KEGG   PATHWAY: rn00520
Entry
rn00520                     Pathway                                
Name
Amino sugar and nucleotide sugar metabolism
Class
Metabolism; Glycan biosynthesis and metabolism
Pathway map
rn00520  Amino sugar and nucleotide sugar metabolism
rn00520

Module
M00549  UDP-Glc biosynthesis, Glc => UDP-Glc [PATH:rn00520]
M00554  UDP-Gal biosynthesis, Gal => UDP-Gal [PATH:rn00520]
M00892  UDP-GlcNAc biosynthesis, eukaryotes, Fru-6P => UDP-GlcNAc [PATH:rn00520]
M00909  UDP-GlcNAc biosynthesis, prokaryotes, Fru-6P => UDP-GlcNAc [PATH:rn00520]
M00994  UDP-GlcA biosynthesis, myo-inositol => GlcA => UDP-GlcA [PATH:rn00520]
M00995  UDP-MurNAc biosynthesis, Fru-6P => UDP-MurNAc [PATH:rn00520]
M00996  UDP-MurNAc biosynthesis, anhMurNAc => UDP-MurNAc [PATH:rn00520]
M00997  UDP-Xyl/L-Ara biosynthesis, UDP-Glc => UDP-Xyl => UDP-L-Ala [PATH:rn00520]
M00998  UDP-L-Ara biosynthesis, L-Ala => UDP-L-Ala [PATH:rn00520]
M00999  UDP-GlcA/GalA biosynthesis, UDP-Glc => UDP-GlcA => UDP-GalA [PATH:rn00520]
M01000  GDP-Man biosynthesis, Fru-6P => GDP-Man [PATH:rn00520]
M01001  GDP-L-Fuc biosynthesis, L-Fuc => GDP-L-Fuc [PATH:rn00520]
M01002  UDP-GalNAc biosynthesis, Fru-6P => UDP-GalNAc [PATH:rn00520]
M01003  UDP-GlcNAc biosynthesis, GlcNAc => UDP-GlcNAc [PATH:rn00520]
M01004  UDP-Galf biosynthesis, UDP-Glc => UDP-Galf [PATH:rn00520]
M01006  GDP-D-Rha4N biosynthesis, Fru-6P => GDP-D-Rha4N [PATH:rn00520]
M01015  GDP-Man biosynthesis, Man => GDP-Man [PATH:rn00520]
Other DBs
GO: 0006040 0009225
Reaction
R00022  chitobiose N-acetylglucosaminohydrolase
R00286  UDP-glucose:NAD+ 6-oxidoreductase
R00289  UTP:alpha-D-glucose-1-phosphate uridylyltransferase
R00291  UDP-glucose 4-epimerase; UDP-alpha-D-glucose 4-epimerase
R00416  UTP:N-acetyl-alpha-D-glucosamine-1-phosphate uridylyltransferase
R00418  UDP-N-acetyl-D-glucosamine 4-epimerase
R00420  UDP-N-acetyl-D-glucosamine 2-epimerase
R00501  UDP-alpha-D-galactose:NAD+ 6-oxidoreductase
R00502  UTP:alpha-D-galactose-1-phosphate uridylyltransferase
R00505  UDP-alpha-D-galactopyranose furanomutase
R00660  phosphoenolpyruvate:UDP-N-acetyl-D-glucosamine 1-carboxyvinyl-transferase
R00760  ATP:D-fructose 6-phosphotransferase
R00765  D-glucosamine-6-phosphate aminohydrolase (ketol isomerizing); D-glucosamine-6-phosphate ketol-isomerase(deaminating)
R00768  L-glutamine:D-fructose-6-phosphate isomerase (deaminating); L-glutamine:D-fructose-6-phosphate aminotransferase (hexose isomerizing)
R00772  D-mannose-6-phosphate aldose-ketose-isomerase
R00880  GDP-D-mannose:NAD+ 6-oxidoreductase
R00883  GDP:D-mannose-1-phosphate guanylyltransferase
R00885  GTP:alpha-D-mannose-1-phosphate guanylyltransferase
R00889  GDP-mannose 3,5-epimerase
R00948  ATP:alpha-D-glucose-1-phosphate adenylyltransferase
R00954  GTP:alpha-D-glucose-1-phosphate guanylyltransferase
R00955  UDP-glucose:alpha-D-galactose-1-phosphate uridylyltransferase
R00956  CTP:alpha-D-glucose-1-phosphate cytidylyltransferase
R00959  alpha-D-glucose 1-phosphate 1,6-phosphomutase
R01092  ATP:alpha-D-galactose 1-phosphotransferase
R01200  N-acetyl-D-glucosamine amidohydrolase
R01201  ATP:N-acetyl-D-glucosamine 6-phosphotransferase
