KEGG   PATHWAY: vag02010
Entry
vag02010                    Pathway                                
Name
ABC transporters - Vibrio alginolyticus
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
Pathway map
vag02010  ABC transporters
vag02010

Other DBs
GO: 0043190 0043191 0043192
TC: 3.A.1
Organism
Vibrio alginolyticus [GN:vag]
Gene
N646_0557  hypothetical protein [KO:K05772]
N646_0556  ABC transporter, permease protein [KO:K05773]
N646_0555  ABC transporter, ATP-binding protein [KO:K06857] [EC:7.3.2.6]
N646_4429  nitrate ABC transporter nitrate-binding protein [KO:K15576]
N646_4428  putative nitrate transporter [KO:K15577]
N646_4427  hypothetical protein [KO:K15578] [EC:7.3.2.4]
N646_3566  hypothetical protein [KO:K15598]
N646_3567  ABC transporter permease protein [KO:K15599]
N646_3568  putative ABC transporter, ATP-binding protein [KO:K15600]
N646_4316  molybdenum ABC transporter, periplasmic molybdenum-binding protein [KO:K02020]
N646_4315  molybdate ABC transporter permease protein [KO:K02018]
N646_4314  molybdenum ABC transporter, ATP-binding protein [KO:K02017] [EC:7.3.2.5]
N646_4560  ATP-binding component of molybdate transport system [KO:K05776]
N646_1588  Iron-utilization periplasmic protein [KO:K02012]
N646_3670  putative 2-aminoethylphosphonate ABC transport system, 1-aminoethylphosphonate-binding protein component [KO:K02012]
N646_1587  iron(III) ABC transporter, permease protein [KO:K02011]
N646_3672  ABC transporter, permease protein [KO:K02011]
N646_1586  iron(III) ABC transporter, ATP-binding protein [KO:K02010] [EC:7.2.2.7]
N646_3671  ABC transporter, ATP-binding protein [KO:K02010] [EC:7.2.2.7]
N646_2505  thiamin ABC transporter, periplasmic thiamin-binding protein [KO:K02064]
N646_2506  thiamin ABC transporter membrane protein [KO:K02063]
N646_2507  putative thiamine ABC transporter, ATP-binding protein [KO:K02062] [EC:7.6.2.15]
N646_0575  spermidine/putrescine ABC transporter, periplasmic spermidine/putrescine-binding protein [KO:K11069]
N646_0576  spermidine/putrescine ABC transporter, periplasmic spermidine/putrescine-binding protein [KO:K11069]
N646_3784  spermidine/putrescine ABC transporter, periplasmic spermidine/putrescine-binding protein [KO:K11069]
N646_0577  spermidine/putrescine ABC transporter membrane protein [KO:K11070]
N646_0578  spermidine/putrescine ABC transporter membrane protein [KO:K11071]
N646_0579  putrescine/spermidine ABC transporter ATPase protein [KO:K11072] [EC:7.6.2.11]
N646_0436  ABC superfamily (glycine/betaine/proline transport protein) [KO:K02002]
N646_4490  hypothetical protein [KO:K02002]
N646_4063  putative glycine betaine-binding ABC transporter [KO:K02002]
N646_0437  glycine betaine/L-proline transport system permease [KO:K02001]
N646_3747  putative permease [KO:K02001]
N646_4064  putative permease of ABC transporter [KO:K02001]
N646_0438  ABC superfamily (glycine/betaine/proline transport protein) [KO:K02000] [EC:7.6.2.9]
N646_3746  putative glycine betaine ABC transporter ATP-binding protein [KO:K02000] [EC:7.6.2.9]
N646_4065  putative ATP-binding component of ABC transporter [KO:K02000] [EC:7.6.2.9]
N646_4524  Putative ABC transport protein [KO:K05845]
N646_4525  Putative ABC transporter permease [KO:K05846]
N646_4527  putative inner-membrane permease [KO:K05846]
N646_4526  putative ABC transporter ATP binding protein [KO:K05847] [EC:7.6.2.9]
