KEGG   PATHWAY: suam03070
Entry
suam03070                   Pathway                                
Name
Bacterial secretion system - Sulfitobacter alexandrii
Description
Gram-negative bacteria secrete a wide range of proteins whose functions include biogenesis of organelles, such as pilli and flagella, nutrient acquisition, virulence, and efflux of drugs and other toxins. Six distinct secretion systems have been shown to mediate protein export through the inner and outer membranes of Gram-negative bacteria. These pathways are highly conserved throughout the Gram-negative bacterial species. In Gram-positive bacteria, secreted proteins are commonly translocated across the single membrane by the Sec pathway or the two-arginine (Tat) pathway.
Class
Environmental Information Processing; Membrane transport
Pathway map
suam03070  Bacterial secretion system
suam03070

Other DBs
GO: 0030253 0015628 0030254 0030255 0046819 0033103 0044098 0043952 0043953
Organism
Sulfitobacter alexandrii [GN:suam]
Gene
BOO69_12615  transporter [KO:K12340]
BOO69_00255  type II secretion system protein GspD [KO:K02453]
BOO69_00620  type II secretion system protein GspD [KO:K02453]
BOO69_00250  hypothetical protein [KO:K02452]
BOO69_00215  type II secretion system protein GspF [KO:K02455]
BOO69_00610  general secretion pathway protein GspF [KO:K02455]
BOO69_00235  type II secretion system protein GspG [KO:K02456]
BOO69_00665  type II secretion system protein GspG [KO:K02456]
BOO69_00240  type II secretion system protein GspH [KO:K02457]
BOO69_00660  hypothetical protein [KO:K02457]
BOO69_00245  type II secretion system protein GspI [KO:K02458]
BOO69_00200  hypothetical protein [KO:K02459]
BOO69_00650  hypothetical protein [KO:K02459]
BOO69_00195  hypothetical protein [KO:K02460]
BOO69_00645  hypothetical protein [KO:K02460]
BOO69_00640  hypothetical protein [KO:K02461]
BOO69_00225  hypothetical protein [KO:K02462]
BOO69_00220  type II secretion system protein GspE [KO:K02454] [EC:7.4.2.8]
BOO69_00615  type II secretion system protein GspE [KO:K02454] [EC:7.4.2.8]
BOO69_11515  protein-export membrane protein SecD [KO:K03072]
BOO69_11510  protein-export membrane protein SecF [KO:K03074]
BOO69_01885  preprotein translocase subunit SecE [KO:K03073]
BOO69_05580  preprotein translocase subunit SecG [KO:K03075]
BOO69_02100  preprotein translocase subunit SecY [KO:K03076]
BOO69_11520  preprotein translocase subunit YajC [KO:K03210]
BOO69_02205  membrane protein insertase YidC [KO:K03217]
BOO69_18380  preprotein translocase subunit SecA [KO:K03070] [EC:7.4.2.8]
BOO69_05925  signal recognition particle-docking protein FtsY [KO:K03110]
BOO69_17965  protein-export chaperone SecB [KO:K03071]
BOO69_01470  signal recognition particle protein [KO:K03106] [EC:3.6.5.4]
BOO69_11150  hypothetical protein [KO:K03116]
BOO69_11145  twin arginine-targeting protein translocase TatB [KO:K03117]
BOO69_11140  twin arginine-targeting protein translocase TatC [KO:K03118]
BOO69_19630  VIRB2 type IV secretion [KO:K03197]
BOO69_21855  VIRB2 type IV secretion [KO:K03197]
BOO69_22265  hypothetical protein [KO:K03197]
BOO69_22270  type IV secretion system protein VirB3 [KO:K03198]
BOO69_19635  type IV secretion system protein VirB3 [KO:K03198]
BOO69_21860  type IV secretion system protein VirB3 [KO:K03198]
BOO69_19650  conjugal transfer protein TraF [KO:K03200]
BOO69_20235  conjugal transfer protein TraF [KO:K03200]
BOO69_21875  conjugal transfer protein TraF [KO:K03200]
BOO69_22285  hypothetical protein [KO:K03200]
BOO69_19660  conjugal transfer protein TrbG [KO:K03204]
BOO69_20225  conjugal transfer protein TrbG [KO:K03204]
BOO69_21885  conjugal transfer protein TrbG [KO:K03204]
BOO69_22305  conjugal transfer protein TrbG [KO:K03204]
BOO69_13335  hypothetical protein [KO:K03201]
