KEGG   PATHWAY: sanh03008
Entry
sanh03008                   Pathway                                
Name
Ribosome biogenesis in eukaryotes - Sinocyclocheilus anshuiensis
Description
Ribosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It requires hundreds of factors not present in the mature particle. In the absence of these proteins, ribosome biogenesis is stalled and cell growth is terminated even under optimal growth conditions. The primary pre-rRNA transcript is assembled into the 90S pre-ribosome, which contains both 40S and 60S assembly factors. Within this complex, the pre-rRNA is cleaved. pre-60S ribosomes are subjected to several sequential processing steps in the nucleoplasm involving numerous assembly intermediates before it is exported to the cytoplasm and matured into the 60S ribosomal subunit. The pre-40S ribosome is matured to the small ribosomal subunit in the cytoplasm by cleavage.
Class
Genetic Information Processing; Translation
Pathway map
sanh03008  Ribosome biogenesis in eukaryotes
sanh03008

Organism
Sinocyclocheilus anshuiensis [GN:sanh]
Gene
107677476  casein kinase II subunit beta-like [KO:K03115]
107694362  casein kinase II subunit beta [KO:K03115]
107686841  casein kinase II subunit alpha' [KO:K03097] [EC:2.7.11.1]
107696034  casein kinase II subunit alpha-like [KO:K03097] [EC:2.7.11.1]
107704901  casein kinase II subunit alpha isoform X1 [KO:K03097] [EC:2.7.11.1]
107671775  casein kinase II subunit alpha-like [KO:K03097] [EC:2.7.11.1]
107674961  casein kinase II subunit alpha'-like [KO:K03097] [EC:2.7.11.1]
107663022  casein kinase II subunit alpha'-like [KO:K03097] [EC:2.7.11.1]
107693292  casein kinase II subunit alpha-like [KO:K03097] [EC:2.7.11.1]
107683644  casein kinase II subunit alpha-like isoform X1 [KO:K03097] [EC:2.7.11.1]
107670008  casein kinase II subunit alpha-like [KO:K03097] [EC:2.7.11.1]
107654166  casein kinase II subunit alpha'-like [KO:K03097] [EC:2.7.11.1]
107699715  nucleolar protein 6-like [KO:K14544]
107682412  ribosomal RNA-processing protein 7 homolog A-like [KO:K14545]
107670852  wdr43; WD repeat-containing protein 43 [KO:K14546]
107654884  WD repeat-containing protein 43-like [KO:K14546]
107684668  utp4; U3 small nucleolar RNA-associated protein 4 homolog isoform X1 [KO:K14548]
107670149  U3 small nucleolar RNA-associated protein 4 homolog [KO:K14548]
107662854  U3 small nucleolar RNA-associated protein 15 homolog [KO:K14549]
107686557  U3 small nucleolar RNA-associated protein 15 homolog [KO:K14549]
107684774  heatr1; HEAT repeat-containing protein 1 [KO:K14550]
107675669  HEAT repeat-containing protein 1-like [KO:K14550]
107660592  WD repeat-containing protein 75-like [KO:K14552]
107657531  WD repeat-containing protein 75-like [KO:K14552]
107703637  U3 small nucleolar RNA-associated protein 18 homolog isoform X1 [KO:K14553]
107676120  U3 small nucleolar RNA-associated protein 18 homolog isoform X1 [KO:K14553]
107691776  LOW QUALITY PROTEIN: WD repeat-containing protein 36-like [KO:K14554]
107684338  WD repeat-containing protein 36-like [KO:K14554]
107690018  tbl3; transducin beta-like protein 3 [KO:K14555]
107658238  WD repeat-containing protein 3-like [KO:K14556]
107668854  LOW QUALITY PROTEIN: WD repeat-containing protein 3-like [KO:K14556]
107698692  utp6; U3 small nucleolar RNA-associated protein 6 homolog [KO:K14557]
107669540  U3 small nucleolar RNA-associated protein 6 homolog [KO:K14557]
107700106  periodic tryptophan protein 2 homolog [KO:K14558]
107667659  periodic tryptophan protein 2 homolog [KO:K14558]
107700437  LOW QUALITY PROTEIN: U3 small nucleolar ribonucleoprotein protein MPP10-like [KO:K14559]
107670762  U3 small nucleolar ribonucleoprotein protein MPP10-like [KO:K14559]
107671714  U3 small nucleolar ribonucleoprotein protein IMP3-like [KO:K14560]
107681808  U3 small nucleolar ribonucleoprotein protein IMP3-like isoform X1 [KO:K14560]
107672800  U3 small nucleolar ribonucleoprotein protein IMP4-like [KO:K14561]
