KEGG   PATHWAY: ppam04721
Entry
ppam04721                   Pathway                                
Name
Synaptic vesicle cycle - Pteronotus mesoamericanus (Parnell's mustached bat)
Description
Communication between neurons is mediated by the release of neurotransmitter from synaptic vesicles (SVs). At the nerve terminal, SVs cycle through repetitive episodes of exocytosis and endocytosis. SVs are filled with neurotransmitters by active transport. The loaded SVs are then docked at a specialized region of the presynaptic plasma membrane known as the active zone, where they undergo a priming reaction. Upon arrival of an action potential, Ca2+ enters through voltage-gated channels and neurotransmitter is released by exocytosis, usually in less than a millisecond. After fusion, the vesicle is retrieved by endocytosis and reloaded for another round of exocytosis.
Class
Organismal Systems; Nervous system
Pathway map
ppam04721  Synaptic vesicle cycle
ppam04721

Other DBs
GO: 0016079 0048488
Organism
Pteronotus mesoamericanus (Parnell's mustached bat) [GN:ppam]
Gene
129061443  DNM2; dynamin-2 isoform X1 [KO:K23484]
129062544  CACNA1A; voltage-dependent P/Q-type calcium channel subunit alpha-1A isoform X1 [KO:K04344]
129062716  STX3; syntaxin-3 [KO:K08486]
129062792  ATP6V1F; V-type proton ATPase subunit F [KO:K02151]
129062812  ATP6V0E2; V-type proton ATPase subunit e 2 [KO:K02153]
129063243  [KO:K02153]
129063486  ATP6V0A4; V-type proton ATPase 116 kDa subunit a 4 [KO:K02154]
129064235  UNC13C; protein unc-13 homolog C isoform X1 [KO:K15293]
129064665  ATP6V1E2; V-type proton ATPase subunit E 2 [KO:K02150]
129065184  [KO:K11825]
129065953  ATP6V1D; V-type proton ATPase subunit D [KO:K02149]
129066383  SLC6A7; sodium-dependent proline transporter [KO:K05040]
129066473  [KO:K02153]
129066475  [KO:K02153]
129066712  CLTB; clathrin light chain B isoform X1 [KO:K04645]
129066957  [KO:K11825]
129067305  ATP6V1G2; V-type proton ATPase subunit G 2 isoform X1 [KO:K02152]
129067570  [KO:K15291]
129067603  ATP6V1C2; V-type proton ATPase subunit C 2 [KO:K02148]
129068134  SLC6A2; sodium-dependent noradrenaline transporter [KO:K05035]
129068339  TCIRG1; V-type proton ATPase 116 kDa subunit a 3 [KO:K02154]
129068487  AP2A2; AP-2 complex subunit alpha-2 isoform X1 [KO:K11824]
129069105  ATP6V0B; V-type proton ATPase 21 kDa proteolipid subunit c'' [KO:K03661]
129069381  SLC6A9; sodium- and chloride-dependent glycine transporter 1 isoform X1 [KO:K05038]
129069662  SLC18A3; vesicular acetylcholine transporter [KO:K14636]
129069754  SLC1A7; excitatory amino acid transporter 5 isoform X1 [KO:K05618]
129069822  CPLX2; complexin-2 [KO:K15294]
129070328  SLC6A4; sodium-dependent serotonin transporter [KO:K05037]
129070456  SLC32A1; vesicular inhibitory amino acid transporter [KO:K15015]
129070826  [KO:K11825]
129070863  SNAP25; synaptosomal-associated protein 25 [KO:K18211]
129071276  SLC17A8; vesicular glutamate transporter 3 isoform X1 [KO:K12302]
129071566  CLTC; clathrin heavy chain 1 isoform X1 [KO:K04646]
129071576  NSF; vesicle-fusing ATPase isoform X1 [KO:K06027] [EC:3.6.4.6]
129072281  VAMP2; vesicle-associated membrane protein 2 [KO:K13504]
129072869  ATP6V1G3; V-type proton ATPase subunit G 3 [KO:K02152]
129073422  SLC6A13; sodium- and chloride-dependent GABA transporter 2 isoform X1 [KO:K05046]
129073510  SLC6A12; sodium- and chloride-dependent betaine transporter isoform X1 [KO:K05045]
