Entry
Name
ABC transporters - Streptomyces coelicolor
Description
The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class
Environmental Information Processing; Membrane transport
BRITE hierarchy
Pathway map
Other DBs
Organism
Streptomyces coelicolor [GN:
sco ]
Gene
SCO0291 SCF85.19; binding protein dependent transport protein [KO:K10118 ]
SCO0292 SC5G9.01; sugar ABC-transporter integral membrane protein [KO:K10119 ]
SCO0353 SCF41.12; binding protein dependent transport protein [KO:K10118 ]
SCO0354 SCF41.13; binding-protein-dependent transport protein [KO:K10119 ]
SCO0494 SCF34.13c; iron-siderophore binding lipoprotein [KO:K25286 ]
SCO0495 SCF34.14c; iron-siderophore ABC-transporter ATP-binding protein [KO:K23188 ]
SCO0496 SCF34.15c; iron-siderophore permease transmembrane protein [KO:K23187 ]
SCO0497 SCF34.16c; iron-siderophore permease transmembrane protein [KO:K23186 ]
SCO0531 SCF11.11; sugar transporter sugar binding protein [KO:K17329 ]
SCO0707 SCF42.17c; branched-chain amino acid ABC transporter permease [KO:K01998 ]
SCO0708 SCF42.18c; branched-chain amino acid ABC transporter [KO:K01997 ]
SCO0709 SCF42.19c; ABC transporter ATP-binding protein [KO:K01995 ]
SCO0710 SCF42.20c; ABC transporter ATP-binding protein [KO:K01996 ]
SCO0811 SCF43.22c; ABC transporter ATP-binding protein [KO:K10562 ] [EC:7.5.2.-]
SCO1063 SCG22.09c; sugar transport integral membrane protein [KO:K10190 ]
SCO1064 SCG22.10c; sugar transport integral membrane protein [KO:K10189 ]
SCO1065 SCG22.11c; sugar transport sugar binding protein [KO:K10188 ]
SCO1367 SC10A9.09c; ABC transporter ATP-binding protein [KO:K09814 ] [EC:7.6.2.-]
SCO1559 SCL11.15c; ABC transporter ATP-binding protein [KO:K02071 ]
SCO1707 SCI30A.28c; ABC sugar transporter, ATP-binding subunit [KO:K10112 ] [EC:7.5.2.-]
SCO1785 SCI51.25c; iron-siderophore uptake system ATP-binding protein [KO:K23188 ]
SCO1786 SCI51.26c; iron-siderophore uptake system transmembrane protein [KO:K23187 ]
SCO1787 SCI51.27c; iron-siderophore uptake system transmembrane protein [KO:K23186 ]
SCO1899 SCI7.17; integral membrane sugar transport protein [KO:K10228 ]
SCO1900 SCI7.18; integral membrane sugar transport protein [KO:K10229 ]
SCO2008 SC7H2.22; branched-chain amino acid ABC transporter substrate-binding protein [KO:K01999 ]
SCO2009 SC7H2.23; branched-chain amino acid ABC transporter permease [KO:K01997 ]
SCO2010 SC7H2.24; branched-chain amino acid ABC transporter permease [KO:K01998 ]
SCO2011 SC7H2.25; ABC transporter ATP-binding protein [KO:K01995 ]
SCO2012 SC7H2.26; ABC transporter ATP-binding protein [KO:K01996 ]
SCO2257 SCC75A.03; ABC transporter ATP-binding protein [KO:K18232 ]
SCO2405 SC4A7.33; sugar-transport ATP binding protein [KO:K10548 ] [EC:7.5.2.-]
SCO2420 SC8A2.08c; ABC-transporter integral membrane protein [KO:K02066 ]
SCO2421 SCC42.02c; ABC-transporter integral membrane protein [KO:K02066 ]
SCO2422 SCC42.03c; ABC transporter ATP-binding protein [KO:K02065 ]
SCO2505 SCC121.08; ABC-transporter metal-binding lipoprotein [KO:K09815 ]
SCO2795 2SCC13.03; sugar binding hypothetical protein [KO:K10240 ]
SCO2933 SCE19A.33; permease binding-protein component [KO:K05845 ]
SCO2944 SCE59.03c; sugar transporter membrane protein [KO:K17331 ]
SCO2945 SCE59.04c; sugar transporter membrane protein [KO:K17330 ]
SCO2946 SCE59.05c; sugar transporter sugar-binding protein [KO:K17329 ]
SCO2979 SCE50.07; integral membrane transport protein [KO:K10233 ]
SCO2980 SCE50.08; integral membrane transport protein [KO:K10234 ]
SCO3160 SCE87.11; integral membrane transport protein [KO:K02008 ]
SCO3161 SCE87.12; ABC transporter ATP-binding protein [KO:K02006 ]
SCO3704 SCH35.20c; substrate-binding transport protein [KO:K02020 ]
SCO4240 msiK; ABC transporter ATP-binding protein [KO:K10112 ] [EC:7.5.2.-]
SCO4831 SC2A6.16; glycine/betaine ABC transporter integral membrane protein [KO:K02001 ]
SCO4832 SC2A6.17; glycine/betaine-binding lipoprotein [KO:K02002 ]
SCO4886 2SCK8.12; sugar ABC transporter ATP-binding protein [KO:K23537 ]
SCO4887 2SCK8.13; sugar ABC transporter integral membrane protein [KO:K23535 ]
SCO4888 2SCK8.14; sugar ABC transporter integral membrane protein [KO:K23536 ]
SCO5117 SC9E12.02; peptide transport system peptide-binding protein [KO:K15580 ]
SCO5118 SC9E12.03; peptide transport system integral membrane protein [KO:K15581 ]
SCO5119 SC9E12.04; peptide transport system integral membrane protein [KO:K15582 ]
