KEGG   PATHWAY: spin03440
Entry
spin03440                   Pathway                                
Name
Homologous recombination - Skermania pinensis
Description
Homologous recombination (HR) is essential for the accurate repair of DNA double-strand breaks (DSBs), potentially lethal lesions. HR takes place in the late S-G2 phase of the cell cycle and involves the generation of a single-stranded region of DNA, followed by strand invasion, formation of a Holliday junction, DNA synthesis using the intact strand as a template, branch migration and resolution. It is investigated that RecA/Rad51 family proteins play a central role. The breast cancer susceptibility protein Brca2 and the RecQ helicase BLM (Bloom syndrome mutated) are tumor suppressors that maintain genome integrity, at least in part, through HR.
Class
Genetic Information Processing; Replication and repair
Pathway map
spin03440  Homologous recombination
spin03440

Other DBs
GO: 0000724
Organism
Skermania pinensis [GN:spin]
Gene
KV203_00010  dnaN; DNA polymerase III subunit beta [KO:K02338] [EC:2.7.7.7]
KV203_00015  recF; DNA replication/repair protein RecF [KO:K03629]
KV203_01440  [KO:K02343] [EC:2.7.7.7]
KV203_01495  recR; recombination mediator RecR [KO:K06187]
KV203_01870  [KO:K02341] [EC:2.7.7.7]
KV203_05705  [KO:K02342] [EC:2.7.7.7]
KV203_06035  holA; DNA polymerase III subunit delta [KO:K02340] [EC:2.7.7.7]
KV203_06195  recO; DNA repair protein RecO [KO:K03584]
KV203_06850  [KO:K02342] [EC:2.7.7.7]
KV203_07170  dnaE; DNA polymerase III subunit alpha [KO:K02337] [EC:2.7.7.7]
KV203_07370  recA; recombinase RecA [KO:K03553]
KV203_08955  ruvC; crossover junction endodeoxyribonuclease RuvC [KO:K01159] [EC:3.1.21.10]
KV203_08960  ruvA; Holliday junction branch migration protein RuvA [KO:K03550]
KV203_08965  ruvB; Holliday junction branch migration DNA helicase RuvB [KO:K03551] [EC:5.6.2.4]
KV203_09305  [KO:K04066] [EC:5.6.2.4]
KV203_10575  recD; exodeoxyribonuclease V subunit alpha [KO:K03581] [EC:3.1.11.5]
KV203_10580  [KO:K03582] [EC:3.1.11.5]
KV203_10585  recC; exodeoxyribonuclease V subunit gamma [KO:K03583] [EC:3.1.11.5]
KV203_11410  polA; DNA polymerase I [KO:K02335] [EC:2.7.7.7]
KV203_12315  recG; ATP-dependent DNA helicase RecG [KO:K03655] [EC:5.6.2.4]
KV203_13320  [KO:K03111]
KV203_14260  [KO:K03111]
KV203_18125  [KO:K03111]
Reference
  Authors
Maloisel L, Fabre F, Gangloff S.
  Title
DNA polymerase delta is preferentially recruited during homologous recombination to promote heteroduplex DNA extension.
  Journal
Mol Cell Biol 28:1373-82 (2008)
DOI:10.1128/MCB.01651-07
Reference
  Authors
Haruta-Takahashi N, Iwasaki H.
  Title
[Recombination mediators]
  Journal
Seikagaku 79:449-53 (2007)
Reference
  Authors
Ouyang KJ, Woo LL, Ellis NA.
  Title
Homologous recombination and maintenance of genome integrity: Cancer and aging through the prism of human RecQ helicases.
  Journal
Mech Ageing Dev 129:425-40 (2008)
DOI:10.1016/j.mad.2008.03.003
Reference
  Authors
Kawabata M, Kawabata T, Nishibori M.
  Title
Role of recA/RAD51 family proteins in mammals.
  Journal
Acta Med Okayama 59:1-9 (2005)
DOI:10.18926/AMO/31987
Reference
  Authors
Prado F, Cortes-Ledesma F, Huertas P, Aguilera A.
  Title
Mitotic recombination in Saccharomyces cerevisiae.
  Journal
Curr Genet 42:185-98 (2003)
DOI:10.1007/s00294-002-0346-3
Reference
  Authors
Heyer WD, Li X, Rolfsmeier M, Zhang XP.
  Title
Rad54: the Swiss Army knife of homologous recombination?
  Journal
Nucleic Acids Res 34:4115-25 (2006)
DOI:10.1093/nar/gkl481
Reference
  Authors
Michel B, Boubakri H, Baharoglu Z, LeMasson M, Lestini R.
  Title
Recombination proteins and rescue of arrested replication forks.
  Journal
DNA Repair (Amst) 6:967-80 (2007)
DOI:10.1016/j.dnarep.2007.02.016
KO pathway
ko03440   

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