The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
cysT; sulfate/thiosulfate transporter subunit,Sulfate transport system permease protein CysW,sulfate/thiosulfate transporter subunit,ABC-type sulfate transport system, permease component,sulfate ABC transporter, permease protein,Binding-protein-dependent transport system inner membrane component [KO:K02046]
cysW; sulfate/thiosulfate transporter permease subunit,Sulfate transport system permease protein CysW,sulfate/thiosulfate transporter permease subunit,ABC-type sulfate transport system, permease component,sulfate ABC transporter, permease protein,Binding-protein-dependent transport system inner membrane component [KO:K02047]
modB; molybdate ABC transporter permease,Molybdenum transport system permease protein modB,molybdate ABC transporter permease protein,ABC-type molybdate transport system, permease component,molybdate ABC transporter, permease protein,Binding-protein-dependent transport system inner membrane component [KO:K02018]
modF; putative molybdenum transport ATP-binding protein ModF,Xylose import ATP-binding protein XylG,putative molybdenum transport ATP-binding protein ModF,ABC-type uncharacterized transport system, ATPase component,ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system,ABC transporter [KO:K05776]
thiP; thiamine transporter membrane protein,Sulfate transport system permease protein CysW,thiamine transporter membrane protein,ABC-type uncharacterized transport system, permease component,thiamine/thiamine pyrophosphate ABC transporter, permease protein,Binding-protein-dependent transport system inner membrane component [KO:K02063]
potB; spermidine/putrescine ABC transporter membrane protein,Spermidine/putrescine transport system permease protein PotB,spermidine/putrescine ABC transporter membrane protein,ABC-type spermidine/putrescine transport systems, ATPase components,NifC-like ABC-type porter,Binding-protein-dependent transport system inner membrane component [KO:K11071]
potH; putrescine ABC transporter membrane protein,Putrescine transport system permease protein PotH,putrescine transporter subunit: membrane component of ABC superfamily,ABC-type spermidine/putrescine transport systems, ATPase components,putative 2-aminoethylphosphonate ABC transporter, permease protein,Binding-protein-dependent transport system inner membrane component [KO:K11075]
proV_2; Glycine betaine/L-proline transport ATP-binding protein,Glycine betaine/L-proline transport ATP-binding protein ProV,glycine betaine transporter ATP-binding subunit,ABC-type proline/glycine betaine transport system, ATPase component,glycine betaine/L-proline transport ATP binding subunit,ABC transporter [KO:K02000] [EC:7.6.2.9]
yehZ; transport system permease,Choline-binding protein precursor,ABC-type proline/glycine betaine transport systems, periplasmic components,Substrate binding domain of ABC-type glycine betaine transport system [KO:K05845]
malF; Maltose transport system permease protein malF,Maltose transport system permease protein malF,maltose transporter membrane protein,ABC-type polysaccharide transport system, permease component,NifC-like ABC-type porter,Binding-protein-dependent transport system inner membrane component [KO:K10109]
malG; Part of maltose permease, inner membrane protein,Maltose transport system permease protein malG,maltose transporter permease,ABC-type maltose transport systems, permease component,NifC-like ABC-type porter,Binding-protein-dependent transport system inner membrane component [KO:K10110]
yphD; transport system permease,Ribose transport system permease protein rbsC,ribose ABC transporter permease protein,Predicted ABC-type sugar transport system, permease component,urea ABC transporter, permease protein UrtC,Branched-chain amino acid transport system / permease component [KO:K23546]
mlaD; Mce family protein,Probable phospholipid ABC transporter-binding protein mlaD,virulence factor Mce family protein,mce related protein [KO:K02067]
mlaF; putative ABC transporter ATP-binding protein YrbF,Probable phospholipid import ATP-binding protein MlaF,putative ABC transporter ATP-binding protein YrbF,ABC-type spermidine/putrescine transport systems, ATPase components,glycine betaine/L-proline transport ATP binding subunit,ABC transporter [KO:K02065]
rbsC; ribose ABC transporter permease,Ribose transport system permease protein rbsC,ribose ABC transporter permease protein,Predicted ABC-type sugar transport system, permease component,urea ABC transporter, permease protein UrtB,Branched-chain amino acid transport system / permease component [KO:K10440]
rbsD; D-ribose high-affinity transport system; membrane-associated protein,D-ribose pyranase,D-ribose pyranase,ABC-type ribose transport system, auxiliary component,RbsD / FucU transport protein family [KO:K06726] [EC:5.4.99.62]
araF_1; L-arabinose ABC transporter periplasmic L-arabinose-binding protein,L-arabinose-binding periplasmic protein precursor,ABC-type sugar transport system, periplasmic component,Periplasmic binding proteins and sugar binding domain of LacI family [KO:K10537]
