PATHWAY: ko03008 Help
Entry Name Ribosome biogenesis in eukaryotes
Description Ribosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It requires hundreds of factors not present in the mature particle. In the absence of these proteins, ribosome biogenesis is stalled and cell growth is terminated even under optimal growth conditions. The primary pre-rRNA transcript is assembled into the 90S pre-ribosome, which contains both 40S and 60S assembly factors. Within this complex, the pre-rRNA is cleaved. pre-60S ribosomes are subjected to several sequential processing steps in the nucleoplasm involving numerous assembly intermediates before it is exported to the cytoplasm and matured into the 60S ribosomal subunit. The pre-40S ribosome is matured to the small ribosomal subunit in the cytoplasm by cleavage.
Class Genetic Information Processing; TranslationBRITE hierarchy
Pathway map ko03008 Ribosome biogenesis in eukaryotes
Orthology K01979 SSUrRNA; small subunit 18S ribosomal RNA
K01981 LSU5S; large subunit 5S ribosomal RNA
K01982 LSUrRNA; large subunit 28S/25S ribosomal RNA
K01986 LSU5.8S; large subunit 5.8S ribosomal RNA
K03115 CSNK2B; casein kinase II subunit beta
K03264 EIF6; translation initiation factor 6
K03539 RPP1, RPP30; ribonuclease P/MRP protein subunit RPP1 [EC:3.1.26.5 ]
K06943 NOG1; nucleolar GTP-binding protein
K07562 NMD3; 60S ribosomal export protein NMD3
K07936 RAN; GTP-binding nuclear protein Ran
K11108 RCL1; RNA 3'-terminal phosphate cyclase-like protein
K11128 GAR1, NOLA1; H/ACA ribonucleoprotein complex subunit 1
K11129 NHP2, NOLA2; H/ACA ribonucleoprotein complex subunit 2
K11130 NOP10, NOLA3; H/ACA ribonucleoprotein complex subunit 3
K11131 DKC1, NOLA4, CBF5; H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]
K11883 NOB1; RNA-binding protein NOB1
K12618 XRN1, SEP1, KEM1; 5'-3' exoribonuclease 1 [EC:3.1.13.-]
K12619 XRN2, RAT1; 5'-3' exoribonuclease 2 [EC:3.1.13.-]
K12845 SNU13, NHP2L; U4/U6 small nuclear ribonucleoprotein SNU13
K13288 orn, REX2, REXO2; oligoribonuclease [EC:3.1.-.-]
K14284 NXF, TAP, MEX67; nuclear RNA export factor
K14285 NXT1_2, P15; NTF2-related export protein 1/2
K14483 SNORD3, U3, SNR17; small nucleolar RNA SNORD3
K14521 NAT10, KRE33; N-acetyltransferase 10 [EC:2.3.1.-]
K14526 POP7, RPP2; ribonuclease P/MRP protein subunit POP7 [EC:3.1.26.5 ]
K14527 RPP20, POP7; ribonuclease P/MRP protein subunit RPP20 [EC:3.1.26.5 ]
K14531 SNM1; ribonuclease MRP protein subunit SNM1
K14532 RMP1; ribonuclease MRP protein subunit RMP1
K14536 RIA1; ribosome assembly protein 1 [EC:3.6.5.-]
K14537 NUG2, GNL2; nuclear GTP-binding protein
K14538 NUG1, GNL3; nuclear GTP-binding protein
K14539 LSG1; large subunit GTPase 1 [EC:3.6.1.-]
K14543 MTR2; mRNA transport regulator MTR2
K14544 UTP22, NOL6; U3 small nucleolar RNA-associated protein 22
K14545 RRP7; ribosomal RNA-processing protein 7
K14546 UTP5, WDR43; U3 small nucleolar RNA-associated protein 5
K14547 UTP8; U3 small nucleolar RNA-associated protein 8
K14548 UTP4, CIRH1A; U3 small nucleolar RNA-associated protein 4
K14549 UTP15; U3 small nucleolar RNA-associated protein 15
K14550 UTP10, HEATR1; U3 small nucleolar RNA-associated protein 10
K14551 UTP9; U3 small nucleolar RNA-associated protein 9
K14552 NAN1, UTP17, WDR75; NET1-associated nuclear protein 1 (U3 small nucleolar RNA-associated protein 17)
K14553 UTP18; U3 small nucleolar RNA-associated protein 18
K14554 UTP21, WDR36; U3 small nucleolar RNA-associated protein 21
K14555 UTP13, TBL3; U3 small nucleolar RNA-associated protein 13
K14556 DIP2, UTP12, WDR3; U3 small nucleolar RNA-associated protein 12
K14557 UTP6; U3 small nucleolar RNA-associated protein 6
K14558 PWP2, UTP1; periodic tryptophan protein 2
K14559 MPP10; U3 small nucleolar RNA-associated protein MPP10
K14560 IMP3; U3 small nucleolar ribonucleoprotein protein IMP3
K14561 IMP4; U3 small nucleolar ribonucleoprotein protein IMP4
K14562 TCOF1; Treacher Collins syndrome protein
K14563 NOP1, FBL; rRNA 2'-O-methyltransferase fibrillarin [EC:2.1.1.-]
K14564 NOP56; nucleolar protein 56
K14565 NOP58; nucleolar protein 58
K14566 UTP24, FCF1; U3 small nucleolar RNA-associated protein 24
K14567 UTP14; U3 small nucleolar RNA-associated protein 14
K14568 EMG1, NEP1; rRNA small subunit pseudouridine methyltransferase Nep1 [EC:2.1.1.260 ]
K14569 BMS1; ribosome biogenesis protein BMS1
K14570 REX1, REXO1, REXO5, RNH70; RNA exonuclease [EC:3.1.-.-]
K14571 RIX7, NVL; ribosome biogenesis ATPase
K14573 NOP4, RBM28; nucleolar protein 4
K14574 SDO1, SBDS; ribosome maturation protein SDO1
K14575 AFG2, DRG1, SPATA5; AAA family ATPase
K14576 RMRP; small nucleolar RNA MRP
K26477 NME1; small nucleolar RNA MRP
Reference Authors Freed EF, Bleichert F, Dutca LM, Baserga SJ
Title When ribosomes go bad: diseases of ribosome biogenesis.
Journal Reference Authors Perez-Fernandez J, Roman A, De Las Rivas J, Bustelo XR, Dosil M
Title The 90S preribosome is a multimodular structure that is assembled through a hierarchical mechanism.
Journal Reference Authors Strunk BS, Karbstein K
Title Powering through ribosome assembly.
Journal Reference Authors Granneman S, Baserga SJ
Title Ribosome biogenesis: of knobs and RNA processing.
Journal Reference Authors Kressler D, Hurt E, Bassler J
Title Driving ribosome assembly.
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