129073566  [KO:K02150]
129073664  ATP6V1A; V-type proton ATPase catalytic subunit A [KO:K02145] [EC:7.1.2.2]
129074725  SLC6A3; LOW QUALITY PROTEIN: sodium-dependent dopamine transporter [KO:K05036]
129074796  SLC1A6; excitatory amino acid transporter 4 [KO:K05617]
129074831  UNC13A; protein unc-13 homolog A [KO:K15293]
129074867  SLC18A1; chromaffin granule amine transporter isoform X1 [KO:K08155]
129074971  RAB3A; ras-related protein Rab-3A [KO:K07882]
129075004  ATP6V1B2; V-type proton ATPase subunit B, brain isoform [KO:K02147]
129075272  ATP6V0D1; V-type proton ATPase subunit d 1 [KO:K02146]
129075909  SYT1; synaptotagmin-1 isoform X1 [KO:K15290]
129077031  [KO:K05037]
129077058  AP2M1; AP-2 complex subunit mu [KO:K11826]
129077203  SLC18A2; synaptic vesicular amine transporter [KO:K08155]
129077472  CPLX1; complexin-1 [KO:K15294]
129078020  STX1B; syntaxin-1B isoform X1 [KO:K08486]
129078293  SLC1A1; excitatory amino acid transporter 3 [KO:K05612]
129078755  CPLX4; complexin-4 [KO:K15295]
129078992  SLC1A3; excitatory amino acid transporter 1 [KO:K05614]
129079241  DNM1; dynamin-1 isoform X1 [KO:K01528] [EC:3.6.5.5]
129079254  STXBP1; syntaxin-binding protein 1 isoform X1 [KO:K15292]
129079326  ATP6V1G1; V-type proton ATPase subunit G 1 [KO:K02152]
129079422  CLTA; clathrin light chain A isoform X1 [KO:K04644]
129079439  UNC13B; protein unc-13 homolog B isoform X1 [KO:K15293]
129079505  CACNA1B; voltage-dependent N-type calcium channel subunit alpha-1B [KO:K04849]
129079930  CPLX3; complexin-3 [KO:K15295]
129080463  SLC1A2; excitatory amino acid transporter 2 isoform X1 [KO:K05613]
129080506  SLC17A6; vesicular glutamate transporter 2 [KO:K12302]
129080679  SLC6A5; sodium- and chloride-dependent glycine transporter 2 [KO:K05038]
129080989  ATP6V1E1; V-type proton ATPase subunit E 1 [KO:K02150]
129081391  ATP6V1B1; V-type proton ATPase subunit B, kidney isoform [KO:K02147]
129082036  DNM3; dynamin-3 isoform X1 [KO:K01528] [EC:3.6.5.5]
129082772  AP2S1; AP-2 complex subunit sigma [KO:K11827]
129082802  SLC17A7; vesicular glutamate transporter 1 [KO:K12302]
129082887  NAPA; alpha-soluble NSF attachment protein [KO:K15296]
129082942  AP2A1; AP-2 complex subunit alpha-1 isoform X1 [KO:K11824]
129083421  STX1A; syntaxin-1A [KO:K04560]
129083613  ATP6V0C; V-type proton ATPase 16 kDa proteolipid subunit c [KO:K02155]
129084258  ATP6V1C1; V-type proton ATPase subunit C 1 [KO:K02148]
129086551  AP2B1; AP-2 complex subunit beta isoform X1 [KO:K11825]
129086936  ATP6V0A1; V-type proton ATPase 116 kDa subunit a 1 isoform X1 [KO:K02154]
129087268  STX2; syntaxin-2 isoform X1 [KO:K08486]
129087389  ATP6V0A2; V-type proton ATPase 116 kDa subunit a 2 isoform X1 [KO:K02154]
129088281  ATP6V1H; V-type proton ATPase subunit H isoform X1 [KO:K02144]
129088501  SLC6A1; sodium- and chloride-dependent GABA transporter 1 [KO:K05034]
129088507  SLC6A11; sodium- and chloride-dependent GABA transporter 3 [KO:K05044]
129088520  ATP6V0D2; V-type proton ATPase subunit d 2 [KO:K02146]
Compound
C00002  ATP
C00025  L-Glutamate
C00037  Glycine
C00076  Calcium cation
C00080  H+
C00334  4-Aminobutanoate
C00388  Histamine
C00547  L-Noradrenaline
C00780  Serotonin
C01996  Acetylcholine
C03758  Dopamine
C16041  Leu-enkephalin
Reference
  Authors
Li L, Chin LS
  Title
The molecular machinery of synaptic vesicle exocytosis.