araH; L-arabinose transporter permease,Ribose transport system permease protein rbsC,L-arabinose transporter permease protein,Predicted ABC-type sugar transport system, permease component,Branched-chain amino acid transport system / permease component [KO:K10538]
mglC; beta-methylgalactoside transporter inner membrane protein,Galactoside transport system permease protein mglC,beta-methylgalactoside transporter inner membrane component,ABC-type glucose/galactose transport system, permease component,Branched-chain amino acid transport system / permease component [KO:K10541]
xylF; Xylose binding protein transport system,D-xylose-binding periplasmic protein precursor,D-xylose transporter subunit XylF,ABC-type xylose transport system, periplasmic component,D-xylose ABC transporter, D-xylose-binding protein,Periplasmic binding proteins and sugar binding domain of LacI family [KO:K10543]
xylH; D-xylose ABC transporter permease,Xylose transport system permease protein xylH,ribose ABC transporter permease protein,Predicted ABC-type sugar transport system, permease component,urea ABC transporter, permease protein UrtC,Branched-chain amino acid transport system / permease component [KO:K10544]
ugpA; glycerol-3-phosphate transporter permease,sn-glycerol-3-phosphate transport system permease protein ugpA,glycerol-3-phosphate transporter permease,ABC-type polysaccharide transport system, permease component,putative 2-aminoethylphosphonate ABC transporter, permease protein,Binding-protein-dependent transport system inner membrane component [KO:K05814]
pstC; phosphate transporter permease subunit PstC,Phosphate transport system permease protein pstC,phosphate transporter permease subunit PstC,ABC-type phosphate transport system, permease component,phosphate ABC transporter, permease protein PstC,Binding-protein-dependent transport system inner membrane component [KO:K02037]
pstA; phosphate transporter permease subunit PtsA,Phosphate transport system permease protein pstA,phosphate transporter permease subunit PtsA,ABC-type phosphate transport system, permease component,phosphate ABC transporter, permease protein PstA,Binding-protein-dependent transport system inner membrane component [KO:K02038]
hisM; histidine ABC transporter permease HisM,Histidine transport system permease protein hisM,histidine/lysine/arginine/ornithine ABC transporter permease HisM,ABC-type amino acid transport system, permease component,ectoine/hydroxyectoine ABC transporter, permease protein EhuC,Binding-protein-dependent transport system inner membrane component [KO:K10015]
hisQ; histidine ABC transporter permease HisQ,Histidine transport system permease protein hisQ,histidine/lysine/arginine/ornithine ABC transporter permease HisQ,ABC-type amino acid transport system, permease component,ectoine/hydroxyectoine ABC transporter, permease protein EhuC,Binding-protein-dependent transport system inner membrane component [KO:K10016]
glnP; glutamine ABC transporter permease,Glutamine transport system permease protein glnP,glutamine ABC transporter permease protein,ABC-type amino acid transport system, permease component,ectoine/hydroxyectoine ABC transporter, permease protein EhuC,Binding-protein-dependent transport system inner membrane component [KO:K10037]
gltK_1; glutamate/aspartate ABC transporter permease GltK,Glutamate/aspartate transport system permease protein gltK,glutamate/aspartate transport system permease GltK,ABC-type amino acid transport system, permease component,ectoine/hydroxyectoine ABC transporter, permease protein EhuC,Binding-protein-dependent transport system inner membrane component [KO:K10002]
gltJ; glutamate/aspartate ABC transporter permease GltJ,Inner membrane amino-acid ABC transporter permease protein yecS,glutamate/aspartate transport system permease GltK,ABC-type amino acid transport system, permease component,ectoine/hydroxyectoine ABC transporter, permease protein EhuC,Binding-protein-dependent transport system inner membrane component [KO:K10003]
gltK_2; polar amino acid ABC transporter inner membrane subunit,Glutamate/aspartate transport system permease protein gltK,amino acid ABC transporter permease,ABC-type amino acid transport system, permease component,ectoine/hydroxyectoine ABC transporter, permease protein EhuC,Binding-protein-dependent transport system inner membrane component [KO:K09970]
yhdY; transport system permease,Inner membrane amino-acid ABC transporter permease protein yhdY,amino acid ABC transporter permease,ABC-type amino acid transport system, permease component,ectoine/hydroxyectoine ABC transporter, permease protein EhuC,Binding-protein-dependent transport system inner membrane component [KO:K09971]
livJ; high-affinity amino acid transport system periplasmic binding protein,Leu/Ile/Val-binding protein precursor,leucine ABC transporter subunit substrate-binding protein LivK,urea ABC transporter, urea binding protein,Receptor family ligand binding region [KO:K01999]
metI; DL-methionine transporter permease,D-methionine transport system permease protein metI,DL-methionine transporter permease subunit,ABC-type phosphate/phosphonate transport system, permease component,phosphonate ABC transporter, permease protein PhnE,Binding-protein-dependent transport system inner membrane component [KO:K02072]
