KEGG   PATHWAY: ko00360
Entry
ko00360                     Pathway                                
Name
Phenylalanine metabolism
Class
Metabolism; Amino acid metabolism
Pathway map
ko00360  Phenylalanine metabolism
ko00360

Module
M00545  Trans-cinnamate degradation, trans-cinnamate => acetyl-CoA [PATH:ko00360]
M00878  Phenylacetate degradation, phenylaxetate => acetyl-CoA/succinyl-CoA [PATH:ko00360]
Other DBs
GO: 0006558
Orthology
K00055  E1.1.1.90; aryl-alcohol dehydrogenase [EC:1.1.1.90]
K00074  paaH, hbd, fadB, mmgB; 3-hydroxybutyryl-CoA dehydrogenase [EC:1.1.1.157]
K00129  ALDH3; aldehyde dehydrogenase (NAD(P)+) [EC:1.2.1.5]
K00146  feaB, tynC; phenylacetaldehyde dehydrogenase [EC:1.2.1.39]
K00270  pdh; phenylalanine dehydrogenase [EC:1.4.1.20]
K00274  MAO, aofH; monoamine oxidase [EC:1.4.3.4]
K00276  AOC3, AOC2, tynA; primary-amine oxidase [EC:1.4.3.21]
K00285  dadA; D-amino-acid dehydrogenase [EC:1.4.5.1]
K00457  HPD, hppD; 4-hydroxyphenylpyruvate dioxygenase [EC:1.13.11.27]
K00500  phhA, PAH; phenylalanine-4-hydroxylase [EC:1.14.16.1]
K00529  hcaD; 3-phenylpropionate/trans-cinnamate dioxygenase ferredoxin reductase component [EC:1.18.1.3]
K00811  ASP5; aspartate aminotransferase, chloroplastic [EC:2.6.1.1]
K00812  aspB; aspartate aminotransferase [EC:2.6.1.1]
K00813  aspC; aspartate aminotransferase [EC:2.6.1.1]
K00815  TAT; tyrosine aminotransferase [EC:2.6.1.5]
K00817  hisC; histidinol-phosphate aminotransferase [EC:2.6.1.9]
K00824  dat; D-alanine transaminase [EC:2.6.1.21]
K00832  tyrB; aromatic-amino-acid transaminase [EC:2.6.1.57]
K00838  ARO8; aromatic amino acid aminotransferase I / 2-aminoadipate transaminase [EC:2.6.1.57 2.6.1.39 2.6.1.27 2.6.1.5]
K01426  E3.5.1.4, amiE; amidase [EC:3.5.1.4]
K01593  DDC, TDC; aromatic-L-amino-acid/L-tryptophan decarboxylase [EC:4.1.1.28 4.1.1.105]
K01666  mhpE; 4-hydroxy 2-oxovalerate aldolase [EC:4.1.3.39]
K01692  paaF, echA; enoyl-CoA hydratase [EC:4.2.1.17]
K01912  paaK; phenylacetate-CoA ligase [EC:6.2.1.30]
K02554  mhpD; 2-keto-4-pentenoate hydratase [EC:4.2.1.80]
K02609  paaA; ring-1,2-phenylacetyl-CoA epoxidase subunit PaaA [EC:1.14.13.149]
K02610  paaB; ring-1,2-phenylacetyl-CoA epoxidase subunit PaaB
K02611  paaC; ring-1,2-phenylacetyl-CoA epoxidase subunit PaaC [EC:1.14.13.149]
K02612  paaD; ring-1,2-phenylacetyl-CoA epoxidase subunit PaaD
K02613  paaE; ring-1,2-phenylacetyl-CoA epoxidase subunit PaaE
K02614  paaI; acyl-CoA thioesterase [EC:3.1.2.-]
K02615  paaJ; 3-oxo-5,6-didehydrosuberyl-CoA/3-oxoadipyl-CoA thiolase [EC:2.3.1.223 2.3.1.174]
K02618  paaZ; oxepin-CoA hydrolase / 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase [EC:3.3.2.12 1.2.1.91]
K03334  IL4I1; L-amino-acid oxidase [EC:1.4.3.2]
K03782  katG; catalase-peroxidase [EC:1.11.1.21]
K03825  aaaT; L-phenylalanine/L-methionine N-acetyltransferase [EC:2.3.1.53 2.3.1.-]
K04073  mhpF; acetaldehyde dehydrogenase [EC:1.2.1.10]
K05708  hcaE, hcaA1; 3-phenylpropionate/trans-cinnamate dioxygenase subunit alpha [EC:1.14.12.19]
