KEGG   PATHWAY: snev00290
Entry
snev00290                   Pathway                                
Name
Valine, leucine and isoleucine biosynthesis - Serratia nevei
Class
Metabolism; Amino acid metabolism
Pathway map
snev00290  Valine, leucine and isoleucine biosynthesis
snev00290

Module
snev_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:snev00290]
snev_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:snev00290]
snev_M00570  Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine [PATH:snev00290]
Other DBs
GO: 0009097 0009098 0009099
Organism
Serratia nevei [GN:snev]
Gene
OI978_06395  threonine/serine dehydratase [KO:K01754] [EC:4.3.1.19]
OI978_07345  ilvA; threonine ammonia-lyase, biosynthetic [KO:K01754] [EC:4.3.1.19]
OI978_03035  leuC; 3-isopropylmalate dehydratase large subunit [KO:K01703] [EC:4.2.1.33 4.2.1.35]
OI978_03040  leuD; 3-isopropylmalate dehydratase small subunit [KO:K01704] [EC:4.2.1.33 4.2.1.35]
OI978_03030  leuB; 3-isopropylmalate dehydrogenase [KO:K00052] [EC:1.1.1.85]
OI978_03010  ilvI; acetolactate synthase 3 large subunit [KO:K01652] [EC:2.2.1.6]
OI978_03085  ilvB; acetolactate synthase large subunit [KO:K01652] [EC:2.2.1.6]
OI978_07325  ilvG; acetolactate synthase 2 catalytic subunit [KO:K01652] [EC:2.2.1.6]
OI978_11050  thiamine pyrophosphate-binding protein [KO:K01652] [EC:2.2.1.6]
OI978_14650  alsS; acetolactate synthase AlsS [KO:K01652] [EC:2.2.1.6]
OI978_03005  ilvN; acetolactate synthase small subunit [KO:K01653] [EC:2.2.1.6]
OI978_03090  ilvN; acetolactate synthase small subunit [KO:K01653] [EC:2.2.1.6]
OI978_07330  ilvM; acetolactate synthase 2 small subunit [KO:K11258] [EC:2.2.1.6]
OI978_07365  ilvC; ketol-acid reductoisomerase [KO:K00053] [EC:1.1.1.86]
OI978_07340  ilvD; dihydroxy-acid dehydratase [KO:K01687] [EC:4.2.1.9]
OI978_07335  branched-chain amino acid transaminase [KO:K00826] [EC:2.6.1.42]
OI978_06350  valine--pyruvate transaminase [KO:K00835] [EC:2.6.1.66]
OI978_15360  pyridoxal phosphate-dependent aminotransferase [KO:K14260] [EC:2.6.1.66 2.6.1.2]
OI978_03025  leuA; 2-isopropylmalate synthase [KO:K01649] [EC:2.3.3.13]
OI978_23925  leuA; 2-isopropylmalate synthase [KO:K01649] [EC:2.3.3.13]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00109  2-Oxobutanoate
C00123  L-Leucine
C00141  3-Methyl-2-oxobutanoic acid
C00183  L-Valine
C00188  L-Threonine
C00233  4-Methyl-2-oxopentanoate
C00407  L-Isoleucine
C00671  (S)-3-Methyl-2-oxopentanoic acid
C02226  2-Methylmaleate
C02504  alpha-Isopropylmalate
C02612  (R)-2-Methylmalate
C02631  2-Isopropylmaleate
C04181  3-Hydroxy-3-methyl-2-oxobutanoic acid
C04236  (2S)-2-Isopropyl-3-oxosuccinate
C04272  (R)-2,3-Dihydroxy-3-methylbutanoate
C04411  (2R,3S)-3-Isopropylmalate
C06006  (S)-2-Aceto-2-hydroxybutanoate
C06007  (R)-2,3-Dihydroxy-3-methylpentanoate
C06010  (S)-2-Acetolactate
C06032  D-erythro-3-Methylmalate
C14463  (R)-3-Hydroxy-3-methyl-2-oxopentanoate
Reference
  Authors
Xu H, Zhang Y, Guo X, Ren S, Staempfli AA, Chiao J, Jiang W, Zhao G.
  Title
Isoleucine biosynthesis in Leptospira interrogans serotype lai strain 56601 proceeds via a threonine-independent pathway.
  Journal
J Bacteriol 186:5400-9 (2004)
DOI:10.1128/JB.186.16.5400-5409.2004
Related
pathway
snev00260  Glycine, serine and threonine metabolism
snev00280  Valine, leucine and isoleucine degradation
snev00620  Pyruvate metabolism
KO pathway
ko00290   
LinkDB

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