KEGG   PATHWAY: rn01055
Entry
rn01055                     Pathway                                
Name
Biosynthesis of vancomycin group antibiotics
Class
Metabolism; Metabolism of terpenoids and polyketides
Pathway map
rn01055  Biosynthesis of vancomycin group antibiotics
rn01055

Drug
D00212  Vancomycin (USP)
Reaction
R05518  dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose hydro-lyase (dTDP-2,6-dideoxy-D-glycero-hex-2-enos-4-ulose-forming)
R06513  dTDPglucose 4,6-hydro-lyase
R06624  3,5-dihydroxyphenylacetyl-CoA:oxygen oxidoreductase (3,5-dihydroxyphenylglyoxylate-forming)
R06625  malonyl-CoA:malonyl-CoA malonyltransferase (3,5-dihydroxyphenylacetyl-CoA-forming)
R06626  
R06627  
R06628  dTDP-3-amino-2,3,6-trideoxy-C-methyl-D-erythro-hexopyranos-4-ulose 5-epimerase
R06629  
R06630  
R06631  dTDP-3-amino-2,3,6-trideoxy-4-keto-D-glucose:2-oxoglutarate aminotransferase
R06632  4-hydroxyphenylpyruvate:oxygen oxidoreductase (decarboxylating)
R06633  (S)-4-hydroxymandelate:oxygen 1-oxidoreductase
R06634  (S)-3,5-dihydroxyphenylglycine:2-oxoglutarate aminotransferase
Compound
C00082  L-Tyrosine
C00083  Malonyl-CoA
C00842  dTDP-glucose
C01179  3-(4-Hydroxyphenyl)pyruvate
C03198  (S)-4-Hydroxymandelate
C03590  4-Hydroxyphenylglyoxylate
C06620  dTDP-3,4-dioxo-2,6-dideoxy-D-glucose
C06689  Vancomycin
C11907  dTDP-4-oxo-6-deoxy-D-glucose
C12014  Chloroeremomycin
C12026  3,5-Dihydroxy-phenylglycine
C12318  dTDP-3-amino-2,3,6-trideoxy-4-keto-D-glucose
C12319  dTDP-3-amino-2,3,6-trideoxy-C-methyl-D-erythro-hexopyranos-4-ulose
C12320  dTDP-L-4-oxovancosamine
C12321  dTDP-L-epivancosamine
C12322  dTDP-L-vancosamine
C12323  L-4-Hydroxyphenylglycine
C12324  3,5-Dihydroxyphenylacetyl-CoA
C12325  3,5-Dihydroxyphenylglyoxylate
Reference
PMID:24884615
  Authors
Xu L, Huang H, Wei W, Zhong Y, Tang B, Yuan H, Zhu L, Huang W, Ge M, Yang S, Zheng H, Jiang W, Chen D, Zhao GP, Zhao W
  Title
Complete genome sequence and comparative genomic analyses of the vancomycin-producing Amycolatopsis orientalis.
  Journal
BMC Genomics 15:363 (2014)
DOI:10.1186/1471-2164-15-363
Reference
PMID:12596194
  Authors
Hubbard BK, Walsh CT.
  Title
Vancomycin assembly: nature's way.
  Journal
Angew Chem Int Ed Engl 42:730-65 (2003)
DOI:10.1002/anie.200390202
Reference
PMID:11035791
  Authors
Chen H, Thomas MG, Hubbard BK, Losey HC, Walsh CT, Burkart MD.
  Title
Deoxysugars in glycopeptide antibiotics: enzymatic synthesis of TDP-L-epivancosamine in chloroeremomycin biosynthesis.
  Journal
Proc Natl Acad Sci U S A 97:11942-7 (2000)
DOI:10.1073/pnas.210395097
Reference
PMID:9545426
  Authors
van Wageningen AM, Kirkpatrick PN, Williams DH, Harris BR, Kershaw JK, Lennard NJ, Jones M, Jones SJ, Solenberg PJ.
  Title
Sequencing and analysis of genes involved in the biosynthesis of a vancomycin group antibiotic.
  Journal
Chem Biol 5:155-62 (1998)
DOI:10.1016/S1074-5521(98)90060-6
Related
pathway
rn00400  Phenylalanine, tyrosine and tryptophan biosynthesis
rn00520  Amino sugar and nucleotide sugar metabolism
rn00620  Pyruvate metabolism
KO pathway
ko01055   

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