Pan troglodytes (chimpanzee): 450955
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Entry
450955 CDS
T01005
Symbol
TH
Name
(RefSeq) tyrosine 3-monooxygenase isoform X1
KO
K00501
tyrosine 3-monooxygenase [EC:
1.14.16.2
]
Organism
ptr
Pan troglodytes (chimpanzee)
Pathway
ptr00350
Tyrosine metabolism
ptr00790
Folate biosynthesis
ptr01100
Metabolic pathways
ptr04728
Dopaminergic synapse
ptr04917
Prolactin signaling pathway
ptr05012
Parkinson disease
ptr05030
Cocaine addiction
ptr05031
Amphetamine addiction
ptr05034
Alcoholism
Module
ptr_M00042
Catecholamine biosynthesis, tyrosine => dopamine => noradrenaline => adrenaline
Brite
KEGG Orthology (KO) [BR:
ptr00001
]
09100 Metabolism
09105 Amino acid metabolism
00350 Tyrosine metabolism
450955 (TH)
09108 Metabolism of cofactors and vitamins
00790 Folate biosynthesis
450955 (TH)
09150 Organismal Systems
09152 Endocrine system
04917 Prolactin signaling pathway
450955 (TH)
09156 Nervous system
04728 Dopaminergic synapse
450955 (TH)
09160 Human Diseases
09164 Neurodegenerative disease
05012 Parkinson disease
450955 (TH)
09165 Substance dependence
05030 Cocaine addiction
450955 (TH)
05031 Amphetamine addiction
450955 (TH)
05034 Alcoholism
450955 (TH)
Enzymes [BR:
ptr01000
]
1. Oxidoreductases
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.16 With reduced pteridine as one donor, and incorporation of one atom of oxygen into the other donor
1.14.16.2 tyrosine 3-monooxygenase
450955 (TH)
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Gene cluster
GFIT
Motif
Pfam:
Biopterin_H
TH_ACT
TOH_N
LTP_2
Motif
Other DBs
NCBI-GeneID:
450955
NCBI-ProteinID:
XP_016775673
Ensembl:
ENSPTRG00000003173
VGNC:
988
LinkDB
All DBs
Position
9:complement(6430981..6438888)
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AA seq
501 aa
AA seq
DB search
MPTPDATTPQAKGFRRAVSELDAKQAEAIMVRGQSPRFIGRRQSLIEDARKEREAAVAAA
AAAVPSEPGDPLEAVAFEEKEGKAVLNLLFSPRATKPSALSRAVKVFETFEAKIHHLETR
PAQRPRAGGPHLEYFVRLEVRLGDLAALLSGVRQVSEDVRSPAGPKVPWFPRKVSELDKC
HHLVTKFDPDLDLDHPGFSDQVYRQRRKLIAEIAFQYRHGDPIPRVEYTAEEIATWKEVY
TTLKGLYATHACGEHLEAFALLERFSGYREDNIPQLEDVSRFLKERTGFQLRPVAGLLSA
RDFLASLAFRVFQCTQYIRHASSPMHSPEPDCCHELLGHVPMLADRTFAQFSQDIGLASL
GASDEEIEKLSTLYWFTVEFGLCKQNGEVKAYGAGLLSSYGELLHCLSEEPEIRAFDPEA
AAVQPYQDQTYQSVYFVSESFSDAKDKLRSYASRIQRPFSVKFDPYTLAIDVLDSPQAVR
RSLEGVQDELDTLAHALSAIG
NT seq
1506 nt
NT seq
+upstream
nt +downstream
nt
atgcccacccccgacgccaccacgccacaggccaagggcttccgcagggccgtgtctgag
ctggatgccaagcaggcagaggccatcatggtaagagggcagtccccgcggttcattggg
cgcaggcagagcctcatcgaggacgcccgcaaggagcgggaggcggcggtggcagcagcg
gccgctgcagtcccctcggagcccggggaccccctggaggccgtggcctttgaggagaag
gaggggaaggccgtgctaaacctgctcttctccccgagggccaccaagccctccgcgctg
tcccgagctgtgaaggtgtttgagacgtttgaagccaaaatccaccatctagagacccgg
cccgcccagaggccgcgagctgggggcccccacctggagtacttcgtgcgcctcgaggtg
cgcctaggggacctggccgccctgctcagtggtgtgcgccaggtgtcagaggacgtgcgc
agccccgcggggcccaaggtcccctggttcccaagaaaagtgtcagagctggacaagtgt
catcacctggtcaccaagttcgaccctgacctggacttggaccacccgggcttctcggac
caggtgtaccgccagcgcaggaagctgattgctgagatcgccttccagtacaggcatggc
gacccgattccccgtgtggagtacaccgccgaggagattgccacctggaaggaggtctac
accacgctgaagggcctctacgccacgcacgcctgcggggagcacctggaggcctttgct
ttgctggagcgcttcagcggctaccgggaagacaatatcccccagctggaggacgtctcc
cgcttcctgaaggagcgcacgggcttccagctgcggcctgtggccggcctgctgtccgcc
cgggacttcctggccagcctggccttccgcgtgttccagtgcacccagtatatccgccac
gcgtcctcgcccatgcactcccctgagccggactgctgccacgagctgctggggcacgtg
cccatgctggctgaccgcaccttcgcgcagttctcgcaggacattggcctggcatccctg
ggggcctcggatgaggaaattgagaagctgtccacgctgtactggttcacggtggagttc
gggctgtgtaagcagaatggggaggtgaaggcctatggtgccgggctgctgtcctcctac
ggggagctcctgcactgcctgtctgaggagcccgagattcgggccttcgaccctgaagct
gcagccgtgcagccctaccaagaccagacgtaccagtcagtctacttcgtgtctgagagc
ttcagtgacgccaaggacaagctcaggagctatgcctcacgcatccagcgccccttctcc
gtgaagttcgacccgtacacgctggccatcgacgtgctggacagcccccaggccgtgcgg
cgctccctggagggtgtccaggatgagctggacacccttgcccatgcgctgagtgccatt
ggctag
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