K05709  hcaF, hcaA2; 3-phenylpropionate/trans-cinnamate dioxygenase subunit beta [EC:1.14.12.19]
K05710  hcaC; 3-phenylpropionate/trans-cinnamate dioxygenase ferredoxin component
K05711  hcaB; 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase [EC:1.3.1.87]
K05712  mhpA; 3-(3-hydroxy-phenyl)propionate hydroxylase [EC:1.14.13.127]
K05713  mhpB; 2,3-dihydroxyphenylpropionate 1,2-dioxygenase [EC:1.13.11.16]
K05714  mhpC; 2-hydroxy-6-oxonona-2,4-dienedioate hydrolase [EC:3.7.1.14]
K05821  ARO9; aromatic amino acid aminotransferase II [EC:2.6.1.58 2.6.1.28]
K07253  MIF; phenylpyruvate tautomerase [EC:5.3.2.1]
K10437  PHAA, PHACA, CYP504A1; phenylacetate 2-hydroxylase [EC:1.14.14.54]
K10775  PAL; phenylalanine ammonia-lyase [EC:4.3.1.24]
K10797  enr; 2-enoate reductase [EC:1.3.1.31]
K11358  yhdR; aspartate aminotransferase [EC:2.6.1.1]
K12732  ARO10; phenylpyruvate decarboxylase [EC:4.1.1.-]
K13064  PTAL; phenylalanine/tyrosine ammonia-lyase [EC:4.3.1.25]
K13371  aauA; aralkylamine dehydrogenase light chain [EC:1.4.9.2]
K13372  aauB; aralkylamine dehydrogenase heavy chain [EC:1.4.9.2]
K13574  hcxB; hydroxycarboxylate dehydrogenase B [EC:1.1.1.237 1.1.1.-]
K14454  GOT1; aspartate aminotransferase, cytoplasmic [EC:2.6.1.1]
K14455  GOT2; aspartate aminotransferase, mitochondrial [EC:2.6.1.1]
K15517  GLYAL; glycine N-phenylacetyltransferase [EC:2.3.1.192]
K15849  PAT, AAT; bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase [EC:2.6.1.1 2.6.1.78 2.6.1.79]
K15866  paaG; 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA isomerase [EC:5.3.3.18]
K18355  padG; phenylglyoxylate dehydrogenase alpha subunit [EC:1.2.1.58]
K18356  padI; phenylglyoxylate dehydrogenase beta subunit [EC:1.2.1.58]
K18357  padE; phenylglyoxylate dehydrogenase gamma subunit [EC:1.2.1.58]
K18358  padF; phenylglyoxylate dehydrogenase delta subunit [EC:1.2.1.58]
K18359  padH; phenylglyoxylate dehydrogenase epsilon subunit [EC:1.2.1.58]
K18360  padA; phenylacetyl-CoA:acceptor oxidoreductase accessory protein
K18361  padB; phenylacetyl-CoA:acceptor oxidoreductase [EC:1.17.5.1 3.1.2.25]
K18362  padC; phenylacetyl-CoA:acceptor oxidoreductase 27-kDa subunit
K18363  padD; phenylacetyl-CoA:acceptor oxidoreductase 26-kDa subunit
K18606  HPPR; hydroxyphenylpyruvate reductase [EC:1.1.1.237]
K21795  pao; phenylalanine 2-monooxygenase [EC:1.13.12.9]
K22328  PAAS; phenylacetaldehyde synthase [EC:4.1.1.109]
K22427  AADC; phenylalanine decarboxylase [EC:4.1.1.53]
K23109  fldH; aromatic 2-oxoacid reductase
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00042  Succinate
C00079  L-Phenylalanine
C00082  L-Tyrosine
C00084  Acetaldehyde
C00091  Succinyl-CoA
C00122  Fumarate
C00166  Phenylpyruvate
C00423  trans-Cinnamate
C00512  Benzoyl-CoA
C00582  Phenylacetyl-CoA
C00596  2-Hydroxy-2,4-pentadienoate
C00601  Phenylacetaldehyde
C00642  4-Hydroxyphenylacetate
C01198  3-(2-Hydroxyphenyl)propanoate
C01772  trans-2-Hydroxycinnamate
C02137  alpha-Oxo-benzeneacetic acid
C02232  3-Oxoadipyl-CoA
C02265  D-Phenylalanine
C02505  2-Phenylacetamide