N646_3116  maltose ABC transporter periplasmic protein [KO:K10108]
N646_3115  maltose ABC transporter, permease protein [KO:K10109]
N646_3114  maltose ABC transporter, permease protein [KO:K10110]
N646_3117  maltose/maltodextrin ABC transporter, ATP-binding protein [KO:K10111] [EC:7.5.2.-]
N646_1753  hypothetical protein [KO:K07323]
N646_1754  putative ABC superfamily transport protein [KO:K02067]
N646_1755  putative ABC superfamily transport protein [KO:K02066]
N646_1752  putative anti-sigma B factor antagonist [KO:K07122]
N646_1756  hypothetical protein [KO:K02065]
N646_4091  ribose ABC transporter, periplasmic D-ribose-binding protein [KO:K10439]
N646_4090  D-ribose transport system permease protein [KO:K10440]
N646_4089  ribose ABC transporter, ATP-binding protein [KO:K10441] [EC:7.5.2.7]
N646_4088  ribose ABC transporter protein [KO:K06726] [EC:5.4.99.62]
N646_3180  phosphate ABC transporter, periplasmic phosphate-binding protein [KO:K02040]
N646_2726  putative phosphate ABC transporter, periplasmic phosphate-binding protein [KO:K02040]
N646_4557  ABC transporter, periplasmic substrate-binding protein [KO:K02040]
N646_3179  phosphate ABC transporter, permease protein [KO:K02037]
N646_2730  phosphate ABC transporter, permease protein [KO:K02037]
N646_3178  phosphate ABC transporter, permease protein [KO:K02038]
N646_2731  phosphate ABC transporter, permease protein [KO:K02038]
N646_3177  phosphate ABC transporter, ATP-binding protein [KO:K02036] [EC:7.3.2.1]
N646_2732  phosphate ABC transporter, ATP-binding protein [KO:K02036] [EC:7.3.2.1]
N646_4487  arginine ABC transporter, periplasmic arginine-binding protein [KO:K09997]
N646_4485  arginine ABC transporter, permease protein [KO:K09998]
N646_4486  ABC-type arginine transport system, permease component [KO:K09999]
N646_4488  arginine ABC transporter, ATP-binding protein [KO:K10000] [EC:7.4.2.1]
N646_0645  amino acid ABC transporter, periplasmic amino acid-binding protein [KO:K09969]
N646_0647  amino acid ABC transporter, permease protein [KO:K09970]
N646_0648  amino acid ABC transporter, permease protein [KO:K09971]
N646_0649  amino acid ABC transporter, ATP-binding protein [KO:K09972] [EC:7.4.2.1]
N646_2188  amino acid ABC transporter, periplasmic amino acid-binding portion [KO:K16961]
N646_2187  amino acid ABC transporter, permease protein [KO:K16962]
N646_2186  amino acid ABC transporter, ATP-binding protein [KO:K16963]
N646_0063  amino acid ABC transporter, periplasmic amino acid-binding protein [KO:K10022]
N646_0685  hypothetical protein [KO:K10022]
N646_0066  amino acid ABC transporter, permease protein [KO:K10023]
N646_0065  membrane protein [KO:K10024]
N646_0062  amino acid ABC transporter, ATP-binding protein [KO:K10025] [EC:7.4.2.1]
N646_4028  hypothetical protein [KO:K01999]
N646_4026  putative ABC transporter, membrane spanning protein [KO:K01997]
N646_4027  putative high-affinity branched-chain amino acid transport permease protein [KO:K01998]
N646_4024  putative high-affinity branched-chain amino acid transport ATP-binding protein [KO:K01995]
N646_4029  putative high-affinity branched-chain amino acid transport ATP-binding protein [KO:K01996]
N646_2559  putative ABC transporter substrate binding protein [KO:K02073]
N646_2859  lipoprotein YaeC [KO:K02073]
N646_2860  ABC transporter, permease protein [KO:K02072]
