KEGG   PATHWAY: sed03070
Entry
sed03070                    Pathway                                
Name
Bacterial secretion system - Salmonella enterica subsp. enterica serovar Dublin
Description
Gram-negative bacteria secrete a wide range of proteins whose functions include biogenesis of organelles, such as pilli and flagella, nutrient acquisition, virulence, and efflux of drugs and other toxins. Six distinct secretion systems have been shown to mediate protein export through the inner and outer membranes of Gram-negative bacteria. These pathways are highly conserved throughout the Gram-negative bacterial species. In Gram-positive bacteria, secreted proteins are commonly translocated across the single membrane by the Sec pathway or the two-arginine (Tat) pathway.
Class
Environmental Information Processing; Membrane transport
Pathway map
sed03070  Bacterial secretion system
sed03070

Other DBs
GO: 0030253 0015628 0030254 0030255 0046819 0033103 0044098 0043952 0043953
Organism
Salmonella enterica subsp. enterica serovar Dublin [GN:sed]
Gene
SeD_A3539  outer membrane protein TolC [KO:K12340]
SeD_A1937  eprI; type III secretion apparatus needle protein [KO:K03221]
SeD_A3183  eprI; type III secretion apparatus needle protein [KO:K03221]
SeD_A1948  type III secretion outer membrane pore, YscC/HrcC family [KO:K03219]
SeD_A1934  type III secretion apparatus lipoprotein, YscJ/HrcJ family [KO:K03222]
SeD_A1924  epaP; type III secretion apparatus protein, YscR/HrcR family [KO:K03226]
SeD_A1923  secretion system apparatus protein SsaS [KO:K03227]
SeD_A1922  epaR; type III secretion apparatus protein SpaR/YscT/HrcT [KO:K03228]
SeD_A1921  secretion system apparatus protein SsaU [KO:K03229]
SeD_A1929  secretion system apparatus protein SsaV [KO:K03230]
SeD_A3206  invasion protein InvA [KO:K03230]
SeD_A1928  flagellum-specific ATP synthase [KO:K03224] [EC:7.4.2.8]
SeD_A1925  epaO; type III secretion apparatus protein, YscQ/HrcQ family [KO:K03225]
SeD_A3201  epaO; type III secretion apparatus protein, YscQ/HrcQ family [KO:K03225]
SeD_A0447  secD; protein-export membrane protein SecD [KO:K03072]
SeD_A0448  secF; protein-export membrane protein SecF [KO:K03074]
SeD_A4553  secE; preprotein translocase subunit secE [KO:K03073]
SeD_A3650  secG; preprotein translocase, SecG subunit [KO:K03075]
SeD_A3787  secY; preprotein translocase, SecY subunit [KO:K03076]
SeD_A0446  yajC; preprotein translocase, YajC subunit [KO:K03210]
SeD_A4233  inner membrane protein OxaA [KO:K03217]
SeD_A0145  secA; preprotein translocase, SecA subunit [KO:K03070] [EC:7.4.2.8]
SeD_A3942  cell division protein FtsY [KO:K03110]
SeD_A4087  secB; protein-export chaperone SecB [KO:K03071]
SeD_A3005  ffh; signal recognition particle protein [KO:K03106] [EC:3.6.5.4]
SeD_A4360  Sec-independent protein translocase protein TatA [KO:K03116]
SeD_A4361  Sec-independent protein translocase protein TatB [KO:K03117]
SeD_A4362  tatC; twin arginine-targeting protein translocase TatC [KO:K03118]
SeD_A0733  twin arginine-targeting protein translocase, TatA/E family [KO:K03425]
SeD_B0104  pilx1 protein [KO:K03194]
SeD_B0101  pilx5 protein [KO:K03200]
SeD_B0096  pilx9 protein [KO:K03204]
SeD_B0099  pilx6 protein [KO:K03201]
SeD_B0097  pilx8 protein [KO:K03203]
SeD_B0095  pilx10 protein [KO:K03195]
SeD_B0102  pilx4 protein [KO:K03199] [EC:7.4.2.8]
SeD_B0092  TaxB [KO:K03205] [EC:7.4.2.8]
SeD_A1234  type VI secretion system Vgr family protein [KO:K11904]
SeD_A0310  Rhs-family protein [KO:K11904]
SeD_A3476  putative cytoplasmic protein [KO:K11903]
SeD_A1233  hcp [KO:K11903]
SeD_A0300  hemolysin-coregulated protein [KO:K11903]
SeD_A1224  type VI secretion lipoprotein family protein [KO:K11906]
SeD_A0301  SciN protein [KO:K11906]
SeD_A0306  SciS protein [KO:K11891]
SeD_A1218  Pmt1 [KO:K11891]
SeD_A1222  Aec26 [KO:K11892]
SeD_A0303  SciP protein [KO:K11892]
SeD_A0295  ATPase AAA-2 domain protein [KO:K11907]
SeD_A1221  clpB; chaperone protein clpB [KO:K11907]
Compound
C00002  ATP
Reference
PMID:11173102
  Authors
Kim JF.
