KEGG   PATHWAY: xac03070
Entry
xac03070                    Pathway                                
Name
Bacterial secretion system - Xanthomonas citri pv. citri 306
Description
Gram-negative bacteria secrete a wide range of proteins whose functions include biogenesis of organelles, such as pilli and flagella, nutrient acquisition, virulence, and efflux of drugs and other toxins. Six distinct secretion systems have been shown to mediate protein export through the inner and outer membranes of Gram-negative bacteria. These pathways are highly conserved throughout the Gram-negative bacterial species. In Gram-positive bacteria, secreted proteins are commonly translocated across the single membrane by the Sec pathway or the two-arginine (Tat) pathway.
Class
Environmental Information Processing; Membrane transport
Pathway map
xac03070  Bacterial secretion system
xac03070

Other DBs
GO: 0030253 0015628 0030254 0030255 0046819 0033103 0044098 0043952 0043953
Organism
Xanthomonas citri pv. citri 306 [GN:xac]
Gene
XAC3463  tolC; TolC protein [KO:K12340]
XAC2201  hlyD; hemolysin secretion protein D [KO:K11003]
XAC2202  hlyB; hemolysin secretion protein B [KO:K11004]
XAC0415  hrcC; HrcC protein [KO:K03219]
XAC0409  hrcJ; HrcJ protein [KO:K03222]
XAC0402  hrcR; HrcR protein [KO:K03226]
XAC0401  hrcS; HrcS protein [KO:K03227]
XAC0414  hrcT; HrcT protein [KO:K03228]
XAC0406  hrcU; HrcU protein [KO:K03229]
XAC0405  hrcV; HrcV protein [KO:K03230]
XAC0412  hrcN; HrcN protein [KO:K03224] [EC:7.4.2.8]
XAC0403  hrcQ; HrcQ protein [KO:K03225]
XAC0411  hrpB5; HrpB5 protein [KO:K03223]
XAC0695  xcsD; type II secretion system protein D [KO:K02453]
XAC3534  xpsD; general secretion pathway protein D [KO:K02453]
XAC0694  xcsC; type II secretion system protein C [KO:K02452]
XAC0697  xcsF; type II secretion system protein F [KO:K02455]
XAC3543  xpsF; general secretion pathway protein F [KO:K02455]
XAC0698  xcsG; type II secretion system protein G [KO:K02456]
XAC3542  xpsG; general secretion pathway protein G [KO:K02456]
XAC0699  xcsH; type II secretion system protein H [KO:K02457]
XAC3541  xpsH; general secretion pathway protein H [KO:K02457]
XAC0700  xcsI; type II secretion system protein I [KO:K02458]
XAC3540  xpsI; general secretion pathway protein I [KO:K02458]
XAC0701  xcsJ; type II secretion system protein J [KO:K02459]
XAC3539  xpsJ; general secretion pathway protein J [KO:K02459]
XAC0702  xcsK; type II secretion system protein K [KO:K02460]
XAC3538  xpsK; general secretion pathway protein K [KO:K02460]
XAC0703  xcsL; type II secretion system protein L [KO:K02461]
XAC3537  xpsL; general secretion pathway protein L [KO:K02461]
XAC0704  xcsM; type II secretion system protein M [KO:K02462]
XAC3536  xpsM; general secretion pathway protein M [KO:K02462]
XAC0696  xcsE; type II secretion system protein E [KO:K02454] [EC:7.4.2.8]
XAC3544  xpsE; general secretion pathway protein E [KO:K02454] [EC:7.4.2.8]
XAC4212  gspE; general secretory pathway related protein [KO:K02454] [EC:7.4.2.8]
XAC2511  secD; protein-export membrane protein [KO:K03072]
XAC2510  secF; protein-export membrane protein [KO:K03074]
XAC0959  secE; preprotein translocase subunit [KO:K03073]
XAC2706  secG; protein-export membrane protein [KO:K03075]
XAC0992  secY; preprotein translocase SecY subunit [KO:K03076]
XAC2512  yajC; preprotein translocase YajC subunit [KO:K03210]
XAC4372  60 kDa inner-membrane protein [KO:K03217]
XAC0788  secA; preprotein translocase SecA subunit [KO:K03070] [EC:7.4.2.8]
XAC2552  ftsY; cell division protein [KO:K03110]
XAC0221  secB; protein-export protein [KO:K03071]
XAC1289  ffh; signal recognition particle protein [KO:K03106] [EC:3.6.5.4]
XAC4218  tatA; sec-independent protein translocase [KO:K03116]
XAC4217  tatB; sec-independent protein translocase [KO:K03117]
XAC4216  tatC; sec-independent protein translocase [KO:K03118]