oppB; oligopeptide transporter permease,Oligopeptide transport system permease protein oppB,oligopeptide transporter permease,nickel ABC transporter, permease subunit NikB,Binding-protein-dependent transport system inner membrane component [KO:K15581]
dppB; dipeptide transporter permease DppB,Dipeptide transport system permease protein dppB,dipeptide transporter permease DppB,nickel ABC transporter, permease subunit NikB,Binding-protein-dependent transport system inner membrane component [KO:K12369]
dppC; dipeptide transporter,Dipeptide transport system permease protein dppC,dipeptide transporter,ABC-type antimicrobial peptide transport system, permease component,nickel ABC transporter, permease subunit NikC,Binding-protein-dependent transport system inner membrane component [KO:K12370]
sapF; peptide ABC transporter ATP-binding protein SapF,Glutathione import ATP-binding protein GsiA,antimicrobial peptide ABC system ATP-binding protein SapF,ABC-type antimicrobial peptide transport system, ATPase component,nickel import ATP-binding protein NikE,ABC transporter [KO:K19230]
nikB; nickel transporter permease NikB,Nickel transport system permease protein nikB,nickel transporter permease NikB,nickel ABC transporter, permease subunit NikB,Binding-protein-dependent transport system inner membrane component [KO:K15585]
nikC; nickel transporter permease NikC,Nickel transport system permease protein nikC,nickel transporter permease NikC,ABC-type antimicrobial peptide transport system, permease component,nickel ABC transporter, permease subunit NikC,Binding-protein-dependent transport system inner membrane component [KO:K15586]
fepD; Ferric enterobactin (Enterochelin) transport protein,Ferric enterobactin transport system permease protein fepD,iron-enterobactin transporter membrane protein,ABC-type Fe3+-siderophore transport system, permease component,proposed F420-0 ABC transporter, permease protein,FecCD transport family [KO:K23186]
fepG; iron-enterobactin transporter permease,Ferric enterobactin transport system permease protein fepG,iron-enterobactin transporter permease,ABC-type enterobactin transport system, permease component,proposed F420-0 ABC transporter, permease protein,FecCD transport family [KO:K23187]
btuF; Vitamin B12-binding protein precursor,Vitamin B12-binding protein precursor,vitamin B12-transporter protein BtuF,ABC-type hemin transport system, periplasmic component,putative ABC transporter PGF-CTERM-modified substrate-binding protein,Periplasmic binding protein [KO:K06858]
btuC; vtamin B12-transporter permease,Vitamin B12 import system permease protein BtuC,vtamin B12-transporter permease,ABC-type cobalamin transport system, permease component,proposed F420-0 ABC transporter, permease protein,FecCD transport family [KO:K06073]
sitC_2; iron/manganese transport system inner membrane protein SitC,Manganese transport system membrane protein mntB,high-affinity zinc transporter membrane component,anchored repeat-type ABC transporter, permease subunit,ABC 3 transport family [KO:K11605]
mntB; chelated iron transport system membrane protein yfeD,Manganese transport system membrane protein mntB,high-affinity zinc transporter membrane component,anchored repeat-type ABC transporter, permease subunit,ABC 3 transport family [KO:K11606]
lsrB_2; Autoinducer 2-binding protein lsrB precursor,autoinducer 2-binding protein lsrB,ABC-type sugar transport system, periplasmic component,rhamnose ABC transporter, rhamnose-binding protein [KO:K10555]
lsrD; putative Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components,Autoinducer 2 import system permease protein lsrD,autoinducer 2 import system permease LsrD,Predicted ABC-type sugar transport system, permease component,Branched-chain amino acid transport system / permease component [KO:K10557]
lolC; Lipoprotein-releasing system transmembrane protein lolC,Lipoprotein-releasing system transmembrane protein lolC,outer membrane-specific lipoprotein transporter subunit LolC,lipoprotein releasing system, transmembrane protein, LolC/E family,FtsX-like permease family [KO:K09808]
ccmA; Cytochrome c biogenesis ATP-binding export protein ccmA,Cytochrome c biogenesis ATP-binding export protein CcmA,cytochrome c biogenesis protein CcmA,ABC-type transport system involved in cytochrome c biogenesis, ATPase component,heme ABC exporter, ATP-binding protein CcmA,ABC transporter [KO:K02193] [EC:7.6.2.5]
yjgQ; Inner membrane protein yjgQ,Lipopolysaccharide export system permease protein lptG,lipopolysaccharide ABC transporter permease,Predicted permeases,Predicted permease YjgP/YjgQ family [KO:K11720]
ftsX; cell division protein FtsX,Cell division protein FtsX,cell division ABC transporter subunit FtsX,putative protein insertion permease FtsX,FtsX-like permease family [KO:K09811]
ftsE; cell division protein FtsE,Cell division ATP-binding protein FtsE,cell division protein FtsE,ABC-type spermidine/putrescine transport systems, ATPase components,cell division ATP-binding protein FtsE,ABC transporter [KO:K09812]
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.