KEGG   PATHWAY: sbq04721
Entry
sbq04721                    Pathway                                
Name
Synaptic vesicle cycle - Saimiri boliviensis boliviensis (Bolivian squirrel monkey)
Description
Communication between neurons is mediated by the release of neurotransmitter from synaptic vesicles (SVs). At the nerve terminal, SVs cycle through repetitive episodes of exocytosis and endocytosis. SVs are filled with neurotransmitters by active transport. The loaded SVs are then docked at a specialized region of the presynaptic plasma membrane known as the active zone, where they undergo a priming reaction. Upon arrival of an action potential, Ca2+ enters through voltage-gated channels and neurotransmitter is released by exocytosis, usually in less than a millisecond. After fusion, the vesicle is retrieved by endocytosis and reloaded for another round of exocytosis.
Class
Organismal Systems; Nervous system
Pathway map
sbq04721  Synaptic vesicle cycle
sbq04721

Other DBs
GO: 0016079 0048488
Organism
Saimiri boliviensis boliviensis (Bolivian squirrel monkey) [GN:sbq]
Gene
101031715  SLC32A1; vesicular inhibitory amino acid transporter [KO:K15015]
101044005  SLC18A2; synaptic vesicular amine transporter [KO:K08155]
101050367  SLC18A1; chromaffin granule amine transporter isoform X1 [KO:K08155]
101043767  SLC18A3; vesicular acetylcholine transporter [KO:K14636]
101029577  SLC17A8; vesicular glutamate transporter 3 isoform X1 [KO:K12302]
101031504  SLC17A6; vesicular glutamate transporter 2 [KO:K12302]
101053804  SLC17A7; vesicular glutamate transporter 1 [KO:K12302]
101033588  SYT1; synaptotagmin-1 isoform X1 [KO:K15290]
101050658  VAMP2; vesicle-associated membrane protein 2 isoform X2 [KO:K13504]
101036830  RAB3A; ras-related protein Rab-3A [KO:K07882]
101054154  RIMS1; regulating synaptic membrane exocytosis protein 1 isoform X25 [KO:K15291]
101030442  STX1A; syntaxin-1A [KO:K04560]
101042279  STX1B; syntaxin-1B [KO:K08486]
101038783  STX3; syntaxin-3 isoform X3 [KO:K08486]
101031721  STX2; syntaxin-2 isoform X1 [KO:K08486]
101039345  STXBP1; syntaxin-binding protein 1 [KO:K15292]
101051957  UNC13C; protein unc-13 homolog C [KO:K15293]
101031450  UNC13A; protein unc-13 homolog A isoform X1 [KO:K15293]
101044601  UNC13B; protein unc-13 homolog B [KO:K15293]
101044415  SNAP25; synaptosomal-associated protein 25 [KO:K18211]
101043462  CPLX1; complexin-1 [KO:K15294]
101034250  CPLX2; complexin-2 [KO:K15294]
101046293  CPLX4; complexin-4 [KO:K15295]
101037053  CPLX3; complexin-3 [KO:K15295]
101046396  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A [KO:K04344]
101049976  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
101047038  NSF; vesicle-fusing ATPase [KO:K06027] [EC:3.6.4.6]
101036925  NAPA; alpha-soluble NSF attachment protein [KO:K15296]
101038089  DNM1; dynamin-1 isoform X1 [KO:K01528] [EC:3.6.5.5]
101038308  DNM3; dynamin-3 isoform X2 [KO:K01528] [EC:3.6.5.5]
101039773  DNM2; dynamin-2 isoform X1 [KO:K23484] [EC:3.6.5.5]
101048519  clathrin light chain A-like [KO:K04644]
101044263  CLTA; clathrin light chain A isoform X4 [KO:K04644]
101036111  LOW QUALITY PROTEIN: uncharacterized protein LOC101036111 [KO:K04644]
101032662  CLTB; clathrin light chain B [KO:K04645]
101039277  CLTC; clathrin heavy chain 1 isoform X2 [KO:K04646]
101054474  CLTCL1; clathrin heavy chain 2 isoform X1 [KO:K04646]
101044143  AP2A1; AP-2 complex subunit alpha-1 isoform X1 [KO:K11824]
101032070  AP2A2; AP-2 complex subunit alpha-2 [KO:K11824]
101050435  AP2B1; AP-2 complex subunit beta isoform X1 [KO:K11825]
