KEGG   PATHWAY: ume00360
Entry
ume00360                    Pathway                                
Name
Phenylalanine metabolism - Umezawaea sp. Da 62-37
Class
Metabolism; Amino acid metabolism
Pathway map
ume00360  Phenylalanine metabolism
ume00360

Other DBs
GO: 0006558
Organism
Umezawaea sp. Da 62-37 [GN:ume]
Gene
RM788_45195  aldehyde dehydrogenase family protein [KO:K00129] [EC:1.2.1.5]
RM788_11535  paaK; phenylacetate--CoA ligase PaaK [KO:K01912] [EC:6.2.1.30]
RM788_17515  paaI; hydroxyphenylacetyl-CoA thioesterase PaaI [KO:K02614] [EC:3.1.2.-]
RM788_05865  paaA; 1,2-phenylacetyl-CoA epoxidase subunit PaaA [KO:K02609] [EC:1.14.13.149]
RM788_22820  paaA; 1,2-phenylacetyl-CoA epoxidase subunit PaaA [KO:K02609] [EC:1.14.13.149]
RM788_05860  paaB; 1,2-phenylacetyl-CoA epoxidase subunit PaaB [KO:K02610]
RM788_22815  paaB; 1,2-phenylacetyl-CoA epoxidase subunit PaaB [KO:K02610]
RM788_05855  paaC; 1,2-phenylacetyl-CoA epoxidase subunit PaaC [KO:K02611] [EC:1.14.13.149]
RM788_22810  paaC; 1,2-phenylacetyl-CoA epoxidase subunit PaaC [KO:K02611] [EC:1.14.13.149]
RM788_05850  paaD; 1,2-phenylacetyl-CoA epoxidase subunit PaaD [KO:K02612]
RM788_22805  paaD; 1,2-phenylacetyl-CoA epoxidase subunit PaaD [KO:K02612]
RM788_05845  2Fe-2S iron-sulfur cluster-binding protein [KO:K02613]
RM788_22800  paaE; 1,2-phenylacetyl-CoA epoxidase subunit PaaE [KO:K02613]
RM788_09095  enoyl-CoA hydratase/isomerase family protein [KO:K15866] [EC:5.3.3.18]
RM788_29945  enoyl-CoA hydratase-related protein [KO:K15866] [EC:5.3.3.18]
RM788_38860  paaZ; phenylacetic acid degradation bifunctional protein PaaZ [KO:K02618] [EC:3.3.2.12 1.2.1.91]
RM788_08130  enoyl-CoA hydratase-related protein [KO:K01692] [EC:4.2.1.17]
RM788_17755  enoyl-CoA hydratase-related protein [KO:K01692] [EC:4.2.1.17]
RM788_22665  enoyl-CoA hydratase [KO:K01692] [EC:4.2.1.17]
RM788_38980  enoyl-CoA hydratase-related protein [KO:K01692] [EC:4.2.1.17]
RM788_11170  3-hydroxybutyryl-CoA dehydrogenase [KO:K00074] [EC:1.1.1.157]
RM788_18010  3-hydroxybutyryl-CoA dehydrogenase [KO:K00074] [EC:1.1.1.157]
RM788_28620  3-hydroxyacyl-CoA dehydrogenase family protein [KO:K00074] [EC:1.1.1.157]
RM788_44930  3-hydroxyacyl-CoA dehydrogenase family protein [KO:K00074] [EC:1.1.1.157]
RM788_22400  pyridoxal phosphate-dependent aminotransferase [KO:K00812] [EC:2.6.1.1]
RM788_02100  aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme [KO:K00817] [EC:2.6.1.9]
RM788_02135  aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme [KO:K00817] [EC:2.6.1.9]
RM788_15645  histidinol-phosphate transaminase [KO:K00817] [EC:2.6.1.9]
RM788_26125  hisC; histidinol-phosphate transaminase [KO:K00817] [EC:2.6.1.9]
RM788_30500  cobC; Rv2231c family pyridoxal phosphate-dependent protein CobC [KO:K00817] [EC:2.6.1.9]
RM788_29475  hppD; 4-hydroxyphenylpyruvate dioxygenase [KO:K00457] [EC:1.13.11.27]
RM788_44845  FAD-dependent oxidoreductase [KO:K00285] [EC:1.4.5.1]
RM788_48510  katG; catalase/peroxidase HPI [KO:K03782] [EC:1.11.1.21]
RM788_00485  amidase [KO:K01426] [EC:3.5.1.4]
RM788_41640  amidase family protein [KO:K01426] [EC:3.5.1.4]
RM788_47020  amidase [KO:K01426] [EC:3.5.1.4]
RM788_37515  bifunctional 3-phenylpropionate/cinnamic acid dioxygenase ferredoxin subunit [KO:K05710]
RM788_39935  non-heme iron oxygenase ferredoxin subunit [KO:K05710]
RM788_13220  2,3-dihydroxyphenylpropionate 1,2-dioxygenase [KO:K05713] [EC:1.13.11.16]
RM788_13215  alpha/beta fold hydrolase [KO:K05714] [EC:3.7.1.14]
RM788_13225  fumarylacetoacetate hydrolase family protein [KO:K02554] [EC:4.2.1.80]