XAC2617  virB1; VirB1 protein [KO:K03194]
XACb0036  virB1; VirB1 protein [KO:K03194]
XAC2616  virB2; VirB2 protein [KO:K03197]
XACb0047  virB2; VirB2 protein [KO:K03197]
XAC2615  virB3; VirB3 protein [KO:K03198]
XACb0046  virB3; VirB3 protein [KO:K03198]
XAC2613  hypothetical protein [KO:K03200]
XACb0044  virB5; VirB5 protein [KO:K03200]
XAC2620  virB9; VirB9 protein [KO:K03204]
XACb0039  virB9; VirB9 protein [KO:K03204]
XAC2612  virB6; VirB6 protein [KO:K03201]
XAC2607  virB6; VirB6 protein [KO:K03201]
XAC2608  VirB6 protein [KO:K03201]
XACb0041  virB6; VirB6 protein [KO:K03201]
XAC2621  virB8; VirB8 protein [KO:K03203]
XACb0040  virB8; VirB8 protein [KO:K03203]
XAC2619  virB10; VirB10 protein [KO:K03195]
XACb0038  virB10; VirB10 protein [KO:K03195]
XAC2614  virB4; VirB4 protein [KO:K03199] [EC:7.4.2.8]
XACb0045  virB4; VirB4 protein [KO:K03199] [EC:7.4.2.8]
XAC2618  virB11; VirB11 protein [KO:K03196] [EC:7.4.2.8]
XACb0037  virB11; VirB11 protein [KO:K03196] [EC:7.4.2.8]
XAC2623  virD4; VirD4 protein [KO:K03205] [EC:7.4.2.8]
XAC4124  conserved hypothetical protein [KO:K11904]
XAC4145  conserved hypothetical protein [KO:K11903]
XAC4119  conserved hypothetical protein [KO:K11891]
XAC4120  conserved hypothetical protein [KO:K11892]
XAC4140  clpB; ClpB [KO:K11907]
Compound
C00002  ATP
Reference
PMID:11173102
  Authors
Kim JF.
  Title
Revisiting the chlamydial type III protein secretion system: clues to the origin of type III protein secretion.
  Journal
Trends Genet 17:65-9 (2001)
DOI:10.1016/S0168-9525(00)02175-2
Reference
PMID:11309112
  Authors
Plano GV, Day JB, Ferracci F.
  Title
Type III export: new uses for an old pathway.
  Journal
Mol Microbiol 40:284-93 (2001)
DOI:10.1046/j.1365-2958.2001.02354.x
Reference
PMID:11413015
  Authors
Gauthier A, Finlay BB.
  Title
Bacterial pathogenesis: the answer to virulence is in the pore.
  Journal
Curr Biol 11:R264-7 (2001)
DOI:10.1016/S0960-9822(01)00134-8
Reference
PMID:10047550
  Authors
Burns DL.
  Title
Biochemistry of type IV secretion.
  Journal
Curr Opin Microbiol 2:25-9 (1999)
DOI:10.1016/S1369-5274(99)80004-6
Reference
PMID:10920394
  Authors
Christie PJ, Vogel JP.
  Title
Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cells.
  Journal
Trends Microbiol 8:354-60 (2000)
DOI:10.1016/S0966-842X(00)01792-3
Reference
PMID:11309113
  Authors
Christie PJ.
  Title
Type IV secretion: intercellular transfer of macromolecules by systems ancestrally related to conjugation machines.
  Journal
Mol Microbiol 40:294-305 (2001)
DOI:10.1046/j.1365-2958.2001.02302.x
Reference
PMID:10481178
  Authors
Nunn D.
  Title
Bacterial type II protein export and pilus biogenesis: more than just homologies?
  Journal
Trends Cell Biol 9:402-8 (1999)
DOI:10.1016/S0962-8924(99)01634-7
Reference
PMID:11309111
  Authors
Sandkvist M.
  Title
Biology of type II secretion.
  Journal
Mol Microbiol 40:271-83 (2001)
DOI:10.1046/j.1365-2958.2001.02403.x
Reference
PMID:11349009
  Authors
Sandkvist M.
  Title
Type II secretion and pathogenesis.
  Journal
Infect Immun 69:3523-35 (2001)
DOI:10.1128/IAI.69.6.3523-3535.2001
Reference
PMID:15546664
  Authors
Delepelaire P
  Title
Type I secretion in gram-negative bacteria.
  Journal
Biochim Biophys Acta 1694:149-61 (2004)
DOI:10.1016/j.bbamcr.2004.05.001
Reference
PMID:18406342
  Authors
Hazes B, Frost L
  Title
Towards a systems biology approach to study type II/IV secretion systems.
  Journal
Biochim Biophys Acta 1778:1839-50 (2008)
DOI:10.1016/j.bbamem.2008.03.011
Reference
PMID:16448494
  Authors
Johnson TL, Abendroth J, Hol WG, Sandkvist M
  Title
Type II secretion: from structure to function.
  Journal
FEMS Microbiol Lett 255:175-86 (2006)
DOI:10.1111/j.1574-6968.2006.00102.x
Reference
PMID:15546665
  Authors
Filloux A
  Title
The underlying mechanisms of type II protein secretion.
