KEGG   PATHWAY: sil00290
Entry
sil00290                    Pathway                                
Name
Valine, leucine and isoleucine biosynthesis - Ruegeria pomeroyi
Class
Metabolism; Amino acid metabolism
Pathway map
sil00290  Valine, leucine and isoleucine biosynthesis
sil00290

Module
sil_M00019  Valine/isoleucine biosynthesis, pyruvate => valine / 2-oxobutanoate => isoleucine [PATH:sil00290]
sil_M00432  Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate [PATH:sil00290]
sil_M00570  Isoleucine biosynthesis, threonine => 2-oxobutanoate => isoleucine [PATH:sil00290]
Other DBs
GO: 0009097 0009098 0009099
Organism
Ruegeria pomeroyi [GN:sil]
Gene
SPO3341  pyridoxal-phosphate dependent enzyme family protein [KO:K01754] [EC:4.3.1.19]
SPOA0435  pyridoxal-phosphate dependent enzyme [KO:K01754] [EC:4.3.1.19]
SPO1142  threonine dehydratase, putative [KO:K01754] [EC:4.3.1.19]
SPO0020  ilvA; threonine dehydratase [KO:K01754] [EC:4.3.1.19]
SPOA0145  pyridoxal-phosphate dependent enzyme [KO:K01754] [EC:4.3.1.19]
SPO0216  leuC-1; 3-isopropylmalate dehydratase, large subunit [KO:K01703] [EC:4.2.1.33 4.2.1.35]
SPO1476  leuC-2; 3-isopropylmalate dehydratase, large subunit [KO:K01703] [EC:4.2.1.33 4.2.1.35]
SPO0215  leuD-1; 3-isopropylmalate dehydratase, small subunit [KO:K01704] [EC:4.2.1.33 4.2.1.35]
SPO1477  leuD-2; 3-isopropylmalate dehydratase, small subunit [KO:K01704] [EC:4.2.1.33 4.2.1.35]
SPO0210  leuB; 3-isopropylmalate dehydrogenase [KO:K00052] [EC:1.1.1.85]
SPO2578  ilvB; acetolactate synthase, large subunit, biosynthetic type [KO:K01652] [EC:2.2.1.6]
SPO2883  thiamine pyrophosphate-binding domain protein [KO:K01652] [EC:2.2.1.6]
SPO2885  acetolactate synthase, catabolic, putative [KO:K01652] [EC:2.2.1.6]
SPOA0065  thiamine pyrophosphate-dependent enzyme [KO:K01652] [EC:2.2.1.6]
SPOA0418  acetolactate synthase, large subunit, putative [KO:K01652] [EC:2.2.1.6]
SPO2385  benzaldehyde lyase, putative [KO:K01652] [EC:2.2.1.6]
SPO2579  ilvN; acetolactate synthase, small subunit [KO:K01653] [EC:2.2.1.6]
SPO1366  ilvC; ketol-acid reductoisomerase [KO:K00053] [EC:1.1.1.86]
SPO3314  ilvD; dihydroxy-acid dehydratase [KO:K01687] [EC:4.2.1.9]
SPO0388  aminotransferase, class IV [KO:K00826] [EC:2.6.1.42]
SPO0253  ilvE; branched-chain amino acid aminotransferase [KO:K00826] [EC:2.6.1.42]
SPOA0291  branched-chain amino acid aminotransferase, putative [KO:K00826] [EC:2.6.1.42]
SPO0390  glutamate/leucine/phenylalanine/valine dehydrogenase family protein [KO:K00263] [EC:1.4.1.9]
SPO2130  2-isopropylmalate synthase/homocitrate synthase family protein [KO:K01649] [EC:2.3.3.13]
SPO0422  leuA; 2-isopropylmalate synthase [KO:K01649] [EC:2.3.3.13]
Compound
C00022  Pyruvate
C00024  Acetyl-CoA
C00109  2-Oxobutanoate
C00123  L-Leucine
C00141  3-Methyl-2-oxobutanoic acid
C00183  L-Valine
C00188  L-Threonine
C00233  4-Methyl-2-oxopentanoate
C00407  L-Isoleucine
C00671  (S)-3-Methyl-2-oxopentanoic acid
C02226  2-Methylmaleate
C02504  alpha-Isopropylmalate
C02612  (R)-2-Methylmalate
C02631  2-Isopropylmaleate
C04181  3-Hydroxy-3-methyl-2-oxobutanoic acid
C04236  (2S)-2-Isopropyl-3-oxosuccinate
C04272  (R)-2,3-Dihydroxy-3-methylbutanoate
C04411  (2R,3S)-3-Isopropylmalate
C06006  (S)-2-Aceto-2-hydroxybutanoate
C06007  (R)-2,3-Dihydroxy-3-methylpentanoate
C06010  (S)-2-Acetolactate
C06032  D-erythro-3-Methylmalate
C14463  (R)-3-Hydroxy-3-methyl-2-oxopentanoate
Reference
PMID:15292141
  Authors
Xu H, Zhang Y, Guo X, Ren S, Staempfli AA, Chiao J, Jiang W, Zhao G.
  Title
Isoleucine biosynthesis in Leptospira interrogans serotype lai strain 56601 proceeds via a threonine-independent pathway.
  Journal
J Bacteriol 186:5400-9 (2004)
DOI:10.1128/JB.186.16.5400-5409.2004
Related
pathway
sil00260  Glycine, serine and threonine metabolism
sil00280  Valine, leucine and isoleucine degradation
sil00620  Pyruvate metabolism
KO pathway
ko00290   
LinkDB

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