  Title
Revisiting the chlamydial type III protein secretion system: clues to the origin of type III protein secretion.
  Journal
Trends Genet 17:65-9 (2001)
DOI:10.1016/S0168-9525(00)02175-2
Reference
PMID:11309112
  Authors
Plano GV, Day JB, Ferracci F.
  Title
Type III export: new uses for an old pathway.
  Journal
Mol Microbiol 40:284-93 (2001)
DOI:10.1046/j.1365-2958.2001.02354.x
Reference
PMID:11413015
  Authors
Gauthier A, Finlay BB.
  Title
Bacterial pathogenesis: the answer to virulence is in the pore.
  Journal
Curr Biol 11:R264-7 (2001)
DOI:10.1016/S0960-9822(01)00134-8
Reference
PMID:10047550
  Authors
Burns DL.
  Title
Biochemistry of type IV secretion.
  Journal
Curr Opin Microbiol 2:25-9 (1999)
DOI:10.1016/S1369-5274(99)80004-6
Reference
PMID:10920394
  Authors
Christie PJ, Vogel JP.
  Title
Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cells.
  Journal
Trends Microbiol 8:354-60 (2000)
DOI:10.1016/S0966-842X(00)01792-3
Reference
PMID:11309113
  Authors
Christie PJ.
  Title
Type IV secretion: intercellular transfer of macromolecules by systems ancestrally related to conjugation machines.
  Journal
Mol Microbiol 40:294-305 (2001)
DOI:10.1046/j.1365-2958.2001.02302.x
Reference
PMID:10481178
  Authors
Nunn D.
  Title
Bacterial type II protein export and pilus biogenesis: more than just homologies?
  Journal
Trends Cell Biol 9:402-8 (1999)
DOI:10.1016/S0962-8924(99)01634-7
Reference
PMID:11309111
  Authors
Sandkvist M.
  Title
Biology of type II secretion.
  Journal
Mol Microbiol 40:271-83 (2001)
DOI:10.1046/j.1365-2958.2001.02403.x
Reference
PMID:11349009
  Authors
Sandkvist M.
  Title
Type II secretion and pathogenesis.
  Journal
Infect Immun 69:3523-35 (2001)
DOI:10.1128/IAI.69.6.3523-3535.2001
Reference
PMID:15546664
  Authors
Delepelaire P
  Title
Type I secretion in gram-negative bacteria.
  Journal
Biochim Biophys Acta 1694:149-61 (2004)
DOI:10.1016/j.bbamcr.2004.05.001
Reference
PMID:18406342
  Authors
Hazes B, Frost L
  Title
Towards a systems biology approach to study type II/IV secretion systems.
  Journal
Biochim Biophys Acta 1778:1839-50 (2008)
DOI:10.1016/j.bbamem.2008.03.011
Reference
PMID:16448494
  Authors
Johnson TL, Abendroth J, Hol WG, Sandkvist M
  Title
Type II secretion: from structure to function.
  Journal
FEMS Microbiol Lett 255:175-86 (2006)
DOI:10.1111/j.1574-6968.2006.00102.x
Reference
PMID:15546665
  Authors
Filloux A
  Title
The underlying mechanisms of type II protein secretion.
  Journal
Biochim Biophys Acta 1694:163-79 (2004)
DOI:10.1016/j.bbamcr.2004.05.003
Reference
PMID:19396170
  Authors
Spreter T, Yip CK, Sanowar S, Andre I, Kimbrough TG, Vuckovic M, Pfuetzner RA, Deng W, Yu AC, Finlay BB, Baker D, Miller SI, Strynadka NC
  Title
A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system.