  Journal
Biochim Biophys Acta 1694:163-79 (2004)
DOI:10.1016/j.bbamcr.2004.05.003
Reference
PMID:19396170
  Authors
Spreter T, Yip CK, Sanowar S, Andre I, Kimbrough TG, Vuckovic M, Pfuetzner RA, Deng W, Yu AC, Finlay BB, Baker D, Miller SI, Strynadka NC
  Title
A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system.
  Journal
Nat Struct Mol Biol 16:468-76 (2009)
DOI:10.1038/nsmb.1603
Reference
PMID:15590783
  Authors
Ghosh P
  Title
Process of protein transport by the type III secretion system.
  Journal
Microbiol Mol Biol Rev 68:771-95 (2004)
DOI:10.1128/MMBR.68.4.771-795.2004
Reference
PMID:12360191
  Authors
Cornelis GR
  Title
The Yersinia Ysc-Yop 'type III' weaponry.
  Journal
Nat Rev Mol Cell Biol 3:742-52 (2002)
DOI:10.1038/nrm932
Reference
PMID:17215876
  Authors
Baron C
  Title
VirB8: a conserved type IV secretion system assembly factor and drug target.
  Journal
Biochem Cell Biol 84:890-9 (2006)
DOI:10.1139/o06-148
Reference
PMID:17943123
  Authors
Kwok T, Zabler D, Urman S, Rohde M, Hartig R, Wessler S, Misselwitz R, Berger J, Sewald N, Konig W, Backert S
  Title
Helicobacter exploits integrin for type IV secretion and kinase activation.
  Journal
Nature 449:862-6 (2007)
DOI:10.1038/nature06187
Reference
PMID:16092524
  Authors
Christie PJ, Cascales E
  Title
Structural and dynamic properties of bacterial type IV secretion systems (review).
  Journal
Mol Membr Biol 22:51-61 (2005)
DOI:10.1080/09687860500063316
Reference
PMID:15546668
  Authors
Christie PJ
  Title
Type IV secretion: the Agrobacterium VirB/D4 and related conjugation systems.
  Journal
Biochim Biophys Acta 1694:219-34 (2004)
DOI:10.1016/j.bbamcr.2004.02.013
Reference
PMID:15590781
  Authors
Henderson IR, Navarro-Garcia F, Desvaux M, Fernandez RC, Ala'Aldeen D
  Title
Type V protein secretion pathway: the autotransporter story.
  Journal
Microbiol Mol Biol Rev 68:692-744 (2004)
DOI:10.1128/MMBR.68.4.692-744.2004
Reference
PMID:9778731
  Authors
Henderson IR, Navarro-Garcia F, Nataro JP
  Title
The great escape: structure and function of the autotransporter proteins.
  Journal
Trends Microbiol 6:370-8 (1998)
DOI:10.1016/S0966-842X(98)01318-3
Reference
PMID:18524912
  Authors
Filloux A, Hachani A, Bleves S
  Title
The bacterial type VI secretion machine: yet another player for protein transport across membranes.
  Journal
Microbiology 154:1570-83 (2008)
DOI:10.1099/mic.0.2008/016840-0
Reference
PMID:19251641
  Authors
Leiman PG, Basler M, Ramagopal UA, Bonanno JB, Sauder JM, Pukatzki S, Burley SK, Almo SC, Mekalanos JJ
  Title
Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin.
  Journal
Proc Natl Acad Sci U S A 106:4154-9 (2009)
DOI:10.1073/pnas.0813360106
Reference
PMID:17603507
  Authors
Kulasekara HD, Miller SI
  Title
Threonine phosphorylation times bacterial secretion.
  Journal
Nat Cell Biol 9:734-6 (2007)
DOI:10.1038/ncb0707-734
Reference
PMID:18078384
  Authors
Driessen AJ, Nouwen N
  Title
Protein translocation across the bacterial cytoplasmic membrane.
  Journal
Annu Rev Biochem 77:643-67 (2008)
DOI:10.1146/annurev.biochem.77.061606.160747
Reference
PMID:14641032
  Authors
Pool MR
  Title
Getting to the membrane: how is co-translational protein targeting to the endoplasmic reticulum regulated?
  Journal
Biochem Soc Trans 31:1232-7 (2003)
DOI:10.1042/bst0311232
Reference
PMID:19299134
  Authors
Desvaux M, Hebraud M, Talon R, Henderson IR
  Title
Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
  Journal
Trends Microbiol 17:139-45 (2009)
DOI:10.1016/j.tim.2009.01.004
Reference
PMID:15063851
  Authors
Nakatogawa H, Murakami A, Ito K
  Title
Control of SecA and SecM translation by protein secretion.
  Journal
Curr Opin Microbiol 7:145-50 (2004)
DOI:10.1016/j.mib.2004.01.001
KO pathway
ko03070   
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