminase B [KO:K01425] [EC:3.5.1.2]
I2123_13920  cytochrome ubiquinol oxidase subunit I [KO:K00425] [EC:7.1.1.7]
I2123_17390  cydA; cytochrome ubiquinol oxidase subunit I [KO:K00425] [EC:7.1.1.7]
I2123_22975  cytochrome ubiquinol oxidase subunit I [KO:K00425] [EC:7.1.1.7]
I2123_13925  cydB; cytochrome d ubiquinol oxidase subunit II [KO:K00426] [EC:7.1.1.7]
I2123_17385  cydB; cytochrome d ubiquinol oxidase subunit II [KO:K00426] [EC:7.1.1.7]
I2123_22980  cydB; cytochrome d ubiquinol oxidase subunit II [KO:K00426] [EC:7.1.1.7]
I2123_17380  cydX; cytochrome bd-I oxidase subunit CydX [KO:K00424] [EC:7.1.1.7]
I2123_05130  tolC; outer membrane channel protein TolC [KO:K12340]
I2123_19610  polysaccharide export protein [KO:K01991]
I2123_19690  polysaccharide export protein [KO:K01991]
I2123_19605  low molecular weight phosphotyrosine protein phosphatase [KO:K25307] [EC:3.1.3.48]
I2123_19685  low molecular weight phosphotyrosine protein phosphatase [KO:K25307] [EC:3.1.3.48]
I2123_19600  polysaccharide biosynthesis tyrosine autokinase [KO:K16692] [EC:2.7.10.3]
I2123_19680  polysaccharide biosynthesis tyrosine autokinase [KO:K16692] [EC:2.7.10.3]
I2123_00895  wecB; UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing) [KO:K01791] [EC:5.1.3.14]
I2123_00890  wecC; UDP-N-acetyl-D-mannosamine dehydrogenase [KO:K02472] [EC:1.1.1.336]
I2123_17180  putative acyl-CoA thioester hydrolase [KO:K01051] [EC:3.1.1.11]
I2123_13380  FecR domain-containing protein [KO:K07165]
I2123_10955  flgM; anti-sigma-28 factor FlgM [KO:K02398]
Compound
C00007  Oxygen
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00034  Manganese
C00036  Oxaloacetate
C00038  Zinc cation
C00042  Succinate
C00049  L-Aspartate
C00064  L-Glutamine
C00070  Copper
C00088  Nitrite
C00092  D-Glucose 6-phosphate
C00122  Fumarate
C00149  (S)-Malate
C00158  Citrate
C00164  Acetoacetate
C00237  CO
C00238  Potassium cation
C00244  Nitrate
C00282  Hydrogen
C00291  Nickel
C00305  Magnesium cation
C00399  Ubiquinone
C00533  Nitric oxide
C00547  L-Noradrenaline
C00697  Nitrogen
C00788  L-Adrenaline
C00828  Menaquinone
C01019  L-Fucose
C01104  Trimethylamine N-oxide
C01667  Bacitracin
C02084  Tetrathionate
C05757  (3R)-3-Hydroxydodecanoyl-[acyl-carrier protein]
C05818  2-Demethylmenaquinone
C06230  Fe-enterobactin
C06689  Vancomycin
C06696  Lead
C11612  Polymyxin B
C11842  N-(3-(S)-Hydroxybutyryl)homoserine lactone
C11849  3-Hydroxy-palmitic acid methyl ester
C12008  Ramoplanin A2
C13768  Colistin sulfate
C14819  Fe3+
C16421  AI-2
C16463  3',5'-Cyclic diGMP
C16640  CAI-1
C16665  12-Methyltetradecanoic acid
C18206  cis-11-Methyl-2-dodecenoic acid
C21220  AIP-1
C21221  CSP
C21241  AIP-2
C21242  AIP-3
C21243  AIP-4
C21245  AgrD1 peptide
D07746  Colistin (INN)
D08401  Polymyxin B (INN)
Reference
PMID:15522865
  Authors
Yamamoto K, Hirao K, Oshima T, Aiba H, Utsumi R, Ishihama A.
  Title
Functional characterization in vitro of all two-component signal transduction systems from Escherichia coli.
  Journal
J Biol Chem 280:1448-56 (2005)
DOI:10.1074/jbc.M410104200
Reference
PMID:16030210
  Authors
Abdel-Fattah WR, Chen Y, Eldakak A, Hulett FM.
