KEGG   PATHWAY: xcv03070
Entry
xcv03070                    Pathway                                
Name
Bacterial secretion system - Xanthomonas campestris pv. vesicatoria
Description
Gram-negative bacteria secrete a wide range of proteins whose functions include biogenesis of organelles, such as pilli and flagella, nutrient acquisition, virulence, and efflux of drugs and other toxins. Six distinct secretion systems have been shown to mediate protein export through the inner and outer membranes of Gram-negative bacteria. These pathways are highly conserved throughout the Gram-negative bacterial species. In Gram-positive bacteria, secreted proteins are commonly translocated across the single membrane by the Sec pathway or the two-arginine (Tat) pathway.
Class
Environmental Information Processing; Membrane transport
Pathway map
xcv03070  Bacterial secretion system
xcv03070

Other DBs
GO: 0030253 0015628 0030254 0030255 0046819 0033103 0044098 0043952 0043953
Organism
Xanthomonas campestris pv. vesicatoria [GN:xcv]
Gene
XCV3591  raxC; outer membrane efflux protein RaxC [KO:K12340]
XCV0435  hrcC; HrcC protein [KO:K03219]
XCV0429  hrcJ; HrcJ protein [KO:K03222]
XCV0422  hrcR; HrcR protein [KO:K03226]
XCV0421  hrcS; HrcS protein [KO:K03227]
XCV0434  hrcT; HrcT protein [KO:K03228]
XCV0426  hrcU; HrcU protein [KO:K03229]
XCV0425  hrcV; HrcV protein [KO:K03230]
XCV0432  hrcN; HrcN protein [KO:K03224] [EC:7.4.2.8]
XCV0423  hrcQ; HrcQ protein [KO:K03225]
XCV0431  hrcL; HrcL protein [KO:K03223]
XCV3658  xpsD; type II secretory pathway component [KO:K02453]
XCV0756  xcsD; type II secretory pathway protein D [KO:K02453]
XCV0755  xcsC; type II secretion system protein C [KO:K02452]
XCV3667  xpsF; type II secretory pathway component [KO:K02455]
XCV0758  xcsF; type II secretion system protein F [KO:K02455]
XCV3666  xpsG; type II secretory pathway pseudopilin [KO:K02456]
XCV0759  xcsG; type II secretory pathway pseudopilin [KO:K02456]
XCV3665  xpsH; general secretion pathway protein [KO:K02457]
XCV0760  xcsH; type II secretion system protein H [KO:K02457]
XCV3664  xpsI; type II secretory pathway pseudopilin [KO:K02458]
XCV0761  xcsI; type II secretory pathway pseudopilin [KO:K02458]
XCV3663  xpsJ; general secretion pathway protein J [KO:K02459]
XCV0762  xcsJ; type II secretion system protein J [KO:K02459]
XCV3662  xpsK; general secretion pathway protein K [KO:K02460]
XCV0763  xcsK; type II secretion system protein K [KO:K02460]
XCV3661  xpsL; general secretion pathway protein [KO:K02461]
XCV0764  xcsL; type II secretion system protein L [KO:K02461]
XCV3660  xpsM; general secretion pathway protein M [KO:K02462]
XCV0765  xcsM; type II secretion system protein M [KO:K02462]
XCV4312  type II secretory pathway ATPase [KO:K02454] [EC:7.4.2.8]
XCV3668  xpsE; type II secretory pathway ATPase [KO:K02454] [EC:7.4.2.8]
XCV0757  xcsE; type II secretory pathway ATPase [KO:K02454] [EC:7.4.2.8]
XCV2693  secD; preprotein translocase subunit SecD [KO:K03072]
XCV2692  secF; preprotein translocase subunit SecF [KO:K03074]
XCV0985  secE; preprotein translocase subunit SecE [KO:K03073]
XCV2854  secG; preprotein translocase subunit SecG [KO:K03075]
XCV1019  secY; preprotein translocase subunit SecY [KO:K03076]
XCV2694  yajC; preprotein translocase subunit YajC [KO:K03210]
XCV4485  yidC; preprotein translocase subunit YidC [KO:K03217]
XCV0839  secA; preprotein translocase subunit SecA [KO:K03070] [EC:7.4.2.8]
XCV2750  ftsY; cell division protein FtsY [KO:K03110]
XCV0206  secB; preprotein translocase subunit SecB [KO:K03071]
XCV1338  ffh; Signal recognition particle protein [KO:K03106] [EC:3.6.5.4]
XCV4321  tatA; Sec-independent protein translocase TatA [KO:K03116]
XCV4320  tatB; Sec-independent protein translocase TatB [KO:K03117]
XCV4319  tatC; Sec-independent protein translocase TatC [KO:K03118]
XCVc0028  virB1; type IV secretion system protein VirB1 [KO:K03194]
XCVc0042  virB2; type IV secretion system protein VirB2 [KO:K03197]
XCVc0035  virB5; putative type IV secretion system protein VirB5 [KO:K03200]
