Entry Name ABC transporters - Salmonella enterica subsp. enterica serovar Typhimurium UK-1
Description The ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of a wide variety of substrates such as ions, sugars, lipids, sterols, peptides, proteins, and drugs. The structure of a prokaryotic ABC transporter usually consists of three components; typically two integral membrane proteins each having six transmembrane segments, two peripheral proteins that bind and hydrolyze ATP, and a periplasmic (or lipoprotein) substrate-binding protein. Many of the genes for the three components form operons as in fact observed in many bacterial and archaeal genomes. On the other hand, in a typical eukaryotic ABC transporter, the membrane spanning protein and the ATP-binding protein are fused, forming a multi-domain protein with the membrane-spanning domain (MSD) and the nucleotide-binding domain (NBD).
Class Environmental Information Processing; Membrane transportBRITE hierarchy
Pathway map Other DBs Organism Salmonella enterica subsp. enterica serovar Typhimurium UK-1 [GN:
sej ]
Gene STMUK_0195 fhuD; iron-hydroxamate transporter substrate-binding subunit [KO:K23227 ]
STMUK_0247 metQ; DL-methionine transporter substrate-binding subunit [KO:K02073 ]
STMUK_0468 mdlA; putative multidrug transporter membrane ATP-binding components [KO:K18889 ]
STMUK_0469 mdlB; putative multidrug transporter membrane ATP-binding components [KO:K18890 ]
STMUK_0517 sfbA; putative ABC-type transport system ATPase component [KO:K02073 ]
STMUK_0518 sfbB; putative ABC-type transport system ATPase component [KO:K02071 ]
STMUK_0599 fepB; iron-enterobactin transporter periplasmic binding protein [KO:K23185 ]
STMUK_0783 modF; putative molybdenum transport ATP-binding protein ModF [KO:K05776 ]
STMUK_0854 yliB; putative ABC transporter periplasmic binding protein [KO:K13889 ]
STMUK_0855 yliC; putative ABC transporter periplasmic binding protein [KO:K13890 ]
STMUK_0883 potF; putrescine transporter subunit: periplasmic-binding component of ABC superfamily [KO:K11073 ]
STMUK_0885 potH; putrescine transporter subunit: membrane component of ABC superfamily [KO:K11075 ]
STMUK_0886 potI; putrescine transporter subunit: membrane component of ABC superfamily [KO:K11074 ]
STMUK_0910 ybjZ; macrolide transporter ATP-binding/permease protein [KO:K05685 ] [EC:7.6.2.-]
STMUK_0924 cydC; cysteine/glutathione ABC transporter membrane/ATP-binding component [KO:K16012 ]
STMUK_0925 cydD; cysteine/glutathione ABC transporter membrane/ATP-binding component [KO:K16013 ]
STMUK_1185 ycfU; outer membrane-specific lipoprotein transporter subunit LolC [KO:K09808 ]
STMUK_1186 lolD; lipoprotein transporter ATP-binding subunit [KO:K09810 ] [EC:7.6.2.-]
STMUK_1187 ycfW; outer membrane-specific lipoprotein transporter subunit LolE [KO:K09808 ]
STMUK_1190 potD; spermidine/putrescine ABC transporter periplasmic substrate-binding protein [KO:K11069 ]
STMUK_1191 potC; spermidine/putrescine ABC transporter membrane protein [KO:K11070 ]
STMUK_1193 potB; spermidine/putrescine ABC transporter membrane protein [KO:K11071 ]
STMUK_1871 yebL; high-affinity zinc transporter periplasmic component [KO:K09815 ]
STMUK_1931 yecS; putative ABC-type amino acid transporter permease component [KO:K10009 ]
STMUK_2192 yehW; putative ABC-type proline/glycine betaine transport system permease component [KO:K05846 ]
STMUK_2193 yehX; putative ABC-type proline/glycine betaine transport system ATPase component [KO:K05847 ] [EC:7.6.2.9 ]
STMUK_2194 yehY; putative ABC-type proline/glycine betaine transport system permease component [KO:K05846 ]
STMUK_2218 mglC; beta-methylgalactoside transporter inner membrane component [KO:K10541 ]
STMUK_2246 yejA; putative ABC transporter periplasmic binding protein [KO:K13893 ]
STMUK_2247 yejB; putative ABC-type dipeptide/oligopeptide/nickel transport system permease [KO:K13894 ]
STMUK_2248 yejE; putative ABC-type dipeptide/oligopeptide/nickel transport system permease component [KO:K13895 ]