  Title
Bacillus subtilis phosphorylated PhoP: direct activation of the E(sigma)A- and repression of the E(sigma)E-responsive phoB-PS+V promoters during pho response.
  Journal
J Bacteriol 187:5166-78 (2005)
DOI:10.1128/JB.187.15.5166-5178.2005
Reference
PMID:15813739
  Authors
Navarre WW, Halsey TA, Walthers D, Frye J, McClelland M, Potter JL, Kenney LJ, Gunn JS, Fang FC, Libby SJ.
  Title
Co-regulation of Salmonella enterica genes required for virulence and resistance to antimicrobial peptides by SlyA and PhoP/PhoQ.
  Journal
Mol Microbiol 56:492-508 (2005)
DOI:10.1111/j.1365-2958.2005.04553.x
Reference
PMID:11973328
  Authors
Cai SJ, Inouye M.
  Title
EnvZ-OmpR interaction and osmoregulation in Escherichia coli.
  Journal
J Biol Chem 277:24155-61 (2002)
DOI:10.1074/jbc.M110715200
Reference
PMID:16077119
  Authors
Batchelor E, Walthers D, Kenney LJ, Goulian M.
  Title
The Escherichia coli CpxA-CpxR envelope stress response system regulates expression of the porins ompF and ompC.
  Journal
J Bacteriol 187:5723-31 (2005)
DOI:10.1128/JB.187.16.5723-5731.2005
Reference
PMID:12107133
  Authors
Nagakubo S, Nishino K, Hirata T, Yamaguchi A.
  Title
The putative response regulator BaeR stimulates multidrug resistance of Escherichia coli via a novel multidrug exporter system, MdtABC.
  Journal
J Bacteriol 184:4161-7 (2002)
DOI:10.1128/JB.184.15.4161-4167.2002
Reference
PMID:15322361
  Authors
Hagiwara D, Yamashino T, Mizuno T.
  Title
A Genome-wide view of the Escherichia coli BasS-BasR two-component system implicated in iron-responses.
  Journal
Biosci Biotechnol Biochem 68:1758-67 (2004)
DOI:10.1271/bbb.68.1758
Reference
PMID:11004187
  Authors
Munson GP, Lam DL, Outten FW, O'Halloran TV.
  Title
Identification of a copper-responsive two-component system on the chromosome of Escherichia coli K-12.
  Journal
J Bacteriol 182:5864-71 (2000)
DOI:10.1128/JB.182.20.5864-5871.2000
Reference
PMID:11929534
  Authors
Sperandio V, Torres AG, Kaper JB.
  Title
Quorum sensing Escherichia coli regulators B and C (QseBC): a novel two-component regulatory system involved in the regulation of flagella and motility by quorum sensing in E. coli.
  Journal
Mol Microbiol 43:809-21 (2002)
DOI:10.1046/j.1365-2958.2002.02803.x
Reference
PMID:14604015
  Authors
Epstein W.
  Title
The roles and regulation of potassium in bacteria.
  Journal
Prog Nucleic Acid Res Mol Biol 75:293-320 (2003)
DOI:10.1016/S0079-6603(03)75008-9
Reference
PMID:10648521
  Authors
Ansaldi M, Simon G, Lepelletier M, Mejean V.
  Title
The TorR high-affinity binding site plays a key role in both torR autoregulation and torCAD operon expression in Escherichia coli.
  Journal
J Bacteriol 182:961-6 (2000)
DOI:10.1128/JB.182.4.961-966.2000
Reference
PMID:15326287
  Authors
Malpica R, Franco B, Rodriguez C, Kwon O, Georgellis D.
  Title
Identification of a quinone-sensitive redox switch in the ArcB sensor kinase.
  Journal
Proc Natl Acad Sci U S A 101:13318-23 (2004)
DOI:10.1073/pnas.0403064101
Reference
PMID:2666399
  Authors
Widenhorn KA, Somers JM, Kay WW.
  Title
Genetic regulation of the tricarboxylate transport operon (tctI) of Salmonella typhimurium.
  Journal
J Bacteriol 171:4436-41 (1989)
DOI:10.1128/JB.171.8.4436-4441.1989
Reference
PMID:11555295
  Authors
Hyyrylainen HL, Bolhuis A, Darmon E, Muukkonen L, Koski P, Vitikainen M, Sarvas M, Pragai Z, Bron S, van Dijl JM, Kontinen VP.
  Title
A novel two-component regulatory system in Bacillus subtilis for the survival of severe secretion stress.