SCO5120 SC9E12.05; peptide transport system ATP-binding protein [KO:K15583 ]
SCO5121 SC9E12.06; peptide transport system ATP-binding protein [KO:K10823 ]
SCO5232 SC7E4.29; sugar transporter sugar binding protein [KO:K17329 ]
SCO5233 SC7E4.30; sugar transporter integral membrane protein [KO:K17330 ]
SCO5234 SC7E4.31; sugar transporter integral membrane protein [KO:K17331 ]
SCO5667 SC8B7.11c; ABC transporter substrate-binding protein [KO:K11069 ]
SCO5669 SC8B7.09c; polyamine ABC-transporter integral memb rane protein [KO:K11071 ]
SCO5670 SC8B7.08c; polyamine ABC-transporter integral memb rane protein [KO:K11070 ]
SCO5687 SC5H4.11; transport system integral membrane protein [KO:K17319 ]
SCO5688 SC5H4.12; transport system integral membrane protein [KO:K17320 ]
SCO5958 cbiO; cobalt transport system ATP binding protein [KO:K02006 ]
SCO5959 cbiQ; cobalt transport integral membrane protein [KO:K02008 ]
SCO6094 SCBAC1A6.18c; transport system integral membrane protein [KO:K15554 ]
SCO6231 SC2H4.13c; sugar transport system sugar-binding lipoprotein [KO:K10117 ]
SCO6816 SC1A2.25c; ABC transporter binding lipoprotein [KO:K02040 ]
SCO7029 SC1H10.18; binding-protein-dependent transport protein [KO:K17327 ]
SCO7030 SC1H10.19; binding-protein-dependent transport protein [KO:K17328 ]
SCO7165 SC9A4.27c; sugar-binding integral membrane transport protein [KO:K10119 ]
SCO7166 SC9A4.28c; sugar-transporter integral membrane protein [KO:K10118 ]
SCO7181 SC8A11.09; ABC transporter ATP-binding protein [KO:K01995 ]
SCO7182 SC8A11.10; ABC transporter ATP-binding protein [KO:K01996 ]
SCO7183 SC8A11.11; branched amino acid transport system permease [KO:K01997 ]
SCO7184 SC8A11.12; branched amino acid transport system permease [KO:K01998 ]
SCO7185 SC8A11.13; branched amino acid binding hypothetical protein [KO:K01999 ]
SCO7398 SC10G8.26c; iron-hydroxamate transporter permease subunit [KO:K23228 ]
SCO7399 SC10G8.27c; binding-protein-dependent transport lipoprotein [KO:K23227 ]
SCO7557 SC5F1.11; sugar transport integral membrane protein [KO:K10242 ]
SCO7689 SC4C2.24; ABC transporter ATP-binding protein [KO:K14698 ] [EC:7.-.-.-]
SCO7690 SC4C2.25; ABC transporter ATP-binding protein [KO:K14699 ] [EC:7.-.-.-]
Compound
C00093 sn-Glycerol 3-phosphate
C01153 Orthophosphoric monoester
C01181 4-Trimethylammoniobutanoate
C01279 4-Amino-5-hydroxymethyl-2-methylpyrimidine
C03557 2-Aminoethylphosphonate
C03611 Galactose oligosaccharide
C03619 Methyl beta-D-galactoside
C04114 (E)-4-(Trimethylammonio)but-2-enoate
C06705 Capsular polysaccharide
C19872 N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570 alpha-1,5-L-Arabinobiose
C20571 alpha-1,5-L-Arabinotriose
C20572 alpha-1,5-L-Arabinotetraose
Reference
Authors
Tomii K, Kanehisa M.
Title
A comparative analysis of ABC transporters in complete microbial genomes.
Journal
Reference
Authors
Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
Title
Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal
Reference
Authors
Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
Title
Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal
Reference
Authors
Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
Title
Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
Journal
Reference
Authors
Quintero MJ, Montesinos ML, Herrero A, Flores E
Title
Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
Journal
Reference
Authors
Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
Title
ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
Journal
Reference
Authors
Valladares A, Montesinos ML, Herrero A, Flores E.
Title
An ABC-type, high-affinity urea permease identified in cyanobacteria.
Journal
Reference
Authors
Richard-Fogal CL, Frawley ER, Kranz RG
Title
Topology and function of CcmD in cytochrome c maturation.
Journal
Reference
Authors
Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
Title
The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
Journal
Reference
Authors
Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
Title
The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
Journal
Reference
Authors
Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
Title
Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
Journal
Reference
Authors
Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
Title
MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
Journal
KO pathway