R01204  acetyl-CoA:D-glucosamine N-acetyltransferase
R01206  [1,4-(N-acetyl-beta-D-glucosaminyl)]n glycanohydrolase
R01207  N-acetyl-D-glucosamine 2-epimerase
R01326  ATP:D-mannose 6-phosphotransferase
R01381  UTP:1-phospho-alpha-D-glucuronate uridylyltransferase
R01384  UDP-D-glucuronate carboxy-lyase (UDP-D-xylose-forming)
R01385  UDP-glucuronate 4-epimerase
R01386  UDP-D-glucuronate carboxy-lyase (UDP-D-apiose-forming)
R01433  D-xylose xylohydrolase
R01471  UTP:alpha-D-xylose-1-phosphate uridylyltransferase
R01473  UDP-L-arabinose 4-epimerase
R01476  ATP:D-glucuronate 1-phosphotransferase
R01754  ATP:L-arabinose 1-phosphotransferase
R01762  alpha-L-arabinan arabinofuranohydrolase
R01786  ATP:alpha-D-glucose 6-phosphotransferase
R01818  D-mannose 6-phosphate 1,6-phosphomutase
R01951  GTP:beta-L-fucose-1-phosphate guanylyltransferase
R01961  ATP:D-glucosamine 6-phosphotransferase
R01966  beta-D-glucosaminide glucosaminohydrolase
R01980  ATP:D-galacturonate 1-phosphotransferase
R02058  acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase
R02059  N-acetyl-D-glucosamine-6-phosphate amidohydrolase
R02060  D-glucosamine 1-phosphate 1,6-phosphomutase; D-glucosamine 1,6-phosphomutase
R02087  N-acetyl-D-glucosamine 6-phosphate 2-epimerase
R02189  polyphosphate:D-glucose 6-phosphotransferase
R02328  dTTP:alpha-D-glucose-1-phosphate thymidylyltransferase
R02333  chitin amidohydrolase
R02334  [1,4-(N-acetyl-beta-D-glucosaminyl)]n glycanohydrolase
R02335  UDP-N-acetyl-D-glucosamine:chitin 4-beta-N-acetylglucosaminyl-transferase
R02630  protein-N(pi)-phosphohistidine:D-mannose 6-phosphotransferase
R02631  protein-N(pi)-phosphohistidine:D-glucosamine 6-phosphotransferase
R02634  UTP:1-phospho-alpha-D-galacturonate uridylyltransferase; UDP-D-galacturonate pyrophospholylase
R02636  UDP-D-galacturonate carboxy-lyase
R02705  ATP:N-acyl-D-mannosamine 6-phosphotransferase
R02738  protein-N(pi)-phosphohistidine:D-glucose 6-phosphotransferase
R02833  chitosan N-acetylglucosaminohydrolase
R03077  UTP:beta-L-arabinose-1-phosphate uridylyltransferase
R03078  
R03161  ATP:L-fucose 1-phosphotransferase
R03191  UDP-N-acetylmuramate:NADP+ oxidoreductase
R03192  UDP-N-acetylmuramate:NADP+ oxidoreductase
R03928  UDP-D-xylose:1,4-beta-D-xylan 4-beta-D-xylosyltransferase
R05168  N-acetyl-D-galactosamine 6-phosphate amidohydrolase
R05191  UDP-D-galacturonate:1,4-alpha-poly-D-galacturonate 4-alpha-D-galacturonosyltransferase
R05199  protein-N(pi)-phosphohistidine:N-acetyl-D-glucosamine 6-phosphotransferase
R05332  acetyl-CoA:D-glucosamine-1-phosphate N-acetyltransferase
R05775  UDP-6-sulfo-6-deoxyglucose sulfohydrolase
R07672  GDP-mannose 5-epimerase
R08193  N-acetyl-D-glucosamine 1-phosphate 1,6-phosphomutase
R08366  protein-N(pi)-phosphohistidine:N-acetyl-D-galactosamine 6-phosphotransferase
R08367  protein-N(pi)-phosphohistidine:D-galactosamine 6-phosphotransferase
R08555  (R)-lactate hydro-lyase (adding N-acetyl-D-glucosamine 6-phosphate; N-acetylmuramate 6-phosphate-forming)
R08559  protein-N(pi)-phosphohistidine:N-acetylmuramate 6-phosphotransferase
R08967  ATP:N-acetyl-D-galactosamine 1-phosphotransferase
R08968  ATP:N-acetyl-D-glucosamine 1-phosphotransferase