  Journal
Mol Microbiol 41:1159-72 (2001)
DOI:10.1046/j.1365-2958.2001.02576.x
Reference
PMID:10972837
  Authors
Zhang X, Hulett FM.
  Title
ResD signal transduction regulator of aerobic respiration in Bacillus subtilis: ctaA promoter regulation.
  Journal
Mol Microbiol 37:1208-19 (2000)
DOI:10.1046/j.1365-2958.2000.02076.x
Reference
PMID:15937169
  Authors
Senadheera MD, Guggenheim B, Spatafora GA, Huang YC, Choi J, Hung DC, Treglown JS, Goodman SD, Ellen RP, Cvitkovitch DG.
  Title
A VicRK signal transduction system in Streptococcus mutans affects gtfBCD, gbpB, and ftf expression, biofilm formation, and genetic competence development.
  Journal
J Bacteriol 187:4064-76 (2005)
DOI:10.1128/JB.187.12.4064-4076.2005
Reference
PMID:15601704
  Authors
He H, Zahrt TC.
  Title
Identification and characterization of a regulatory sequence recognized by Mycobacterium tuberculosis persistence regulator MprA.
  Journal
J Bacteriol 187:202-12 (2005)
DOI:10.1128/JB.187.1.202-212.2005
Reference
PMID:17448786
  Authors
Hutchings MI
  Title
Unusual two-component signal transduction pathways in the actinobacteria.
  Journal
Adv Appl Microbiol 61:1-26 (2007)
DOI:10.1016/S0065-2164(06)61001-0
Reference
PMID:19308662
  Authors
Kramer R
  Title
Osmosensing and osmosignaling in Corynebacterium glutamicum.
  Journal
Amino Acids 37:487-97 (2009)
DOI:10.1007/s00726-009-0271-6
Reference
PMID:7751278
  Authors
Eraso JM, Kaplan S.
  Title
Oxygen-insensitive synthesis of the photosynthetic membranes of Rhodobacter sphaeroides: a mutant histidine kinase.
  Journal
J Bacteriol 177:2695-706 (1995)
DOI:10.1128/JB.177.10.2695-2706.1995
Reference
PMID:10089160
  Authors
Haydel SE, Dunlap NE, Benjamin WH Jr.
  Title
In vitro evidence of two-component system phosphorylation between the Mycobacterium tuberculosis TrcR/TrcS proteins.
  Journal
Microb Pathog 26:195-206 (1999)
DOI:10.1006/mpat.1998.0265
Reference
PMID:11673427
  Authors
Quisel JD, Burkholder WF, Grossman AD.
  Title
In vivo effects of sporulation kinases on mutant Spo0A proteins in Bacillus subtilis.
  Journal
J Bacteriol 183:6573-8 (2001)
DOI:10.1128/JB.183.22.6573-6578.2001
Reference
PMID:11889485
  Authors
Kaspar S, Bott M.
  Title
The sensor kinase CitA (DpiB) of Escherichia coli functions as a high-affinity citrate receptor.
  Journal
Arch Microbiol 177:313-21 (2002)
DOI:10.1007/s00203-001-0393-z
Reference
PMID:12167640
  Authors
Janausch IG, Garcia-Moreno I, Unden G.
  Title
Function of DcuS from Escherichia coli as a fumarate-stimulated histidine protein kinase in vitro.
  Journal
J Biol Chem 277:39809-14 (2002)
DOI:10.1074/jbc.M204482200
Reference
PMID:8550490
  Authors
Brunskill EW, Bayles KW.
  Title
Identification and molecular characterization of a putative regulatory locus that affects autolysis in Staphylococcus aureus.
  Journal
J Bacteriol 178:611-8 (1996)
DOI:10.1128/JB.178.3.611-618.1996
Reference
PMID:10940023
  Authors
Fujimoto DF, Brunskill EW, Bayles KW.
  Title
Analysis of genetic elements controlling Staphylococcus aureus lrgAB expression: potential role of DNA topology in SarA regulation.
  Journal
J Bacteriol 182:4822-8 (2000)
DOI:10.1128/JB.182.17.4822-4828.2000
Reference
PMID:11807079
  Authors
Dufour P, Jarraud S, Vandenesch F, Greenland T, Novick RP, Bes M, Etienne J, Lina G.
  Title
High genetic variability of the agr locus in Staphylococcus species.