BOO69_20200  conjugal transfer protein TrbL [KO:K03201]
BOO69_22295  conjugal transfer protein TrbL [KO:K03201]
BOO69_21910  conjugal transfer protein TrbL [KO:K03201]
BOO69_19655  hypothetical protein [KO:K03203]
BOO69_20230  hypothetical protein [KO:K03203]
BOO69_21880  hypothetical protein [KO:K03203]
BOO69_22300  type IV secretion system protein VirB8 [KO:K03203]
BOO69_19665  conjugal transfer protein [KO:K03195]
BOO69_20220  conjugal transfer protein [KO:K03195]
BOO69_22310  type IV secretion system protein B10 [KO:K03195]
BOO69_21890  conjugal transfer protein [KO:K03195]
BOO69_19640  type IV secretion system protein B4 [KO:K03199] [EC:7.4.2.8]
BOO69_22275  type IV secretion system protein B4 [KO:K03199] [EC:7.4.2.8]
BOO69_21865  type IV secretion system protein B4 [KO:K03199] [EC:7.4.2.8]
BOO69_19670  type II secretion system protein E [KO:K03196] [EC:7.4.2.8]
BOO69_20215  type II secretion system protein E [KO:K03196] [EC:7.4.2.8]
BOO69_22315  P-type DNA transfer ATPase VirB11 [KO:K03196] [EC:7.4.2.8]
BOO69_21895  type II secretion system protein E [KO:K03196] [EC:7.4.2.8]
BOO69_19990  hypothetical protein [KO:K03205] [EC:7.4.2.8]
BOO69_22335  type VI secretion protein [KO:K03205] [EC:7.4.2.8]
BOO69_21925  type VI secretion protein [KO:K03205] [EC:7.4.2.8]
Compound
C00002  ATP
Reference
PMID:11173102
  Authors
Kim JF.
  Title
Revisiting the chlamydial type III protein secretion system: clues to the origin of type III protein secretion.
  Journal
Trends Genet 17:65-9 (2001)
DOI:10.1016/S0168-9525(00)02175-2
Reference
PMID:11309112
  Authors
Plano GV, Day JB, Ferracci F.
  Title
Type III export: new uses for an old pathway.
  Journal
Mol Microbiol 40:284-93 (2001)
DOI:10.1046/j.1365-2958.2001.02354.x
Reference
PMID:11413015
  Authors
Gauthier A, Finlay BB.
  Title
Bacterial pathogenesis: the answer to virulence is in the pore.
  Journal
Curr Biol 11:R264-7 (2001)
DOI:10.1016/S0960-9822(01)00134-8
Reference
PMID:10047550
  Authors
Burns DL.
  Title
Biochemistry of type IV secretion.
  Journal
Curr Opin Microbiol 2:25-9 (1999)
DOI:10.1016/S1369-5274(99)80004-6
Reference
PMID:10920394
  Authors
Christie PJ, Vogel JP.
  Title
Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cells.
  Journal
Trends Microbiol 8:354-60 (2000)
DOI:10.1016/S0966-842X(00)01792-3
Reference
PMID:11309113
  Authors
Christie PJ.
  Title
Type IV secretion: intercellular transfer of macromolecules by systems ancestrally related to conjugation machines.
  Journal
Mol Microbiol 40:294-305 (2001)
DOI:10.1046/j.1365-2958.2001.02302.x
Reference
PMID:10481178
  Authors
Nunn D.
  Title
Bacterial type II protein export and pilus biogenesis: more than just homologies?
  Journal
Trends Cell Biol 9:402-8 (1999)
DOI:10.1016/S0962-8924(99)01634-7
Reference
PMID:11309111
  Authors
Sandkvist M.
  Title
Biology of type II secretion.
  Journal
Mol Microbiol 40:271-83 (2001)
DOI:10.1046/j.1365-2958.2001.02403.x
Reference
PMID:11349009
  Authors
Sandkvist M.
  Title
Type II secretion and pathogenesis.
  Journal
Infect Immun 69:3523-35 (2001)
DOI:10.1128/IAI.69.6.3523-3535.2001
Reference
PMID:15546664
  Authors
Delepelaire P
  Title
Type I secretion in gram-negative bacteria.
  Journal
Biochim Biophys Acta 1694:149-61 (2004)
DOI:10.1016/j.bbamcr.2004.05.001
Reference
PMID:18406342
  Authors
Hazes B, Frost L
  Title
Towards a systems biology approach to study type II/IV secretion systems.
  Journal
Biochim Biophys Acta 1778:1839-50 (2008)
DOI:10.1016/j.bbamem.2008.03.011
Reference
PMID:16448494
  Authors
Johnson TL, Abendroth J, Hol WG, Sandkvist M
  Title
Type II secretion: from structure to function.
  Journal
FEMS Microbiol Lett 255:175-86 (2006)
DOI:10.1111/j.1574-6968.2006.00102.x
Reference
PMID:15546665
  Authors
Filloux A
  Title
The underlying mechanisms of type II protein secretion.