RM788_04360  hypothetical protein [KO:K01666] [EC:4.1.3.39]
RM788_13235  dmpG; 4-hydroxy-2-oxovalerate aldolase [KO:K01666] [EC:4.1.3.39]
RM788_13230  acetaldehyde dehydrogenase (acetylating) [KO:K04073] [EC:1.2.1.10]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00042  Succinate
C00079  L-Phenylalanine
C00082  L-Tyrosine
C00084  Acetaldehyde
C00091  Succinyl-CoA
C00122  Fumarate
C00166  Phenylpyruvate
C00423  trans-Cinnamate
C00512  Benzoyl-CoA
C00582  Phenylacetyl-CoA
C00596  2-Hydroxy-2,4-pentadienoate
C00601  Phenylacetaldehyde
C00642  4-Hydroxyphenylacetate
C01198  3-(2-Hydroxyphenyl)propanoate
C01772  trans-2-Hydroxycinnamate
C02137  alpha-Oxo-benzeneacetic acid
C02232  3-Oxoadipyl-CoA
C02265  D-Phenylalanine
C02505  2-Phenylacetamide
C02763  2-Hydroxy-3-phenylpropenoate
C03519  N-Acetyl-L-phenylalanine
C03589  4-Hydroxy-2-oxopentanoate
C04044  3-(2,3-Dihydroxyphenyl)propanoate
C04148  Phenylacetylglutamine
C04479  2-Hydroxy-6-oxonona-2,4-diene-1,9-dioate
C05332  Phenethylamine
C05593  3-Hydroxyphenylacetate
C05598  Phenylacetylglycine
C05607  Phenyllactate
C05629  Phenylpropanoate
C05852  2-Hydroxyphenylacetate
C05853  Phenylethyl alcohol
C06207  2,6-Dihydroxyphenylacetate
C07086  Phenylacetic acid
C11457  3-(3-Hydroxyphenyl)propanoic acid
C11588  cis-3-(Carboxy-ethyl)-3,5-cyclo-hexadiene-1,2-diol
C12621  trans-3-Hydroxycinnamate
C12622  cis-3-(3-Carboxyethenyl)-3,5-cyclohexadiene-1,2-diol
C12623  trans-2,3-Dihydroxycinnamate
C12624  2-Hydroxy-6-ketononatrienedioate
C14144  5-Carboxy-2-pentenoyl-CoA
C14145  (3S)-3-Hydroxyadipyl-CoA
C15524  Phenylglyoxylyl-CoA
C19945  3-Oxo-5,6-dehydrosuberyl-CoA
C19946  3-Oxo-5,6-dehydrosuberyl-CoA semialdehyde
C19975  2-Oxepin-2(3H)-ylideneacetyl-CoA
C20062  2-(1,2-Epoxy-1,2-dihydrophenyl)acetyl-CoA
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:10537203
  Authors
Arai H, Yamamoto T, Ohishi T, Shimizu T, Nakata T, Kudo T.
  Title
Genetic organization and characteristics of the 3-(3-hydroxyphenyl)propionic acid degradation pathway of Comamonas testosteroni TA441.
  Journal
Microbiology 145 ( Pt 10):2813-20 (1999)
DOI:10.1099/00221287-145-10-2813
Reference
PMID:9603882
  Authors
Diaz E, Ferrandez A, Garcia JL.
  Title
Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12.
  Journal
J Bacteriol 180:2915-23 (1998)
DOI:10.1128/JB.180.11.2915-2923.1998
Reference
PMID:9098055
  Authors
Ferrandez A, Garcia JL, Diaz E.
  Title
Genetic characterization and expression in heterologous hosts of the 3-(3-hydroxyphenyl)propionate catabolic pathway of Escherichia coli K-12.
  Journal
J Bacteriol 179:2573-81 (1997)
DOI:10.1128/JB.179.8.2573-2581.1997
Reference
PMID:19016485
  Authors
Hwang JY, Park J, Seo JH, Cha M, Cho BK, Kim J, Kim BG
  Title
Simultaneous synthesis of 2-phenylethanol and L-homophenylalanine using aromatic transaminase with yeast Ehrlich pathway.
  Journal
Biotechnol Bioeng 102:1323-9 (2009)
DOI:10.1002/bit.22178
Reference
PMID:20660314
  Authors
Teufel R, Mascaraque V, Ismail W, Voss M, Perera J, Eisenreich W, Haehnel W, Fuchs G
  Title
Bacterial phenylalanine and phenylacetate catabolic pathway revealed.
  Journal
Proc Natl Acad Sci U S A 107:14390-5 (2010)
DOI:10.1073/pnas.1005399107
Related
pathway
ume00010  Glycolysis / Gluconeogenesis
ume00020  Citrate cycle (TCA cycle)
ume00350  Tyrosine metabolism
ume00362  Benzoate degradation
ume00400  Phenylalanine, tyrosine and tryptophan biosynthesis
ume00643  Styrene degradation
KO pathway
ko00360   
LinkDB

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