  Journal
J Bacteriol 184:1180-6 (2002)
DOI:10.1128/JB.184.4.1180-1186.2002
Reference
PMID:8501030
  Authors
Rabin RS, Stewart V.
  Title
Dual response regulators (NarL and NarP) interact with dual sensors (NarX and NarQ) to control nitrate- and nitrite-regulated gene expression in Escherichia coli K-12.
  Journal
J Bacteriol 175:3259-68 (1993)
DOI:10.1128/JB.175.11.3259-3268.1993
Reference
PMID:9220011
  Authors
Chiang RC, Cavicchioli R, Gunsalus RP.
  Title
'Locked-on' and 'locked-off' signal transduction mutations in the periplasmic domain of the Escherichia coli NarQ and NarX sensors affect nitrate- and nitrite-dependent regulation by NarL and NarP.
  Journal
Mol Microbiol 24:1049-60 (1997)
DOI:10.1046/j.1365-2958.1997.4131779.x
Reference
PMID:12107138
  Authors
Verhamme DT, Postma PW, Crielaard W, Hellingwerf KJ.
  Title
Cooperativity in signal transfer through the Uhp system of Escherichia coli.
  Journal
J Bacteriol 184:4205-10 (2002)
DOI:10.1128/JB.184.15.4205-4210.2002
Reference
PMID:13129944
  Authors
Hagiwara D, Sugiura M, Oshima T, Mori H, Aiba H, Yamashino T, Mizuno T.
  Title
Genome-wide analyses revealing a signaling network of the RcsC-YojN-RcsB phosphorelay system in Escherichia coli.
  Journal
J Bacteriol 185:5735-46 (2003)
DOI:10.1128/JB.185.19.5735-5746.2003
Reference
PMID:12951338
  Authors
Hirakawa H, Nishino K, Yamada J, Hirata T, Yamaguchi A.
  Title
Beta-lactam resistance modulated by the overexpression of response regulators of two-component signal transduction systems in Escherichia coli.
  Journal
J Antimicrob Chemother 52:576-82 (2003)
DOI:10.1093/jac/dkg406
Reference
PMID:12193630
  Authors
Suzuki K, Wang X, Weilbacher T, Pernestig AK, Melefors O, Georgellis D, Babitzke P, Romeo T.
  Title
Regulatory circuitry of the CsrA/CsrB and BarA/UvrY systems of Escherichia coli.
  Journal
J Bacteriol 184:5130-40 (2002)
DOI:10.1128/JB.184.18.5130-5140.2002
Reference
PMID:10923791
  Authors
Kato A, Ohnishi H, Yamamoto K, Furuta E, Tanabe H, Utsumi R.
  Title
Transcription of emrKY is regulated by the EvgA-EvgS two-component system in Escherichia coli K-12.
  Journal
Biosci Biotechnol Biochem 64:1203-9 (2000)
DOI:10.1271/bbb.64.1203
Reference
PMID:14679219
  Authors
Ansaldi M, Dubnau D.
  Title
Diversifying selection at the Bacillus quorum-sensing locus and determinants of modification specificity during synthesis of the ComX pheromone.
  Journal
J Bacteriol 186:15-21 (2004)
DOI:10.1128/JB.186.1.15-21.2004
Reference
PMID:16035234
  Authors
Gabdrakhmanova L, Vishniakov I, Sharipova M, Balaban N, Kostrov S, Leshchinskaya I.
  Title
Salt stress induction of glutamyl endopeptidase biosynthesis in Bacillus intermedius.
  Journal
Microbiol Res 160:233-42 (2005)
DOI:10.1016/j.micres.2004.05.005
Reference
PMID:11285232
  Authors
Aguilar PS, Hernandez-Arriaga AM, Cybulski LE, Erazo AC, de Mendoza D.
  Title
Molecular basis of thermosensing: a two-component signal transduction thermometer in Bacillus subtilis.
  Journal
EMBO J 20:1681-91 (2001)
DOI:10.1093/emboj/20.7.1681
Reference
PMID:12864861
  Authors
Kuroda M, Kuroda H, Oshima T, Takeuchi F, Mori H, Hiramatsu K.
  Title
Two-component system VraSR positively modulates the regulation of cell-wall biosynthesis pathway in Staphylococcus aureus.
  Journal
Mol Microbiol 49:807-21 (2003)
DOI:10.1046/j.1365-2958.2003.03599.x
Reference
PMID:15073296
  Authors
Saini DK, Malhotra V, Dey D, Pant N, Das TK, Tyagi JS.