107673382  imp4; U3 small nucleolar ribonucleoprotein protein IMP4 [KO:K14561]
107666874  rRNA 2'-O-methyltransferase fibrillarin-like isoform X1 [KO:K14563] [EC:2.1.1.-]
107686016  rRNA 2'-O-methyltransferase fibrillarin-like [KO:K14563] [EC:2.1.1.-]
107665238  nucleolar protein 56-like isoform X1 [KO:K14564]
107661748  nucleolar protein 56-like isoform X1 [KO:K14564]
107677590  nucleolar protein 58-like [KO:K14565]
107660025  nucleolar protein 58-like isoform X1 [KO:K14565]
107675984  NHP2-like protein 1 [KO:K12845]
107695558  NHP2-like protein 1 [KO:K12845]
107684777  NHP2-like protein 1 [KO:K12845]
107661706  H/ACA ribonucleoprotein complex subunit 4-like isoform X1 [KO:K11131] [EC:5.4.99.-]
107703090  H/ACA ribonucleoprotein complex subunit 4-like [KO:K11131] [EC:5.4.99.-]
107673822  H/ACA ribonucleoprotein complex subunit 2-like protein [KO:K11129]
107684699  H/ACA ribonucleoprotein complex subunit 2-like protein [KO:K11129]
107680945  H/ACA ribonucleoprotein complex subunit 1 [KO:K11128]
107696299  H/ACA ribonucleoprotein complex subunit 1-like isoform X1 [KO:K11128]
107704360  rRNA-processing protein FCF1 homolog [KO:K14566]
107672355  rRNA-processing protein FCF1 homolog [KO:K14566]
107662081  LOW QUALITY PROTEIN: U3 small nucleolar RNA-associated protein 14 homolog A-like [KO:K14567]
107702944  U3 small nucleolar RNA-associated protein 14 homolog A-like isoform X1 [KO:K14567]
107674881  ribonuclease 3-like [KO:K03685] [EC:3.1.26.3]
107653254  drosha; ribonuclease 3 [KO:K03685] [EC:3.1.26.3]
107699927  ribosomal RNA small subunit methyltransferase NEP1-like [KO:K14568] [EC:2.1.1.260]
107685516  ribosomal RNA small subunit methyltransferase NEP1-like [KO:K14568] [EC:2.1.1.260]
107675025  ribosome biogenesis protein BMS1 homolog [KO:K14569]
107689949  ribosome biogenesis protein BMS1 homolog [KO:K14569]
107657627  RNA cytidine acetyltransferase-like isoform X1 [KO:K14521] [EC:2.3.1.-]
107656848  RNA cytidine acetyltransferase-like [KO:K14521] [EC:2.3.1.-]
107701854  RNA 3'-terminal phosphate cyclase-like protein [KO:K11108]
107655287  RNA 3'-terminal phosphate cyclase-like protein isoform X1 [KO:K11108]
107705025  ribonucleases P/MRP protein subunit POP1-like [KO:K01164] [EC:3.1.26.5]
107689877  ribonuclease P protein subunit p38-like [KO:K14523] [EC:3.1.26.5]
107698632  ribonuclease P protein subunit p29-like [KO:K03538] [EC:3.1.26.5]
107696626  ribonuclease P protein subunit p29-like [KO:K03538] [EC:3.1.26.5]
107657326  pop5; ribonuclease P/MRP protein subunit POP5 [KO:K03537] [EC:3.1.26.5]
107666877  ribonuclease P protein subunit p25-like protein [KO:K14525] [EC:3.1.26.5]
107676404  ribonuclease P protein subunit p25-like protein [KO:K14525] [EC:3.1.26.5]
107668321  ribonuclease P protein subunit p25-like protein [KO:K14525] [EC:3.1.26.5]
107665446  ribonuclease P protein subunit p25-like [KO:K14525] [EC:3.1.26.5]
107696231  ribonuclease P protein subunit p25-like protein [KO:K14525] [EC:3.1.26.5]
107678979  ribonuclease P protein subunit p25-like protein [KO:K14525] [EC:3.1.26.5]
107659735  ribonuclease P protein subunit p20-like [KO:K14527] [EC:3.1.26.5]
107664267  ribonuclease P protein subunit p20-like [KO:K14527] [EC:3.1.26.5]
107664285  ribonuclease P protein subunit p20-like [KO:K14527] [EC:3.1.26.5]
107669172  ribonuclease P protein subunit p30-like [KO:K03539] [EC:3.1.26.5]
107683719  ribonuclease P protein subunit p30-like isoform X1 [KO:K03539] [EC:3.1.26.5]
107688445  ribonuclease P protein subunit p40-like [KO:K14530] [EC:3.1.26.5]
107689405  ribonuclease P protein subunit p40-like [KO:K14530] [EC:3.1.26.5]
107695255  RNA exonuclease 1 homolog [KO:K14570] [EC:3.1.-.-]
107676931  rexo1; RNA exonuclease 1 homolog [KO:K14570] [EC:3.1.-.-]
107678317  putative RNA exonuclease NEF-sp [KO:K14570] [EC:3.1.-.-]
107684447  RNA exonuclease 1 homolog isoform X1 [KO:K14570] [EC:3.1.-.-]
107679530  rexo2; oligoribonuclease, mitochondrial [KO:K13288] [EC:3.1.-.-]
107688924  oligoribonuclease, mitochondrial-like [KO:K13288] [EC:3.1.-.-]