N646_2861  ABC transporter, ATP-binding protein [KO:K02071]
N646_0381  oligopeptide ABC transporter, periplasmic oligopeptide-binding protein [KO:K15580]
N646_1166  oligopeptide ABC transporter, periplasmic oligopeptide-binding protein [KO:K15580]
N646_3452  oligopeptide ABC transporter, periplasmic oligopeptide-binding protein [KO:K15580]
N646_0380  oligopeptide ABC transporter, permease protein [KO:K15581]
N646_1165  oligopeptide permease ABC transporter membrane protein [KO:K15581]
N646_0379  oligopeptide ABC transporter, permease protein [KO:K15582]
N646_1164  oligopeptide ABC transporter, permease protein [KO:K15582]
N646_0378  oligopeptide ABC transporter, ATP-binding protein [KO:K15583]
N646_1163  oligopeptide transporter ATP-binding component [KO:K15583]
N646_3215  ABC transporter, ATP-binding protein [KO:K10823 K15583]
N646_0377  oligopeptide ABC transporter, ATP-binding protein [KO:K10823]
N646_1162  oligopeptide ABC transporter, ATP-binding protein [KO:K10823]
N646_0219  peptide ABC transporter, periplasmic peptide-binding protein [KO:K19226]
N646_0218  peptide ABC transporter, permease protein [KO:K19227]
N646_0217  peptide ABC transporter, permease protein [KO:K19228]
N646_0216  peptide ABC transporter, ATP-binding protein [KO:K19229]
N646_0215  peptide ABC transporter, ATP-binding protein [KO:K19230]
N646_2362  ABC-type oligopeptide transport system, periplasmic component [KO:K13893]
N646_1100  hypothetical protein [KO:K13893]
N646_2360  ABC-type transport system, permease component [KO:K13894]
N646_2361  putative peptide ABC transporter, permease protein [KO:K13895]
N646_3390  putative FecB [KO:K23181]
N646_3388  putative ferrichrome ABC transporter [KO:K23182]
N646_3389  putative ferrichrome ABC transporter (permease) [KO:K23183]
N646_3387  ATP-binding component of citrate-dependent iron(III) transport protein [KO:K23184] [EC:7.2.2.18]
N646_0828  ferrienterobactin-binding periplasmic protein fepB [KO:K23185]
N646_0831  ferric enterobactin transport system permease protein fepD [KO:K23186]
N646_0832  ferric enterobactin transport system permease protein fepG [KO:K23187]
N646_0833  ABC transporter ATP-binding protein [KO:K23188] [EC:7.2.2.17 7.2.2.-]
N646_0487  ferrichrome-binding protein [KO:K23227]
N646_3159  iron(III) ABC transporter, periplasmic iron-compound-binding protein [KO:K23227]
N646_0488  ABC type hydroxamate-dependent iron uptake permease [KO:K23228]
N646_3160  iron(III) ABC transporter, permease protein [KO:K23228]
N646_3158  iron(III) ABC transporter, ATP-binding protein [KO:K10829] [EC:7.2.2.16]
N646_0486  hypothetical protein [KO:K10829] [EC:7.2.2.16]
N646_2631  Vitamin B12 transport protein btuF precursor [KO:K06858]
N646_0349  vtamin B12-transporter permease [KO:K06073]
N646_0350  vitamin B12-transporter ATPase [KO:K06074] [EC:7.6.2.8]
N646_3005  zinc ABC transporter, periplasmic zinc-binding protein [KO:K09815]
N646_3596  putative adhesion protein [KO:K09815]
N646_3598  putative permease of ABC transporter [KO:K09816]
N646_3003  zinc ABC transporter, permease protein [KO:K09816]
N646_3597  putative ATP-binding component of ABC transporter [KO:K09817] [EC:7.2.2.20]
N646_3004  zinc ABC transporter, ATP-binding protein [KO:K09817] [EC:7.2.2.20]
N646_3202  putative ABC transporter membrane-spanning permease [KO:K16785]
N646_0043  hypothetical protein [KO:K09808]
N646_0045  hypothetical protein [KO:K09808]