  Title
DevR-DevS is a bona fide two-component system of Mycobacterium tuberculosis that is hypoxia-responsive in the absence of the DNA-binding domain of DevR.
  Journal
Microbiology 150:865-75 (2004)
DOI:10.1099/mic.0.26218-0
Reference
PMID:12426351
  Authors
Fedtke I, Kamps A, Krismer B, Gotz F.
  Title
The nitrate reductase and nitrite reductase operons and the narT gene of Staphylococcus carnosus are positively controlled by the novel two-component system NreBC.
  Journal
J Bacteriol 184:6624-34 (2002)
DOI:10.1128/JB.184.23.6624-6634.2002
Reference
PMID:8416895
  Authors
Shiau SP, Chen P, Reitzer LJ.
  Title
Effects of insertions and deletions in glnG (ntrC) of Escherichia coli on nitrogen regulator I-dependent DNA binding and transcriptional activation.
  Journal
J Bacteriol 175:190-9 (1993)
DOI:10.1128/JB.175.1.190-199.1993
Reference
PMID:11243806
  Authors
Leonhartsberger S, Huber A, Lottspeich F, Bock A.
  Title
The hydH/G Genes from Escherichia coli code for a zinc and lead responsive two-component regulatory system.
  Journal
J Mol Biol 307:93-105 (2001)
DOI:10.1006/jmbi.2000.4451
Reference
PMID:15200682
  Authors
Lioliou EE, Kyriakidis DA.
  Title
The role of bacterial antizyme: From an inhibitory protein to AtoC transcriptional regulator.
  Journal
Microb Cell Fact 3:8 (2004)
DOI:10.1186/1475-2859-3-8
Reference
PMID:15773991
  Authors
Yamamoto K, Ishihama A
  Title
Transcriptional response of Escherichia coli to external copper.
  Journal
Mol Microbiol 56:215-27 (2005)
DOI:10.1111/j.1365-2958.2005.04532.x
Reference
PMID:10585546
  Authors
Ashby MK, Mullineaux CW
  Title
Cyanobacterial ycf27 gene products regulate energy transfer from phycobilisomes to photosystems I and II.
  Journal
FEMS Microbiol Lett 181:253-60 (1999)
DOI:10.1111/j.1574-6968.1999.tb08852.x
Reference
PMID:11849552
  Authors
Lopez-Maury L, Garcia-Dominguez M, Florencio FJ, Reyes JC
  Title
A two-component signal transduction system involved in nickel sensing in the cyanobacterium Synechocystis sp. PCC 6803.
  Journal
Mol Microbiol 43:247-56 (2002)
DOI:10.1046/j.1365-2958.2002.02741.x
Reference
PMID:17526710
  Authors
Glover RT, Kriakov J, Garforth SJ, Baughn AD, Jacobs WR Jr
  Title
The two-component regulatory system senX3-regX3 regulates phosphate-dependent gene expression in Mycobacterium smegmatis.
  Journal
J Bacteriol 189:5495-503 (2007)
DOI:10.1128/JB.00190-07
Reference
PMID:15175302
  Authors
Hsiao HY, He Q, Van Waasbergen LG, Grossman AR
  Title
Control of photosynthetic and high-light-responsive genes by the histidine kinase DspA: negative and positive regulation and interactions between signal transduction pathways.
  Journal
J Bacteriol 186:3882-8 (2004)
DOI:10.1128/JB.186.12.3882-3888.2004
Reference
PMID:12626498
  Authors
Mutsuda M, Michel KP, Zhang X, Montgomery BL, Golden SS
  Title
Biochemical properties of CikA, an unusual phytochrome-like histidine protein kinase that resets the circadian clock in Synechococcus elongatus PCC 7942.
  Journal
J Biol Chem 278:19102-10 (2003)
DOI:10.1074/jbc.M213255200
Reference
PMID:9278513
  Authors
Yeh KC, Wu SH, Murphy JT, Lagarias JC
  Title
A cyanobacterial phytochrome two-component light sensory system.
  Journal
Science 277:1505-8 (1997)
DOI:10.1126/science.277.5331.1505
Reference
PMID:7635815
  Authors
Niu S, Jiang SQ, Hong J
  Title
Salmonella typhimurium pgtB mutants conferring constitutive expression of phosphoglycerate transporter pgtP independent of pgtC.