107677707  xrn1; 5'-3' exoribonuclease 1 [KO:K12618] [EC:3.1.13.-]
107700493  LOW QUALITY PROTEIN: 5'-3' exoribonuclease 1-like [KO:K12618] [EC:3.1.13.-]
107669450  5'-3' exoribonuclease 2-like [KO:K12619] [EC:3.1.13.-]
107704080  5'-3' exoribonuclease 2-like [KO:K12619] [EC:3.1.13.-]
107690210  nucleolar GTP-binding protein 1-like [KO:K06943]
107659538  nucleolar GTP-binding protein 1-like [KO:K06943]
107704956  nucleolar GTP-binding protein 2-like [KO:K14537]
107700739  LOW QUALITY PROTEIN: nucleolar GTP-binding protein 2-like [KO:K14537]
107680445  guanine nucleotide-binding protein-like 3 [KO:K14538]
107699353  gnl3; guanine nucleotide-binding protein-like 3 [KO:K14538]
107655048  guanine nucleotide-binding protein-like 3-like protein [KO:K14538]
107685674  guanine nucleotide-binding protein-like 3-like protein isoform X1 [KO:K14538]
107699138  nvl; nuclear valosin-containing protein-like isoform X1 [KO:K14571]
107683937  LOW QUALITY PROTEIN: midasin-like [KO:K14572]
107665348  midasin-like [KO:K14572]
107673146  RNA-binding protein 28-like [KO:K14573]
107672592  RNA-binding protein 28-like [KO:K14573]
107662904  nob1; RNA-binding protein NOB1 [KO:K11883]
107661941  ran; GTP-binding nuclear protein Ran [KO:K07936]
107682846  GTP-binding nuclear protein Ran-like [KO:K07936]
107689808  exportin-1-like isoform X1 [KO:K14290]
107670850  exportin-1 [KO:K14290]
107703835  exportin-1-like [KO:K14290]
107662587  60S ribosomal export protein NMD3-like [KO:K07562]
107703003  nmd3; 60S ribosomal export protein NMD3 [KO:K07562]
107669360  nuclear RNA export factor 1-like isoform X1 [KO:K14284]
107700021  nuclear RNA export factor 1-like isoform X1 [KO:K14284]
107698029  nuclear RNA export factor 1-like isoform X1 [KO:K14284]
107666598  NTF2-related export protein 2-like [KO:K14285]
107670178  NTF2-related export protein 2-like isoform X1 [KO:K14285]
107666083  eif6; eukaryotic translation initiation factor 6 [KO:K03264]
107703958  sbds; ribosome maturation protein SBDS [KO:K14574]
107662269  efl1; elongation factor-like GTPase 1 [KO:K14536] [EC:3.6.5.-]
107685997  large subunit GTPase 1 homolog [KO:K14539] [EC:3.6.1.-]
107677512  large subunit GTPase 1 homolog [KO:K14539] [EC:3.6.1.-]
107685959  large subunit GTPase 1 homolog [KO:K14539] [EC:3.6.1.-]
107694402  spata5; spermatogenesis-associated protein 5 [KO:K14575]
107672794  ak6; adenylate kinase isoenzyme 6 [KO:K18532] [EC:2.7.4.3]
107673357  adenylate kinase isoenzyme 6-like [KO:K18532] [EC:2.7.4.3]
107688531  LOW QUALITY PROTEIN: serine/threonine-protein kinase RIO1-like [KO:K07178] [EC:2.7.11.1]
107689403  serine/threonine-protein kinase RIO1-like [KO:K07178] [EC:2.7.11.1]
107676637  serine/threonine-protein kinase RIO2-like [KO:K07179] [EC:2.7.11.1]
107681048  serine/threonine-protein kinase RIO2-like [KO:K07179] [EC:2.7.11.1]
Reference
PMID:20174677
  Authors
Freed EF, Bleichert F, Dutca LM, Baserga SJ
  Title
When ribosomes go bad: diseases of ribosome biogenesis.
  Journal
Mol Biosyst 6:481-93 (2010)
DOI:10.1039/b919670f
Reference
PMID:17515605
  Authors
Perez-Fernandez J, Roman A, De Las Rivas J, Bustelo XR, Dosil M
  Title
The 90S preribosome is a multimodular structure that is assembled through a hierarchical mechanism.
  Journal
Mol Cell Biol 27:5414-29 (2007)
DOI:10.1128/MCB.00380-07
Reference
PMID:19850913
  Authors
Strunk BS, Karbstein K
  Title
Powering through ribosome assembly.
  Journal
RNA 15:2083-104 (2009)
DOI:10.1261/rna.1792109
Reference
PMID:15120992
  Authors
Granneman S, Baserga SJ
  Title
Ribosome biogenesis: of knobs and RNA processing.
  Journal
Exp Cell Res 296:43-50 (2004)
DOI:10.1016/j.yexcr.2004.03.016
Reference
PMID:19879902
  Authors
Kressler D, Hurt E, Bassler J
  Title
Driving ribosome assembly.
  Journal
Biochim Biophys Acta 1803:673-83 (2010)
DOI:10.1016/j.bbamcr.2009.10.009
Related
pathway
sanh03010  Ribosome
KO pathway
ko03008   
LinkDB

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