N646_0044  ABC transporter, ATP-binding protein [KO:K09810] [EC:7.6.2.-]
N646_1323  heme exporter protein D [KO:K02196]
N646_1324  heme exporter protein C [KO:K02195]
N646_1325  heme exporter protein B [KO:K02194]
N646_1326  heme exporter protein A [KO:K02193] [EC:7.6.2.5]
N646_1736  putative permease [KO:K07091]
N646_1735  putative permease [KO:K11720]
N646_1761  ABC transporter, ATP-binding protein [KO:K06861] [EC:7.5.2.5]
N646_2050  cell division protein FtsX [KO:K09811]
N646_2051  cell division ATP-binding protein FtsE [KO:K09812]
N646_0048  transport ATP-binding protein MsbA [KO:K11085] [EC:7.5.2.6]
N646_0492  ATP-binding component of a transport system [KO:K18889]
N646_0491  putative ATP-binding component of a transport system [KO:K18890]
N646_3426  ABC transporter, ATP-binding protein [KO:K18893]
N646_3156  putative hemolysin secretion ATP-binding protein [KO:K18893]
N646_0459  Toxin secretion ATP-binding protein [KO:K12541]
N646_3446  toxin secretion ATP-binding protein [KO:K12541]
N646_4607  hypothetical protein [KO:K12541]
N646_4608  hypothetical protein [KO:K12541]
N646_3163  putative transport protein [KO:K12536]
N646_0286  transport ATP-binding protein CydC [KO:K16012]
N646_0287  transport ATP-binding protein CydD [KO:K16013]
N646_3660  macrolide-specific ABC-type efflux carrier [KO:K05685] [EC:7.6.2.-]
Compound
C00009  Orthophosphate
C00025  L-Glutamate
C00031  D-Glucose
C00032  Heme
C00034  Manganese
C00037  Glycine
C00038  Zinc cation
C00041  L-Alanine
C00047  L-Lysine
C00049  L-Aspartate
C00051  Glutathione
C00059  Sulfate
C00062  L-Arginine
C00064  L-Glutamine
C00065  L-Serine
C00070  Copper
C00077  L-Ornithine
C00079  L-Phenylalanine
C00086  Urea
C00088  Nitrite
C00089  Sucrose
C00093  sn-Glycerol 3-phosphate
C00095  D-Fructose
C00098  Oligopeptide
C00107  Dipeptide
C00114  Choline
C00116  Glycerol
C00120  Biotin
C00121  D-Ribose
C00123  L-Leucine
C00134  Putrescine
C00135  L-Histidine
C00137  myo-Inositol
C00140  N-Acetyl-D-glucosamine
C00148  L-Proline
C00151  L-Amino acid
C00159  D-Mannose
C00175  Cobalt ion
C00181  D-Xylose
C00183  L-Valine
C00185  Cellobiose
C00188  L-Threonine
C00208  Maltose
C00212  Adenosine
C00243  Lactose
C00244  Nitrate
C00245  Taurine
C00255  Riboflavin
C00259  L-Arabinose
C00288  HCO3-
C00291  Nickel
C00294  Inosine
C00299  Uridine
C00315  Spermidine
C00320  Thiosulfate
C00330  Deoxyguanosine
C00333  D-Galacturonate
C00338  Lipopolysaccharide
C00378  Thiamine
C00379  Xylitol
C00387  Guanosine
C00392  Mannitol
C00407  L-Isoleucine
C00430  5-Aminolevulinate
C00470  Pectate
C00475  Cytidine
C00487  Carnitine
C00491  L-Cystine
C00492  Raffinose
C00503  Erythritol
C00526  Deoxyuridine
C00559  Deoxyadenosine
C00719  Betaine
C00794  D-Sorbitol
C00855  D-Methionine
C00865  Phospholipid
C00881  Deoxycytidine
C00919  Choline sulfate
C00973  Cyclomaltodextrin
C01083  alpha,alpha-Trehalose
C01153  Orthophosphoric monoester
C01157  Hydroxyproline
C01177  Inositol 1-phosphate
C01181  4-Trimethylammoniobutanoate
C01279  4-Amino-5-hydroxymethyl-2-methylpyrimidine
C01330  Sodium cation
C01417  Cyanate
C01487  D-Allose
C01606  Phthalate
C01630  Xylobiose
C01667  Bacitracin
C01674  Chitobiose
C01682  Nopaline
C01684  D-Rhamnose
C01762  Xanthosine
C01834  Lipoprotein
C01835  Maltotriose
C01935  Maltodextrin
C01946  Oleandomycin
C02160  Isomaltotriose