R09009  UDP-L-arabinopyranose furanomutase
R09942  N,N'-diacetylchitobiose:phosphate N-acetyl-D-glucosaminyltransferase
R10183  UTP:N-acetyl-alpha-D-galactosamine-1-phosphate uridylyltransferase
R11024  ATP:N-acetyl-D-muramate 1-phosphotransferase
R11025  UTP:N-acetyl-alpha-D-muramate-1-phosphate uridylyltransferase
R11785  N-acetyl-D-muramate 6-phosphate phosphohydrolase
R12220  D-glucosamine 6-phosphate 4-epimerase
R12221  alpha-D-galactosamine 1,6-phosphomutase
R12242  acetyl-CoA:alpha-D-galactosamine-1-phosphate N-acetyltransferase
R12755  ATP:1,6-anhydro-N-acetyl-beta-muramate 6-phosphotransferase
R12824  ATP:D-arabinose 1-phosphotransferase
R12825  GTP:alpha-D-arabinopyranose-1-phosphate guanylyltransferase
R13199  alpha-D-glucose-6-phosphate aldose-ketose-isomerase
R13489  
Compound
C00029  UDP-glucose
C00031  D-Glucose
C00043  UDP-N-acetyl-alpha-D-glucosamine
C00052  UDP-alpha-D-galactose
C00085  D-Fructose 6-phosphate
C00095  D-Fructose
C00096  GDP-mannose
C00103  D-Glucose 1-phosphate
C00140  N-Acetyl-D-glucosamine
C00159  D-Mannose
C00167  UDP-glucuronate
C00181  D-Xylose
C00190  UDP-D-xylose
C00191  D-Glucuronate
C00203  UDP-N-acetyl-D-galactosamine
C00216  D-Arabinose
C00259  L-Arabinose
C00267  alpha-D-Glucose
C00275  D-Mannose 6-phosphate
C00325  GDP-L-fucose
C00329  D-Glucosamine
C00333  D-Galacturonate
C00352  D-Glucosamine 6-phosphate
C00357  N-Acetyl-D-glucosamine 6-phosphate
C00394  GDP-glucose
C00446  alpha-D-Galactose 1-phosphate
C00461  Chitin
C00498  ADP-glucose
C00501  CDP-glucose
C00617  UDP-D-galacturonate
C00636  D-Mannose 1-phosphate
C00645  N-Acetyl-D-mannosamine
C00668  alpha-D-Glucose 6-phosphate
C00714  Pectin
C00734  Chitosan
C00842  dTDP-glucose
C00935  UDP-L-arabinose
C00976  GDP-D-mannuronate
C00984  alpha-D-Galactose
C01019  L-Fucose
C01050  UDP-N-acetylmuramate
C01132  N-Acetyl-D-galactosamine
C01170  UDP-N-acetyl-D-mannosamine
C01623  UDP-apiose
C01674  Chitobiose
C02262  D-Galactosamine
C02280  GDP-L-galactose
C02352  1,4-beta-D-Xylan
C02474  Arabinan
C02713  N-Acetylmuramate
C02985  L-Fucose 1-phosphate
C03733  UDP-alpha-D-galactofuranose
C03737  alpha-D-Xylose 1-phosphate
C03906  beta-L-Arabinose 1-phosphate
C04037  1-Phospho-alpha-D-galacturonate
C04257  N-Acetyl-D-mannosamine 6-phosphate
C04501  N-Acetyl-alpha-D-glucosamine 1-phosphate
C04631  UDP-N-acetyl-3-(1-carboxyvinyl)-D-glucosamine
C05385  D-Glucuronate 1-phosphate
C06023  D-Glucosaminide
C06156  alpha-D-Glucosamine 1-phosphate
C06376  N-Acetyl-D-galactosamine 6-phosphate
C06377  D-Galactosamine 6-phosphate
C11521  UDP-6-sulfoquinovose
C15925  GDP-L-gulose
C16183  alpha-D-Arabinopyranose 1-phosphate
C16698  N-Acetylmuramic acid 6-phosphate
C17269  GDP-D-arabinopyranose
C18060  N-Acetyl-alpha-D-galactosamine 1-phosphate
C18094  UDP-L-arabinofuranose
C19769  1,6-Anhydro-N-acetyl-beta-muramate
C21027  N-Acetylmuramic acid alpha-1-phosphate
C22029  alpha-D-Galactosamine 1-phosphate
Reference
PMID:2793832
  Authors
Wyk P, Reeves P
  Title
Identification and sequence of the gene for abequose synthase, which confers antigenic specificity on group B salmonellae: homology with galactose epimerase.