  Journal
J Bacteriol 177:4297-302 (1995)
DOI:10.1128/JB.177.15.4297-4302.1995
Reference
PMID:16882723
  Authors
Takai N, Nakajima M, Oyama T, Kito R, Sugita C, Sugita M, Kondo T, Iwasaki H
  Title
A KaiC-associating SasA-RpaA two-component regulatory system as a major circadian timing mediator in cyanobacteria.
  Journal
Proc Natl Acad Sci U S A 103:12109-14 (2006)
DOI:10.1073/pnas.0602955103
Reference
PMID:11803016
  Authors
Janausch IG, Zientz E, Tran QH, Kroger A, Unden G
  Title
C4-dicarboxylate carriers and sensors in bacteria.
  Journal
Biochim Biophys Acta 1553:39-56 (2002)
DOI:10.1016/S0005-2728(01)00233-X
Reference
PMID:18725229
  Authors
Zhou YF, Nan B, Nan J, Ma Q, Panjikar S, Liang YH, Wang Y, Su XD
  Title
C4-dicarboxylates sensing mechanism revealed by the crystal structures of DctB sensor domain.
  Journal
J Mol Biol 383:49-61 (2008)
DOI:10.1016/j.jmb.2008.08.010
Reference
PMID:14523104
  Authors
Novick RP, Jiang D
  Title
The staphylococcal saeRS system coordinates environmental signals with agr quorum sensing.
  Journal
Microbiology 149:2709-17 (2003)
DOI:10.1099/mic.0.26575-0
Reference
PMID:17981963
  Authors
Leech AJ, Sprinkle A, Wood L, Wozniak DJ, Ohman DE
  Title
The NtrC family regulator AlgB, which controls alginate biosynthesis in mucoid Pseudomonas aeruginosa, binds directly to the algD promoter.
  Journal
J Bacteriol 190:581-9 (2008)
DOI:10.1128/JB.01307-07
Reference
PMID:18455986
  Authors
Paul R, Jaeger T, Abel S, Wiederkehr I, Folcher M, Biondi EG, Laub MT, Jenal U
  Title
Allosteric regulation of histidine kinases by their cognate response regulator determines cell fate.
  Journal
Cell 133:452-61 (2008)
DOI:10.1016/j.cell.2008.02.045
Reference
PMID:15101991
  Authors
Whitchurch CB, Leech AJ, Young MD, Kennedy D, Sargent JL, Bertrand JJ, Semmler AB, Mellick AS, Martin PR, Alm RA, Hobbs M, Beatson SA, Huang B, Nguyen L, Commolli JC, Engel JN, Darzins A, Mattick JS.
  Title
Characterization of a complex chemosensory signal transduction system which controls twitching motility in Pseudomonas aeruginosa.
  Journal
Mol Microbiol 52:873-93 (2004)
DOI:10.1111/j.1365-2958.2004.04026.x
Reference
PMID:15170479
  Authors
Yoshihara S, Ikeuchi M.
  Title
Phototactic motility in the unicellular cyanobacterium Synechocystis sp. PCC 6803.
  Journal
Photochem Photobiol Sci 3:512-8 (2004)
DOI:10.1039/b402320j
Reference
PMID:12039966
  Authors
Ogawa T, Bao DH, Katoh H, Shibata M, Pakrasi HB, Bhattacharyya-Pakrasi M
  Title
A two-component signal transduction pathway regulates manganese homeostasis in Synechocystis 6803, a photosynthetic organism.
  Journal
J Biol Chem 277:28981-6 (2002)
DOI:10.1074/jbc.M204175200
Reference
PMID:12417709
  Authors
Yamaguchi K, Suzuki I, Yamamoto H, Lyukevich A, Bodrova I, Los DA, Piven I, Zinchenko V, Kanehisa M, Murata N
  Title
A two-component Mn2+-sensing system negatively regulates expression of the mntCAB operon in Synechocystis.
  Journal
Plant Cell 14:2901-13 (2002)
DOI:10.1105/tpc.006262
Reference
PMID:15273097
  Authors
Mascher T, Zimmer SL, Smith TA, Helmann JD
  Title
Antibiotic-inducible promoter regulated by the cell envelope stress-sensing two-component system LiaRS of Bacillus subtilis.
  Journal
Antimicrob Agents Chemother 48:2888-96 (2004)
DOI:10.1128/AAC.48.8.2888-2896.2004
Reference
PMID:15856219
  Authors
Hyyrylainen HL, Sarvas M, Kontinen VP
  Title
Transcriptome analysis of the secretion stress response of Bacillus subtilis.