C02273  Digalacturonate
C03557  2-Aminoethylphosphonate
C03611  Galactose oligosaccharide
C03619  Methyl beta-D-galactoside
C04114  (E)-4-(Trimethylammonio)but-2-enoate
C04137  Octopine
C05349  Ciprofloxacin
C05402  Melibiose
C05512  Deoxyinosine
C05776  Vitamin B12
C06227  Fe(III)hydroxamate
C06229  Fe(III)dicitrate
C06230  Fe-enterobactin
C06232  Molybdate
C06687  Norfloxacin
C06705  Capsular polysaccharide
C06706  Lipo-oligosaccharide
C06707  Teichoic acid
C06767  Hemine
C07662  Sparfloxacin
C07663  Moxifloxacin
C11612  Polymyxin B
C13768  Colistin sulfate
C14818  Fe2+
C14819  Fe3+
C15521  Alkanesulfonate
C15719  Coelichelin
C16421  AI-2
C16692  Mannopine
C19609  Nickel(2+)
C19872  N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570  alpha-1,5-L-Arabinobiose
C20571  alpha-1,5-L-Arabinotriose
C20572  alpha-1,5-L-Arabinotetraose
C20573  Aldotetraouronic acid
C20679  Tungstate
C21066  D-Galactofuranose
C22040  S-Methyl-L-cysteine
G00457  Maltotetraose
Reference
PMID:9799792
  Authors
Tomii K, Kanehisa M.
  Title
A comparative analysis of ABC transporters in complete microbial genomes.
  Journal
Genome Res 8:1048-59 (1998)
DOI:10.1101/gr.8.10.1048
Reference
  Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
  Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
J Bacteriol 190:4460-9 (2008)
DOI:10.1128/JB.00270-08
Reference
  Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
  Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
  Journal
Proc Natl Acad Sci U S A 105:5537-42 (2008)
DOI:10.1073/pnas.0801196105
Reference
  Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
  Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
  Journal
Proc Natl Acad Sci U S A 96:13571-6 (1999)
DOI:10.1073/pnas.96.23.13571
Reference
  Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
  Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
  Journal
Genome Res 11:2034-40 (2001)
DOI:10.1101/gr.196301
Reference
  Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
  Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
  Journal
Mol Microbiol 57:1582-92 (2005)
DOI:10.1111/j.1365-2958.2005.04791.x
Reference
  Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
  Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
  Journal
Mol Microbiol 43:703-15 (2002)
DOI:10.1046/j.1365-2958.2002.02778.x
Reference
  Authors
Richard-Fogal CL, Frawley ER, Kranz RG
  Title
Topology and function of CcmD in cytochrome c maturation.
  Journal
J Bacteriol 190:3489-93 (2008)
DOI:10.1128/JB.00146-08
Reference
  Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
  Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
  Journal
J Bacteriol 187:5861-7 (2005)
DOI:10.1128/JB.187.17.5861-5867.2005
Reference
  Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
  Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
  Journal
J Bacteriol 189:8361-5 (2007)
DOI:10.1128/JB.01028-07
Reference
  Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
  Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
  Journal
Mol Microbiol 63:895-910 (2007)
DOI:10.1111/j.1365-2958.2006.05549.x
Reference
  Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
  Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
  Journal
J Bacteriol 190:7693-8 (2008)
DOI:10.1128/JB.00853-08
KO pathway
ko02010   
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