XCV3556  putative secreted protein [KO:K03200]
XCVc0031  virB9; type IV secretion system protein VirB9 [KO:K03204]
XCV2807  virB9; type IV secretion system protein VirB9 [KO:K03204]
XCV3390  virB6; type IV secretion system protein VirB6 [KO:K03201]
XCV3558  virB6; type IV secretion system protein VirB6 [KO:K03201]
XCVc0033  virB6; type IV secretion system protein VirB6 [KO:K03201]
XCV3561  virB6; type IV secretion system protein VirB6 [KO:K03201]
XCV3564  virB6; type IV secretion system protein VirB6 [KO:K03201]
XCVc0032  virB8; type IV secretion system protein VirB8 [KO:K03203]
XCV2808  virB8; type IV secretion system protein VirB8 [KO:K03203]
XCVc0030  virB10; type IV secretion system protein VirB10 [KO:K03195]
XCVc0041  virB4; type IV secretion system protein VirB4 [KO:K03199] [EC:7.4.2.8]
XCVc0029  virB11; type IV secretion system protein VirB11 [KO:K03196] [EC:7.4.2.8]
XCV2810  virD4; type IV secretion system protein VirD4 [KO:K03205] [EC:7.4.2.8]
XCV2133  conserved hypothetical protein [KO:K11904]
XCV4217  conserved hypothetical protein [KO:K11904]
XCV4241  conserved hypothetical protein [KO:K11903]
XCV2122  conserved hypothetical protein [KO:K11903]
XCV4209  putative membrane protein [KO:K11891]
XCV2138  putative membrane protein [KO:K11891]
XCV4210  putative membrane protein [KO:K11892]
XCV2137  OmpA family membrane protein [KO:K11892]
XCV4236  clpB; ClpB protein [KO:K11907]
XCV2127  clpB1; ATP-dependent Clp protease subunit [KO:K11907]
Compound
C00002  ATP
Reference
PMID:11173102
  Authors
Kim JF.
  Title
Revisiting the chlamydial type III protein secretion system: clues to the origin of type III protein secretion.
  Journal
Trends Genet 17:65-9 (2001)
DOI:10.1016/S0168-9525(00)02175-2
Reference
PMID:11309112
  Authors
Plano GV, Day JB, Ferracci F.
  Title
Type III export: new uses for an old pathway.
  Journal
Mol Microbiol 40:284-93 (2001)
DOI:10.1046/j.1365-2958.2001.02354.x
Reference
PMID:11413015
  Authors
Gauthier A, Finlay BB.
  Title
Bacterial pathogenesis: the answer to virulence is in the pore.
  Journal
Curr Biol 11:R264-7 (2001)
DOI:10.1016/S0960-9822(01)00134-8
Reference
PMID:10047550
  Authors
Burns DL.
  Title
Biochemistry of type IV secretion.
  Journal
Curr Opin Microbiol 2:25-9 (1999)
DOI:10.1016/S1369-5274(99)80004-6
Reference
PMID:10920394
  Authors
Christie PJ, Vogel JP.
  Title
Bacterial type IV secretion: conjugation systems adapted to deliver effector molecules to host cells.
  Journal
Trends Microbiol 8:354-60 (2000)
DOI:10.1016/S0966-842X(00)01792-3
Reference
PMID:11309113
  Authors
Christie PJ.
  Title
Type IV secretion: intercellular transfer of macromolecules by systems ancestrally related to conjugation machines.
  Journal
Mol Microbiol 40:294-305 (2001)
DOI:10.1046/j.1365-2958.2001.02302.x
Reference
PMID:10481178
  Authors
Nunn D.
  Title
Bacterial type II protein export and pilus biogenesis: more than just homologies?
  Journal
Trends Cell Biol 9:402-8 (1999)
DOI:10.1016/S0962-8924(99)01634-7
Reference
PMID:11309111
  Authors
Sandkvist M.
  Title
Biology of type II secretion.
  Journal
Mol Microbiol 40:271-83 (2001)
DOI:10.1046/j.1365-2958.2001.02403.x
Reference
PMID:11349009
  Authors
Sandkvist M.
  Title
Type II secretion and pathogenesis.
  Journal
Infect Immun 69:3523-35 (2001)
DOI:10.1128/IAI.69.6.3523-3535.2001
Reference
PMID:15546664
  Authors
Delepelaire P
  Title
Type I secretion in gram-negative bacteria.
  Journal
Biochim Biophys Acta 1694:149-61 (2004)
DOI:10.1016/j.bbamcr.2004.05.001
Reference
PMID:18406342
  Authors
Hazes B, Frost L
  Title
Towards a systems biology approach to study type II/IV secretion systems.
  Journal
Biochim Biophys Acta 1778:1839-50 (2008)
DOI:10.1016/j.bbamem.2008.03.011
Reference
PMID:16448494
  Authors
Johnson TL, Abendroth J, Hol WG, Sandkvist M
  Title
Type II secretion: from structure to function.
  Journal
FEMS Microbiol Lett 255:175-86 (2006)
DOI:10.1111/j.1574-6968.2006.00102.x
Reference
PMID:15546665
  Authors
Filloux A
  Title
The underlying mechanisms of type II protein secretion.