101045037  AP2M1; AP-2 complex subunit mu [KO:K11826]
101032271  AP2S1; AP-2 complex subunit sigma [KO:K11827]
101041261  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
101051309  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
101043270  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
101042857  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
101046103  ATP6V1C2; V-type proton ATPase subunit C 2 isoform X1 [KO:K02148]
101033128  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
101050200  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
101052229  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
101044983  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
101048930  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
101035408  ATP6V1G3; LOW QUALITY PROTEIN: V-type proton ATPase subunit G 3 [KO:K02152]
101032939  ATP6V1G2; V-type proton ATPase subunit G 2 [KO:K02152]
101029359  ATP6V0E2; V-type proton ATPase subunit e 2 [KO:K02153]
101042407  ATP6V0E1; V-type proton ATPase subunit e 1 [KO:K02153]
101053813  TCIRG1; V-type proton ATPase 116 kDa subunit a isoform 3 isoform X1 [KO:K02154]
101037096  ATP6V0A2; LOW QUALITY PROTEIN: V-type proton ATPase 116 kDa subunit a isoform 2 [KO:K02154]
101049040  ATP6V0A1; V-type proton ATPase 116 kDa subunit a isoform 1 [KO:K02154]
101045262  ATP6V0A4; V-type proton ATPase 116 kDa subunit a isoform 4 isoform X1 [KO:K02154]
101028542  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
101053174  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
101047328  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
101047790  LOW QUALITY PROTEIN: V-type proton ATPase 16 kDa proteolipid subunit-like [KO:K02155]
101030201  LOW QUALITY PROTEIN: V-type proton ATPase 16 kDa proteolipid subunit-like [KO:K02155]
101053104  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit [KO:K02155]
101039958  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit [KO:K03661]
101031662  SLC6A1; sodium- and chloride-dependent GABA transporter 1 isoform X1 [KO:K05034]
101043156  SLC6A2; sodium-dependent noradrenaline transporter isoform X2 [KO:K05035]
101032424  SLC6A3; sodium-dependent dopamine transporter [KO:K05036]
101034538  SLC6A4; sodium-dependent serotonin transporter [KO:K05037]
101038382  SLC6A9; sodium- and chloride-dependent glycine transporter 1 isoform X2 [KO:K05038]
101029603  SLC6A5; LOW QUALITY PROTEIN: sodium- and chloride-dependent glycine transporter 2 [KO:K05038]
101041135  SLC6A7; sodium-dependent proline transporter isoform X1 [KO:K05040]
101051062  SLC6A11; sodium- and chloride-dependent GABA transporter 3 [KO:K05044]
101053237  SLC6A12; sodium- and chloride-dependent betaine transporter [KO:K05045]
101032222  SLC6A13; sodium- and chloride-dependent GABA transporter 2 isoform X1 [KO:K05046]
101054091  SLC1A1; excitatory amino acid transporter 3 [KO:K05612]
101029496  SLC1A2; excitatory amino acid transporter 2 isoform X1 [KO:K05613]
101039681  SLC1A3; excitatory amino acid transporter 1 [KO:K05614]
101032059  SLC1A6; excitatory amino acid transporter 4 isoform X1 [KO:K05617]
101034461  SLC1A7; LOW QUALITY PROTEIN: excitatory amino acid transporter 5 [KO:K05618]
Compound
C00002  ATP
C00025  L-Glutamate
C00037  Glycine
C00076  Calcium cation
C00080  H+
C00334  4-Aminobutanoate
C00388  Histamine
C00547  L-Noradrenaline
C00780  Serotonin
C01996  Acetylcholine
C03758  Dopamine
C16041  Leu-enkephalin
Reference
PMID:12827282
  Authors
Li L, Chin LS
  Title
The molecular machinery of synaptic vesicle exocytosis.