  Journal
Biochim Biophys Acta 1694:163-79 (2004)
DOI:10.1016/j.bbamcr.2004.05.003
Reference
PMID:19396170
  Authors
Spreter T, Yip CK, Sanowar S, Andre I, Kimbrough TG, Vuckovic M, Pfuetzner RA, Deng W, Yu AC, Finlay BB, Baker D, Miller SI, Strynadka NC
  Title
A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system.
  Journal
Nat Struct Mol Biol 16:468-76 (2009)
DOI:10.1038/nsmb.1603
Reference
PMID:15590783
  Authors
Ghosh P
  Title
Process of protein transport by the type III secretion system.
  Journal
Microbiol Mol Biol Rev 68:771-95 (2004)
DOI:10.1128/MMBR.68.4.771-795.2004
Reference
PMID:12360191
  Authors
Cornelis GR
  Title
The Yersinia Ysc-Yop 'type III' weaponry.
  Journal
Nat Rev Mol Cell Biol 3:742-52 (2002)
DOI:10.1038/nrm932
Reference
PMID:17215876
  Authors
Baron C
  Title
VirB8: a conserved type IV secretion system assembly factor and drug target.
  Journal
Biochem Cell Biol 84:890-9 (2006)
DOI:10.1139/o06-148
Reference
PMID:17943123
  Authors
Kwok T, Zabler D, Urman S, Rohde M, Hartig R, Wessler S, Misselwitz R, Berger J, Sewald N, Konig W, Backert S
  Title
Helicobacter exploits integrin for type IV secretion and kinase activation.
  Journal
Nature 449:862-6 (2007)
DOI:10.1038/nature06187
Reference
PMID:16092524
  Authors
Christie PJ, Cascales E
  Title
Structural and dynamic properties of bacterial type IV secretion systems (review).
  Journal
Mol Membr Biol 22:51-61 (2005)
DOI:10.1080/09687860500063316
Reference
PMID:15546668
  Authors
Christie PJ
  Title
Type IV secretion: the Agrobacterium VirB/D4 and related conjugation systems.
  Journal
Biochim Biophys Acta 1694:219-34 (2004)
DOI:10.1016/j.bbamcr.2004.02.013
Reference
PMID:15590781
  Authors
Henderson IR, Navarro-Garcia F, Desvaux M, Fernandez RC, Ala'Aldeen D
  Title
Type V protein secretion pathway: the autotransporter story.
  Journal
Microbiol Mol Biol Rev 68:692-744 (2004)
DOI:10.1128/MMBR.68.4.692-744.2004
Reference
PMID:9778731
  Authors
Henderson IR, Navarro-Garcia F, Nataro JP
  Title
The great escape: structure and function of the autotransporter proteins.
  Journal
Trends Microbiol 6:370-8 (1998)
DOI:10.1016/S0966-842X(98)01318-3
Reference
PMID:18524912
  Authors
Filloux A, Hachani A, Bleves S
  Title
The bacterial type VI secretion machine: yet another player for protein transport across membranes.
  Journal
Microbiology 154:1570-83 (2008)
DOI:10.1099/mic.0.2008/016840-0
Reference
PMID:19251641
  Authors
Leiman PG, Basler M, Ramagopal UA, Bonanno JB, Sauder JM, Pukatzki S, Burley SK, Almo SC, Mekalanos JJ
  Title
Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin.
  Journal
Proc Natl Acad Sci U S A 106:4154-9 (2009)
DOI:10.1073/pnas.0813360106
Reference
PMID:17603507
  Authors
Kulasekara HD, Miller SI
  Title
Threonine phosphorylation times bacterial secretion.
  Journal
Nat Cell Biol 9:734-6 (2007)
DOI:10.1038/ncb0707-734
Reference
PMID:18078384
  Authors
Driessen AJ, Nouwen N
  Title
Protein translocation across the bacterial cytoplasmic membrane.
  Journal
Annu Rev Biochem 77:643-67 (2008)
DOI:10.1146/annurev.biochem.77.061606.160747
Reference
PMID:14641032
  Authors
Pool MR
  Title
Getting to the membrane: how is co-translational protein targeting to the endoplasmic reticulum regulated?
  Journal
Biochem Soc Trans 31:1232-7 (2003)
DOI:10.1042/bst0311232
Reference
PMID:19299134
  Authors
Desvaux M, Hebraud M, Talon R, Henderson IR
  Title
Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
  Journal
Trends Microbiol 17:139-45 (2009)
DOI:10.1016/j.tim.2009.01.004
Reference
PMID:15063851
  Authors
Nakatogawa H, Murakami A, Ito K
  Title
Control of SecA and SecM translation by protein secretion.
  Journal
Curr Opin Microbiol 7:145-50 (2004)
DOI:10.1016/j.mib.2004.01.001
KO pathway
ko03070   
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