KEGG   PATHWAY: sgf00290
Entry
sgf00290                    Pathway                                
Name
Valine, leucine and isoleucine biosynthesis - Streptomyces griseofuscus
Class
Metabolism; Amino acid metabolism
Pathway map
sgf00290  Valine, leucine and isoleucine biosynthesis
sgf00290

Module
sgf_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:sgf00290]
sgf_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:sgf00290]
sgf_M00570  Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine [PATH:sgf00290]
Other DBs
GO: 0009097 0009098 0009099
Organism
Streptomyces griseofuscus [GN:sgf]
Gene
HEP81_00146  [KO:K14260] [EC:2.6.1.66 2.6.1.2]
HEP81_01635  ilvB; acetolactate synthase I/II/III large subunit [KO:K01652] [EC:2.2.1.6]
HEP81_01646  [KO:K14260] [EC:2.6.1.66 2.6.1.2]
HEP81_01758  [KO:K00826] [EC:2.6.1.42]
HEP81_01768  [KO:K14260] [EC:2.6.1.66 2.6.1.2]
HEP81_02480  leuD; 3-isopropylmalate dehydratase small subunit [KO:K01704] [EC:4.2.1.33 4.2.1.35]
HEP81_02481  leuC; 3-isopropylmalate dehydratase large subunit [KO:K01703] [EC:4.2.1.33 4.2.1.35]
HEP81_02512  [KO:K01649] [EC:2.3.3.13]
HEP81_02520  [KO:K00826] [EC:2.6.1.42]
HEP81_02521  [KO:K00052] [EC:1.1.1.85]
HEP81_02530  [KO:K00053] [EC:1.1.1.86]
HEP81_02531  ilvN; acetolactate synthase small subunit [KO:K01653] [EC:2.2.1.6]
HEP81_02532  [KO:K01652] [EC:2.2.1.6]
HEP81_03005  [KO:K14260] [EC:2.6.1.66 2.6.1.2]
HEP81_03020  [KO:K01754] [EC:4.3.1.19]
HEP81_03493  [KO:K01687] [EC:4.2.1.9]
HEP81_05028  [KO:K01652] [EC:2.2.1.6]
HEP81_05256  leuA; 2-isopropylmalate synthase [KO:K01649] [EC:2.3.3.13]
HEP81_06241  [KO:K00826] [EC:2.6.1.42]
HEP81_07048  [KO:K01754] [EC:4.3.1.19]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00109  2-Oxobutanoate
C00123  L-Leucine
C00141  3-Methyl-2-oxobutanoic acid
C00183  L-Valine
C00188  L-Threonine
C00233  4-Methyl-2-oxopentanoate
C00407  L-Isoleucine
C00671  (S)-3-Methyl-2-oxopentanoic acid
C02226  2-Methylmaleate
C02504  alpha-Isopropylmalate
C02612  (R)-2-Methylmalate
C02631  2-Isopropylmaleate
C04181  3-Hydroxy-3-methyl-2-oxobutanoic acid
C04236  (2S)-2-Isopropyl-3-oxosuccinate
C04272  (R)-2,3-Dihydroxy-3-methylbutanoate
C04411  (2R,3S)-3-Isopropylmalate
C06006  (S)-2-Aceto-2-hydroxybutanoate
C06007  (R)-2,3-Dihydroxy-3-methylpentanoate
C06010  (S)-2-Acetolactate
C06032  D-erythro-3-Methylmalate
C14463  (R)-3-Hydroxy-3-methyl-2-oxopentanoate
Reference
  Authors
Xu H, Zhang Y, Guo X, Ren S, Staempfli AA, Chiao J, Jiang W, Zhao G.
  Title
Isoleucine biosynthesis in Leptospira interrogans serotype lai strain 56601 proceeds via a threonine-independent pathway.
  Journal
J Bacteriol 186:5400-9 (2004)
DOI:10.1128/JB.186.16.5400-5409.2004
Related
pathway
sgf00260  Glycine, serine and threonine metabolism
sgf00280  Valine, leucine and isoleucine degradation
sgf00620  Pyruvate metabolism
KO pathway
ko00290   

DBGET integrated database retrieval system