  Journal
Biochim Biophys Acta 1694:163-79 (2004)
DOI:10.1016/j.bbamcr.2004.05.003
Reference
PMID:19396170
  Authors
Spreter T, Yip CK, Sanowar S, Andre I, Kimbrough TG, Vuckovic M, Pfuetzner RA, Deng W, Yu AC, Finlay BB, Baker D, Miller SI, Strynadka NC
  Title
A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system.
  Journal
Nat Struct Mol Biol 16:468-76 (2009)
DOI:10.1038/nsmb.1603
Reference
PMID:15590783
  Authors
Ghosh P
  Title
Process of protein transport by the type III secretion system.
  Journal
Microbiol Mol Biol Rev 68:771-95 (2004)
DOI:10.1128/MMBR.68.4.771-795.2004
Reference
PMID:12360191
  Authors
Cornelis GR
  Title
The Yersinia Ysc-Yop 'type III' weaponry.
  Journal
Nat Rev Mol Cell Biol 3:742-52 (2002)
DOI:10.1038/nrm932
Reference
PMID:17215876
  Authors
Baron C
  Title
VirB8: a conserved type IV secretion system assembly factor and drug target.
  Journal
Biochem Cell Biol 84:890-9 (2006)
DOI:10.1139/o06-148
Reference
PMID:17943123
  Authors
Kwok T, Zabler D, Urman S, Rohde M, Hartig R, Wessler S, Misselwitz R, Berger J, Sewald N, Konig W, Backert S
  Title
Helicobacter exploits integrin for type IV secretion and kinase activation.
  Journal
Nature 449:862-6 (2007)
DOI:10.1038/nature06187
Reference
PMID:16092524
  Authors
Christie PJ, Cascales E
  Title
Structural and dynamic properties of bacterial type IV secretion systems (review).
  Journal
Mol Membr Biol 22:51-61 (2005)
DOI:10.1080/09687860500063316
Reference
PMID:15546668
  Authors
Christie PJ
  Title
Type IV secretion: the Agrobacterium VirB/D4 and related conjugation systems.
  Journal
Biochim Biophys Acta 1694:219-34 (2004)
DOI:10.1016/j.bbamcr.2004.02.013
Reference
PMID:15590781
  Authors
Henderson IR, Navarro-Garcia F, Desvaux M, Fernandez RC, Ala'Aldeen D
  Title
Type V protein secretion pathway: the autotransporter story.
  Journal
Microbiol Mol Biol Rev 68:692-744 (2004)
DOI:10.1128/MMBR.68.4.692-744.2004
Reference
PMID:9778731
  Authors
Henderson IR, Navarro-Garcia F, Nataro JP
  Title
The great escape: structure and function of the autotransporter proteins.
  Journal
Trends Microbiol 6:370-8 (1998)
DOI:10.1016/S0966-842X(98)01318-3
Reference
PMID:18524912
  Authors
Filloux A, Hachani A, Bleves S
  Title
The bacterial type VI secretion machine: yet another player for protein transport across membranes.
  Journal
Microbiology 154:1570-83 (2008)
DOI:10.1099/mic.0.2008/016840-0
Reference
PMID:19251641
  Authors
Leiman PG, Basler M, Ramagopal UA, Bonanno JB, Sauder JM, Pukatzki S, Burley SK, Almo SC, Mekalanos JJ
  Title
Type VI secretion apparatus and phage tail-associated protein complexes share a common evolutionary origin.
  Journal
Proc Natl Acad Sci U S A 106:4154-9 (2009)
DOI:10.1073/pnas.0813360106
Reference
PMID:17603507
  Authors
Kulasekara HD, Miller SI
  Title
Threonine phosphorylation times bacterial secretion.
  Journal
Nat Cell Biol 9:734-6 (2007)
DOI:10.1038/ncb0707-734
Reference
PMID:18078384
  Authors
Driessen AJ, Nouwen N
  Title
Protein translocation across the bacterial cytoplasmic membrane.
  Journal
Annu Rev Biochem 77:643-67 (2008)
DOI:10.1146/annurev.biochem.77.061606.160747
Reference
PMID:14641032
  Authors
Pool MR
  Title
Getting to the membrane: how is co-translational protein targeting to the endoplasmic reticulum regulated?
  Journal
Biochem Soc Trans 31:1232-7 (2003)
DOI:10.1042/bst0311232
Reference
PMID:19299134
  Authors
Desvaux M, Hebraud M, Talon R, Henderson IR
  Title
Secretion and subcellular localizations of bacterial proteins: a semantic awareness issue.
  Journal
Trends Microbiol 17:139-45 (2009)
DOI:10.1016/j.tim.2009.01.004
Reference
PMID:15063851
  Authors
Nakatogawa H, Murakami A, Ito K
  Title
Control of SecA and SecM translation by protein secretion.
  Journal
Curr Opin Microbiol 7:145-50 (2004)
DOI:10.1016/j.mib.2004.01.001
KO pathway
ko03070   
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