C02763  2-Hydroxy-3-phenylpropenoate
C03519  N-Acetyl-L-phenylalanine
C03589  4-Hydroxy-2-oxopentanoate
C04044  3-(2,3-Dihydroxyphenyl)propanoate
C04148  Phenylacetylglutamine
C04479  2-Hydroxy-6-oxonona-2,4-diene-1,9-dioate
C05332  Phenethylamine
C05593  3-Hydroxyphenylacetate
C05598  Phenylacetylglycine
C05607  Phenyllactate
C05629  Phenylpropanoate
C05852  2-Hydroxyphenylacetate
C05853  Phenylethyl alcohol
C06207  2,6-Dihydroxyphenylacetate
C07086  Phenylacetic acid
C11457  3-(3-Hydroxyphenyl)propanoic acid
C11588  cis-3-(Carboxy-ethyl)-3,5-cyclo-hexadiene-1,2-diol
C12621  trans-3-Hydroxycinnamate
C12622  cis-3-(3-Carboxyethenyl)-3,5-cyclohexadiene-1,2-diol
C12623  trans-2,3-Dihydroxycinnamate
C12624  2-Hydroxy-6-ketononatrienedioate
C14144  5-Carboxy-2-pentenoyl-CoA
C14145  (3S)-3-Hydroxyadipyl-CoA
C15524  Phenylglyoxylyl-CoA
C19945  3-Oxo-5,6-dehydrosuberyl-CoA
C19946  3-Oxo-5,6-dehydrosuberyl-CoA semialdehyde
C19975  2-Oxepin-2(3H)-ylideneacetyl-CoA
C20062  2-(1,2-Epoxy-1,2-dihydrophenyl)acetyl-CoA
Reference
  Authors
Nishizuka Y, Seyama Y, Ikai A, Ishimura Y, Kawaguchi A (eds).
  Title
[Cellular Functions and Metabolic Maps] (In Japanese)
  Journal
Tokyo Kagaku Dojin (1997)
Reference
PMID:10537203
  Authors
Arai H, Yamamoto T, Ohishi T, Shimizu T, Nakata T, Kudo T.
  Title
Genetic organization and characteristics of the 3-(3-hydroxyphenyl)propionic acid degradation pathway of Comamonas testosteroni TA441.
  Journal
Microbiology 145 ( Pt 10):2813-20 (1999)
DOI:10.1099/00221287-145-10-2813
Reference
PMID:9603882
  Authors
Diaz E, Ferrandez A, Garcia JL.
  Title
Characterization of the hca cluster encoding the dioxygenolytic pathway for initial catabolism of 3-phenylpropionic acid in Escherichia coli K-12.
  Journal
J Bacteriol 180:2915-23 (1998)
DOI:10.1128/JB.180.11.2915-2923.1998
Reference
PMID:9098055
  Authors
Ferrandez A, Garcia JL, Diaz E.
  Title
Genetic characterization and expression in heterologous hosts of the 3-(3-hydroxyphenyl)propionate catabolic pathway of Escherichia coli K-12.
  Journal
J Bacteriol 179:2573-81 (1997)
DOI:10.1128/JB.179.8.2573-2581.1997
Reference
PMID:19016485
  Authors
Hwang JY, Park J, Seo JH, Cha M, Cho BK, Kim J, Kim BG
  Title
Simultaneous synthesis of 2-phenylethanol and L-homophenylalanine using aromatic transaminase with yeast Ehrlich pathway.
  Journal
Biotechnol Bioeng 102:1323-9 (2009)
DOI:10.1002/bit.22178
Reference
PMID:20660314
  Authors
Teufel R, Mascaraque V, Ismail W, Voss M, Perera J, Eisenreich W, Haehnel W, Fuchs G
  Title
Bacterial phenylalanine and phenylacetate catabolic pathway revealed.
  Journal
Proc Natl Acad Sci U S A 107:14390-5 (2010)
DOI:10.1073/pnas.1005399107
Related
pathway
ko00010  Glycolysis / Gluconeogenesis
ko00020  Citrate cycle (TCA cycle)
ko00350  Tyrosine metabolism
ko00362  Benzoate degradation
ko00400  Phenylalanine, tyrosine and tryptophan biosynthesis
ko00643  Styrene degradation
ko00960  Tropane, piperidine and pyridine alkaloid biosynthesis

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