  Journal
Appl Microbiol Biotechnol 67:389-96 (2005)
DOI:10.1007/s00253-005-1898-1
Reference
PMID:15941986
  Authors
Serizawa M, Sekiguchi J
  Title
The Bacillus subtilis YdfHI two-component system regulates the transcription of ydfJ, a member of the RND superfamily.
  Journal
Microbiology 151:1769-78 (2005)
DOI:10.1099/mic.0.27619-0
Reference
PMID:12890034
  Authors
Ohki R, Giyanto, Tateno K, Masuyama W, Moriya S, Kobayashi K, Ogasawara N
  Title
The BceRS two-component regulatory system induces expression of the bacitracin transporter, BceAB, in Bacillus subtilis.
  Journal
Mol Microbiol 49:1135-44 (2003)
DOI:10.1046/j.1365-2958.2003.03653.x
Reference
PMID:17322186
  Authors
Ogura M, Tsukahara K, Hayashi K, Tanaka T
  Title
The Bacillus subtilis NatK-NatR two-component system regulates expression of the natAB operon encoding an ABC transporter for sodium ion extrusion.
  Journal
Microbiology 153:667-75 (2007)
DOI:10.1099/mic.0.2006/003673-0
Reference
PMID:10972810
  Authors
Yamamoto H, Murata M, Sekiguchi J
  Title
The CitST two-component system regulates the expression of the Mg-citrate transporter in Bacillus subtilis.
  Journal
Mol Microbiol 37:898-912 (2000)
DOI:10.1046/j.1365-2958.2000.02055.x
Reference
PMID:15995196
  Authors
Satomura T, Shimura D, Asai K, Sadaie Y, Hirooka K, Fujita Y
  Title
Enhancement of glutamine utilization in Bacillus subtilis through the GlnK-GlnL two-component regulatory system.
  Journal
J Bacteriol 187:4813-21 (2005)
DOI:10.1128/JB.187.14.4813-4821.2005
Reference
PMID:12949160
  Authors
Doan T, Servant P, Tojo S, Yamaguchi H, Lerondel G, Yoshida K, Fujita Y, Aymerich S
  Title
The Bacillus subtilis ywkA gene encodes a malic enzyme and its transcription is activated by the YufL/YufM two-component system in response to malate.
  Journal
Microbiology 149:2331-43 (2003)
DOI:10.1099/mic.0.26256-0
Reference
PMID:12949159
  Authors
Tanaka K, Kobayashi K, Ogasawara N
  Title
The Bacillus subtilis YufLM two-component system regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium.
  Journal
Microbiology 149:2317-29 (2003)
DOI:10.1099/mic.0.26257-0
Reference
PMID:10708364
  Authors
Asai K, Baik SH, Kasahara Y, Moriya S, Ogasawara N
  Title
Regulation of the transport system for C4-dicarboxylic acids in Bacillus subtilis.
  Journal
Microbiology 146 ( Pt 2):263-71 (2000)
DOI:10.1099/00221287-146-2-263
Reference
PMID:8455557
  Authors
Hamblin MJ, Shaw JG, Kelly DJ
  Title
Sequence analysis and interposon mutagenesis of a sensor-kinase (DctS) and response-regulator (DctR) controlling synthesis of the high-affinity C4-dicarboxylate transport system in Rhodobacter capsulatus.
  Journal
Mol Gen Genet 237:215-24 (1993)
DOI:10.1007/BF00282803
Reference
PMID:9287004
  Authors
Forward JA, Behrendt MC, Wyborn NR, Cross R, Kelly DJ
  Title
TRAP transporters: a new family of periplasmic solute transport systems encoded by the dctPQM genes of Rhodobacter capsulatus and by homologs in diverse gram-negative bacteria.
  Journal
J Bacteriol 179:5482-93 (1997)
DOI:10.1128/JB.179.17.5482-5493.1997
Reference
PMID:16820295
  Authors
Martin B, Quentin Y, Fichant G, Claverys JP
  Title
Independent evolution of competence regulatory cascades in streptococci?
  Journal
Trends Microbiol 14:339-45 (2006)
DOI:10.1016/j.tim.2006.06.007
Reference
PMID:10231485
  Authors
Hensel M, Hinsley AP, Nikolaus T, Sawers G, Berks BC
  Title
The genetic basis of tetrathionate respiration in Salmonella typhimurium.