STMUK_2249 yejF; putative ABC-type transport system ATPase component [KO:K13896 ]
STMUK_2294 yojI; multidrug transporter membrane component/ATP-binding component [KO:K06159 ]
STMUK_2382 hisM; histidine/lysine/arginine/ornithine transport protein [KO:K10015 ]
STMUK_2383 hisQ; histidine/lysine/arginine/ornithine transport protein [KO:K10016 ]
STMUK_3542 ugpB; glycerol-3-phosphate transporter periplasmic binding protein [KO:K05813 ]
STMUK_3545 livF; leucine/isoleucine/valine transporter ATP-binding subunit [KO:K01996 ]
STMUK_3546 livG; leucine/isoleucine/valine transporter ATP-binding subunit [KO:K01995 ]
STMUK_3547 livM; leucine/isoleucine/valine transporter permease subunit [KO:K01998 ]
STMUK_3548 livH; branched-chain amino acid transporter permease subunit LivH [KO:K01997 ]
STMUK_3549 livK; high-affinity branched-chain amino acid transporter [KO:K01999 ]
STMUK_3552 livJ; high-affinity branched-chain amino acid transporter [KO:K01999 ]
STMUK_3846 pstS; phosphate ABC transporter periplasmic substrate-binding protein PstS [KO:K02040 ]
STMUK_4059 ego; putative ABC-type aldose transport system ATPase component [KO:K10558 ]
STMUK_4215 malK; maltose/maltodextrin transporter ATP-binding protein [KO:K10111 ] [EC:7.5.2.-]
Compound C00093 sn-Glycerol 3-phosphate
C01153 Orthophosphoric monoester
C01181 4-Trimethylammoniobutanoate
C01279 4-Amino-5-hydroxymethyl-2-methylpyrimidine
C03557 2-Aminoethylphosphonate
C03611 Galactose oligosaccharide
C03619 Methyl beta-D-galactoside
C04114 (E)-4-(Trimethylammonio)but-2-enoate
C06705 Capsular polysaccharide
C19872 N-Formyl-4-amino-5-aminomethyl-2-methylpyrimidine
C20570 alpha-1,5-L-Arabinobiose
C20571 alpha-1,5-L-Arabinotriose
C20572 alpha-1,5-L-Arabinotetraose
Reference Authors Tomii K, Kanehisa M.
Title A comparative analysis of ABC transporters in complete microbial genomes.
Journal Reference Authors Sperandeo P, Lau FK, Carpentieri A, De Castro C, Molinaro A, Deho G, Silhavy TJ, Polissi A
Title Functional analysis of the protein machinery required for transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal Reference Authors Ruiz N, Gronenberg LS, Kahne D, Silhavy TJ
Title Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli.
Journal Reference Authors Omata T, Price GD, Badger MR, Okamura M, Gohta S, Ogawa T
Title Identification of an ATP-binding cassette transporter involved in bicarbonate uptake in the cyanobacterium Synechococcus sp. strain PCC 7942.
Journal Reference Authors Quintero MJ, Montesinos ML, Herrero A, Flores E
Title Identification of genes encoding amino acid permeases by inactivation of selected ORFs from the Synechocystis genomic sequence.
Journal Reference Authors Picossi S, Montesinos ML, Pernil R, Lichtle C, Herrero A, Flores E
Title ABC-type neutral amino acid permease N-I is required for optimal diazotrophic growth and is repressed in the heterocysts of Anabaena sp. strain PCC 7120.
Journal Reference Authors Valladares A, Montesinos ML, Herrero A, Flores E.
Title An ABC-type, high-affinity urea permease identified in cyanobacteria.
Journal Reference Authors Richard-Fogal CL, Frawley ER, Kranz RG
Title Topology and function of CcmD in cytochrome c maturation.
Journal Reference Authors Suzuki H, Koyanagi T, Izuka S, Onishi A, Kumagai H
Title The yliA, -B, -C, and -D genes of Escherichia coli K-12 encode a novel glutathione importer with an ATP-binding cassette.
Journal Reference Authors Novikova M, Metlitskaya A, Datsenko K, Kazakov T, Kazakov A, Wanner B, Severinov K
Title The Escherichia coli Yej transporter is required for the uptake of translation inhibitor microcin C.
Journal Reference Authors Tikhonova EB, Devroy VK, Lau SY, Zgurskaya HI
Title Reconstitution of the Escherichia coli macrolide transporter: the periplasmic membrane fusion protein MacA stimulates the ATPase activity of MacB.
Journal Reference Authors Yamanaka H, Kobayashi H, Takahashi E, Okamoto K
Title MacAB is involved in the secretion of Escherichia coli heat-stable enterotoxin II.
Journal KO pathway