  Journal
J Bacteriol 171:5687-93 (1989)
DOI:10.1128/JB.171.10.5687-5693.1989
Reference
PMID:8071227
  Authors
Thorson JS, Lo SF, Ploux O, He X, Liu HW
  Title
Studies of the biosynthesis of 3,6-dideoxyhexoses: molecular cloning and characterization of the asc (ascarylose) region from Yersinia pseudotuberculosis serogroup VA.
  Journal
J Bacteriol 176:5483-93 (1994)
DOI:10.1128/JB.176.17.5483-5493.1994
Reference
PMID:8444803
  Authors
Kessler AC, Haase A, Reeves PR
  Title
Molecular analysis of the 3,6-dideoxyhexose pathway genes of Yersinia pseudotuberculosis serogroup IIA.
  Journal
J Bacteriol 175:1412-22 (1993)
DOI:10.1128/JB.175.5.1412-1422.1993
Reference
PMID:9811644
  Authors
Danese PN, Oliver GR, Barr K, Bowman GD, Rick PD, Silhavy TJ
  Title
Accumulation of the enterobacterial common antigen lipid II biosynthetic intermediate stimulates degP transcription in Escherichia coli.
  Journal
J Bacteriol 180:5875-84 (1998)
DOI:10.1128/JB.180.22.5875-5884.1998
Reference
  Authors
Skurnik M, Peippo A, Ervela E
  Title
Characterization of the O-antigen gene clusters of Yersinia pseudotuberculosis and the cryptic O-antigen gene cluster of Yersinia pestis shows that the plague bacillus is most closely related to and has evolved from Y. pseudotuberculosis serotype O:1b.
  Journal
Mol Microbiol 37:316-30 (2000)
DOI:10.1046/j.1365-2958.2000.01993.x
Reference
  Authors
Stover CK, Pham XQ, Erwin AL, Mizoguchi SD, Warrener P, Hickey MJ, Brinkman FS, Hufnagle WO, Kowalik DJ, Lagrou M, Garber RL, Goltry L, Tolentino E, Westbrock-Wadman S, Yuan Y, Brody LL, Coulter SN, Folger KR, Kas A, Larbig K, Lim R, Smith K, Spencer D, Wong GK, Wu Z, Paulsen IT, Reizer J, Saier MH, Hancock RE, Lory S, Olson MV
  Title
Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen.
  Journal
Nature 406:959-64 (2000)
DOI:10.1038/35023079
Reference
  Authors
Ringenberg M, Lichtensteiger C, Vimr E
  Title
Redirection of sialic acid metabolism in genetically engineered Escherichia coli.
  Journal
Glycobiology 11:533-9 (2001)
DOI:10.1093/glycob/11.7.533
Reference
  Authors
McCoy AJ, Sandlin RC, Maurelli AT
  Title
In vitro and in vivo functional activity of Chlamydia MurA, a UDP-N-acetylglucosamine enolpyruvyl transferase involved in peptidoglycan synthesis and fosfomycin resistance.
  Journal
J Bacteriol 185:1218-28 (2003)
DOI:10.1128/JB.185.4.1218-1228.2003
Reference
  Authors
JACOBSON B, DAVIDSON EA
  Title
Biosynthesis of uronic acids by skin enzymes. I. Uridine diphosphate-D-glucuronic acid-5-epimerase.
  Journal
J Biol Chem 237:638-42 (1962)
Reference
  Authors
Seifert GJ
  Title
Nucleotide sugar interconversions and cell wall biosynthesis: how to bring the inside to the outside.
  Journal
Curr Opin Plant Biol 7:277-84 (2004)
DOI:10.1016/j.pbi.2004.03.004
Reference
  Authors
Uehara T, Park JT
  Title
The N-acetyl-D-glucosamine kinase of Escherichia coli and its role in murein recycling.
  Journal
J Bacteriol 186:7273-9 (2004)
DOI:10.1128/JB.186.21.7273-7279.2004
Reference
  Authors
Breazeale SD, Ribeiro AA, McClerren AL, Raetz CR.
  Title
A formyltransferase required for polymyxin resistance in Escherichia coli and the modification of lipid A with 4-Amino-4-deoxy-L-arabinose. Identification and function oF UDP-4-deoxy-4-formamido-L-arabinose.
  Journal
J Biol Chem 280:14154-67 (2005)
DOI:10.1074/jbc.M414265200
Reference
  Authors
Williams GJ, Breazeale SD, Raetz CR, Naismith JH.
  Title
Structure and function of both domains of ArnA, a dual function decarboxylase and a formyltransferase, involved in 4-amino-4-deoxy-L-arabinose biosynthesis.