  Journal
Cell Mol Life Sci 60:942-60 (2003)
DOI:10.1007/s00018-003-2240-7
Reference
  Authors
Nestler EJ, Hyman SE, Malenka RC.
  Title
Molecular neuropharmacology: A foundation for clinical neuroscience
  Journal
The McGraw-Hill Companies, Inc. (2001)
Reference
  Authors
Chapman ER
  Title
How does synaptotagmin trigger neurotransmitter release?
  Journal
Annu Rev Biochem 77:615-41 (2008)
DOI:10.1146/annurev.biochem.77.062005.101135
Reference
  Authors
Benfenati F, Onofri F, Giovedi S
  Title
Protein-protein interactions and protein modules in the control of neurotransmitter release.
  Journal
Philos Trans R Soc Lond B Biol Sci 354:243-57 (1999)
DOI:10.1098/rstb.1999.0376
Reference
  Authors
de Saint Basile G, Menasche G, Fischer A
  Title
Molecular mechanisms of biogenesis and exocytosis of cytotoxic granules.
  Journal
Nat Rev Immunol 10:568-79 (2010)
DOI:10.1038/nri2803
Reference
  Authors
Carr CM, Munson M
  Title
Tag team action at the synapse.
  Journal
EMBO Rep 8:834-8 (2007)
DOI:10.1038/sj.embor.7401051
Reference
  Authors
Sudhof TC
  Title
The synaptic vesicle cycle.
  Journal
Annu Rev Neurosci 27:509-47 (2004)
DOI:10.1146/annurev.neuro.26.041002.131412
Reference
  Authors
Gundelfinger ED, Kessels MM, Qualmann B
  Title
Temporal and spatial coordination of exocytosis and endocytosis.
  Journal
Nat Rev Mol Cell Biol 4:127-39 (2003)
DOI:10.1038/nrm1016
Reference
  Authors
Tang J, Maximov A, Shin OH, Dai H, Rizo J, Sudhof TC
  Title
A complexin/synaptotagmin 1 switch controls fast synaptic vesicle exocytosis.
  Journal
Cell 126:1175-87 (2006)
DOI:10.1016/j.cell.2006.08.030
Reference
  Authors
Chapman ER
  Title
Synaptotagmin: a Ca(2+) sensor that triggers exocytosis?
  Journal
Nat Rev Mol Cell Biol 3:498-508 (2002)
DOI:10.1038/nrm855
Reference
PMID:7791897
  Authors
Sudhof TC
  Title
The synaptic vesicle cycle: a cascade of protein-protein interactions.
  Journal
Nature 375:645-53 (1995)
DOI:10.1038/375645a0
Reference
  Authors
Rizo J, Sudhof TC
  Title
Snares and Munc18 in synaptic vesicle fusion.
  Journal
Nat Rev Neurosci 3:641-53 (2002)
DOI:10.1038/nrn898
Reference
  Authors
Malsam J, Kreye S, Sollner TH
  Title
Membrane fusion: SNAREs and regulation.
  Journal
Cell Mol Life Sci 65:2814-32 (2008)
DOI:10.1007/s00018-008-8352-3
Related
pathway
ppam04144  Endocytosis
ppam04724  Glutamatergic synapse
ppam04725  Cholinergic synapse
ppam04726  Serotonergic synapse
ppam04727  GABAergic synapse
ppam04728  Dopaminergic synapse
KO pathway
ko04721   

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