KEGG   PATHWAY: sor03030
Entry
sor03030                    Pathway                                
Name
DNA replication - Streptococcus oralis
Description
A complex network of interacting proteins and enzymes is required for DNA replication. Generally, DNA replication follows a multistep enzymatic pathway. At the DNA replication fork, a DNA helicase (DnaB or MCM complex) precedes the DNA synthetic machinery and unwinds the duplex parental DNA in cooperation with the SSB or RPA. On the leading strand, replication occurs continuously in a 5 to 3 direction, whereas on the lagging strand, DNA replication occurs discontinuously by synthesis and joining of short Okazaki fragments. In prokaryotes, the leading strand replication apparatus consists of a DNA polymerase (pol III core), a sliding clamp (beta), and a clamp loader (gamma delta complex). The DNA primase (DnaG) is needed to form RNA primers. Normally, during replication of the lagging-strand DNA template, an RNA primer is removed either by an RNase H or by the 5 to 3 exonuclease activity of DNA pol I, and the DNA ligase joins the Okazaki fragments. In eukaryotes, three DNA polymerases (alpha, delta, and epsilon) have been identified. DNA primase forms a permanent complex with DNA polymerase alpha. PCNA and RFC function as a clamp and a clamp loader. FEN 1 and RNase H1 remove the RNA from the Okazaki fragments and DNA ligase I joins the DNA.
Class
Genetic Information Processing; Replication and repair
Pathway map
sor03030  DNA replication
sor03030

Organism
Streptococcus oralis [GN:sor]
Gene
SOR_1102  dnaQ; DNA polymerase III, epsilon chain [KO:K02342] [EC:2.7.7.7]
SOR_1150  dnaE; DNA polymerase III subunit alpha [KO:K02337] [EC:2.7.7.7]
SOR_0209  polC; DNA polymerase III, alpha subunit [KO:K03763] [EC:2.7.7.7]
SOR_0833  dnaX; DNA polymerase III subunits gamma and tau [KO:K02343] [EC:2.7.7.7]
SOR_1225  holB; DNA polymerase III, delta prime subunit [KO:K02341] [EC:2.7.7.7]
SOR_0780  holA; DNA polymerase III subunit delta [KO:K02340] [EC:2.7.7.7]
SOR_0002  dnaN; DNA polymerase III subunit beta [KO:K02338] [EC:2.7.7.7]
SOR_1944  dnaB; replicative DNA helicase [KO:K02314] [EC:5.6.2.3]
SOR_1161  dnaG; DNA primase [KO:K02316] [EC:2.7.7.101]
SOR_0402  ssbB; single-strand DNA-binding protein B [KO:K03111]
SOR_0642  ssbA; single-strand DNA-binding protein [KO:K03111]
SOR_1002  rnhB; ribonuclease HII [KO:K03470] [EC:3.1.26.4]
SOR_1619  ribonuclease HIII [KO:K03471] [EC:3.1.26.4]
SOR_1940  polI; DNA-directed DNA polymerase [KO:K02335] [EC:2.7.7.7]
SOR_0958  ligA; DNA ligase, NAD-dependent [KO:K01972] [EC:6.5.1.2]
Reference
PMID:8087839
  Authors
Stillman B.
  Title
Smart machines at the DNA replication fork.
  Journal
Cell 78:725-8 (1994)
DOI:10.1016/S0092-8674(94)90362-X
Reference
PMID:9759502
  Authors
Waga S, Stillman B.
  Title
The DNA replication fork in eukaryotic cells.
  Journal
Annu Rev Biochem 67:721-51 (1998)
DOI:10.1146/annurev.biochem.67.1.721
KO pathway
ko03030   
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