  Journal
Mol Microbiol 32:275-87 (1999)
DOI:10.1046/j.1365-2958.1999.01345.x
Reference
PMID:18028314
  Authors
Guvener ZT, Harwood CS
  Title
Subcellular location characteristics of the Pseudomonas aeruginosa GGDEF protein, WspR, indicate that it produces cyclic-di-GMP in response to growth on surfaces.
  Journal
Mol Microbiol 66:1459-73 (2007)
DOI:10.1111/j.1365-2958.2007.06008.x
Reference
PMID:17339222
  Authors
Bantinaki E, Kassen R, Knight CG, Robinson Z, Spiers AJ, Rainey PB
  Title
Adaptive divergence in experimental populations of Pseudomonas fluorescens. III. Mutational origins of wrinkly spreader diversity.
  Journal
Genetics 176:441-53 (2007)
DOI:10.1534/genetics.106.069906
Reference
PMID:11069677
  Authors
Jiang M, Shao W, Perego M, Hoch JA
  Title
Multiple histidine kinases regulate entry into stationary phase and sporulation in Bacillus subtilis.
  Journal
Mol Microbiol 38:535-42 (2000)
DOI:10.1046/j.1365-2958.2000.02148.x
Reference
PMID:19781638
  Authors
Jenal U
  Title
The role of proteolysis in the Caulobacter crescentus cell cycle and development.
  Journal
Res Microbiol 160:687-95 (2009)
DOI:10.1016/j.resmic.2009.09.006
Reference
PMID:19246239
  Authors
Jenal U, Galperin MY
  Title
Single domain response regulators: molecular switches with emerging roles in cell organization and dynamics.
  Journal
Curr Opin Microbiol 12:152-60 (2009)
DOI:10.1016/j.mib.2009.01.010
Reference
PMID:16640581
  Authors
Drepper T, Wiethaus J, Giaourakis D, Gross S, Schubert B, Vogt M, Wiencek Y, McEwan AG, Masepohl B
  Title
Cross-talk towards the response regulator NtrC controlling nitrogen metabolism in Rhodobacter capsulatus.
  Journal
FEMS Microbiol Lett 258:250-6 (2006)
DOI:10.1111/j.1574-6968.2006.00228.x
Reference
PMID:1661370
  Authors
Pawlowski K, Klosse U, de Bruijn FJ
  Title
Characterization of a novel Azorhizobium caulinodans ORS571 two-component regulatory system, NtrY/NtrX, involved in nitrogen fixation and metabolism.
  Journal
Mol Gen Genet 231:124-38 (1991)
DOI:10.1007/BF00293830
Reference
PMID:18422428
  Authors
Chatterjee S, Almeida RP, Lindow S
  Title
Living in two worlds: the plant and insect lifestyles of Xylella fastidiosa.
  Journal
Annu Rev Phytopathol 46:243-71 (2008)
DOI:10.1146/annurev.phyto.45.062806.094342
Reference
PMID:18506032
  Authors
Dow M
  Title
Diversification of the function of cell-to-cell signaling in regulation of virulence within plant pathogenic xanthomonads.
  Journal
Sci Signal 1:pe23 (2008)
DOI:10.1126/stke.121pe23
Reference
PMID:17902112
  Authors
Colnaghi Simionato AV, da Silva DS, Lambais MR, Carrilho E
  Title
Characterization of a putative Xylella fastidiosa diffusible signal factor by HRGC-EI-MS.
  Journal
J Mass Spectrom 42:1375-81 (2007)
DOI:10.1002/jms.1325
Reference
PMID:19203648
  Authors
Miller LD, Russell MH, Alexandre G
  Title
Diversity in bacterial chemotactic responses and niche adaptation.
  Journal
Adv Appl Microbiol 66:53-75 (2009)
DOI:10.1016/S0065-2164(08)00803-4
Reference
PMID:8760916
  Authors
Eder S, Shi L, Jensen K, Yamane K, Hulett FM
  Title
A Bacillus subtilis secreted phosphodiesterase/alkaline phosphatase is the product of a Pho regulon gene, phoD.
  Journal
Microbiology 142 ( Pt 8):2041-7 (1996)
DOI:10.1099/13500872-142-8-2041
Related
pathway
riu00190  Oxidative phosphorylation
riu00550  Peptidoglycan biosynthesis
riu00910  Nitrogen metabolism
riu02030  Bacterial chemotaxis
riu02040  Flagellar assembly
riu03070  Bacterial secretion system
KO pathway
ko02020   
LinkDB

DBGET integrated database retrieval system