  Journal
Cell Mol Life Sci 60:942-60 (2003)
DOI:10.1007/s00018-003-2240-7
Reference
  Authors
Nestler EJ, Hyman SE, Malenka RC.
  Title
Molecular neuropharmacology: A foundation for clinical neuroscience
  Journal
The McGraw-Hill Companies, Inc. (2001)
Reference
PMID:18275379
  Authors
Chapman ER
  Title
How does synaptotagmin trigger neurotransmitter release?
  Journal
Annu Rev Biochem 77:615-41 (2008)
DOI:10.1146/annurev.biochem.77.062005.101135
Reference
PMID:10212473
  Authors
Benfenati F, Onofri F, Giovedi S
  Title
Protein-protein interactions and protein modules in the control of neurotransmitter release.
  Journal
Philos Trans R Soc Lond B Biol Sci 354:243-57 (1999)
DOI:10.1098/rstb.1999.0376
Reference
PMID:20634814
  Authors
de Saint Basile G, Menasche G, Fischer A
  Title
Molecular mechanisms of biogenesis and exocytosis of cytotoxic granules.
  Journal
Nat Rev Immunol 10:568-79 (2010)
DOI:10.1038/nri2803
Reference
PMID:17767192
  Authors
Carr CM, Munson M
  Title
Tag team action at the synapse.
  Journal
EMBO Rep 8:834-8 (2007)
DOI:10.1038/sj.embor.7401051
Reference
PMID:15217342
  Authors
Sudhof TC
  Title
The synaptic vesicle cycle.
  Journal
Annu Rev Neurosci 27:509-47 (2004)
DOI:10.1146/annurev.neuro.26.041002.131412
Reference
PMID:12563290
  Authors
Gundelfinger ED, Kessels MM, Qualmann B
  Title
Temporal and spatial coordination of exocytosis and endocytosis.
  Journal
Nat Rev Mol Cell Biol 4:127-39 (2003)
DOI:10.1038/nrm1016
Reference
PMID:16990140
  Authors
Tang J, Maximov A, Shin OH, Dai H, Rizo J, Sudhof TC
  Title
A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis.
  Journal
Cell 126:1175-87 (2006)
DOI:10.1016/j.cell.2006.08.030
Reference
PMID:12094216
  Authors
Chapman ER
  Title
Synaptotagmin: a Ca(2+) sensor that triggers exocytosis?
  Journal
Nat Rev Mol Cell Biol 3:498-508 (2002)
DOI:10.1038/nrm855
Reference
PMID:7791897
  Authors
Sudhof TC
  Title
The synaptic vesicle cycle: a cascade of protein-protein interactions.
  Journal
Nature 375:645-53 (1995)
DOI:10.1038/375645a0
Reference
PMID:12154365
  Authors
Rizo J, Sudhof TC
  Title
Snares and Munc18 in synaptic vesicle fusion.
  Journal
Nat Rev Neurosci 3:641-53 (2002)
DOI:10.1038/nrn898
Reference
PMID:18726177
  Authors
Malsam J, Kreye S, Sollner TH
  Title
Membrane fusion: SNAREs and regulation.
  Journal
Cell Mol Life Sci 65:2814-32 (2008)
DOI:10.1007/s00018-008-8352-3
Related
pathway
sbq04144  Endocytosis
sbq04724  Glutamatergic synapse
sbq04725  Cholinergic synapse
sbq04726  Serotonergic synapse
sbq04727  GABAergic synapse
sbq04728  Dopaminergic synapse
KO pathway
ko04721   
LinkDB

DBGET integrated database retrieval system