  Journal
Nat Struct Mol Biol 16:468-76 (2009)
DOI:10.1038/nsmb.1603
Reference
PMID:15590783
  Authors
Ghosh P
  Title
Process of protein transport by the type III secretion system.
  Journal
Microbiol Mol Biol Rev 68:771-95 (2004)
DOI:10.1128/MMBR.68.4.771-795.2004
Reference
PMID:12360191
  Authors
Cornelis GR
  Title
The Yersinia Ysc-Yop 'type III' weaponry.
  Journal
Nat Rev Mol Cell Biol 3:742-52 (2002)
DOI:10.1038/nrm932
Reference
PMID:17215876
  Authors
Baron C
  Title
VirB8: a conserved type IV secretion system assembly factor and drug target.
  Journal
Biochem Cell Biol 84:890-9 (2006)
DOI:10.1139/o06-148
Reference
PMID:17943123
  Authors
Kwok T, Zabler D, Urman S, Rohde M, Hartig R, Wessler S, Misselwitz R, Berger J, Sewald N, Konig W, Backert S
  Title
Helicobacter exploits integrin for type IV secretion and kinase activation.
  Journal
Nature 449:862-6 (2007)
DOI:10.1038/nature06187
Reference
PMID:16092524
  Authors
Christie PJ, Cascales E
  Title
Structural and dynamic properties of bacterial type IV secretion systems (review).
  Journal
Mol Membr Biol 22:51-61 (2005)
DOI:10.1080/09687860500063316
Reference
PMID:15546668
  Authors
Christie PJ
  Title
Type IV secretion: the Agrobacterium VirB/D4 and related conjugation systems.
  Journal
Biochim Biophys Acta 1694:219-34 (2004)
DOI:10.1016/j.bbamcr.2004.02.013
Reference
PMID:15590781
  Authors
Henderson IR, Navarro-Garcia F, Desvaux M, Fernandez RC, Ala'Aldeen D
  Title
Type V protein secretion pathway: the autotransporter story.
  Journal
Microbiol Mol Biol Rev 68:692-744 (2004)
DOI:10.1128/MMBR.68.4.692-744.2004
Reference
PMID:9778731
  Authors
Henderson IR, Navarro-Garcia F, Nataro JP
  Title
The great escape: structure and function of the autotransporter proteins.
  Journal
Trends Microbiol 6:370-8 (1998)
DOI:10.1016/S0966-842X(98)01318-3
Reference
PMID:18524912
  Authors
Filloux A, Hachani A, Bleves S
  Title
The bacterial type VI secretion machine: yet another player for protein transport across membranes.
  Journal
Microbiology 154:1570-83 (2008)
DOI:10.1099/mic.0.2008/016840-0
Reference
PMID:19251641
  Authors
Leiman PG, Basler M, Ramagopal UA, Bonanno JB, Sauder JM, Pukatzki S, Burley SK, Almo SC, Mekalanos JJ
  Title
Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin.
  Journal
Proc Natl Acad Sci U S A 106:4154-9 (2009)
DOI:10.1073/pnas.0813360106
Reference
PMID:17603507
  Authors
Kulasekara HD, Miller SI
  Title
Threonine phosphorylation times bacterial secretion.
  Journal
Nat Cell Biol 9:734-6 (2007)
DOI:10.1038/ncb0707-734
Reference
PMID:18078384
  Authors
Driessen AJ, Nouwen N
  Title
Protein translocation across the bacterial cytoplasmic membrane.
  Journal
Annu Rev Biochem 77:643-67 (2008)
DOI:10.1146/annurev.biochem.77.061606.160747
Reference
PMID:14641032
  Authors
Pool MR
  Title
Getting to the membrane: how is co-translational protein targeting to the endoplasmic reticulum regulated?
  Journal
Biochem Soc Trans 31:1232-7 (2003)
DOI:10.1042/bst0311232
Reference
PMID:19299134
  Authors
Desvaux M, Hebraud M, Talon R, Henderson IR
  Title
Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
  Journal
Trends Microbiol 17:139-45 (2009)
DOI:10.1016/j.tim.2009.01.004
Reference
PMID:15063851
  Authors
Nakatogawa H, Murakami A, Ito K
  Title
Control of SecA and SecM translation by protein secretion.
  Journal
Curr Opin Microbiol 7:145-50 (2004)
DOI:10.1016/j.mib.2004.01.001
KO pathway
ko03070   
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