  Journal
J Biol Chem 280:23000-8 (2005)
DOI:10.1074/jbc.M501534200
Reference
  Authors
Maliekal P, Vertommen D, Delpierre G, Van Schaftingen E
  Title
Identification of the sequence encoding N-acetylneuraminate-9-phosphate phosphatase.
  Journal
Glycobiology 16:165-72 (2006)
DOI:10.1093/glycob/cwj050
Reference
  Authors
Campbell CT, Yarema KJ
  Title
Large-scale approaches for glycobiology.
  Journal
Genome Biol 6:236 (2005)
DOI:10.1186/gb-2005-6-11-236
Reference
  Authors
Uehara T, Suefuji K, Jaeger T, Mayer C, Park JT
  Title
MurQ Etherase is required by Escherichia coli in order to metabolize anhydro-N-acetylmuramic acid obtained either from the environment or from its own cell wall.
  Journal
J Bacteriol 188:1660-2 (2006)
DOI:10.1128/JB.188.4.1660-1662.2006
Reference
  Authors
Lanot A, Hodge D, Jackson RG, George GL, Elias L, Lim EK, Vaistij FE, Bowles DJ
  Title
The glucosyltransferase UGT72E2 is responsible for monolignol 4-O-glucoside production in Arabidopsis thaliana.
  Journal
Plant J 48:286-95 (2006)
DOI:10.1111/j.1365-313X.2006.02872.x
Reference
  Authors
Muller R, Morant M, Jarmer H, Nilsson L, Nielsen TH
  Title
Genome-wide analysis of the Arabidopsis leaf transcriptome reveals interaction of phosphate and sugar metabolism.
  Journal
Plant Physiol 143:156-71 (2007)
DOI:10.1104/pp.106.090167
Reference
  Authors
Oka T, Nemoto T, Jigami Y
  Title
Functional analysis of Arabidopsis thaliana RHM2/MUM4, a multidomain protein involved in UDP-D-glucose to UDP-L-rhamnose conversion.
  Journal
J Biol Chem 282:5389-403 (2007)
DOI:10.1074/jbc.M610196200
Reference
  Authors
Greenberg DE, Porcella SF, Zelazny AM, Virtaneva K, Sturdevant DE, Kupko JJ 3rd, Barbian KD, Babar A, Dorward DW, Holland SM.
  Title
Genome sequence analysis of the emerging human pathogenic acetic acid bacterium Granulibacter bethesdensis.
  Journal
J Bacteriol 189:8727-36 (2007)
DOI:10.1128/JB.00793-07
Reference
  Authors
Kotake T, Hojo S, Tajima N, Matsuoka K, Koyama T, Tsumuraya Y
  Title
A bifunctional enzyme with L-fucokinase and GDP-L-fucose pyrophosphorylase activities salvages free L-fucose in Arabidopsis.
  Journal
J Biol Chem 283:8125-35 (2008)
DOI:10.1074/jbc.M710078200
Reference
  Authors
Vorholter FJ, Schneiker S, Goesmann A, Krause L, Bekel T, Kaiser O, Linke B, Patschkowski T, Ruckert C, Schmid J, Sidhu VK, Sieber V, Tauch A, Watt SA, Weisshaar B, Becker A, Niehaus K, Puhler A.
  Title
The genome of Xanthomonas campestris pv. campestris B100 and its use for the reconstruction of metabolic pathways involved in xanthan biosynthesis.
  Journal
J Biotechnol 134:33-45 (2008)
DOI:10.1016/j.jbiotec.2007.12.013
Reference
  Authors
Albermann C, Piepersberg W
  Title
Expression and identification of the RfbE protein from Vibrio cholerae O1 and its use for the enzymatic synthesis of GDP-D-perosamine.
  Journal
Glycobiology 11:655-61 (2001)
DOI:10.1093/glycob/11.8.655
Related
pathway
rn00010  Glycolysis / Gluconeogenesis
rn00040  Pentose and glucuronate interconversions
rn00051  Fructose and mannose metabolism
rn00052  Galactose metabolism
rn00053  Ascorbate and aldarate metabolism
rn00500  Starch and sucrose metabolism
rn00510  N-Glycan biosynthesis
rn00521  Streptomycin biosynthesis
rn00523  Polyketide sugar unit biosynthesis
rn00524  Neomycin, kanamycin and gentamicin biosynthesis
rn00525  Acarbose and validamycin biosynthesis
rn00540  Lipopolysaccharide biosynthesis
rn00541  Biosynthesis of various nucleotide sugars
rn00550  Peptidoglycan biosynthesis
KO pathway
ko00520   

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